Current Nucleic Acid Therapeutics News and Events

Current Nucleic Acid Therapeutics News and Events, Nucleic Acid Therapeutics News Articles.
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University of Minnesota researchers develop two new rapid COVID-19 diagnostic tests
University of Minnesota Medical School researchers have developed two new rapid diagnostic tests for COVID-19 - one to detect COVID-19 variants and one to help differentiate with other illnesses that have COVID-19-like symptoms. (2021-02-23)

Attachable skin monitors that wick the sweat away?
A new preparation technique fabricates thin, silicone-based patches that rapidly wick water away from the skin. The technique could reduce the redness and itching caused by wearable biosensors that trap sweat beneath them. The technique was developed by bioengineer and professor Young-Ho Cho and his colleagues at KAIST and reported in the journal Scientific Reports last month. (2021-02-22)

Researchers discover potential new therapeutic targets on SARS-CoV-2 Spike protein
The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention. (2021-02-22)

Modeling a better catalyst for PIBSAs
Polyisobutenyl succinic anhydrides (PIBSAs) are important for the auto industry because of their wide use in lubricant and fuel formulations. New research led by the Computer-Aided Nano and Energy Lab (CANELa) at the University of Pittsburgh, in collaboration with the Lubrizol Corporation, builds a deeper understanding of the catalyst used to synthesize PIBSAs. (2021-02-17)

A glimpse into the formation of mitoribosome
SciLifeLab Fellow Alexey Amunts and his team together with researchers from the Czech Academy of Sciences report an assembly intermediate of the ribosome in mitochondria. It reveals 22 associated factors that cooperatively organize the biogenesis process. (2021-02-16)

Experimental tests of relativistic chemistry will update the periodic table
Researchers from Osaka University used a particle accelerator and co-precipitation to study the chemical reactivity of single rutherfordium atoms. Such experiments will continue the advancement of relativistic chemistry that is pertinent to a range of applications including renewable energy and new materials. (2021-02-16)

Researchers take early step toward leukemia drug therapy
The team has discovered that for acute myeloid leukemia (AML) patients, there is a dopamine receptor pathway that becomes abnormally activated in the cancer stem cells. This inspired the clinical investigation of a dopamine receptor-inhibiting drug thioridazine as a new therapy for patients, and their focus on adult AML has revealed encouraging results. (2021-02-16)

Cheap, potent pathway to pandemic therapeutics
By capitalizing on a convergence of chemical, biological and artificial intelligence advances, scientists have developed an unusually fast and efficient method for discovering tiny antibody fragments with big potential for development into therapeutics against deadly diseases. (2021-02-15)

To improve immunotherapy, researchers look to shift immune cells' access to sugar
New research from Memorial Sloan Kettering scientists suggests that a way to improve immunotherapy is by altering immune cells' access to sugar. (2021-02-15)

New synthetic peptides could attenuate atherosclerosis
Atherosclerosis, a lipid-triggered chronic inflammatory disease of our arteries, is the main cause of strokes and heart attacks. An international team of researchers led by the Technical University of Munich (TUM) and the LMU University Hospital has developed novel synthetic peptides that can help to prevent atherosclerosis in vitro, that is in the test tube, as well as in animal models. (2021-02-12)

Detecting single molecules and diagnosing diseases with a smartphone
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers show that the light emitted by a single molecule can be detected with a low-cost optical setup. Their prototype could facilitate medical diagnostics. (2021-02-12)

Assessing brain capillaries in COVID-19
This case series analyzes brains from autopsies of patients who died of COVID-19 as confirmed by nucleic acid test and with severe pulmonary pathology. (2021-02-12)

Artificial intelligence generates new diversity of AAV capsids for broader gene therapy
Research in Nature Biotechnology demonstrates the use of machine learning to generate unprecedented diversity of functional AAV capsids, towards evading immune system neutralization to allow more patients to benefit from gene therapies. It is estimated that up to 50-70% of the human population have pre-existing immunity to natural forms of the AAV vectors currently used in gene therapies. Dyno Therapeutics is applying CapsidMap™ and partnering with gene therapy companies to develop next-generation AAV vectors. (2021-02-11)

