Current Osteosarcoma News and Events

Current Osteosarcoma News and Events, Osteosarcoma News Articles.
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Study demonstrates the reasons to screen children with cancer for inherited cancer genes
Experts at MSK Kids, the pediatric oncology program at MSK, have found that inherited cancer genes are more common than expected in children with cancer. (2021-02-16)

New improved dog reference genome will aid a new generation of investigation
Researchers at Uppsala University and the Swedish University of Agricultural Sciences have used new methods for DNA sequencing and annotation to build a new, and more complete, dog reference genome. This tool will serve as the foundation for a new era of research, helping scientists to better understand the link between DNA and disease, in dogs and in their human friends. The research is presented in the journal Communications Biology. (2021-02-10)

Nixing bone cancer fuel supply offers new treatment approach, mouse study suggests
An innovative approach to treating bone tumors - starving cancer cells of the energy they need to grow - could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. (2021-01-26)

IU researchers publish first article dedicated to Hoosier youth's donated tumor
Researchers at Indiana University School of Medicine have published their work about a specific type of childhood cancer in the peer-reviewed, international oncology journal, Cancers. This research involves a combination therapy that significantly slows tumor growth in models, which includes a model established from cells taken from tumors donated by Tyler Trent. (2020-12-01)

Perspectives of tumor treatment: Researchers investigate combination of carbon ion and immunotherapy
It is still a glance into the future: The combination of carbon ion and immune therapy could become an effective tool in the fight against cancer. Promising results for the potential benefit of this treatment combination have now been published in the journal ''International Journal of Radiation Oncology, Biology, Physics'' of the American Society for Therapeutic Radiation Oncology. The authors are an international team, led by the Biophysics Department at the GSI Helmholtzzentrum für Schwerionenforschung. (2020-11-09)

Researchers use soy to improve bone cancer treatment
Researchers showed that the slow release of soy-based chemical compounds from a 3D-printed bone-like scaffold resulted in a reduction in bone cancer cells while building up healthy cells and reducing harmful inflammation. (2020-09-15)

New model by CHOP researchers identifies noncoding mutations across five pediatric cancers
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a new computational algorithm that has, for the first time, identified a spectrum of mutations in the noncoding portion of the human genome across five major pediatric cancers. The study, which was published today in Science Advances, used the algorithm to analyze more than 500 pediatric cancer patients' mutations and gene expression profiles to develop a comprehensive list of potentially cancer-causing mutations. (2020-07-24)

MU advances chemotherapy-free treatment for cancer in animals and humans
Osteosarcoma, a common bone cancer in dogs, affects more than 10,000 dogs in the US each year. While chemotherapy is generally effective at killing some of the cancer cells, the numerous side effects can be painful and often a subset of cancer cells exist that are resistant to chemotherapy. (2020-07-17)

Scientists discover way to stop spread of devastating childhood cancer
New research reveals a new way to stop the spread of bone cancer in children. The discovery is thought to be the most important breakthrough in the field for more than 40 years. The researchers say their work could lead to 'kinder' treatments for children with bone cancer and save lives. (2020-07-15)

When should you neuter your dog to avoid health risks?
A new, 10-year study by researchers at the University of California, Davis, examined 35 dog breeds and found vulnerability from neutering, and the age at which they are neutered, varies greatly depending on the breed. (2020-07-15)

Journal of Dental Research study: Fluoridation is not associated with increase in osteosarcoma
The Journal of Dental Research published today the results of a study that demonstrated that community water fluoridation is not associated with increased risk of osteosarcoma. (2020-05-12)

NIH study provides genetic insights into osteosarcoma in children
A study by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, offers new insight into genetic alterations associated with osteosarcoma, the most common cancerous bone tumor of children and adolescents. The researchers found that more people with osteosarcoma carry harmful, or likely harmful, variants in known cancer-susceptibility genes than people without osteosarcoma. This finding has implications for genetic testing of children with osteosarcoma, as well as their families. (2020-03-19)

Osteosarcoma profiling reveals why immunotherapy remains ineffective
Comprehensive profiling of tumor samples taken from patients with osteosarcoma shows that multiple factors contribute to the traditionally poor responses observed from treatment with immune checkpoint inhibitors, according to new research from The University of Texas MD Anderson Cancer Center. (2020-02-21)

