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Current Pelvic Organ Prolapse News and Events, Pelvic Organ Prolapse News Articles.
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The economic burden of kidney transplant failure in the United States
A recent analysis published in the American Journal of Transplantation estimates that for the average US patient who has undergone kidney transplantation, failure of the transplanted organ (graft failure) will impose additional medical costs of $78,079 and a loss of 1.66 quality-adjusted life years. (2020-02-05)

Virtual crossmatching improves quality of life for kidney transplant patients
Virtual antibody crossmatching is a safe and efficient way of selecting kidney transplant recipients. Two years after implementing the process, the Medical University of South Carolina (MUSC) division of transplant surgery, Charleston, concluded that the technique was just as accurate and sensitive as physical crossmatch, the current gold standard, and much quicker. (2020-01-31)

MSU researcher aids discovery of new cellular mechanism
Montana State University's Ed Schmidt played a key role on an international team that recently discovered a previously unknown mechanism cells can use to protect themselves from oxidative damage. (2020-01-30)

Hope for enhanced UTI treatments to minimize bladder pain
The fight against Urinary Tract Infection pain, discomfort and a constant urge to urinate has taken a step forward with scientists identifying how the immune systems defence against bladder infection causes nerves to magnify sensations felt by patients. Flinders University researchers at SAHMRI in collaboration with Griffith University on the Gold Coast, have analysed how the immune system responds to urinary tract infections and the direct link this response has to magnifying bladder pain. (2020-01-29)

Mixed chimerism improves long-term kidney transplant outlook
Mixed chimerism - the continued mixing of donor and recipient blood cells following a transplant of blood progenitor cells - could improve outcomes for kidney transplant recipients, according to a new clinical study in about 50 patients. (2020-01-29)

Bone marrow-on-a chip provides new research directions for Shwachman-Diamond Syndrome
A new research tool that mimics the behavior of diseased bone marrow provides a new strategy for understanding the bone marrow disease, Shwachman-Diamond syndrome (SDS), and hopefully, developing new treatments. (2020-01-28)

anti-cancer drug safe and effective for treating light chain (AL) amyloidosis
There's a new treatment option available for patients with AL amyloidosis: daratumumab. Studied in a prospective clinical trial, only one of the two clinical trials of this agent in AL amyloidosis worldwide, researchers have found this anti-cancer drug to be well tolerated and effective in patients with relapsed AL amyloidosis when used with appropriate pre- and post-infusion medications. (2020-01-27)

Enhancing drug testing with human body-on-chip systems
Scientists at Tel Aviv University and Harvard University have devised a functioning comprehensive multi-Organ-on-a-Chip (Organ Chip) platform that enables effective preclinical drug testing of human drug pharmacology. (2020-01-27)

Subtle structural features in donated kidneys may predict risk of transplant failure
Mayo Clinic researchers have discovered that subtle structural features in kidneys from living donors that can only be seen with a microscope may predict the risk of transplant failure in recipients. The findings are published online in the Journal of the American Society of Nephrology. (2020-01-23)

Certain liver cells may help prevent organ rejection after transplant, study finds
Mesenchymal stromal cells from fat tissue and bone marrow are widely used in therapeutic trials for their anti-inflammatory qualities, but new Mayo Clinic research finds that liver cells may be of greater value. The study, published in Liver Transplantation, finds that liver mesenchymal stromal cells have immunoregulatory qualities that make them more effective than similar cells derived from adipose, or fat, tissue and bone marrow. (2020-01-21)

Magnetic nanomaterials become an effective treatment against liver fibrosis
Fibrosis may affect different body organs. It develops as a reaction to long-time inflammation and is supposed to isolate the inflammation site from surrounding tissues. For example, chronic liver fibrosis may occur if the liver is constantly influenced by toxins, viruses, or metabolic disturbances. Liver damage is caused by the hepatocytes death, the main type of liver cells that secure the functioning of the organ. (2020-01-20)

Study quashes controversial vitamin C treatment for sepsis with global trial
A paper published today in the Journal of the American Medical Association by Monash researchers comprehensively quashes the idea that the vitamin C-based cocktail has any positive impact on patients with sepsis. (2020-01-17)

Massachusetts General Hospital performs first-of-its-kind heart transplant in New England
Mass General Hospital recently performed the largest number of adult heart transplants in the country using what are known as Donation after Circulatory Death (DCD) donor hearts. (2020-01-10)

