Current Neurodegenerative Disease News and Events

Current Neurodegenerative Disease News and Events, Neurodegenerative Disease News Articles.
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Basic cell health systems wear down in Huntington's disease, novel analysis shows
A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis. The ''Geomic'' approach can be applied to other diseases, authors say. (2021-02-23)

New therapeutic target for Huntington's treatment
Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations. The origin of this disease has been associated with the anomalous functioning of the mutated protein: mHTT, but recent data showed the involvement of other molecular mechanisms. (2021-02-23)

'Walking' molecule superstructures could help create neurons for regenerative medicine
By discovering a new printable biomaterial that can mimic properties of brain tissue, Northwestern University researchers are now closer to developing a platform capable of conditions using regenerative medicine. (2021-02-22)

Prion diseases: new clues in the structure of prion proteins
A new study carried out by SISSA - Scuola Internazionale Superiore di Studi Avanzati in collaboration with other institutions including Genos Glycoscience. Research Laboratory from Zagreb, Croatia and Elettra Sincrotrone Trieste, provides important information on the differences in structures of the prions, proteins responsible for diseases that at the state of the art are incurable. (2021-02-19)

Differences in walking patterns could predict type of cognitive decline in older adults
Canadian researchers are the first to study how different patterns in the way older adults walk could more accurately diagnose different types of dementia and identify Alzheimer's disease. (2021-02-16)

Genetic study of Lewy body dementia supports ties to Alzheimer's and Parkinson's diseases
In a study led by National Institutes of Health (NIH) researchers, scientists found that five genes may play a critical role in determining whether a person will suffer from Lewy body dementia, a devastating disorder that riddles the brain with clumps of abnormal protein deposits called Lewy bodies. The results also supported the disorder's ties to Parkinson's and Alzheimer diseases. (2021-02-16)

Function identified of 'mystery protein' that kills brain cells of people with Parkinson's
Scientists have made a 'vital step' towards understanding the origins of Parkinson's Disease - the fastest growing neurological condition in the world. A study published in Nature Communications today (Wednesday 10 February) presents a compelling new evidence about what a key protein called alpha-synuclein actually does in neurons in the brain. (2021-02-10)

CWRU researchers uncover biochemical rules between RNA-protein interactions and expr
A team of Case Western Reserve University researchers has found a way to measure key characteristics of proteins that bind to RNA in cells--a discovery that could improve our understanding of how gene function is disturbed in cancer, neurodegenerative disorders or infections. (2021-02-10)

Supersaturation: The barrier between protein folding and misfolding
It's commonly accepted that protein folding/misfolding are alternative reactions of unfolded proteins but the principles governing this remain unknown. Here, researchers from Osaka University describe a general concept that links protein folding and misfolding: protein folding and amyloid formation are separated by the supersaturation barrier of a denatured protein. Breakdown of this supersaturation barrier is required to shift the protein to the amyloid pathway, linking Anfinsen's intramolecular folding universe with the ''outer'' intermolecular misfolding universe. (2021-02-01)

New discovery for how the brain 'tangles' in Alzheimer's Disease
University of Queensland researchers have discovered a new 'seeding' process in brain cells that could be a cause of dementia and Alzheimer's disease. (2021-02-01)

Deep sleep takes out the trash
By examining fruit flies' brain activity and behavior, the researchers found that deep sleep has an ancient, restorative power to clear waste from the brain. This waste potentially includes toxic proteins that may lead to neurodegenerative disease. (2021-01-20)

Different types of neurons interact to make reaching-and-grasping tasks possible
Picking up that cup of coffee? New research from the Okinawa Institute of Science and Technology Graduate University finds that one type of neuron is necessary for the early part of the movement, another for aiming for the cup. (2021-01-19)

Parkinson's: Initial steps to show nerves their growth direction magnetically
One reason why nerve damage in the brain cannot regenerate easily is that the neurites do not know in which direction they should grow. A team of researchers from Ruhr-Universität Bochum (RUB), Sorbonne University Paris, and the Technische Universität Braunschweig is now working on showing them the direction using magnetic nanoparticles. (2021-01-18)

COVID-19 has multiple faces
Scientists from the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have found that COVID-19 comprises at least five different variants. These differ in how the immune system responds to the infection. (2021-01-18)

Increased risk of Parkinson's disease in patients with schizophrenia
A new study conducted at the University of Turku, Finland, shows that patients with a schizophrenia spectrum disorder have an increased risk of Parkinson's disease later in life. The increased risk may be due to alterations in the brain's dopamine system caused by dopamine receptor antagonists or neurobiological effects of schizophrenia. (2021-01-15)

