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Current Pelvic Organ Prolapse News and Events, Pelvic Organ Prolapse News Articles.
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Novel type of bird pollination mechanism discovered in South America
Interactions between flowering plants and their pollinators include some of the most elaborate and intriguing relationships known to science. Agnes Dellinger from the Department of Botany and Biodiversity Research of the University of Vienna and her co-authors have studied the pollination biology of a group of small trees in South American rainforests. What they found is a most unusual relationship with the birds that pollinate the flowers of these plants. The results are published in Current Biology. (2014-07-04)

Unsuspected aspect of immune regulation revealed
Until now, the immune cells known as 'B cells' have been thought to specialise only in the production of antibodies. A discovery by Australian immunologists shows they also have a role to play in regulating another important aspect of the immune system. This finding may benefit research into autoimmunity and transplantation. (2014-07-01)

Researchers seek to tackle transplant tolerance using patients' own T cells
A new Northwestern Medicine clinical trial aims to remove the need for organ transplant patients to take immunosuppressive drugs by increasing the number of their own regulatory T cells. The first-in-human, Phase I clinical trial, known as TRACT (T-regs for adoptive cell transfer), recently enrolled its first three participants in late May at Northwestern Memorial Hospital. Northwestern Memorial is the only enrollment site for this trial. (2014-06-30)

Annals of Internal Medicine tip sheet for July 1, 2014
The July 1, 2014, issue of Annals of Internal Medicine contains the following articles: 'American College of Physicians recommends against routine pelvic exam, finds harms outweigh any demonstrated benefit'; 'Initial treatment with efavirenz-containing antiretroviral regimen doubles risk for suicidal behaviors'; and 'Daily prophylactic oral tenofovir protects against herpes simplex virus 2.' (2014-06-30)

ACP recommends against pelvic exam in asymptomatic, average risk, non-pregnant women
ACP's new evidence-based guideline finds that harms of screening pelvic examination outweigh any demonstrated benefits. (2014-06-30)

Massachusetts General-developed protocol could greatly extend preservation of donor livers
A system developed by investigators at the Massachusetts General Hospital Center for Engineering in Medicine allowed successful transplantation of rat livers after preservation for as long as four days, more than tripling the length of time organs currently can be preserved. (2014-06-29)

Virus infection supports organ acceptance
Chronic hepatitis C virus infections are among the most common reasons for liver transplants. Because existing viruses also infect the new liver, the immune system is highly active there. Despite this, the new organ is not rejected, as scientists from the Helmholtz Zentrum Muenchen and the Technische Universitaet Muenchen have now discovered. The long-term stimulation of the innate immune system by the virus actually increases the probability of tolerance. (2014-06-26)

Scientists find the shocking truth about electric fish
Scientists have found how the electric fish evolved its jolt. Writing June 27, 2014, in the journal Science, a team of researchers led by Michael Sussman of the University of Wisconsin-Madison, Harold Zakon of the University of Texas at Austin and Manoj Samanta of the Systemix Institute in Redmond, Wash., identifies the regulatory molecules involved in the genetic and developmental pathways that electric fish have used to convert a simple muscle into an organ capable of generating a potent electrical field. (2014-06-26)

Stem cell transplantation for severe sclerosis associated with improved long-term survival
Among patients with a severe, life-threatening type of sclerosis, treatment with hematopoietic stem cell transplantation, compared to intravenous infusion of the chemotherapeutic drug cyclophosphamide, was associated with an increased treatment-related risk of death in the first year, but better long-term survival, according to a study in the June 25 issue of JAMA. (2014-06-24)

New study explains how organs coordinate their development with the whole body
A research group led by Christen Mirth at Instituto Gulbenkian de Ciência uncovered that the development of wings in fruit flies does not progress synchronously with the organism's development. Instead, it is coordinated with the whole body only at distinct 'milestones'. This study, published in the latest issue of the scientific journal PLOS Genetics, helps explain how an organism facing environmental and physiological perturbations retains the ability to build correct functional organs and tissues in a proportional adult body. (2014-06-20)

The Lancet Infectious Diseases: Oldest ever schistosomiasis egg found may be first proof of early human technology exacerbating disease burden
The discovery of a schistosomiasis parasite egg in a 6200-year-old grave at a prehistoric town by the Euphrates river in Syria may be the first evidence that agricultural irrigation systems in the Middle East contributed to disease burden, according to new Correspondence published in The Lancet Infectious Diseases. (2014-06-19)

