Current Nucleus News and Events

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New insights on how inflammatory molecule contributes to skin and pancreatic cancers
An immune molecule called interleukin-33 can act within a cell's nucleus to stimulate abnormal growth and division, ultimately resulting in cancer. Targeting interleukin-33 in the nucleus may help prevent certain cancers. (2021-02-22)

Study reveals how a longevity gene protects brain stem cells from stress
A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators. (2021-02-19)

A new piece of the HIV infection puzzle explored
Researchers from the European Molecular Biology Laboratory and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics. (2021-02-18)

Targeting Nsp1 protein could be a pathway for COVID-19 therapy
A study that identifies how a coronavirus protein called Nsp1 blocks the activity of genes that promote viral replication provides hope for new COVID-19 treatments. (2021-02-16)

Cells use concentration gradients as a compass
Biophysicists at Ludwig-Maximilians-Universitaet (LMU) in Munch have developed a new theory, which accounts for the observation that cells can perceive their own shapes, and use this information to direct the distribution of proteins inside the cell. (2021-02-16)

How comparable different stress tests are
Scientists use many different tests to investigate what happens in the brain in people experiencing stress. It is unclear to what extent the various methods with which subjects are placed under stress are comparable to each other. In a meta-analysis, researchers compared 31 previous studies that had investigated stress using functional magnetic resonance imaging. The team worked out which regions of the brain are activated as standard during stress and which stress tests trigger similar activation patterns. (2021-02-12)

In-silico modelling helps with the integrated study of the intervertebral disc in health and disease
Published in the journal Bioinformatics and conducted entirely by members of the BCN MedTech Research Unit, with Laura Baumgartner as first author under the guidance of Jérôme Noailly. (2021-02-05)

New combination therapy offers chance of healing hepatitis B
Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. (2021-02-04)

Researchers identify "rescue" mechanism that helps cells survive malfunctioning split
Cells replicate their genetic material and divide into two identical clones to perpetuate life. Some cells pause in the process with a single, undivided nucleus. When the cell resumes division after such a pause, the nucleus can become caught in the fissure, splitting violently, and killing both cells. But that is not always the case. Researchers from Hiroshima University in Japan are starting to understand how active nuclear displacement rescues cell death. (2021-02-03)

Solving complex physics problems at lightning speed
A calculation so complex that it takes twenty years to complete on a powerful desktop computer can now be done in one hour on a regular laptop. Physicist Andreas Ekström at Chalmers University of Technology, together with international research colleagues, has designed a new method to calculate the properties of atomic nuclei incredibly quickly. (2021-02-01)

Researchers describe a molecular mechanism involved in the pathology's neurodegeneration
Protein alteration in the family of lamins causes several diseases, known as laminopathies, such as progeria or precocious ageing. A study in which UB researchers have taken part states that alterations in the levels of one of these proteins, lamin B1, contribute to the degeneration of neuronal populations in Huntington's disease. Caused by a mutation in the huntingtin gen, this pathology features involuntary movements, cognitive deficit and psychiatric disorders, and has no cure yet. (2021-02-01)

Size of helium nucleus measured more precisely than ever before
In experiments at the Paul Scherrer Institute PSI, an international research collaboration has measured the radius of the atomic nucleus of helium five times more precisely than ever before. With the aid of the new value, fundamental physical theories can be tested and natural constants can be determined even more precisely (2021-01-27)

Change of course on the journey to the island of stability
An international research team succeeded in gaining new insights into the artificially produced superheavy element flerovium, element 114, at the accelerator facilities of the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Under the leadership of Lund University in Sweden and with significant participation of Johannes Gutenberg University Mainz (JGU) as well as the Helmholtz Institute Mainz (HIM) in Germany and other partners, flerovium was produced and investigated to determine whether it has a closed proton shell. (2021-01-26)

Compelling evidence of neutrino process opens physics possibilities
The COHERENT particle physics experiment at the Department of Energy's Oak Ridge National Laboratory has firmly established the existence of a new kind of neutrino interaction. Because neutrinos are electrically neutral and interact only weakly with matter, the quest to observe this interaction drove advances in detector technology and has added new information to theories aiming to explain mysteries of the cosmos. (2021-01-26)

