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Current Peptides News and Events, Peptides News Articles.
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Lab grown tumour models could lead to improved ovarian cancer treatments
Scientists have created a three-dimensional (3D) tumour model in the laboratory for ovarian cancer that could lead to improved understanding and treatment of the disease. (2020-10-02)

An in-depth analysis of antibody responses to SARS-CoV-2
Using a technology called VirScan to study coronavirus antibody responses in a large cohort of SARS-CoV-2-infected and control individuals, researchers identified epitopes recognized by a large fraction of COVID-19 patients, epitopes cross-reactive with antibodies developed in response to other human coronaviruses, and 10 epitopes likely recognized by neutralizing antibodies. (2020-09-29)

Human acid-sensing ion channel 1a inhibition by snake toxin Mambalgin1
USTC initially resolved the hASIC1a and freeze electron structure of the compound of hASCI1a and Mambalgin1 through freeze electron microscopic technology. (2020-09-27)

Giant spider provides promise of pain relief for irritable bowel syndrome
Molecules from the venom of one of the world's largest spiders could help University of Queensland-led researchers tailor pain blockers for people with irritable bowel syndrome (IBS). (2020-09-20)

New targets for melanoma treatment
A collaborative study led by Monash University's Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute (ONJCRI) has uncovered new markers (HLA-associated peptides) that are uniquely present on melanoma tumours and could pave the way for therapeutic vaccines to be developed in the fight against melanoma. (2020-09-16)

How plants ensure regular seed spacing
An international team of researchers led by biologists from Heinrich Heine University Düsseldorf (HHU) has examined how seed formation is coordinated with fruit growth. In the latest edition of the journal Current Biology, they explain the genetic control mechanisms underlying the process. (2020-09-11)

Blood breakdown product commandeers important enzyme
The hemoglobin in the red blood cells ensures that our body cells receive sufficient oxygen. When the blood pigment is broken down, 'heme' is produced, which in turn can influence the protein cocktail in the blood. Researchers at the University of Bonn have now discovered in complex detective work that the 'activated protein C' (APC) can be commandeered by heme. At the same time, APC can also reduce the toxic effect of heme. (2020-09-04)

Estrogen replacement may protect against Alzheimer's disease in women
Amsterdam, September 1, 2020-Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia. It affects more women than men. A new study published in the Journal of Alzheimer's Disease indicates that factors such as age, reproductive stage, hormone levels, and the interplay with other risk factors should be considered in women and proposes a role for early menopausal estrogen replacement to protect against the development of AD. (2020-09-01)

Long-acting, injectable drug could strengthen efforts to prevent, treat HIV
Scientists have developed an injectable drug that blocks HIV from entering cells. They say the new drug potentially offers long-lasting protection from the infection with fewer side effects. The drug, which was tested in non-human primates, could eventually replace or supplement components of combination drug ''cocktail'' therapies currently used to prevent or treat the virus. (2020-08-21)

Blood-thinner with no bleeding side-effects is here
In a study led by EPFL, scientists have developed a synthetic blood-thinner that, unlike all others, doesn't cause bleeding side-effects. The highly potent, highly selective, and highly stable molecule can suppress thrombosis while letting blood clot normally following injury. (2020-08-04)

Phosphoprotein biomarkers to guide cancer therapy are identified
Researchers led by James Bibb, Ph.D., professor of surgery at the University of Alabama at Birmingham, suggest using a broader lens of post-translational modification analysis to identify new biomarkers of cancer drivers that may allow a much more precise prediction of patient responses to treatments. In a study published in Proceedings of the National Academy of Sciences, they demonstrate this diagnostic alternative for neuroendocrine neoplasms driven by an aberrantly activated protein kinase called Cdk5. (2020-07-28)

Temporary salt crystals may provide a permanent solution to Alzheimer's
Researchers at Osaka University have demonstrated that precipitation of a salt crystal occurs even at concentrations much lower than its solubility due to local density fluctuation and this repeated precipitation-dissolution of salt crystals significantly accelerates the production of neurotoxic aggregates of amyloid-β peptides. These results help elucidate the protein aggregation mechanism and the pathogenesis of Alzheimer's disease. (2020-07-27)

