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Current Pathology News and Events

Current Pathology News and Events, Pathology News Articles.
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New therapeutic avenue in the fight against chronic liver disease
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has introduced a novel targeted drug delivery system in the fight against cancer. (2019-01-18)
Air pollution in Mexico City is associated with the development of Alzheimer disease
A new study by researchers at the Universities of Montana, Valle de México, Boise State, Universidad Veracruzana, Instituto Nacional de Pediatría and Paul-Flechsig-Institute for Brain Research heightens together with German company Analytik Jena concerns over the evolving and relentless Alzheimer's pathology observed in young Metropolitan Mexico City (MMC) urbanites. (2018-12-21)
Neurons with good housekeeping are protected from Alzheimer's
A new study finds that some brain cells protect themselves from Alzheimer's with a cellular cleaning system that sweeps away toxic proteins associated with the disease. (2018-12-17)
Amyloid pathology transmission in lab mice and historic medical treatments
A UCL-led study has confirmed that some vials of a hormone used in discontinued medical treatments contained seeds of a protein implicated in Alzheimer's disease, and are able to seed amyloid pathology in mice. (2018-12-13)
Improved understanding of the pathology of dwarfism may lead to new treatment targets
Pseudoachondroplasia (PSACH) is a severe inherited dwarfing condition In PSACH, a genetic mutation leads to abnormal retention of cartilage oligomeric matrix protein (COMP) within the endoplasmic reticulum (ER) of cartilage-producing cells (chondrocytes), which interferes with function and cell viability. (2018-12-12)
New information on the pathological mechanisms of Alzheimer's disease
Researchers at the University of Helsinki have discovered a mechanism by which harmful tau protein aggregates are transmitted between neurons. (2018-11-20)
Big change from small player -- Mitochondria alter body metabolism and gene expression
Mitochondria have their own DNA, but the 13 genes in human mitochondria -- along with DNA sequences for tRNAs, rRNAs and some small peptides -- are massively overshadowed by the 20,000 genes in the human nucleus. (2018-11-09)
Disrupted circadian rhythms may drive anxiety and exacerbate brain disorders
Sleep disruptions are associated with many brain disorders, including anxiety, dementias, and traumatic brain injury. (2018-11-05)
Genetic risk factor for CTE detected
Researchers have identified a genetic variation that may influence chronic traumatic encephalopathy (CTE) disease severity. (2018-11-03)
Becoming more sensitive to pain increases the risk of knee pain not going away
A new study by researchers in Montreal and Boston looks at the role that pain plays in osteoarthritis, a disease that affects over 300 million adults worldwide. (2018-10-30)
Early sleep loss accelerates Alzheimer's pathology in mice
Lack of sleep during adolescence and early adulthood accelerates Alzheimer's disease (AD)-related tau pathology, finds a study of male and female mice published in JNeurosci. (2018-10-15)
Early changes to synapse gene regulation may cause Alzheimer's disease
TMDU-led Japanese research revealed a role for splicing proteins in the pathology of Alzheimer's disease. (2018-10-12)
Pathology test uses AI to predict prostate cancer progression following surgery
A pathology test that applies artificial intelligence (AI) to characterize tissue samples can accurately predict clinically significant prostate cancer disease progression following surgery. (2018-10-02)
Minimally invasive autopsy improves postmortem diagnoses
Minimally invasive autopsy with CT and MRI performs as well as conventional autopsy in detecting cause of death and has the advantage of yielding more diagnoses, according to a new study. (2018-09-25)
Newly discovered enzyme is 'firing pin' for plant immunity
Just like humans, plants have an immune system that helps them fight off infections. (2018-09-17)
Otago researchers find answers as to why some people are at risk of gout
University of Otago researchers have helped characterize a genetic variant that enables new understanding of why some people are at risk of gout, a painful and debilitating arthritic disease. (2018-09-12)
Scientists identified enzyme in milk production as target for novel breast cancer drugs
VCU Massey Cancer Center researchers have identified a protein involved in milk production that stimulates the growth and spread of breast cancer and could ultimately serve as a target for novel therapies to treat breast cancer. (2018-09-11)
New tool to detect fatty liver disease before liver damage
A new test may soon be available to predict advanced fibrosis in people with non-alcoholic fatty liver disease (NAFLD). (2018-09-11)
Colorectal cancer: Tipping the scales
Tumors of the colon are among the most prevalent cancers. (2018-09-04)
Overcoming resistance
In a recent paper published in the journal Clinical Cancer Research (CCR), Carmelo Nucera, M.D., Ph.D., primary investigator in the thyroid cancer research program in the Division of Experimental Pathology in BIDMC's Department of Pathology, and colleagues investigated the role of pericytes as part of the tumor microenvironment in the subset of papillary thyroid cancers modulated by a mutation of the BRAF cancer-promoting gene. (2018-08-31)
