Current Nsaids News and Events

Current Nsaids News and Events, Nsaids News Articles.
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Findings of study comparing analgesics in acute post-trauma pain
The combination of a high?dose NSAID with paracetamol does not increase the analgesic effect compared to paracetamol alone. Researchers also found that paracetamol alone is superior to high?dose NSAID alone for posttraumatic extremity pain. (2021-02-08)

Study shows aspirin before a diagnosis may lower colorectal cancer mortality
A new study finds that long-term aspirin use before a diagnosis of colorectal cancer (CRC) may be associated with lower CRC-specific mortality. (2021-02-02)

ACSL1 as a main catalyst of CoA conjugation of propionic acid-class NSAIDs in liver
Researchers from Kanazawa University have found that propionic acid-class nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, form ''conjugates'' with coenzyme A (CoA) by one of the acyl-CoA synthetases, ACSL1, in liver. These conjugates have the covalent binding ability to cellular proteins that may lead to liver injury, a rare severe side effect of NSAID treatment. This knowledge could help pharmaceutical companies to generate pain control options with fewer risks of severe side effects. (2021-01-22)

NSAIDs might exacerbate or suppress COVID-19 depending on timing, mouse study suggests
New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice. The study appears this week in the Journal of Virology, a publication of the American Society for Microbiology. (2021-01-22)

Plants on aspirin
For centuries humans were using willow barks to treat a headache or an inflamed tooth. Later, the active ingredient, the plant hormone salicylic acid, was used to develop painkillers like Aspirin. But what happens, if plants are treated with these painkillers? By doing so, Scientists at the Institute of Science and Technology (IST) Austria discovered an unexpected bioactivity of human pharmaceuticals in plants. The scientists published their study in the journal Cell Reports. (2020-12-01)

New juvenile idiopathic arthritis guideline emphasizes disease-modifying treatments
The American College of Rheumatology (ACR) will preview the 2021 Guideline for the Treatment of Juvenile Idiopathic Arthritis at ACR Convergence, the ACR's annual meeting. (2020-11-06)

Knee OA guidance for clinicians simplified and streamlined
Researchers review the similarities and differences between OARSI and ESCEO 2019 guidelines for the management of knee OA and provide a narrative to help steer health-care providers through the complexities of non-surgical management of the disease. (2020-10-29)

NSAIDs not associated with more severe coronavirus disease, study finds
The use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and diclofenac, is not associated with any adverse effects in people who have tested positive for COVID-19, according to a new study published September 8 in PLOS Medicine by Anton PottegÄrd of the University of Southern Denmark and colleagues from Aarhus University Hospital and the Danish Medicines Agency. (2020-09-08)

Texas A&M researchers develop treatment for canine ocular condition using turmeric
Researchers at Texas A&M University have produced a therapeutic derived from turmeric, a spice long-praised for its natural anti-inflammatory properties, that shows promise in decreasing ocular inflammation in dogs suffering from uveitis, an inflammation of the eye that leads to pain and reduced vision. (2020-09-03)

NSAIDs increase cardiovascular, bleeding risk in Korean heart attack patients
Use of NSAIDs to treat first-time heart attack patients significantly increased the risk for cardiovascular and bleeding events post-heart attack in a nationwide Korean study, published today in the Journal of the American College of Cardiology. (2020-07-27)

Research shows ibuprofen does not hinder bone fracture healing in children
Doctors have traditionally avoided prescribing nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen to patients with fractures. However, a new study from the University of Missouri School of Medicine and MU Health Care shows ibuprofen is an effective medication for fracture pain in children and its use does not affect fracture healing. (2020-07-22)

LSU Health New Orleans discovers new class of safer analgesics
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. (2020-07-06)

New therapy reduces chronic low back pain in large international study
A new study has found that tanezumab, a monoclonal antibody that inhibits nerve activity, provides relief in patients with chronic low back pain, one of the leading reasons why people seek medical care and the number one cause of disability worldwide. (2020-06-19)

Study helps to identify medications which are safe to use in treatment of COVID-19
A recent study has found that there is no evidence for or against the use of non-steroidal anti-inflammatory drugs such as ibuprofen for patients with COVID-19. (2020-03-30)

