Current Neurodegenerative Diseases News and Events | Page 25

Current Neurodegenerative Diseases News and Events, Neurodegenerative Diseases News Articles.
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New technique targets gene that causes neurodegenerative disease
Neuroscientists at the University of Chicago studying a unique gene that expresses two proteins, one that is necessary for life and another, that when mutated causes a neurodegenerative disease called spinocerebellar ataxia type 6, have developed a technique to selectively block the disease-causing protein without affecting the other. (2016-07-13)

Shedding new light on protein aggregates and the diseases they cause
Researchers from the Massachusetts Institute of Technology and Boston University have developed a system capable of quickly screening millions of yeast cells to measure protein aggregates. Proteins regulate all of the processes that keep cells alive, but when misfolded they can clump into large aggregations, a phenomenon associated with diseases including Alzheimer's, Huntington's and Parkinson's. (2016-07-13)

Power up: growing neurons undergo major metabolic shift
A new understanding of how developing brain cells come to rely on oxygen may inform the treatment of brain diseases. (2016-07-12)

Study: Cancer drug restores brain dopamine, reduces toxic proteins in Parkinson's, dementia
A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson's disease or dementia with Lewy bodies. (2016-07-11)

Resilience affects whether childhood trauma results in harmful gene response
In a first-ever study to identify how trauma affects gene expression among child soldiers, a Duke researcher and colleagues found resilience to be a key factor in determining individual response at the molecular level. (2016-07-11)

Is traumatic brain injury associated with late-life neurodegenerative conditions?
Traumatic brain injury (TBI) with loss of consciousness was not associated with late-life mild cognitive impairment, Alzheimer disease or dementia but it appeared to be associated with increased risk for other neurodegenerative and neuropathologic findings, according to a new article published online by JAMA Neurology. (2016-07-11)

Cells send out stop signs
Signaling molecules can make neuronal extensions retract at a distance. (2016-07-06)

Some genetic causes of ALS may need an epigenetic trigger to activate the disease
A new research report appearing online in The FASEB Journal ( shows why, for some people, having a genetic predisposition to amyotrophic lateral sclerosis may not be enough to actually guarantee having the disease. (2016-07-05)

Iowa State researchers describe copper-induced misfolding of prion proteins
Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins. The researchers also found the copper-induced misfolding and clumping is associated with inflammation and damage to nerve cells in brain tissue from a mouse model. The findings were published today in the journal Science Advances. (2016-07-01)

Researchers discover powerful defense against free radicals that cause aging, disease
Free radicals cause cell damage and death, aging and disease, and scientists have sought new ways to repel them for years. (2016-06-30)

Treating diseases at their origin
Hokkaido University scientists are getting closer to understanding the function of a protein involved in vital cellular processes. This may lead to the discovery of drugs that can treat some cancers and autoimmune disorders. (2016-06-30)

The RNA that snips and stitches RNA
A SISSA/CNR-IOM Democritos study carried out in collaboration with the École Polytechnique Fédérale de Lausanne (EPFL) gives a detailed account of the RNA splicing process, so far totally unknown. The mechanism is thought to be similar to that of the human spliceosome whose malfunctioning can lead to several diseases among which neurodegeneration and cancer. The study has been published in the Journal of the American Chemical Society. (2016-06-30)

Pilot study tests possible diagnostic tools for amyotrophic lateral sclerosis
New animal research has shown that measuring copper concentrations and isotope ratios in blood and other tissue may allow early diagnosis of amyotrophic lateral sclerosis (ALS -- also known as Motor Neuron Disease). At present, there is no test for this disease, meaning that the illness needs to develop before care can begin. The work is being presented at the Goldschmidt conference in Yokohama, Japan. (2016-06-28)

UGR researchers conduct Parkinson's screening to improve early and differential diagnosis
Scientists at the University of Granada, in collaboration with the Virgen de las Nieves and San Cecilio hospitals and University College London, have identified eleven pathogenic mutations in various genes involved in the disease. (2016-06-28)

Coprescribing naloxone with opioids for pain may reduce adverse events
Naloxone, a fast-acting medication used to block the effects of opioids, can be successfully coprescribed to patients receiving opioid analgesics for chronic pain in primary care. (2016-06-27)

Yumanity Therapeutics and the NYSCF Research Institute announce discovery collaboration
Yumanity Therapeutics today announced a discovery collaboration with the New York Stem Cell Foundation Research Institute to generate induced pluripotent stem cell Yumanity Therapeutics and the NYSCF Research Institute announce discovery collaborationlines for use in support of Yumanity Therapeutics' discovery efforts focused on new medicines for neurodegenerative diseases. (2016-06-22)

