Current Pancreatic Cancer News and Events

Current Pancreatic Cancer News and Events, Pancreatic Cancer News Articles.
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Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

Investment needed to bring down pancreatic cancer death rates in Europe
Researchers have called on European policymakers to make adequate resources available to tackle pancreatic cancer, a disease that is almost invariably fatal and where little progress has been made over the past 40 years. The latest predictions for cancer deaths in the EU and UK for 2021, published in the leading cancer journal Annals of Oncology, show that pancreatic death rates are predicted to remain approximately stable for men, but continue to rise in women in most EU countries. (2021-02-21)

Addressing the biological causes of racial disparities in prostate cancer
A new review published in Cancer Reports examines the biological differences in the development of prostate cancer across ethnicities. (2021-02-18)

Physical conditions linked to psychological distress in patients with cancer
Among patients with cancer, having additional physical comorbidities was linked with a higher risk of experiencing psychological distress. The finding comes from a Psycho-Oncology analysis of 2017 data from the National Health Survey of Spain. (2021-02-18)

TGen-led study confirms cell-free DNA in urine as potential method for cancer detection
What if a simple urine sample could detect cancer in its very earliest stages when the disease responds more favorably to treatment and improved outcomes are more likely? That was the question posed by scientists at the Translational Genomics Research Institute (TGen), who have found a way of zeroing in on early-stage cancer by analyzing short strands of cell-free DNA in urine. Their study's findings were published today in the scientific journal Science Translational Medicine. (2021-02-18)

UCLA study finds combination therapy suppresses pancreatic tumor growth in mice
UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN). (2021-02-18)

Fixer-upper: Understanding the DNA repair toolkit to chart cancer evolution
DNA repair pathways exist to correct molecular damage caused by internal and external factors. However, any damage to these pathways can result in the creation of tumors and specific types of cancers. A group of scientists from China have conducted an extensive investigation into the relationship of DNA repair pathways with cancer evolution. Their review, been published in Cancer Biology & Medicine, also shed light on the potential treatment applications of these mechanisms. (2021-02-16)

Exercise now proven to have mental health benefits for prostate cancer
New Edith Cowan University (ECU) research has found that exercise not only has physical benefits for men with prostate cancer, it also helps reduce symptoms of depression and anxiety. (2021-02-15)

Researchers have broken the code for cell communication
Knowledge on how cells communicate is an important key to understanding many biological systems and diseases. A research team led by researchers at the University of Gothenburg has now used a unique combination of methods to map the mechanism behind cellular communication. Their findings can potentially improve understanding of the underlying mechanism behind type 2 diabetes. (2021-02-12)

Oncotarget: Evaluation of cancer-derived myocardial impairments using a mouse model
'The established mouse cachexia model can therefore be considered useful for analyzing cancer-derived myocardial damage' (2021-02-10)

New study discovers possible early detection method for elusive ovarian cancer
A study led by researchers at the University of Minnesota Medical School found a way to detect the presence of ovarian cancer in patients using Pap test samples, normally used to detect cervical cancer. (2021-02-09)

Drug is promising against pancreatic and breast cancers
The drug is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology. A second study, published in the Journal of Experimental Medicine, shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis. Clinical trials are set to begin in 2021. (2021-02-09)

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output. (2021-02-07)

New biomarker may predict which pancreatic cancer patients respond to CD40 immunotherapy
Inflammation in the blood could serve as a new biomarker to help identify patients with advanced pancreatic cancer who won't respond to the immune-stimulating drugs known as CD40 agonists, suggests a new study from researchers in the Abramson Cancer Center of the University of Pennsylvania published in JCI Insight. (2021-02-04)

Researchers assess cognitive impairment in patients with breast cancer
A recent analysis of published studies in Psycho-Oncology estimates that one-quarter of adults with breast cancer have cognitive impairment before starting therapy. (2021-02-03)

More than half of cancer survivors have underlying medical conditions associated with severe COVID
New study finds more than half (56.4%) of cancer survivors in the United States reported having additional underlying medical conditions associated with severe COVID-19 illness. (2021-02-03)

MSK scientists learn how genes and environment conspire in pancreatic cancer development
Both genes and environment are necessary to trigger pancreatic cancer development. A new study from Memorial Sloan Kettering researchers explains why. (2021-02-03)

Study shows aspirin before a diagnosis may lower colorectal cancer mortality
A new study finds that long-term aspirin use before a diagnosis of colorectal cancer (CRC) may be associated with lower CRC-specific mortality. (2021-02-02)

Researchers discover mechanism to overcome drug-resistance in leukemia
In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published online today in the Proceedings of the National Academy of Sciences. (2021-02-01)

Study finds potential therapeutic targets to inhibit colorectal cancer progression
Nagoya University researchers and colleagues have revealed that colorectal cancer tissues contain at least two types of fibroblasts, namely, cancer-promoting fibroblasts and cancer-restraining fibroblasts, and that the balance between them is largely involved in the progression of colorectal cancer. Their findings suggest that artificially altering the balance between the two types of cells could curb the spread of colorectal cancer tumors, which may become an effective strategy for preventing cancer progression. (2021-01-30)

Mechanism for how pancreatic cancer evades immunotherapy elucidated
Pancreatic cancer, one of the most lethal of all cancers, is capable of evading attacks by immune cells by changing its microenvironment so that the immune cells suppress, rather than support, an attack on the tumor. The scientists also found that that some of the mediators of this suppressive response, including a protein called STAT1, represent potential therapeutic targets that could be used to reverse this evasion and point to possible treatment opportunities. (2021-01-28)