Climate research: rapid formation of iodic particles over the Arctic
When sea ice melts and the water surface increases, more iodine-containing vapours rise from the sea. Scientists from the international research network CLOUD have now discovered that aerosol particles form rapidly from iodine vapours, which can serve as condensation nuclei for cloud formation. The CLOUD researchers, among them scientists from the Goethe University Frankfurt, fear a mutual intensification of sea ice melt and cloud formation, which could accelerate the warming of the Arctic and Antarctic. (2021-02-11)

The therapeutic potential of peptides
There are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases. In Nature Reviews Drug Discovery, a team of Austrian and Australian scientists led by Markus Muttenthaler of the University of Vienna present an outlook on the latest trends in peptide drug discovery and development. (2021-02-10)

How the 3-D structure of eye-lens proteins is formed
Chemical bonds within the eye-lens protein gamma-B crystallin hold the protein together and are therefore important for the function of the protein within the lens. Contrary to previous assumptions, some of these bonds, called disulphide bridges, are already formed simultaneously with the synthesis of the protein in the cell. This is what scientists at Goethe University Frankfurt, Max Planck Institute of Biophysics and the French Institute de Biologie Structurale in Grenoble have discovered. (2021-02-10)

CWRU researchers uncover biochemical rules between RNA-protein interactions and expr
A team of Case Western Reserve University researchers has found a way to measure key characteristics of proteins that bind to RNA in cells--a discovery that could improve our understanding of how gene function is disturbed in cancer, neurodegenerative disorders or infections. (2021-02-10)

HIV research yields potential drug target
Understanding the mechanism of activation of a protein called SAMHD1 could be a step forward in the fight against HIV/AIDS. ''If we are able to increase SAMHD1 activity using a specific drug, that could potentially have anti-HIV activity,'' said Corey H. Yu, PhD, postdoctoral fellow in the laboratory of Dmitri Ivanov, PhD, at UT Health San Antonio. (2021-02-10)

New method for asymmetric N,N-acetal synthesis promises advances in drug development
Chiral N,N-acetals are an important component of several bioactive drugs and medicines. Owing to this, chemical reactions that lead to high-purity yield of the desired 'enantiomeric' form are highly sought after. In a new study, scientists from Japan demonstrate high selectivity formation of N,N-acetals from reactions between 2-aminobenzamide and various diketones in presence of bis(imidazoline)-phosphoric acid catalyst and look into the possible mechanism, opening doors to facile synthesis of novel pharmaceutical drugs. (2021-02-09)

Chemists developed a simplified method for pharmaceutical compounds synthesizing
A team of chemists from Immanuel Kant Baltic Federal University and Saint Petersburg State University developed a simple and efficient method to synthesize tetrahydroisoquinolines--important organic molecules for drug discovery. The method consists of just three steps. (2021-02-09)

New synthetic route for biofuel production
A German-Chinese research team has found a new synthetic route to produce biofuel from biomass. The chemists converted the substance 5-hydroxymethylfurfural (HMF) produced from biomass into 2,5-dimethylfuran (DMF), which could be suitable as a biofuel. Compared to previous methods, they achieved a higher yield and selectivity under milder reaction conditions. (2021-02-08)

Iodine oxoacids formed in oceans have major impact on climate
Molecular iodine, a major emission from the ocean, can quickly convert to iodic oxoacids even under weak daylight conditions. These oxoacids lead rapidly to aerosol particles that significantly affect climate and human health. (2021-02-08)

Innovation from Vienna: Ultrasound in the treatment of brain diseases
Ultrasound is not only used as an imaging technique but targeted pulses of ultrasound can be used as a highly accurate treatment for a range of brain diseases. A review jointly written by MedUni Vienna and the University of Toronto shows that the new treatments are already on the brink of broad clinical application. (2021-02-04)

Father's early-life exposure to stress associated with child's brain development
The FinnBrain research of the University of Turku has demonstrated for the first time that the stress the father has experienced in his childhood is connected to the development of the white matter tracts in the child's brain. Whether this connection is transmitted through epigenetic inheritance needs further research. (2021-02-04)

Molecule from nature provides fully recyclable polymers
Plastics are among the most successful materials of modern times. However, they also create a huge waste problem. Scientists from the University of Groningen and the East China University of Science and Technology (ECUST) in Shanghai produced different polymers from lipoic acid, a natural molecule. These polymers are easily depolymerized under mild conditions. Some 87 percent of the monomers can be recovered in their pure form and re-used to make new polymers of virgin quality. (2021-02-04)