Alpha particles lurk at the surface of neutron-rich nuclei
Scientists from an international collaboration have found evidence of alpha particles at the surface of neutron-rich heavy nuclei, providing new insights into the structure of neutron stars, as well as the process of alpha decay. (2021-01-21)

How aerosols are formed
ETH Zurich researchers conducted an experiment to investigate the initial steps in the formation of aerosols. Their findings are now aiding efforts to better understand and model that process - for example, the formation of clouds in the atmosphere. (2021-01-14)

Chloroplasts on the move
How different plants can share their genetic material with each other (2021-01-11)

Novel RNA factors may help cancer cells thrive
Recent work by researchers at Brigham and Women's Hospital pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. The team identified primary actors circ2082, a circular RNA, and RBM3, an RNA-binding protein, which form a complex with DICER to trap it in the nucleus of glioblastoma cells, therefore disrupting the cytoplasmic microRNAome. (2021-01-08)

Stem cells use a piston-like engine to 'drive' to their destinations
Researchers extracted stem cells from bone marrow and used hydrogels to mimic the tissues that compose their biological environments. They found that stem cells propel their nucleus into a needle-like protrusion that penetrates the physical barriers inside the body. The nucleus moves into the protrusion and, through a complex biochemical mechanism, inflates the protrusion like a balloon, creating an opening in the tissue wide enough for the entire stem cell to migrate through. (2021-01-08)

Drug combination increases susceptibility to chemotherapy in cases of severe neuroblastoma
Researchers at the University of Gothenburg now suggest a possible cure for children with hard-to-treat forms of neuroblastoma using a new combination of drugs. In a new study in the journal Cancer Research, they describe how a two small molecule-based drug combination likely inhibit the tumor's growth. (2021-01-07)

Social transmission of pain, fear has different targets in mouse brain
Social contact can transfer the feeling of pain or fear in several animal species, including humans, but the exact neural mechanisms for this transmission are still being studied. (2021-01-07)

The map of nuclear deformation takes the form of a mountain landscape
Until recently, scientists believed that only very massive nuclei could have excited zero-spin states of increased stability with a significantly deformed shape. Meanwhile, an international team of researchers from Romania, France, Italy, the USA and Poland showed in their latest article that such states also exist in much lighter nickel nuclei. Positive verification of the theoretical model used in these experiments allows describing the properties of nuclei unavailable in Earth laboratories. (2020-12-30)

Changing the perspective on the 'Cinderella of the cytoskeleton'
SETD2, known for its involvement on gene expression, also can affect functions controlled by the cytoskeleton, such as movement, metastasis and migration, which are very important for cancer cells. (2020-12-23)

How a large protein complex assembles in a cell
A team of ETH researchers led by Karsten Weis has developed a method that allows them to study the assembly process for large protein complexes in detail for the first time. As their case study, the biologists chose one of the largest cellular complexes: the nuclear pore complex in yeast cells. (2020-12-22)

Study sheds new light on how the brain distinguishes speech from noise
For the first time, researchers have provided physiological evidence that a pervasive neuromodulation system - a group of neurons that regulate the functioning of more specialized neurons - strongly influences sound processing in an important auditory region of the brain. The neuromodulator, acetylcholine, may even help the main auditory brain circuitry distinguish speech from noise. (2020-12-20)

Discovery finds a cellular building block acts as a gel, not liquid as previously believed
University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid? The team found that chromatin is actually more like a gel. This new understanding could lead to a more accurate understanding of how the genome is encoded and decoded. (2020-12-18)

Combined observations of neutron stars constrain their equation of state and the Hubble constant
Combining signals from multiple observations of neutron stars has allowed researchers to better understand the properties of ultra-dense matter and constrain the Hubble constant, which describes how fast the Universe is expanding, according to a new study. (2020-12-17)

Mission to MAARS: Long non-coding RNA may play a key role in cardiovascular disease
Through utilization of genetically modified high-risk atherosclerotic mice, a research team from Brigham and Women's Hospital identified and characterized Macrophage-Associated Atherosclerosis lncRNA Sequence (MAARS), which is expressed specifically in macrophages in atherosclerotic plaques and contributes to the progression of the disease. (2020-12-17)