USC study measures brain volume differences in people with HIV
With access to treatment, HIV has become a lifelong chronic condition for the majority of 38 million people living with it. Understanding how it affects the brain over time is increasingly important for improving both treatment and quality of life. A new study of brain scans of 1,203 HIV-infected adults across 5 continents found that with people with lower white blood cell counts also had less brain volume in the hippocampus and thalamus. (2021-01-15)

MicroRNA may serve as therapeutic targets for traumatic brain injury
WRAIR scientists have shown that traumatic brain injury causes coordinated microRNA dysregulation followed by increased amounts of the beta-site amyloid cleaving enzyme, or BACE1, and loss of amyloid precursor protein. BACE-1 cleaves APP to generate amyloid beta peptides, a hallmark of neurodegenerative disease pathology and brain cells loss, which are the focus of several clinical trials for Alzheimer's disease. Future research will characterize the direct role of miRNAs and their relationship to BACE1 within TBI. (2021-01-14)

Toadlet peptide transforms into a deadly weapon against bacteria
Researchers at the Technion - Israel Institute of Technology and the European Molecular Biology Laboratory in Hamburg have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of novel synthetic drugs to combat bacterial infections (2021-01-14)

New molecular structures associated with ALS
Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of the disease, as well as to propose new solutions to curb it. (2021-01-13)

Scientists discover mutations associated with early onset dementia
Scientists at Trinity College Dublin today announced a significant advance in our understanding of an early onset form of dementia that may also progress our understanding of conditions such as Alzheimer's disease. Adult onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition that manifests initially with psychiatric and behavioural changes in patients followed by a rapid progression of dementia in the third or fourth decade of life. (2020-12-22)

Brain stem cells divide over months
For the first time, scientists at the University of Zurich have been able to observe the way stem cells in the adult brains of mice divide over the course of months to create new nerve cells. Their study shows that brain stem cells are active over a long period, and thus provides new insights that will feed into stem cell research. (2020-12-21)

Alzheimer's disease: regulating copper in the brain stops memory loss among mice
Alzheimer's disease is characterized by the presence of amyloid plaques1 in the patient's brain. These plaques sequester copper, and contain approximately five times as much as a healthy brain. Two CNRS scientists from the Coordination Chemistry Laboratory recently developed, with their colleagues from the Guangdong University of Technology and Shenzhen University (China), a molecule that regulates the circulation of copper in the brain. (2020-12-17)

Additional analyses of pridopidine for HD
Positive results from additional analyses of PRIDE-HD and Open-HART trials with pridopidine published in peer-reviewed journal, The Journal of Huntington's Disease. Exploratory additional efficacy data show pridopidine (45 mg bid) to be first drug to exert a significant and clinically meaningful beneficial effect on Total Functional Capacity. Results from Open-HART trial demonstrate potential durability of effect of pridopidine with less TFC decline over 5 years compared to historical placebo group, as well as positive safety and tolerability data. (2020-12-16)

Two-year study details dynamics of Huntington's disease markers in patients
A new two-year longitudinal study reveals how two proteins linked to Huntington's disease - an incurable neurodegenerative disorder - change over time in patients and in as-yet asymptomatic people who carry a mutation that causes the condition. (2020-12-16)

Researchers discover clue to how to protect neurons and encourage their growth
Researchers have identified a family of enzymes whose inhibition both protects neurons and encourages their growth, a pathway to potential new treatments for neurodegenerative diseases from Alzheimer's to glaucoma. (2020-12-14)

Development of the first biohybrid artificial retina built with silk fibroin and retinal cells.
An international research led by the Complutense University of Madrid has taken a further step to solve Age-related Macular Degeneration (AMD)-derived blidness problem with the development of the first biohybrid artificial retina built with silk fibroin and retinal cells. (2020-12-11)

Researchers identify an action mechanism for a drug against Alzheimer' disease
A study conducted on mice published in the journalGeroscience has identified the action mechanism of a promising compound against Alzheimer's disease, developed by the team of Medical Chemistry and Pharmacology at the University of Barcelona. The new drug belongs to a family of molecules that, when bound to imidazole I2 receptors, these cause a reduction in neuroinflammation and an improvement in cognition and other markers of the progression of this disease, the most prevalent among dementias. (2020-12-09)