Gene network helps to turn white fat into beneficial calorie-burning fat
1.9 billion people in the world are overweight. Of these, 650 million people are obese, which increases the risk of secondary diseases such as cancer. Professor Martin Klingenspor and his team at the Technical University of Munich (TUM) examine how our fat metabolism affects our health. In cooperation with the École Polytechnique Fédérale de Lausanne (EPFL), the team has uncovered a network of genes that could turn energy-storing fat into beneficial calorie-burning fat. (2020-01-09)

Study reveals insights on hidden sexual-arousal disorder
Results indicate that persistent genital arousal disorder can be caused by altered firing of nerves that carry sensations from the genitalia or by damage to the lowest parts of the spinal cord. (2020-01-09)

'Gift of life' marketing fails to motivate many donors
With a global shortage of both blood and organ donors, QUT researchers are suggesting language used to attract donors be changed, especially for organ donor donation. The behavioral economists say focusing on a sense of social obligation rather than 'gift of life term' terminology may have better cut-through with non-donors. (2020-01-09)

Heart transplants from donors with hepatitis C may be safe and could help decrease organ shortage
One-year survival was 90% for adults with severe heart failure who received a heart transplant from a donor with hepatitis C, which was nearly identical to those who received a heart from donors who did not have hepatitis C (91%). Rates of organ rejection, stroke and kidney dialysis were similar between the two groups. More research is needed to assess longer-term results, however, increased use of hearts from donors with hepatitis C could help overcome the national shortage of donor organs. (2020-01-08)

Young women still may be getting unnecessary pelvic exams
Pelvic examinations and cervical cancer screenings are no longer recommended for most females under age 21 during routine health visits, but a new study has found that millions of young women are unnecessarily undergoing the tests, which can lead to false-positive testing, over-treatment, anxiety and needless cost. (2020-01-06)

New research may lead to increased use of available hearts for transplant
A new study provides hope that the number of children dying on the transplantation list while waiting for a new heart could potentially be reduced dramatically. The study, published online in the Annals of Thoracic Surgery, demonstrates that many of the donor hearts deemed 'high-risk' can be transplanted with the same survival rates as 'low-risk' donor hearts. (2020-01-06)

Individualized physical therapy reduces incontinence, pain in men after prostate surgery
For decades, therapy to strengthen pelvic muscles has been the standard treatment for men dealing with urinary incontinence after prostate surgery. But a new study suggests that may not be the best approach. (2019-12-30)

The 'airbag' that protects cells against stress
CNIC scientists have identified the molecular mechanisms that allow our cells to adapt to, protect themselves against, and survive mechanical stress. (2019-12-20)

New study shows how patients' health values can impact vital pelvic floor treatment
Researchers and health professionals in Swansea have revealed the value women put on their own health can have a direct effect on the success of medical treatment for pelvic floor problems. (2019-12-20)

UTHealth's Cynthia Ju awarded NIH grants for liver injury research
Tiny solutions are being sought for big liver problems by a scientist at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth). (2019-12-20)

New 'tooth-on-a-chip' could lead to more personalized dentistry
A so-called ''tooth-on-a-chip'' could one day enable more personalized dentistry, giving dentists the ability to identify dental filling materials that work better and last longer based on a patient's own teeth and oral microbiome. The miniaturized tooth system is a thin slice of a human molar placed in between transparent rubber slides that are etched with tiny channels, through which fluids flow. It mimics a real tooth with a cavity. (2019-12-19)

A test of a customized implant for hip replacement
A team of scientists from the Advanced Manufacturing Technologies Center of the National Technology Initiative (NTI) of Peter the Great St. Petersburg Polytechnic University (SPbPU) developed a mathematical model of an 'endoprosthesis-skeleton' system. Special attention was paid to the geometry and internal structure of hip bones. (2019-12-13)

Print me an organ -- Why are we not there yet?
SUTD leads in-depth review on the impending reality of 3D printed organs and analyses recent accomplishments, limitations and opportunities for future research. (2019-12-11)

Fresh red blood cell transfusions do not help critically ill children more than older cells
Researchers have found that transfusions using fresh red blood cells -- cells that have spent seven days or less in storage -- are no more beneficial than older red blood cells in reducing the risk of organ failure or death in critically ill children. The findings, the researchers said, should reassure doctors that the standard practice of using older red cells is just as safe and effective in these children, who are among the sickest and most fragile of patients. (2019-12-10)