Proteins enable crop-infecting fungi to 'smell' food
New UC Riverside research shows the same proteins that enable human senses such as smell also allow certain fungi to sense something they can eat. (2020-12-15)

Gene could help predict response to cervical cancer treatment
UCLA researchers have identified a potential diagnostic marker that could help predict how likely someone with cervical cancer is to respond to the standard treatment of chemotherapy and radiation. (2020-12-11)

Mystery solved with math: cytoplasmic traffic jam disrupts sleep-wake cycles?
KAIST mathematicians and their collaborators at Florida State University have identified the principle of how aging and diseases like dementia and obesity cause sleep disorders. A combination of mathematical modelling and experiments demonstrated that the cytoplasmic congestion caused by aging, dementia, and/or obesity disrupts the circadian rhythms in the human body and leads to irregular sleep-wake cycles. This finding suggests new treatment strategies for addressing unstable sleep-wake cycles. (2020-12-11)

New compact model for gene regulation in higher organisms
Genes can be turned on and off as needed to adapt to environmental changes. But how do the different molecules involved interact with each other? Scientists from the Institute of Science and Technology Austria (IST Austria) present a candidate mathematical model for gene regulation in eukaryotic cells. The study was published in PNAS. (2020-12-03)

Common neural circuit and potential target for anxiety and obsessive-compulsive disorder
Anxiety disorders are the most frequent comorbid conditions with obsessive-compulsive disorder. Yet the shared neural substrates and the common effective therapeutic target remain unknown. Scientists at School of Life Sciences, Nanjing University dissect a common glutamatergic neuronal circuit, from the prelimbic prefrontal cortex (PrL) to the nucleus accumbens (NAc) core, involved in both anxiety- and obsessive-compulsive-like behaviors. Targeting histamine H3 heteroreceptor in the terminals of glutamatergic PrL-NAc core projections improves stress-induced anxiety- and obsessive-compulsive-like behaviors. (2020-12-02)

Researchers find how stress and the circadian clock affect sleep
Japanese researchers have found a new neural pathway that links the circadian clock, stress, and wakefulness in mammals. They identified a neuron that becomes excessively active when the mammal is under stress, which could trigger insomnia and other sleep disorders. (2020-11-30)

Getting to the core of nuclear speckles
Scaffold of sub-cellular structures identified after a hundred years. (2020-11-28)

Scientists reveal regions of the brain where serotonin promotes patience
In a study on mice conducted by the Neural Computation Unit at the Okinawa Institute of Science and Technology Graduate University (OIST), the authors, Dr. Katsuhiko Miyazaki and Dr. Kayoko Miyazaki, pinpoint specific areas of the brain that individually promote patience through the action of serotonin. (2020-11-27)

Scientists claim controversial results of comets observations are consistent
Astrophysicists from Far Eastern Federal University (FEFU) joined the international research team for explaining the difference in the results of observation of the comet 41P/ Tuttle - Giacobini - Kresak. Researchers believe that data obtained by three independent teams are complementary and its complex analysis helps to unravel the mystery of dust chemical composition of comet 41P and other conundrums of the Universe. A related article appears in Astronomy & Astrophysics. (2020-11-25)

Study: gut hormones' regulation of fat production abnormal in obesity, fatty liver disease
Gut hormones play an important role in regulating fat production in the body. One key hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver, but this regulation is abnormal in obesity, researchers at the University of Illinois Urbana-Champaign found in a new study. (2020-11-24)

Alternative gene control mechanism based on organization of DNA within nucleus
Researchers at the University of Tokyo have identified how the architecture of the cell nucleus can change gene activity in plants. This discovery reveals fundamental knowledge about genome regulation and points towards future methods for potentially manipulating the expression of many genes simultaneously. (2020-11-20)

New technique isolates brain cells associated with Parkinson's disease
Carnegie Mellon University researchers have developed a new technique for isolating a type of brain cell associated with Parkinson's disease symptoms, enabling them to study that cell type in detail. (2020-11-16)

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