Popular painkiller ibuprofen affects liver enzymes in mice
The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from UC Davis. The study in laboratory mice also shows marked differences between males and females. (2020-03-11)

Study: Patients commonly prescribed opioids and antibiotics for dental conditions at EDs
A study in the March issue of The Journal of the American Dental Association from the Centers for Disease Control and Prevention found that antibiotics and opioids are frequently prescribed during emergency department visits for dental conditions, further emphasizing the need for continued efforts to combat both opioid abuse and overuse of antibiotics. (2020-02-24)

Choosing common pain relievers: It's complicated
About 29 million Americans use over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain. Every year in the US, NSAID use is attributed to approximately 100,000 hospitalizations and 17,000 deaths. All of these drugs have benefits and risks, but deciding which one to use is complicated for health care providers and their patients. To assist in clinical decision-making, researchers address cardiovascular risks and beyond, which include gastrointestinal and kidney side effects of pain relievers. (2020-02-05)

For low back pain in older adults, treatment doesn't match guidelines
Many Medicare patients with new episodes of low back pain receive care inconsistent with current guidelines -- including high use of opioids and advanced imaging tests, reports a study in the February issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer. (2020-01-23)

First US study shows strong results for procedure to treat knee pain from OA
Ari Isaacson, M.D., director of clinical research in the UNC School of Medicine's department of radiology, led a pilot study to investigate the effectiveness of using genicular artery embolization for long-term treatment of knee pain caused by osteoarthritis. (2019-12-17)

BU finds concerns about other painkillers contributed to opioid crisis
A new Boston University School of Public Health (BUSPH) study published in JAMA Network Open shows that the decline in prescriptions of non-opioid analgesics -- largely NSAIDs and COX-2 inhibitors -- in the early 2000s coincided with a marked increase in opioid prescribing. (2019-12-11)

Anti-inflammatory agents can effectively and safely curb major depressive symptoms
Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms of major depression, finds a pooled analysis of the available evidence, published online in the Journal of Neurology Neurosurgery & Psychiatry. (2019-10-28)

Kidney function may affect risks associated with prescription opioids
Compared with other pain medications, prescription opioids were linked with higher risks of death and hospitalization, particularly with higher doses. The risk of death associated with opioids was highest among people with lower kidney function. (2019-10-03)

Aspirin may prevent air pollution harms
A new study is the first to report evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin may lessen the adverse effects of air pollution exposure on lung function. The researchers found that the use of any NSAID nearly halved of the effect of PM on lung function, with the association consistent across all four weekly air pollution measurements from same-day to 28 days prior to the lung function test. (2019-10-02)

Opioid prescribing patterns in children after tonsillectomy
National private insurance claims data were used to examine opioid prescribing patterns in children after tonsillectomy and return visits for complications. Opioids are commonly used after tonsillectomy, although American Academy of Otolaryngology clinical practice guidelines recommend nonopioids such as NSAIDs. This analysis included 2016 and 2017 claims data coded for tonsillectomy for nearly 16,000 children; nearly 60% of whom had one or more prescription drug claims for opioids between seven days before to one day after tonsillectomy. (2019-08-08)

Six in 10 children receive opioids after tonsillectomy
Sixty percent of privately insured children undergoing tonsil removal received opioids -- with average prescriptions lasting about six to 10 days -- a new study finds. (2019-08-08)

New data indicate rise in opioid use for migraine treatment
An increasing number of Americans are using opioids to treat their migraine headaches, despite the fact that opioids are not the recommended first-line therapy for migraine in most cases. (2019-08-07)

Pain medications linked to higher cardiovascular risks in patients with osteoarthritis
Nonsteroidal anti-inflammatory drugs (NSAIDs) can help to control the pain and inflammation in individuals with osteoarthritis (OA), but a new Arthritis & Rheumatology study suggests that NSAIDs contribute to cardiovascular side effects in these patients. (2019-08-07)

Opioid use is reduced in patients treated with NSAIDS
Patients receiving a post-surgery prescription of ibuprofen with a rescue prescription of Percocet used less opioids than a group of similar patients who were prescribed just Percocet. The research was presented by a group from the New York University Hospital for Joint Diseases in New York City today at the American Orthopedic Society of Sports Medicine's Annual Meeting. (2019-07-11)