When neurons turn against themselves
Rasmussen's encephalitis is a rare autoimmune disease that primarily affects children and can lead to seizures. (2018-08-30)
Two new truffle species discovered in Florida pecan orchards
Two new species of truffles were recently discovered on the roots of pecan trees in Florida orchards. (2018-08-23)
Researchers test autobiographical memory for early Alzheimer's detection
UA psychologist Matthew Grilli found that carriers of a gene variant that increases the risk for Alzheimer's disease have greater difficulty describing detailed memories of past events. (2018-08-23)
AMP addresses clinical relevance of DNA variants in chronic myeloid neoplasms
AMP published consensus, evidence-based recommendations to aid clinical laboratory professionals with the management of most Chronic Myeloid Neoplasms (CMNs) and development of high-throughput pan-myeloid sequencing testing panels. (2018-08-21)
Cellular escape artists help explain why some women present with advanced ovarian cancer
In a new study published recently in The Journal of Pathology, BWH investigators conducted an exhaustive analysis of 'normal' fallopian tubes from patients with HGSC. (2018-08-13)
Epigenetic reprogramming of human hearts found in congestive heart failure
Congestive heart failure is a terminal disease that affects nearly 6 million Americans. (2018-08-09)
Newly characterized molecule offers possibilities for novel Alzheimer's treatments
A study by researchers from Brigham and Women's Hospital (BWH), recently published in Acta Neuropathologica, investigated lesser-known molecules involved in tauopathies like Alzheimer's. (2018-08-02)
MGH team defines the mechanisms of action of key genetic abnormality in Ewing sarcoma
A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma -- the second most common bone cancer in children and young adults -- unleashes tumor growth. (2018-08-02)
MicroRNA panel can identify malignancy in indeterminate thyroid nodules
A panel of 19 microRNAs identified using next-generation sequencing could categorize indeterminate thyroid nodule samples into malignant and benign. (2018-07-26)
Contact sports associated with Lewy body disease, Parkinson's disease symptoms, dementia
There is mounting evidence that repetitive head impacts from contact sports and other exposures are associated with the neurodegenerative disease chronic traumatic encephalopathy (CTE) and dementia. (2018-07-25)
Scientists reverse aging-associated skin wrinkles and hair loss in a mouse model
Researchers have reversed wrinkled skin and hair loss, hallmarks of aging, in a mouse model. (2018-07-20)
Traumatic brain injury biomarker shows promise to support rapid damage evaluation and predict outcomes
A new study in The American Journal of Pathology found that a brain lipid molecule, lysophosphatidic acid (LPA), was significantly increased after traumatic brain injury (TBI) in a preclinical animal model. (2018-07-16)
UMN Medical School discovery could mean improved immunity against reinfections
University of Minnesota researchers have discovered a connection between the body's memory cells and a unique protein in the body called purinergic receptor P2RX7, influencing the body's long-term immune system. (2018-07-10)
Alternative splicing is crucial to muscle mass maintenance
Alternative splicing plays a crucial role in maintaining adult muscle mass, which has implications in aging and chronic disease. (2018-07-10)
Treating Alzheimer's with aspirin
A low-dose aspirin regimen may represent a new avenue for reducing Alzheimer's disease pathology, according to new research in a mouse model of the disease published in JNeurosci. (2018-07-02)
Can aspirin treat Alzheimer's?
regimen of low-dose aspirin potentially may reduce plaques in the brain, which will reduce Alzheimer's disease pathology and protect memory, according to neurological researchers at Rush University Medical Center, who published the results of their study today in the July issue of The Journal of Neuroscience. (2018-07-02)
Otago researchers' discovery unlocks secrets behind cancer drug resistance
University of Otago research provides insights into an underlying mechanism that could explain why new cancer therapies to help treat metastatic melanoma do not always work on patients, paving the way for predicting which patients will benefit from certain drugs. (2018-06-29)
Immune cells that create and sustain chronic inflammatory bowel disease identified
In preclinical experiments, Laurie Harrington and colleagues have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease. (2018-06-26)
Surgery in space
With renewed public interest in manned space exploration comes the potential need to diagnose and treat medical issues encountered by future space travelers. (2018-06-20)
Sensitive new assay finds abnormalities in tumor cells that other techniques may miss
RNA-Seq, a new next-generation assay, can detect gene fusions in solid tumor cells with high accuracy and excellent reproducibility. (2018-06-18)
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