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Current Oncogene News and Events, Oncogene News Articles.
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New gene hunt reveals potential breast cancer treatment target
Australian and US researchers have developed a way to discover elusive cancer-promoting genes, already identifying one that appears to promote aggressive breast cancers. The University of Queensland and Albert Einstein College of Medicine team developed a statistical approach to reveal many previously hard-to-find genes that contribute to cancer. UQ Australian Institute of Bioengineering and Nanotechnology Associate Professor Jess Mar said the majority of 'oncogenes' identified to date were in most patients with a particular cancer type. (2019-03-08)

The sneaky way estrogen drives brain metastasis in non-estrogen-dependent breast cancers
University of Colorado Cancer Center study shows that while estrogen doesn't directly affect triple-negative breast cancer cells, it can affect surrounding brain cells in ways that promote cancer cell migration and invasiveness (2019-03-01)

Yeast study prompts rethink of DNA safekeeping
DNA replication is more prone to errors at times of stress leading to mutations that could cause disease. (2019-02-04)

MD Anderson study shows FGL2 protein may be an effective target for glioblastoma
Glioblastoma (GBM) does not attract robust T cell immune responses. FGL2 is highly expressed in GBM and when present in tumor cells, controls a specialized group of dendritic cells which activates T cells. (2019-01-25)

Researchers use computer model to predict prostate cancer progression
An international team of cancer researchers from Denmark and Germany have used cancer patient data to develop a computer model that can predict the course of disease for prostate cancer. The model is currently being implemented at a prostate cancer clinic in Germany. The researchers have also found the enzyme that appears to trigger some of the first mutations in prostate cancer. (2018-12-11)

Virus- and oncogene-free reprogramming method for the production of iPSCs published in the journal
Regenerative Medicine is delighted to publish open access original research demonstrating the first virus- and oncogene-free induced pluripotent stem cell (iPSC) technology to produce safer pluripotent stem cells from cord blood and peripheral blood. (2018-12-06)

A study using Drosophila sheds light on the metastatic behavior of human tumors
A study at the Institute for Research in Biomedicine (IRB Barcelona) using Drosophila melanogaster has demonstrated that chromosomal instability itself can induce invasive behavior in epithelial cells and has identified the underlying molecular mechanisms involved. (2018-09-26)

UC Riverside researchers find potent chemical agents that can thwart cancer metastasis
Scientists at the University of California, Riverside, have devised potent chemical agents 135H11 and 135H12 that can thwart cancer metastasis, bringing research closer to drug development. (2018-09-25)

Anticancer drugs delivered by a new drug delivery system reduce tumor size
A joint group of researchers from Osaka University and Tokyo Institute of Technology created a drug delivery system (DDS) using a poly (ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate (PEG-b-PLys(Ube)). The use of this DDS has enabled an increase in the concentration of ubenimex in target CSCs. In addition, combined use of standard anticancer drugs significantly decreased CSCs. (2018-08-08)

Discovery of a new tumor suppressor previously thought to be an oncogene
A gene that has for decades been considered a tumor promoter, the PLK1 gene, can also perform the exact opposite function: halting the development of cancer. The role of PLK1 as a target for powerful drugs must now be reviewed. For the time being, the scientists have discovered that the expression of PLK1 in breast tumors can determine a different prognosis, depending on the tumor sub-type. (2018-08-07)

Cannabinoid improves survival rates of mice with pancreatic cancer
Mice with pancreatic cancer that were treated with a naturally occurring constituent of medicinal cannabis alongside chemotherapy, survived almost three times longer than those treated with chemotherapy alone, a new study reports. (2018-07-30)

Research identifies new breast cancer therapeutic target
Research led by Suresh Alahari, PhD, Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has shown for the first time that a tiny piece of RNA deregulates energy metabolism, an emerging hallmark of cancer. The finding identifies a new target for therapeutic intervention in breast cancer. (2018-07-18)

Drug's impact on amino acid transporter may offer non-small cell lung cancer patients new hope
An amino acid transporter named xCT may affect the growth and progression of non-small cell lung cancer, a discovery that may predict the five-year survival rate of patients suffering from this cancer, now at 16 percent, researchers at Georgia State University and Vanderbilt University Medical Center have concluded. (2018-07-10)

