Current Neuropeptides News and Events

Current Neuropeptides News and Events, Neuropeptides News Articles.
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Biodegradable microcapsules deliver nerve growth factor to guide neuronal development
Researchers from Skoltech and their colleagues have demonstrated that nanoengineered biodegradable microcapsules can guide the development of hippocampal neurons in an in vitro experiment. The microcapsules deliver nerve growth factor, a peptide necessary for neuron growth. (2021-02-16)

Using Nature's strategies in the development of new drugs
Dimerization of the human neuropeptides oxytocin and vasopressin can produce new types of bioactive molecules. Such new constructs provide several opportunities to optimize the efficacy of these neuropeptides for therapeutic application. The researchers were inspired for this approach from naturally occurring dimers. (2021-02-10)

Silkworm's brain determines diapause by thermal information
Silkworms (Bombyx mori) were found to lay diapause eggs at 25°C and non-diapause eggs at 15°C. Females were observed to determine whether to lay diapause eggs or not according to thermal information received by the embryonic Bombyx TRPA1 ortholog (BmTRPA1). In this study scientists at Shinshu University et al. have elucidated that the neuropeptide corazonin regulates the release of the diapause hormone. (2020-12-21)

Neuropeptide discoveries could someday help defeat the dreaded cockroach
Cockroaches are notorious for their abilities to survive and reproduce, much to humanity's chagrin. In addition to scurrying around at night, feeding on human and pet food, and generating an offensive odor, the pests can transmit pathogens and cause allergic reactions. Now, researchers reporting in ACS' Journal of Proteome Research have identified neuropeptides produced by the American cockroach (Periplaneta americana) that could someday be targeted by new, more selective and effective pesticides. (2020-12-09)

How neurons form long-term memories
Harvard Medical School neuroscientists have identified genes that memory neurons use to rewire connections after new experiences. The findings shed light on the biology of long-term memory, with implications for future approaches to intervene when memory deficits occur with age or disease. (2020-12-09)

Antibiotics disrupt development of the 'social brain' in mice
Antibiotic treatment in early life impedes brain signalling pathways that function in social behaviour and pain regulation in mice, a new study by Dr Katerina Johnson and Dr Philip Burnet has found. It was published today in BMC Neuroscience. (2020-07-22)

The immune system facilitates alcohol addiction
The activation of the immune system could eventually perpetuate some of the deleterious effects of alcohol, like addiction. It is the conclusion of a research carried out by an international team led by Dr. Santiago Canals, from the Institute of Neurosciences in Alicante (Spain), a joint center of the Spanish National Research Council and the University Miguel Hernández in Elche, and Dr. Wolfgang Sommer, from the Central Institute of Mental Health of the University of Heidelberg (Germany). (2020-07-21)

Molecular switch plays crucial role in learning from negative experiences
Neurobiologists at KU Leuven have discovered how the signalling molecule Neuromedin U plays a crucial role in our learning process. The protein allows the brain to recall negative memories and, as such, learn from the past. The findings of their study on roundworms have been published in the journal Nature Communications. (2020-04-29)

Harnessing psyllid peptides to fight citrus greening disease
BTI, USDA and UW scientists have identified peptides in the Asian citrus psyllid, an insect that spreads the bacterium that causes citrus greening disease (huanglongbing, HLB). The researchers are using the peptides as starting points for developing an insecticide to halt damage to the U.S.'s multi-billion dollar citrus industry. (2020-04-28)

Researchers gain new insights into pain signaling in the brain
In a new study, researchers from the University of Copenhagen have mapped how a potent neuropeptide binds to a brain receptor involved in causing human pain. The researchers expect that the mechanism could be exploited as a new avenue for painkilling medicine. (2020-03-31)

One step closer to understanding the human brain
An international team of scientists led by researchers at Karolinska Institutet in Sweden has launched a comprehensive overview of all proteins expressed in the brain, published today in the journal Science. The open-access database offers medical researchers an unprecedented resource to deepen their understanding of neurobiology and develop new, more effective therapies and diagnostics targeting psychiatric and neurological diseases. (2020-03-05)

Biomarker predicts which patients with heart failure have a higher risk of dying
A UCLA-led study revealed a new way to predict which patients with 'stable' heart failure -- those who have heart injury but do not require hospitalization -- have a higher risk of dying within one to three years. (2020-01-06)