US dentists out-prescribe UK dentists when it comes to opioids
Researchers from the University of Illinois at Chicago have found that dentists practicing in the US write 37 times more opioid prescriptions than dentists practicing in England. And, the type of opioids they prescribe has a higher potential for abuse. (2019-05-24)

University of Virginia chemist IDs possible addiction-free pain reliever
Pain medication addiction is a major problem in the United States. UVA's Ken Hsu is seeking ways to treat pain and control inflammation without dangerous side effects. (2019-05-16)

HSS researchers advance understandings of the cellular mechanisms driving rheumatoid arthritis
Newly identified subsets of cell types present in the joint tissue of rheumatoid arthritis (RA) patients, and how they interact may help develop future precision medicine strategies. (2019-05-09)

Anti-inflammatory drugs ineffective for prevention of Alzheimer's disease
Researchers have known for decades that inflammation accompanies Alzheimer's disease brain lesions. Several early studies suggested that Nonsteroidal anti-inflammatory drugs could help avoid the disease. After clinical trials showed that NSAIDs don't help patients who already have AD symptoms, doctors wondered whether these drugs could still be helpful to people who were at risk of developing the disease, but weren't yet showing symptoms. (2019-04-05)

Study links Celebrex, heart valve calcification after earlier research declared drug safe
On National Heart Valve Disease Awareness Day, Vanderbilt study disputes that Celebrex has no more impact on valves than older drugs in its class. (2019-02-22)

NSAID impairs immune response in heart failure, worsens heart and kidney damage
Non-steroidal anti-inflammatory drugs, or NSAIDs, are widely known as pain-killers and can relieve pain and inflammation. In a study published in the journal Life Sciences, researchers found that treatment with the NSAID carprofen alone triggered subtle low-grade inflammation in the heart and kidneys. The combination of carprofen pretreatment and heart attack magnified this impact by dysregulating the acute inflammatory response, amplifying inflammation and intensifying the cardiorenal syndrome. (2019-02-06)

Researchers find antidepressants significantly raise risk of GI, intracranial bleeding
Nearly 13 percent of Americans 12 years and older take an antidepressant, and SSRIs are among the most frequently prescribed because they are relatively low-cost, effective and safe. However, patients taking these drugs are 40 percent more likely to develop severe gastrointestinal bleeding, particularly when they also use common over-the-counter pain relievers. (2019-01-30)

Study suggests aspirin may help some patients survive head and neck cancer
Regular use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may help some patients with head and neck cancer survive the disease, according to a study led by Professor Jennifer Grandis at the University of California, San Francisco. The study, which will be published Jan. 25 in the Journal of Experimental Medicine, indicates that NSAIDs are effective in patients with mutations in a gene called PIK3CA, likely by lowering the levels of an inflammatory molecule called prostaglandin E2. (2019-01-25)

Common pain reliever can improve survival in head and neck cancer
Regular use of a common type of medication, such as aspirin and ibuprofen, significantly improves survival for a third or more patients with head and neck cancer, a new study led by UC San Francisco has found. (2019-01-25)

BIODS in search of better non-steroidal, non-acid antiinflammatory agents
Inflammation is defined as the response of immune system cells to damaged or injured tissues. The major symptoms of inflammation include increased blood flow, cellular influx, edema, elevated cellular metabolism, reactive oxygen species (ROS) nitric oxide (NO) and vasodilation. (2019-01-12)

Metabolite from pomegranate diet reduces inflammatory bowel diseases
A team of scientists from inStem, Bangalore, and University of Louisville, USA, have ascertained that a microbial metabolite (Urolithin A) derived from berries and pomegranates, and its novel synthetic analog, can mitigate IBD by increasing proteins that tighten epithelial cell junctions in the gut thereby reducing the gut inflammation. (2019-01-09)

How common pain relievers may promote Clostridium difficile infections
Clostridium difficile causes the most common and most dangerous hospital-born infections in the United States and around the world. People treated with antibiotics are at heightened risk because those drugs disturb the microbial balance of the gut, but observational studies have also identified a link between severe C. difficile infections and use of NSAIDs, or non-steroidal anti-inflammatory drugs. The study is published in the journal, mBio. (2019-01-08)

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