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease
The authors determined that tumor-derived ANGPTL2 stimulates lung epithelial cells, which is essential for primary tumor-induced neutrophil recruitment in lung and subsequent pre-metastatic niche formation. (2020-02-05)

Researchers identify targeted therapy that can help children with deadly nerve cancer
Mount Sinai researchers have identified a targeted therapy for adolescent patients with neuroblastoma, a deadly pediatric nerve cancer, who would otherwise have no treatment options, according to a study published in October in Cancer Cell. (2019-10-17)

Psoriasis drug target offers potential for osteosarcoma
Research reveals a new therapeutic target for the treatment of osteosarcoma. (2019-09-18)

Study reveals genetic similarities of osteosarcoma between dogs and children
A bone cancer known as osteosarcoma is genetically similar in dogs and human children, according to the results of a study published today by Tufts University and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope. The findings could help break the logjam in the treatment of this deadly disease, which hasn't seen a significant medical breakthrough in nearly three decades. (2019-07-19)

Timed release of turmeric stops cancer cell growth
A WSU research team has developed a drug delivery system using curcumin, the main ingredient in the spice turmeric, that successfully inhibits bone cancer cells while promoting growth of healthy bone cells. (2019-06-20)

New study reveals an unexpected survival mechanism of a subset of cancer cells
A research group led by Claus M. Azzalin at iMM has discovered that a human enzyme named FANCM is absolutely required for the survival of ALT tumor cells. The results were now published in the open access journal Nature Communications. Future strategies targeting the activity of this molecule in ALT tumor cells can constitute the basis of a novel therapeutic protocol for the treatment of these tumors. (2019-05-28)

Research brief: Largest study of childhood cancer after IVF
University of Minnesota researchers conducted the largest study of childhood cancer after conception by IVF to date. This population-based cohort study had nearly 2.5 times the number of children conceived by IVF than prior studies of the subject in Scandinavia and the United Kingdom. (2019-04-01)

HER2-targeted CAR T-cell therapy shows promising antitumor activity in patients with sarcoma
A combination of chemotherapy and chimeric antigen receptor (CAR) T cells designed to target the protein HER2 was found to be safe and showed clinical responses in pediatric and adult patients with advanced HER2-positive sarcoma, according to results from a phase I clinical trial presented at the AACR Annual Meeting 2019, March 29-April 3. (2019-03-31)

Case study documents bone cancer in 240-million-year-old stem-turtle
This research letter documents bone cancer in a 240-million-year-old stem-turtle from the Triassic period, helping to provide more data about the history of cancer in tetrapod evolution. This is a case study about a highly malignant bone tumor on the femur of a shell-less stem-turtle. (2019-02-07)

New precision medicine procedure fights cancer, advances treatment for pets and humans
In a first-of-its-kind study, scientists at the University of Missouri have helped advance a patient-specific, precision medicine treatment for bone cancer in dogs. By creating a vaccine from a dog's own tumor, scientists worked with ELIAS Animal Health to target specific cancer cells and avoid the toxic side effects of chemotherapy, while also opening the door for future human clinical trials. (2019-01-28)

Engineered immune cells target broad range of pediatric solid tumors in mice
Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study from the Stanford University School of Medicine. (2019-01-17)

Products of omega-3 fatty acid metabolism may have anticancer effects, study shows
A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer's growth and spread, University of Illinois researchers report in a new study in mice. In mice with tumors of osteosarcoma - a bone cancer that is notoriously painful and difficult to treat -- endocannabinoids slowed the growth of tumors and blood vessels, inhibited the cancer cells from migrating and caused cancer cell death. (2018-07-13)

Genetic discovery will help clinicians identify aggressive versus benign bone tumors
The first genetic marker for the bone tumor, osteoblastoma, has been discovered by scientists at the Wellcome Sanger Institute and their collaborators. Whole-genome and transcriptome sequencing of human bone tumors revealed that a genetic change that affects the transcription factor, FOS, is a hallmark mutation of osteoblastoma. The results, published in Nature Communications, will help clinicians correctly distinguish benign osteoblastoma tumors from aggressive osteosarcoma tumors and direct the correct treatment. (2018-06-12)

Zn-InsP6 complex can enhance excretion of radioactive strontium from the body
Researchers at Kanazawa University have found a new phenomenon that a complex of myo-inositol-hexakisphosphate (InsP6) with zinc enhances excretion of radioactive strontium from the body. (2018-06-01)