Brain metastases common and difficult to treat in ROS1 lung cancer
Brain metastases were found to be fairly common in stage IV ROS1-positive cancers and in 47 percent of ROS1 patients, the brain was the first and only site of progression. (2018-07-10)

Novel RNA-modifying tool corrects genetic diseases
The new tool opens the possibility of creating drugs that can be taken conveniently as pills to correct genetic diseases. (2018-05-29)

The role of 'extra' DNA in cancer evolution and therapy resistance
Researchers tracked genomic alterations detected in patient samples during tumor cell evolution in culture, in patient-derived xenograft (PDX) mouse models from the cultures, as well as before and after treatment in patients. In a recent paper in Nature Genetics, the team reports that tumor progression was often driven by cancer-promoting genes, known as oncogenes, on extrachromosomal pieces of DNA. (2018-04-23)

Two-pronged approach could curb many cases of lung cancer
Lung cancer, a leading killer, has been hard to target with drugs. A team at Boston Children's Hospital took a metabolic approach, looking at what lung tumor cells need to live and grow. When they removed these factors, tumor growth was almost completely suppressed in a mouse model. Their findings suggest that a combination of existing drugs (IGF-1 inhibitors and inhibitors of protein breakdown) could provide an alternative to chemotherapy in curbing this deadly cancer. (2018-04-02)

Greehey Institute team finds link between BRCA1 and Ewing sarcoma
Scientists with the Greehey Children's Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings were made public March 7 online in the journal Nature. (2018-03-07)

Researchers use a molecular Trojan horse to deliver chemotherapeutic drug to cancer cells
A research team at the University of California, Riverside has discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases. Until now, paclitaxel has only been used to target rapidly dividing cancer cells. The team was successful in getting the drug to piggyback on 123B9, an agent they devised to target an oncogene called EphA2. (2018-02-22)

Scientists tackle the aberrant epigenetic programming underlying childhood cancers
Researchers at UFRGS and the US NIH have targeted proteins that regulate chromatin in Ewing sarcoma cells, hindering malignant tumor growth. They induced chromatic relaxation by treating the cells with histone deacetylase inhibitors, reducing expression of the EWSR1-FLI-1 oncogene and other pluripotency/cell viability genes, while impairing sarcoma cell survival and growth. Decreased survival of stem-like cancer cells and re-expression of a neuronal differentiation marker were also observed. (2018-02-20)

A new strategy induces the regression of advanced lung tumors in mice
A study conducted by researchers at the Spanish National Cancer Research Centre (CNIO) shows how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumors in a genetically designed mouse model. It has also been shown that the elimination of the c-Raf protein produces very tolerable toxic effects. This opens a new possibility for the development of new therapies. (2018-01-25)

'Hijacker' drives cancer in some patients with high-risk neuroblastoma
Researchers in Memphis and Boston have collaborated to show c-MYC is an oncogene that drives neuroblastoma in some high-risk patients; the findings help set the stage for much-needed precision medicines (2018-01-22)

Novel nanomedicine inhibits progression of pancreatic cancer in mice
A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene -- a gene that promotes the development of cancer -- and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival. The study may serve as a basis for the development of an effective cocktail of drugs for this deadly disease and other cancers. (2018-01-02)

New understanding of why cancer cells move
A University of Hawai'i Cancer Center researcher has identified how some cancer cells are made to move during metastasis. The research provides a better understanding of how cancer spreads and may create new opportunities for cancer drug development. (2017-12-27)

Low-dose X-ray exposure does not harm human stem cells
Mesenchymal stem cells are being explored for a wide range of diseases, such as cardiovascular, autoimmune and cancer diseases. There is a pressing need to characterize these cells' responses to low-dose diagnostic medical irradiations and the research addresses that need. Researchers also hope that in the long-lasting heated debate about linear-no-threshold vs. threshold hypothesis in the area of radiation protection, their results speak in favor of the former and will eventually help to establish evidence-based radioprotection standards in regenerative medicine. (2017-12-20)

Gaining insight into the molecular mechanisms behind squamous cell cancer
Researchers at Kanazawa University report in EMBO Reports a new molecular mechanisms regulating cellular fate of squamous cell carcinomas. (2017-12-19)