Atopic dermatitis: How allergens get on our nerves
Atopic dermatitis, or eczema, primarily affects infants and children. A skin disease characterized by flare-ups, it is often treated with topical anti-inflammatories. A new study led by Inserm researcher Nicolas Gaudenzio, in collaboration with his colleagues at Stanford University shows that immune cells and sensory neurons interact in the skin to form units that can detect allergens and trigger inflammation. Their findings have now been published in the journal Nature Immunology. (2019-10-07)

Molecular link between chronic pain and depression revealed
Researchers at Hokkaido University have identified the brain mechanism linking chronic pain and depression in rats. Their research, which was recently published in The Journal of Neuroscience, could lead to the development of new treatments for chronic pain and depression. (2019-09-26)

Researchers discover the science behind giving up
Findings, reported July 25 in Cell, offer new insight into the complex world of motivation and reward by discovering the science behind giving up. The study is among the first to describe the effects of the complex nociception modulatory system. The researchers said this discovery could lead to helping people find motivation when they are depressed and conversely decrease motivation for drugs in substance abuse disorders, like addiction. (2019-07-25)

IDIBELL-researchers negatively correlate a neuropeptide with executive functions
Researchers from IDIBELL and the group of Eating Disorders, of the HUB, led by Dr. Fernando Fernández-Aranda, published in Scientific Reports (Nature) a study that negatively correlates the concentration of orexin A (a neuropeptide) with the executive functions in anorexic patients. The study is part of the research program ''Neurocognition and extreme weight conditions: from anorexia to obesity'', carried out at the CIBEROBN. (2019-06-12)

New painkiller lasts longer, is less addictive than morphine
As an alternative to morphine, researchers present a new nano-painkiller they've tested in rodents. In their study, three versions of their natural nanoparticle showed anti-pain effects when administered to inflamed rat paws. (2019-02-13)

New findings could make mosquitos more satisfied -- and safer to be around
Scientists have learned new tricks that could be useful in preventing mosquito-borne illnesses such as Zika and yellow fever. A new study shows that some appetite-reducing drugs can curtail the insects' impulse to feed on warm-blooded hosts. (2019-02-07)

Research gives new insight into the evolution of the nervous system
Pioneering research has given a fascinating fresh insight into how animal nervous systems evolved from simple structures to become the complex network transmitting signals between different parts of the body. (2018-10-18)

Surfing on calcium waves: A larva's journey to becoming a fly
A group of researchers at the National Centre for Biological Sciences, Bangalore, have uncovered the neuronal typeset that determines a larva's decision to pupariate, especially when challenged for nutrients. The group, led by Prof. Gaiti Hasan has investigated this question in fruit flies to understand how they integrate internal and environmental nutritional cues to make decisions on pupariation. (2018-10-11)

The grim, final days of a mother octopus
A new study uses modern genetic sequencing tools to describe several distinct molecular signals produced by the optic gland after a female octopus reproduces. The research also details four separate phases of maternal behavior and links them to these signals, suggesting how the optic gland controls a mother octopus' demise. (2018-09-25)

Substances associated with bee ferocity are discovered
Chemical compounds identified by Brazilian researchers may explain why less aggressive bees become ferocious. Study is published in Journal of Proteome Research. (2018-08-14)

Sleep problems in Parkinson's disease: Can we fix them?
A team of researchers at VIB and KU Leuven has uncovered why people with a hereditary form of Parkinson's disease suffer from sleep disturbances. The molecular mechanisms uncovered in fruit flies and human stem cells also point to candidate targets for the development of new treatments. (2018-06-07)

Inside the brains of killer bees
Africanized honeybees, commonly known as 'killer bees,' are much more aggressive than their European counterparts. Now researchers have examined neuropeptide changes that take place in Africanized honeybees' brains during aggressive behavior. The researchers, who report their results in the Journal of Proteome Research, also showed they could turn gentle bees into angry ones by injecting them with certain peptides. (2018-06-06)

Researchers report four new insights into diet and health
What we eat plays a significant role in our health. The Experimental Biology 2018 meeting (EB 2018) will showcase new research into how diet could be used to fight cancer and how specific eating patterns can encourage weight loss. (2018-04-22)

Neurons derived from super-obese people respond differently to appetite hormones
US scientists have successfully generated hypothalamic-like neurons from human induced pluripotent stem cells (hiPSCs) taken from the blood and skin cells of super-obese individuals and people with a normal body weight. The researchers found that the brain cells derived from the super obese were more likely to dysregulate hormones related to feeding behavior and hunger, as well as obesity-related genes and metabolic pathways. The work appears April 19 in the journal Cell Stem Cell. (2018-04-19)