Iodine oxoacids drive rapid aerosol formation in pristine atmospheric areas
Iodine plays a bigger role than thought in rapid new particle formation (NPF) in relatively pristine regions of the atmosphere, such as along marine coasts, in the Arctic boundary layer or in the upper free troposphere, according to a new study. (2021-02-04)

Retrained generic antibodies can recognize SARS-CoV-2
An alternative approach to train the immunity response is offered by researchers at the University of Illinois Chicago and California State University at Sacramento who have developed a novel strategy that redirects antibodies for other diseases existing in humans to the spike proteins of SARS-CoV-2. (2021-02-03)

Solving a puzzle
University of New Mexico scientists tease out the underlying mechanism of tuberous sclerosis complex (2021-02-03)

Extreme UV laser shows generation of atmospheric pollutant
Hokkaido University scientists show that under laboratory conditions, ultraviolet light reacts with nitrophenol to produce smog-generating nitrous acid. (2021-02-02)

Lactobacillus manipulates bile acids to create favorable gut environment
Probiotic Lactobacillus bacteria use enzymes situationally to manipulate bile acids and promote their own survival in the gut. (2021-02-01)

Halved risk for severe retinal disease in extremely premature infants
Risk for a severe form of retinopathy of prematurity, which can cause blindness in extremely premature babies, was halved when the newborns were given a new supplement combining various fatty acids. This was shown in a Swedish study led from the University of Gothenburg. (2021-02-01)

How vitamins, steroids and potential antivirals might affect SARS-CoV-2
Evidence is emerging that vitamin D -- and possibly vitamins K and A -- might help combat COVID-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they - and other antiviral drugs -- might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so might reduce SARS-CoV-2 infectivity. (2021-01-29)

First hybrid gene therapy shows early promise in treating long QT syndrome
In a new study published in Circulation, Mayo Clinic researchers provide the first preclinical, proof-of-concept study for hybrid gene therapy in long QT syndrome, a potentially lethal heart rhythm condition. (2021-01-28)

Study details N439K variant of SARS-CoV-2
An international team of researchers has characterized the effect and molecular mechanisms of an amino acid change in the SARS-CoV-2 Spike protein N439K. Viruses with this mutation are both common and rapidly spreading around the globe. The peer reviewed version of the study appears January 25 in the journal Cell. (2021-01-28)

Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases. (2021-01-27)

Research shows people with high omega-3 index less likely to die from COVID-19
Researchers with the Fatty Acid Research Institute (FARI) and collaborators at Cedars-Sinai Medical Center in Los Angeles and in Orange County, CA, have published the first direct evidence that higher omega-3 blood levels may reduce risk for death from COVID-19 infection. The report was published in the journal Prostaglandins, Leukotrienes and Essential Fatty Acids on January 20, 2021. (2021-01-26)

Intercontinental study sheds light on the microbial life of sourdough
In a study of 500 sourdough starters spanning four continents, scientists have garnered new insights into the environmental factors that contribute to each sourdough starter's microbial ecosystem, and how different types of microbes influence both a sourdough's aroma and how quickly the sourdough rises. The results may surprise sourdough enthusiasts. (2021-01-26)

Hybrid closed-loop insulin therapy improves glycemic control
Hybrid closed-loop insulin therapy improved glycemic control in adolescents and young adults with type 1 diabetes. These outcomes, derived from the International Diabetes Closed-Loop (iDCL) (2021-01-26)

Ocean toxin a heartbreaking threat for sea otters
Heart disease is a killer threat for southern sea otters feasting on domoic acid in their food web, according to a study led by the University of California, Davis. Climate change projections indicate that toxic blooms and domoic acid exposure will continue to rise. (2021-01-26)

Efficient solid-state depolymerization of waste PET
Despite significant methodological and technological advancements in chemical recycling of synthetic polymers, an effective mechanochemical PET degradation has not yet been described in the scientific literature, until now! Vjekoslav Ĺ trukil from the Rudjer Boskovic Institute (RBI), Zagreb, Croatia, found that the challenging breakdown of waste PET under ambient conditions of temperature and pressure can be achieved by mechanochemical ball milling or vapor-assisted aging. (2021-01-25)

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