Get a clue: Biochemist studies fruit fly to understand Parkinson's disease, muscle wasting
By studying the fruit fly, Kansas State University researchers have found a connection between a gene called clueless and genes that cause Parkinson's disease. (2016-06-22)

New gene therapy strategies emerging to combat vision loss
Diseases of the eye that cause vision loss and blindness, especially neurodegenerative disorders affecting the retina, are ideal targets for gene therapy, including gene replacement and promising corrective gene editing strategies. A comprehensive Review article providing an overview of emerging therapeutic approaches and innovative gene delivery and gene editing tools to treat ocular diseases is published in Human Gene Therapy. (2016-06-22)

Pre and post testing show reversal of memory loss from Alzheimer's disease in 10 patients
A small trial of 10 patients using a personalized systems approach to memory disorders shows an unprecedented reversal of memory loss in those diagnosed with early stage Alzheimers. Pre and post results are based on quantitative MRI and neuropsychological testing. The study, coming from the Buck Institute and UCLA, is based on a protocol dubbed 'metabolic enhancement for neurodegeneration.' (2016-06-16)

Cause of heart arrhythmia in adult muscular dystrophy clarified
An international joint research group found that the cause of heart arrhythmia in myotonic dystrophy was RNA abnormalities in the sodium channel in the heart, clarifying the symptom's mechanism. This finding will be helpful in prevention and early intervention of death in this disease, leading to the development of new treatment. (2016-06-15)

SNMMI Image of the Year: Novel PET imaging shows tau buildup link to neurodegeneration
Positron emission tomography with three different radiotracers can now measure amyloid plaques, tau tangles and metabolic activity in the brains of living Alzheimer's patients. This multimodal study shows significant correlation between increased tau and decreased metabolic activity in the brain -- a clear sign of neurodegeneration -- reveal researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. (2016-06-15)

Mayo Clinic neuropathologist awarded international professional society's highest honor
Dennis W. Dickson, M.D., a neuropathologist at Mayo Clinic's campus in Florida, will receive the highest honor bestowed by the American Association of Neuropathologists, an international society of physicians and scientists who study, diagnose and treat diseases related to the brain, nerves and muscles. (2016-06-14)

PET points to tau protein as leading culprit in Alzheimer's
Alzheimer's is a devastating and incurable disease marked by beta-amyloid and tau protein aggregations in the brain, yet the direct relationship between these proteins and neurodegeneration has remained a mystery. New molecular imaging research is revealing how tau, rather than amyloid-deposition, may be more directly instigating neuronal dysfunction, say presenters at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). (2016-06-13)

PET detects neuroinflammation in multiple sclerosis
The triggers of autoimmune inflammation in multiple sclerosis (MS) have eluded scientists for many years, but molecular imaging is bringing researchers closer to identifying them, while providing a means of evaluating next-generation therapies for MS, say researchers introducing a study at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. (2016-06-12)

Copper essential for burning fat, researchers find
UC Berkeley and Berkeley Lab researchers found that copper is essential to breaking down fat into smaller lipids that can circulate in the blood and be burned for energy. Copper blocks a blocker of fat burning. The discovery suggests that copper deficiency could contribute to obesity or diabetes, since the American diet is low in copper-rich foods such as leafy vegetables and beans. Recent experiments also show the metal's key role in the nervous system. (2016-06-10)

A new biomarker for nerve cell damage
Scientists at the German Center for Neurodegenerative Diseases, the Hertie Institute for Clinical Brain Research and the University of Tübingen have identified proteins in the blood and cerebrospinal fluid that reflect nerve cell damage. The results of the study, published in the journal Neuron, suggest that the concentration of these 'neurofilament light chain proteins' could provide information about the progression of neurodegenerative diseases and the effects of treatment. Such a biomarker would be valuable for developing therapies. (2016-06-09)

Metabolite of multiple sclerosis drug could be safe, effective therapy for Parkinson's disease
The metabolite of a drug that is helping patients battle multiple sclerosis appears to significantly slow the onset of Parkinson's disease, researchers say. (2016-06-08)