Simultaneous determination of Substance P and CGRP in rat brainstem tissue
Substance P and CGRP are neuropeptides that belong to the thachykinin and calcitonin family, respectively. They play an important role in neuropathic pain development and regulation. In this study, simultaneous analysis of Substance P and CGRP in rat brainstem tissue was conducted by using LC-ESI-MS/MS method. (2018-01-30)

Lobachevsky University researchers study the effects of bee venom on living organisms
Researchers of the Lobachevsky University, Institute of Biology and Biomedicine (IBBM) have established as a result of laboratory tests that bee venom and bee products inhibit the growth of malignant tumors, enhance biological activity of the body, and can also be used to treat diabetes mellitus. (2017-12-19)

Nerves control the body's bacterial community
Using the freshwater polyp Hydra as a model organism, Kiel University researchers and their international colleagues investigated how the simple nervous system of these animals interacts with the microbiome. They were able to demonstrate, for the first time, that small molecules secreted by nerve cells help to regulate the composition and colonisation of specific types of beneficial bacteria along the Hydra's body column. (2017-09-26)

Heparin stimulates food intake and body weight gain in mice
Research shows that heparin, which is well known for its role as an anticoagulant, can also promote food intake and body weight increase in animal models. (2017-09-05)

The secret connection between anxiety and sleep
You may have experienced sleepless nights when you were anxious, stressed or too excited. Such emotions are well-known to affect wakefulness and can even cause insomnia, though the underlying mechanisms in our brain have still been unclear. Scientists in the Sleep Institute in Japan spotted neurons that play crucial roles in connecting emotions and sleep, shedding light on the future discovery of drug targets for anxiety disorder and/or sleep disorders. (2017-07-01)

Researchers create model of anorexia nervosa using stem cells
An international research team, led by scientists at University of California San Diego School of Medicine, has created the first cellular model of anorexia nervosa (AN), reprogramming induced pluripotent stem cells (iPSCs) derived from adolescent females with the eating disorder. (2017-03-14)

What causes sleepiness when sickness strikes
It's well known that humans and other animals are fatigued and sleepy when sick, but it's a microscopic roundworm that's providing an explanation of how that occurs, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania. A study published this week in eLife reveals the mechanism for this sleepiness. (2017-01-19)

Machine-learning discovery and design of membrane-active peptides for biomedicine
There are approximately 1,100 known antimicrobial peptides (AMP) with diverse sequences that can permeate microbial membranes. To help discover the 'blueprint' for natural AMP sequences, researchers from the University of Illinois at Urbana-Champaign and the University of California, Los Angeles, have developed a new machine learning approach to discover and design alpha-helical membrane active peptides based on their physicochemical properties. (2016-11-15)

Consumption from within: How the brain controls our appetite
Korean researchers show how our brain activates self-destruct mechanisms when it is low on energy to regulate appetite. (2016-10-03)

New research may help to develop effective pain killers
If you have ever chopped chilies and then accidentally touched your eyes you will be familiar with the burning sensation that this causes. However, the substance responsible for this sensation can also have beneficial effects. Unfortunately, it often causes side effects such as a strong burning sensation. Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg have now identified another substance that could be just as effective at combating severe pain but is much more easily tolerated. (2016-06-30)

An effective but painful treatment
Photodynamic therapy is an effective treatment for early-stage skin cancer. However, this therapy can cause patients severe pain. The reason for this was previous a mystery to researchers. Physiologists at Friedrich-Alexander Universität Erlangen-Nürnberg have now discovered that it is due to two specific ion channels. (2016-06-23)

Caltech biologists identify gene that helps regulate sleep
Caltech biologists have performed the first large-scale screening in a vertebrate animal for genes that regulate sleep, and have identified a gene that when overactivated causes severe insomnia. (2016-02-17)

Starfish reveal the origins of brain messenger molecules
Biologists from Queen Mary University of London (QMUL) have discovered the genes in starfish that encode neuropeptides -- a common type of chemical found in human brains. The revelation gives researchers new insights into how neural function evolved in the animal kingdom. (2016-02-09)

UCLA-Stanford researchers pinpoint origin of sighing reflex in the brain
A UCLA-Stanford study has pinpointed two tiny clusters of neurons in the brain stem that are responsible for transforming normal breaths into sighs. The discovery may one day benefit patients who cannot breathe deeply on their own -- or who suffer from disorders in which frequent sighing becomes debilitating. (2016-02-08)

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