Signalling study sheds light on conditions from alopecia to cancer
Researchers from the University of Dundee and the Francis Crick Institute have made a significant discovery about a cellular pathway associated with developmental defects and a myriad of diseases ranging from alopecia to colorectal cancer. The research, jointly led by Dundee's Dr. Gopal Sapkota and Professor Sir Jim Smith of the Crick, examined the role of a protein called PAWS1 in the Wnt signalling pathway, which is of fundamental importance in shaping developing embryos and controlling cell fate in adults. (2018-03-22)

Researchers inhibit cancer metastases via novel steps
In one of the first successes of its kind, researchers have inhibited the spreading of cancer cells from one part of the body to another. In doing so, they relied on a new model of how cancer metastasizes that emphasizes epigenetics, which examines how genes are turned on and off. (2018-02-12)

Molecular imaging technique identifies lung nodules for resection in osteosarcoma patient
Utility of near-infrared molecular imaging in a patient undergoing pulmonary metastasectomy for osteosarcoma has been reported by researchers from Perelman School of Medicine at the University of Pennsylvania and Purdue University. The work is reported in an article in the Journal of Biomedical Optics published this week by SPIE, the international society for optics and photonics. (2018-01-05)

Cancer overrides the circadian clock to survive
Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, researchers at the Medical University of South Carolina (MUSC) find. A key part of the the circadian clock opposes this process, according to a report published online on December 11 in Nature Cell Biology. (2017-12-28)

Cancer drug starts clinical trials in human brain-cancer patients
A drug that spurs cancer cells to self-destruct has been cleared for use in a clinical trial of human patients with anaplastic astrocytoma, a rare malignant brain tumor, and glioblastoma multiforme, an aggressive late-stage cancer of the brain. (2017-11-27)

HKBU Chinese medicine scholars develop HKBU Chinese medicine scholars develop
Chinese Medicine scholars at Hong Kong Baptist University (HKBU) have succeeded in developing a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma (OS). (2017-11-10)

Study shows diet and exercise improve treatment outcomes for obese pediatric cancer patients
Diet and exercise may improve treatment outcomes in pediatric cancer patients, according to a study at The University of Texas MD Anderson Children's Cancer Hospital. (2017-09-21)

St. Jude unveils powerful resource to advance treatment of pediatric solid tumors
St. Jude Children's Research Hospital is offering the global scientific community no-cost access to an unprecedented collection of pediatric solid tumor samples and data to fuel research and move treatment forward. (2017-08-30)

No longer lost in translation
Mouse models have advanced our understanding of immune function and disease in many ways but they have failed to account for the natural diversity in human immune responses. As a result, insights gained in the lab may be lost in translation. In their latest study, researchers at La Jolla Institute for Allergy and Immunology, developed a new approach to model human immune variation in the lab that overcomes the limitations of traditional mouse models. (2017-07-26)

Elevated cholesterol's link with canine cancer includes a better prognosis
Usually thought of as a health detriment, elevated cholesterol may play a role in longer survival times for dogs with a common form of bone cancer. (2017-07-25)

Tumor-targeting drug shows potential for treating bone cancer patients
The treatment of osteosarcoma, the most common tumor of bone, is challenging. A study led by The University of Texas MD Anderson Cancer Center found a drug known as bone metastasis-targeting peptidomimetic (BMTP-11) has potential as a new therapeutic strategy for this devastating illness. (2017-07-12)

Existing drugs could benefit patients with bone cancer, genetic study suggests
A subgroup of patients with osteosarcoma -- a form of bone cancer -- could be helped by an existing drug, suggest scientists from the Wellcome Trust Sanger Institute and their collaborators. In the largest genetic sequencing study of osteosarcoma to date, scientists discovered that 10 percent of patients with a genetic mutation in particular growth factor signalling genes may benefit from existing drugs, known as IGF1R inhibitors. (2017-06-23)

Steady decrease in severe health problems for childhood cancer survivors
Treatments for childhood cancer are often intense and carry the risk of lifelong health problems for survivors. An analysis of 23,600 childhood cancer survivors in the Childhood Cancer Survivor Study (CCSS), funded by the National Institutes of Health, found that the rate of severe health problems occurring five or more years after diagnosis has declined over time. (2017-06-04)

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