Way to support effective brain performance after head injury backgrounded by lack of sleep
Scientists from the School of Biomedicine of Far Eastern Federal University (FEFU) with colleagues from Italy, Spain, Romania, and Sweden suggest a way to protect the brain and minimize neurodegenerative processes after concussion head injuries in the presence of extensive previous sleep deprivation. This methodology is especially important given the retirement-age increase that has recently become an international trend. A related article appears in the Progress in Brain Research journal. (2020-12-08)

Reductive stress in neuroblastoma cells aggregates protein and impairs neurogenesis
Cells require a balance among oxidation-reduction reactions, or redox homeostasis. Loss of that balance to create oxidative stress is often associated with neurodegeneration. Less is known about how loss of that balance at the other end of the spectrum -- reductive stress -- may affect neurons. Now researchers show for the first time that reductive stress promotes protein aggregation in neuroblastoma cells and impairs neurogenesis. (2020-12-08)

Radicals seem to be good for the brain
Scientists of the German Center for Neurodegenerative Diseases (DZNE) report in the journal Cell Stem Cell that reactive oxygen molecules, also known as 'free radicals.' are important for the brain's ability to adapt -- at least in mice. (2020-12-04)

New pathway in Alzheimer's disease provides earlier target for potential therapies
A novel Alzheimer's disease marker--coming early in progression of the condition--could open significant new fronts of research into possible therapies (2020-12-04)

New childhood dementia insight
Is the eye a window to the brain in Sanfilippo syndrome, an untreatable form of childhood-onset dementia, Australian researchers ask in a new publication. The findings of the NHMRC-funded project, just published in international journal Acta Neuropathologica Communications, highlight the potential for using widely available retinal imaging techniques to learn more about brain disease and monitor treatment efficacy. (2020-12-01)

Study identifies novel mechanisms that cause protein clumping in brain diseases
A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer's disease and several other neurodegenerative disorders. (2020-12-01)

World's first: Drug guides stem cells to desired location, improving their ability to heal
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy--a scientific first and major advance for the field of regenerative medicine. (2020-11-24)

Trinity researchers discover how the brain 're-wires' after disease
Trinity College researchers are studying how the brain re-wires itself in neurological disease. The team is building treatments for today's more common global conditions like Motor Neurone Disease (MND/ALS) and Spinal Muscular Atrophy and their findings could impact rehabilitation for patients, the discovery of effective drugs and quantifying the potential efficacy of new therapies. (2020-11-24)

Can we harness a plant's ability to synthesize medicinal compounds?
Anthraquinones are a class of naturally occurring compounds prized for their medicinal properties, as well as for other applications, including ecologically friendly dyes. Despite wide interest, the mechanism by which plants produce them has remained shrouded in mystery until now. New work reveals a gene responsible for anthraquinone synthesis in plants. Their findings could help scientists cultivate a plant-based mechanism for harvesting these useful compounds in bulk quantities. (2020-11-24)

Dormant threat: Abnormal proteins unleash latent toxicity in neurodegenerative diseases
Though neurodegenerative diseases are becoming more common in today's aging societies, the exact way in which accumulated abnormal proteins become toxic to neurons is unknown. In a recent study conducted at Daegu Gyeongbuk Institute of Science and Technology, Korea, scientists have discovered a new mechanism of action by which these abnormal proteins actually unlock the normally latent toxicity of native proteins. Their results represent a completely new avenue toward the development of effective therapies. (2020-11-20)

Taking out the trash is essential for brain health
Researchers at Tokyo Medical and Dental University (TMDU) have identified a protein called Wipi3 that is essential for cellular waste disposal via the alternative autophagy system. Deletion of Wipi3 in the brains of mice causes growth and motor defects attributed to neuronal accumulation of iron, resulting in neurodegeneration. However, over-expression of another alternative autophagy protein, Dram1, reverses the effects in Wipi3 deficiency, and may represent a novel treatment for neurodegenerative diseases. (2020-11-19)

CLCN6 identified as disease gene for a severe form of lysosomal neurodegenerative disease
A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder. Scientists from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Max Delbrück Center für Molekulare Medizin (MDC), together with an international team of researchers, have now analyzed the effect of a point mutation that was found in three unrelated affected children. (2020-11-19)

Compound for Alzheimer's combats bacterial resistance to last-resort antibiotics in mice
An experimental drug for neurodegenerative diseases can also reverse resistance to ''last-resort'' polymyxin antibiotics among bacteria that cause sepsis, a life-threatening complication from infections. (2020-11-18)

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