Nanoparticle drug delivery technique shows promise for treating pancreatic cancer
Veterans Affairs researchers have designed a new way to deliver pancreatic cancer drugs that could make fighting the disease much easier. (2021-01-28)

Scientists discover a new promising target for diabetes treatment
Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission. (2021-01-27)

Cancer deaths attributable to cigarette smoking in 152 US metropolitan and micropolitan areas
A new study shows 4 in 10 cancer deaths are attributable to cigarette smoking in parts of the South region and Appalachia. (2021-01-26)

Researchers develop virus-based treatment platform to fight pancreatic cancer
Researchers from Queen Mary University of London and Zhengzhou University have developed a powerful therapeutic platform that uses a modified virus for the treatment of pancreatic cancer. (2021-01-26)

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver. (2021-01-22)

Novel target identified that could improve safety of therapy for pancreatic cancer
Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer. Using this protein as a target, the team successfully created a CAR T cell therapy - a type of immunotherapy - that killed pancreatic cancer cells in a pre-clinical model. (2021-01-22)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Pre-surgery chemotherapy is possible for early stage pancreatic cancer patients
A first-of-its-kind randomized clinical trial found that patients with pancreatic cancer didn't live any longer than expected after receiving pre-operative chemotherapy from either of the two standard regimens, according to trial results published in JAMA Oncology. (2021-01-21)

Study updates breast cancer risk estimates for women with no family history
A new multi-institution study led by Fergus Couch, Ph.D., a Mayo Clinic pathologist, provides more accurate estimates of breast cancer risk for U.S. women who harbor inherited mutations in breast cancer predisposition genes. The findings of the CARRIERS Consortium study, published Jan. 20 in The New England Journal of Medicine, may allow health care providers to better assess the risk of breast cancer in women ? many of whom have no family history of breast cancer. (2021-01-21)

Researchers develop a new approach to detect pancreatic cancer
A protein found commonly in human blood might help with the detection of hard-to-diagnose pancreatic tumours. Researchers at Martin Luther University Halle-Wittenberg (MLU), the Alfried Krupp Hospital in Essen and the University of Witten/Herdecke have developed approach using the protein's structure and its function as a proxy for this. In a first study in ACS Pharmacology & Translational Science, the team shows how its method can also be used to differentiate between benign and malignant tumours. (2021-01-20)

Cancer-related suicide declined in the US during the past two decades
Despite increases in overall suicide rates in the United States during the past two decades, cancer-related suicides declined by 2.8% per year, according to a new study by the American Cancer Society. (2021-01-19)

Single-cell test can reveal precisely how drugs kill cancer cells
Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) have developed a method named D2O-probed CANcer Susceptibility Test Ramanometry (D2O-CANST-R) to see, at single-cell/organelle level, how pharmaceuticals induce cancer cell death and how cancer cells adapt. (2021-01-19)

Report shows alcohol consumption linked to portion of cancer incidence and mortality
A new study finds that alcohol consumption accounts for a considerable portion of cancer incidence and mortality in all 50 states and the District of Columbia. (2021-01-19)

New computational tool reliably differentiates between cancer and normal cells from single-cell RNA-sequencing data
MD Anderson researchers have developed a new computational tool to accurately differentiate between cancer cells and normal cells when analyzing large single-cell RNA-sequencing data. (2021-01-18)

A master cancer gene hijacks a 'molecular crowbar' to make breast cancer cells invasive
Researchers investigated how cancer genes lead to the breakdown of the capsule that prevents cancerous cells from invading the surrounding healthy tissues and - find a hijacked ''molecular crowbar''. The new findings help understand the mechanisms of cancer spreading and reveal a cancer vulnerability. (2021-01-18)

Esophageal cancer patients show abundance of oral pathogens
DNA from various oral bacterial pathogens has been found in tumors from esophageal cancer patients. Researchers led by Tokyo Medical and Dental University (TMDU) examined bacterial pathogens in plaque and saliva from esophageal cancer patients, determining that a prevalence of three species in particular, along with alcohol consumption, is associated with a high risk of esophageal cancer. Screening of oral pathogens could therefore be used for early disease detection. (2021-01-14)

New insights into pancreatitis
Acute Pancreatitis (AP) is one of the most common diseases around the world. Associated with a considerable risk of morbidity and even death in patients who suffer a severe form of the disease, to date there is no specific treatment for it. Now international AP experts have published a roadmap in the journal Gut (BMJ) pinpointing the two most significant thresholds in the disease that could serve as a starting point for targeting treatment strategies for this extremely painful condition. (2021-01-13)

Discovery of a new approach to inhibiting a highly treatment-refractory liver cancer
Blocking placental growth factor (PlGF), a member of the vascular endothelial growth factor family, inhibits the progression of intrahepatic cholangiocarcinoma (ICC) and enhances the efficacy of chemotherapy in mouse models. This novel approach to targeting the connective tissue microenvironment of ICC, a rare but notoriously treatment-resistant form of liver cancer, could pave the way for combination therapies, including chemotherapy and immune checkpoint blockade. (2021-01-12)

Deep learning helps predicting occult peritoneal metastasis in stomach cancer
A new study led by the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences shows that deep learning can help predicting the occult peritoneal metastasis in stomach cancer. It provides a novel and noninvasive approach for stomach cancer patients and may inform individualized surgical management of stomach cancer. (2021-01-07)

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