Blood transfusions: Fresh red blood cells no better than older ones
Findings from the ABC-PICU study on critically ill children may alter policies at hospitals where fresh red cells are preferentially used. (2019-12-10)

Researchers create accurate model of organ scarring using stem cells in a lab
A team led by Dr. Brigitte Gomperts at UCLA has developed a 'scar in a dish' model that uses multiple types of cells derived from human stem cells to closely mimic the progressive scarring that occurs in human organs. The researchers used this model to identify a drug candidate that stopped the progression of and even reversed fibrosis in animal models. (2019-12-10)

Air pollution may increase mortality risk after heart transplant
Heart transplant recipients who live in areas where particulate matter (PM2.5) air pollution levels reached above national limits for clean air had a 26% higher risk of mortality due to infection, according to a study published today in the Journal of the American College of Cardiology. (2019-12-09)

Discovery of genes involved in the biosynthesis of antidepressant
Summary: - St. John's Wort Hypericum perforatum is an ancient medicinal plant. It is known for the mild antidepressant properties of its bioactive compound hypericin, which is produced in the dark glands of the plant. - By investigating the flowers of St. John's Wort, researchers identified genes involved in dark gland development and the biosynthesis of hypericin. - The findings were published in the Plant Biotechnology Journal. (2019-12-06)

Using lungs from increased-risk donors expands donor pool, maintains current survival rates
Cleveland Clinic researchers have found that using lungs from donors who are considered high risk for certain infectious diseases compared to standard risk donors results in similar one-year survival for recipients. In addition, researchers saw no difference in rejection or graft (donor lung) survival after one year in patients receiving lungs from increased-risk donors. (2019-12-05)

New study provides insight into chronic kidney disease
Researchers have further analyzed a known signaling pathway they believe brings them one step closer to understanding the complex physiology of patients with chronic kidney disease (CKD), which might provide a path to new treatment options. (2019-12-04)

Endometriosis could be treated with cancer drug, study suggests
The painful symptoms of endometriosis -- a chronic condition which affects millions of women -- could potentially be reduced with a drug that had previously been investigated as a cancer treatment. Researchers found that using dichloroacetate to treat the cells of women with endometriosis lowered the production of lactate -- a potentially harmful waste product -- and stopped abnormal cell growth. The team are now conducting an early phase clinical trial to confirm their findings. (2019-12-02)

New research finds signal of decreased early post transplant survival in new heart transplant system
In an analysis of the new heart organ allocation system for transplant patients in the US, researchers have identified a signal of a decrease in heart transplant survival rates. The study, 'An Early Investigation of Outcomes with the 2018 Donor Heart Allocation System in the United States,' is published as a rapid communication in the Journal of Heart and Lung Transplantation. (2019-11-21)

Atopic eczema linked to increase fracture risk in adults
Adults with atopic eczema could face a raised risk of fracture, with the risk increasing the more severe the condition, according to a new study published in the Journal of Allergy and Clinical Immunology. (2019-11-20)

Complex organ models grown in the lab
Scientists at the University of Würzburg have successfully produced human tissues from stem cells. They have a complexity similar to that of normal tissue and are far superior to previous structures. (2019-11-19)

Are hyoliths Palaeozoic lophophorates?
Liu et al. describe, for the first time, the feeding apparatus of an orthothecid hyolith, Triplicatella opimus, from the Chengjiang biota in South China. The recent interpretation that hyolithids possess a lophophore and pedicle is questioned with new information presented by Liu et al. in National Science Review, suggesting that hyoliths are more likely basal members of the lophotrochozoans, rather than lophophorates closely linked with crown or stem group brachiopods. (2019-11-18)

New study casts doubt on China's organ donation data
The Chinese government may have been systematically misreporting the number of organs it claims it has voluntarily collected since 2010, according to new research published in BMC Medical Ethics. (2019-11-14)

Hospitals given latitude to select transplant candidates don't prioritize sickest patients
Analysis of more than 29,000 adults listed on the national heart transplant registry from 2006 to 2015 shows how rules that give hospitals discretion in determining who gets a transplant result in large discrepancies in how sick patients are when they receive heart transplants at hospitals across the United States. (2019-11-12)

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