New book from CSHLPress provides a comprehensive review of the biology of the skin
'The Skin and Its Diseases' from Cold Spring Harbor Laboratory Press is a vital reference for dermatologists, cancer biologists, cell and developmental biologists, immunologists, and all who seek to understand the numerous functions and diseases of this major organ. (2014-06-13)

Male dwarf spiders make sure offspring is their own
Chastity belts were not first thought out in mediaeval times - members of many animal groups have evolved similar mechanical safeguards to ensure their paternity. Male dwarf spiders, for instance, use mating plugs to block off the genital tract of the female they have just mated with. So says Katrin Kunz and co-authors of the Zoological Institute and Museum in Greifswald, Germany, in an article published in Springer's journal Behavioral Ecology and Sociobiology. (2014-06-10)

Presurgical SPECT/CT shows more cancer than current standard
Startling data from an international multi-center trial provide growing evidence that sentinel node imaging is more effectively accomplished with hybrid functional imaging with single photon emission computed tomography and computed tomography than with another molecular imaging technique called lymphoscintigraphy. This conclusion held after imaging a range of cancers displaying a variety of lymphatic drainage types associated with melanoma, an aggressive skin cancer; breast carcinoma; and malignancies of the pelvis, such as prostate and cervical cancer. (2014-06-09)

Clinical review published in JAMA
Many women experience mixed urinary incontinence, urine loss with laughing, coughing and sneezing AND on their way to the bathroom. Dr. Deborah Myers has published a clinical review on on the topic in JAMA. (2014-06-06)

New research provides better understanding of endometriosis
A mouse model of endometriosis has been developed that produces endometriosis lesions similar to those found in humans, according to a report published in The American Journal of Pathology. This model closely mirrors the human condition as an estrogen-dependent inflammatory disorder, and findings from the study suggest that macrophages present in shed endometrium contribute to the development of the lesions. (2014-06-05)

Mechanism of cell death unraveled -- perspectives for treating inflammatory diseases
Researchers at VIB and Ghent University have unraveled the mechanism of necroptosis. This is a type of cell death that plays a crucial role in numerous diseases, from viral infections and loss of auditory nerve cells to multiple sclerosis, acute heart failure and organ transplantation. Having detailed knowledge of the cell death process enables a targeted search for new drugs. (2014-06-04)

How breast cancer 'expresses itself'
Two Tel Aviv University researchers have found that 'gene regulation,' the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer. Their research proves a significant link between breast-specific genes and the pathology of cancer. (2014-05-29)

UCI researchers identify new functional roles on cell surfaces for estrogen
A discovery by UC Irvine endocrinologists about the importance of cell surface receptors for estrogen has the potential to change how researchers view the hormone's role in normal organ development and function. (2014-05-27)

The Lancet: Scientists invent kidney dialysis machine for babies and safely treat newborn with multiple organ failure
Italian scientists have developed a miniaturized kidney dialysis machine capable of treating the smallest babies, and have for the first time used it to safely treat a newborn baby with multiple organ failure. This technology has the potential to revolutionize the treatment of infants with acute kidney injury, according to new research published in The Lancet. (2014-05-22)

Key genetic link between chronic pain conditions like IBS discovered
Researchers at King's College London have discovered a link between four common chronic pain syndromes, suggesting that some people may be genetically predisposed to suffer from conditions of this type. The study, published in the journal Pain, examined identical and non-identical twins and established that IBS, musculoskeletal pain, pelvic pain and dry eye disease may have hereditary links. Migraine was shown, as previously, to have a degree of genetic susceptibility but was not genetically linked to the other conditions. (2014-05-20)

New kidney allocation policy could improve the success of transplantations in the US
Simulation models predict that a newly approved kidney allocation policy will lead to an average 7.0 percent increase in median patient life-years per transplant and an average 2.8 percent increase in median allograft years of life. The policy may also improve access to transplantation for highly sensitized candidates but reduce access for older patients. (2014-05-15)

Donor livers preserved and improved with room-temperature perfusion system
A system developed by investigators at the Massachusetts General Hospital Center for Engineering in Medicine and the MGH Transplant Center has the potential to increase both the supply and the quality of donor organs for liver transplantation. (2014-05-06)

Clinical opinion published in American Journal of Obstetrics and Gynecology
A clinical opinion by Dr. Charles Rardin about the use of robotics for minimally invasive gynecologic surgery has been published in the May edition of the American Journal of Obstetrics and Gynecology. (2014-05-01)

Studies offer insight on how to improve kidney and liver transplantation
The quality of kidney and liver donations is fundamentally important for the longevity of transplants and the health of recipients. (2014-04-28)