Pitt researchers find key to Parkinson's disease neurodegeneration
Researchers at the University of Pittsburgh School of Medicine have uncovered a major reason why the Parkinson's-related protein alpha-synuclein, a major constituent of the Lewy bodies that are the pathological hallmark of Parkinson's disease (PD), is toxic to neurons in the brain. The finding has the potential to lead to new therapies that could slow or stop progression of the devastating illness. The new research appears online today in Science Translational Medicine. (2016-06-08)

Cell transplants may alleviate Huntington's disease
New research from the University of Copenhagen reveals that the glia cells in the brain could be the key to the cure of the serious neurological disease Huntington's disease. The results may be of great importance to future treatment of neurological diseases. (2016-06-07)

Gene TMEM230 suggests a novel mechanism for Parkinson's disease
TMEM230 is the first gene associated with Parkinson's disease that has been linked to the trafficking of vesicles that carry neurotransmitters between neurons and therefore illuminates a possible mechanism to explain the disease. (2016-06-06)

IU-led brain study suggests new ways to protect against neurodegeneration
A study published June 2 in the journal PLOS Biology led by biomedical researchers at Indiana University has found evidence that an enzyme known as NMNAT2 may help protect against the debilitating effects of certain degenerative brain diseases, including Alzheimer's. (2016-06-02)

Dietary supplement may prevent and reverse severe damage to aging brain, research suggests
A dietary supplement containing a blend of 30 vitamins and minerals -- all natural ingredients widely available in health food stores -- has shown remarkable anti-aging properties that can prevent and even reverse massive brain cell loss, according to new research from McMaster University. It's a mixture scientists believe could someday slow the progress of catastrophic neurological diseases such as Alzheimer's, ALS and Parkinson's. (2016-06-02)

Moonlighting enzyme protects against degenerative brain disease
In a study publishing in PLOS Biology this week, Yousuf Ali, Hui-Chen Lu, and colleagues at Indiana University have found evidence that an enzyme known as NMNAT2 may help protect against the debilitating effects of certain degenerative brain diseases, including Alzheimer's. These conditions, called proteinopathies, occur when proteins do not fold into their normal and functional 3D structure but 'mis-fold', causing them to grow 'sticky' and clump up in the brain in a form often referred to as 'plaques.' (2016-06-02)

Differences in how ALS affects eye and limb muscles act as clue
In an effort to better understand what happens during Amyotrophic Lateral Sclerosis (ALS), researchers at Umea University in Sweden have compared the impact of ALS on the eye and limb muscles. They have focused on specific proteins that are important for muscle-nerve contacts. The eye muscles appear to be better equipped to maintain their muscle-nerve contacts and are thereby less affected. (2016-06-02)

Buck researchers identify new 'druggable' target for sporadic Parkinson's disease
Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson's disease are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally. The research identifies new targets that show promise for drug development for an incurable condition that affects as many as one million Americans. (2016-06-01)

Ancient anti-inflammatory drug salicylic acid has cancer-fighting properties
Scientists from the Gladstone Institutes have identified a new pathway by which salicylic acid -- a key compound in the nonsteroidal anti-inflammatory drugs aspirin and diflunisal -- stops inflammation and tumor growth in cancer. Both salicylic acid and diflunisal suppress two key proteins that help control gene expression throughout the body. By inhibiting these proteins, the two drugs block the activation of other proteins involved in inflammation and cell growth, including one linked to leukemia. (2016-05-31)

Identification of the action mechanism of a protein impacting neural circuit development
Research by Dr. Shernaz Bamji at the University of British Columbia uncovers the action mechanism of an enzyme called DHHC9 in normal development and function of neural networks in the brain. Mutations in DHHC9 have been identified in patients suffering from X-linked Intellectual Disability. Dr. Bamji's work shows DHHC9 plays a vital role in promoting the growth and branching of neurons and in maintaining the balance between excitatory and inhibitory signals being formed onto neurons. (2016-05-30)

Researchers show the transmission of the genetic disorder HD in normal animals
Mice transplanted with cells grown from a patient suffering from Huntington's disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada. (2016-05-30)

How prions kill neurons: New culture system shows early toxicity to dendritic spines
Prion diseases are fatal and incurable neurodegenerative conditions of humans and animals. Yet, how prions kill nerve cells (or neurons) remains unclear. A study published on May 26, 2016 in PLOS Pathogens describes a system in which to study the early assault by prions on brain cells of the infected host. (2016-05-26)

Progranulin and dementia -- a blood sample does not tell the full story!
The key neurodegeneration protein progranulin is regulated differently in cerebrospinal fluid than in serum. (2016-05-25)

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