University of Guelph professor identifies protein key to cancer cells ability to spread
U of G scientists have made a discovery that could reduce the spread of cancer by hindering a protein that binds cancer cells together and allows them to invade tissues. The groundbreaking study identified a protein, known as cadherin-22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 percent. (2017-11-17)

Micro-spectroscopy opens new routes for diagnostics
In recent years, optics and photonics, and in particular the microspectroscopic techniques, have demonstrated their effectiveness for the materials analysis. The work 'Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques' which will appear in the journal Nature-Light: Science & Applications (LSA), introduces the use of a new spectrometer capable of analysing living cells in situ, in non-invasive manner and with sub-micrometric spatial resolution. (2017-11-16)

Computer program finds new uses for old drugs
Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy. In a recent study published in Oncogene, the researchers successfully translated DrugPredict results into the laboratory, and showed common pain medications--like aspirin--can kill patient-derived epithelial ovarian cancer cells. (2017-11-16)

Biology of childhood brain tumor subtypes offers clues to precision treatments
Researchers investigating pediatric low-grade gliomas (PLGG), the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer. By shedding light on subtle distinctions in tumor biology, these findings offer clues to designing more effective anticancer treatments to precisely target tumors in individual patients. (2017-10-16)

Medication that treats parasite infection also has anti-cancer effect
Researchers in Japan and the United States find ivermectin, a drug used to kill parasites, suppresses tumor development in epithelial ovarian cancer (2017-09-28)

Blood tumor markers may warn when lung cancer patients are progressing
University of Colorado Cancer Center study suggests that rather than screening for disease, blood tumor markers could be useful in monitoring therapeutic outcomes in those with already established disease. (2017-09-06)

Upon prolonged irradiation, human stem cells' defenses are activated
Researchers discovered that ionizing radiation causes a cell cycle delay, which leads to faster repairs of radiation-induced DNA double-strand breaks, with fewer errors. It is unclear what the health implications are, particularly how this affects the risk of developing cancer, but this results could become the basis of further research into double breaks in stem cells and their effect on tumor formation. (2017-08-24)

Cell senescence is regulated by innate DNA sensing
EPFL scientists have made new insights into the control of cell senescence, which is intimately linked to the development of cancer and aging. (2017-07-31)

Study sheds light on how ovarian cancer spreads
A team of researchers from the University of California, Riverside and the University of Notre Dame are studying the molecular mechanisms by which ovarian cancer spreads -- or metastasizes -- to uncover new therapeutic opportunities. (2017-06-27)

The complete epigenomes of the most frequent tumors, unveiled
An IDIBELL research team manages to characterize the complete epigenomes of the most frequent tumors, including those of colon, lung and breast cancer. The study represents a big step in the study of origin and progression of these tumors. (2017-06-06)

A new method for creating safer induced pluripotent stem cells
Induced pluripotent stem cells (IPSCs) hold great promise in regenerative medicine, personalized medicine and drug discovery. However, while avoiding the ethical controversies associated with embryonic stem cells, they carry neoplastic risk owing to the use of the oncogenes c-Myc and Lin28. This has limited their utility in the biomedical arena. (2017-05-24)

Ludwig researchers identify counterintuitive approach to treating a brain cancer
The loss of the tumor suppressor gene PTEN has been linked to tumor growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM). Now, Ludwig researchers have shown that one way to override the growth-promoting effects of PTEN deletion is, surprisingly, to inhibit a separate tumor suppressor gene. (2017-05-12)

A protein, a 'molecular staple' and CRISPR to develop an Ewing sarcoma model
A team from the Spanish National Cancer Research Centre (CNIO) has optimized a system capable of generating a cellular model of Ewing sarcoma. The technique, based on CRISPR and described in the pages of Stem Cell Reports, makes it possible to generate cellular models to analyze the mechanisms underlying the origin and progression of this and other diseases, as well as the search for new treatments. (2017-05-10)

A new unexpected key player in melanoma development identified
In The Journal of Clinical Investigation researchers from VIB, KU Leuven (Belgium) together with colleagues from INSERM (France) now report the important role for FES in the initiation and progression of melanoma, a malignant type of skin cancer, that is notoriously quick to metastasize and that responds poorly to existing cancer treatments. Unexpectedly the expression of FES, which encodes a kind of protein better known for their ability to promote cancer development-, is lost in a large fraction of human melanoma. (2017-05-03)

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