Technological advancements extend survival of transplanted hearts across species
The use of transplant organs from animals (xenotransplantation) could help to compensate for the shortage of human organs available for transplant. National Institutes of Health researchers have demonstrated that by using hearts from genetically engineered pigs in combination with target-specific immunosuppression of recipient baboons, organ survival can be significantly prolonged. This has potential for paving the way for the use of animal organs for transplantation into humans. (2014-04-28)

Transplant success tied to naturally high levels of powerful immune molecule package
Patients with highest levels of the most powerful version of the immune molecule HLA-G appear to have the lowest risk of rejecting their transplanted kidney, researchers report. (2014-04-28)

Specialized yoga program could help women with urinary incontinence
An ancient form of meditation and exercise could help women who suffer from urinary incontinence, according to a new study from UC San Francisco. (2014-04-25)

ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer
The American Society for Radiation Oncology (ASTRO) has issued a new guideline, 'The Role of Postoperative Radiation Therapy for Endometrial Cancer: An ASTRO Evidence-Based Guideline,' that details the use of adjuvant radiation therapy in the treatment of endometrial cancer. (2014-04-23)

Feinstein Institute researcher publishes new perspective on sepsis
In a review published in the April issue of Immunity, Kevin J. Tracey, M.D., president of the Feinstein Institute for Medical Research, says it's time to take a fresh look at the medical community's approach to treating sepsis, which kills millions worldwide every year, including more than 200,000 Americans. (2014-04-17)

In sex-reversed cave insects, females have the penises
Researchers reporting in the Cell Press journal Current Biology on April 17 have discovered little-known cave insects with rather novel sex lives. The Brazilian insects, which represent four distinct but related species in the genus Neotrogla, are the first example of an animal with sex-reversed genitalia. (2014-04-17)

Some immune cells defend only 1 organ
Scientists have discovered that some organs have the immunological equivalent of 'neighborhood police' -- specialized squads of defenders that patrol only one area, a single organ, instead of an entire city, the body. (2014-04-16)

To be an organ donor, specific attitudes trump general support, study finds
Most Americans say they support the idea of organ donation, yet fewer than half of eligible donors ever register, national polls show. That may be because supporting a good cause doesn't mean people will take action. However, people are more likely to sign up if they have positive attitudes specifically about registering as a donor, according to research published by the American Psychological Association. (2014-04-11)

Ancient shrimp-like animals had 'modern' hearts and blood vessels
In 520 million-year-old fossil deposits resembling an 'invertebrate version of Pompeii,' researchers have found an ancestor of modern crustaceans revealing the first-known cardiovascular system in exquisitely preserved detail. The organ system is surprisingly complex and adds to the notion that sophisticated body plans had already evolved more than half a billion years ago. (2014-04-07)

Milk thistle extract, silibinin, reduces self-renewal of colorectal cancer stem cells
A University of Colorado Cancer Center study presented today at the American Association for Cancer Research Annual Meeting 2014 shows that the chemical silibinin, purified from milk thistle extract, affects cell signaling associated with inflammation and thus also the formation and survival of colorectal cancer stem cells. (2014-04-07)

Dose-escalated hypofractionated IMRT, conventional IMRT for prostate cancer have like side effects
Dose-escalated intensity modulated radiation therapy with use of a moderate hypofractionation regimen -- 72 Gy in 2.4 Gy fractions -- can safely treat patients with localized prostate cancer with limited grade 2 or 3 late toxicity, according to a study published in the Apr. 1, 2014, edition of the International Journal of Radiation Oncology · Biology · Physics -- Red Journal -- the official scientific journal of the American Society for Radiation Oncology. (2014-04-03)

Transplant drugs may help wipe out persistent HIV infections
New research suggests that drugs commonly used to prevent organ rejection after transplantation may also be helpful for combating HIV. The findings, which are published in the American Journal of Transplantation, suggest a new strategy in the fight against HIV and AIDS. (2014-04-03)

Low sodium levels pre-transplant does not affect liver transplant recipient survival
Researchers report that low levels of sodium, known as hyponatremia, prior to transplantation does not increase the risk of death following liver transplant. Full findings are published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. (2014-04-01)

GW researcher invents 'mini heart' to help return venous blood
Narine Sarvazyan, Ph.D., professor of pharmacology and physiology at the George Washington University School of Medicine and Health Sciences, has invented a new organ to help return blood flow from veins lacking functional valves. (2014-03-27)

Notre Dame scientists develop largest developmental proteomic data set for any animal
Notre Dame researchers have developed the largest data set on developmental proteomics for any organism, and have included the single-cell zygote. (2014-03-27)

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