Mammal cells could struggle to fight space germs
The immune systems of mammals - including humans - might struggle to detect and respond to germs from other planets, new research suggests. (2020-07-23)

New research reveals antifungal symbiotic peptide in legume
Danforth Center scientists, Dilip Shah, PhD, research associate member, Siva Velivelli, PhD, postdoctoral associate, Kirk Czymmek, PhD, principal investigator and director, Advanced Bioimaging Laboratory and their collaborators at the Pacific Northwest National Laboratory have identified a sub class of peptides in the nodules of the legume, Medicago truncatula that proved effective in inhibiting growth of the fungus causing gray mold. (2020-07-20)

Exhaled biomarkers can reveal lung disease
Using specialized nanoparticles, MIT engineers have developed a way to diagnose pneumonia or other lung diseases by analyzing the breath exhaled by the patient. (2020-07-20)

New diagnostic test for heart failure patients could also help COVID-19 patients
A new blood test that reliably predicts outcomes for heart failure patients could lead to new diagnostics and treatments for COVID-19 patients as well, according to newly published research from cardiologists at the University of Alberta. (2020-07-20)

Breakthrough blood test detects positive COVID-19 result in 20 minutes
World-first research by Monash University in Australia has been able to detect positive COVID-19 cases using blood samples in about 20 minutes, and identify whether someone has contracted the virus. (2020-07-16)

New bioink for cell bioprinting in 3D
A research group led by Daniel Aili, associate professor at Linköping University, has developed a bioink to print tissue-mimicking material in 3D printers. The scientists have developed a method and a material that allow cells to survive and thrive. (2020-07-13)

Mirror image tumor treatment
Our immune system ought to be able to recognize and kill tumor cells. However, many tumors deceive the immune system. For example, they induce the so-called immune checkpoints of T-cells to shut down immune responses. In the journal Angewandte Chemie, scientists have now introduced a new approach for immunological tumor treatment. Their method is based on the specific blockade of an immune checkpoint by a stable ''mirror-image'' peptide. (2020-07-08)

Fluorescent peptide nanoparticles, in every color of the rainbow
The discovery of green fluorescent protein (GFP), which is made by a jellyfish, transformed cell biology. It allowed scientists to stitch the GFP sequence to proteins from other organisms to trace their movements and interactions in living cells. Now, researchers reporting in ACS Applied Materials & Interfaces have designed peptide nanoparticles that can each glow in a variety of colors, opening the door for many new biomedical applications. (2020-07-08)

Towards improved wound healing -- Chemical synthesis of a trefoil factor peptide
The family of trefoil factor peptides brings hope to both research and industry to improve the treatment of chronic disorders. For the first time, a team led by ERC awardee Markus Muttenthaler from the Faculty of Chemistry of the University of Vienna succeeded in the synthesis and folding of the peptide TFF1. The study was published in ''Chemical Communications''. (2020-07-07)

Designer peptides show potential for blocking viruses, encourage future study
Chemically engineered peptides, designed and developed by a team of researchers at Rensselaer Polytechnic Institute, could prove valuable in the battle against some of the most persistent human health challenges. The team's findings, recently published in Nature Scientific Reports, demonstrate how researchers can engineer peptides capable of selectively and specifically binding to polysialic acid (PSA) -- a carbohydrate that is present in many human cells and plays a key role in various physiological and pathological processes, including neurological development and disease progression. (2020-06-26)

Novel radiotracer advantageous for imaging of neuroendocrine tumor patients
For neuroendocrine cancer patients with liver metastases, a new radiopharmaceutical, 68Ga-DOTA-JR11, has shown excellent imaging performance in tumor detection, staging and restaging, providing important information to guide treatment. (2020-06-25)

Transgenic rice lowers blood pressure of hypertensive rats
In the future, taking your blood pressure medication could be as simple as eating a spoonful of rice. This 'treatment' could also have fewer side effects than current blood pressure medicines. As a first step, researchers reporting in ACS' Journal of Agricultural and Food Chemistry have made transgenic rice that contains several anti-hypertensive peptides. When given to hypertensive rats, the rice lowered their blood pressure. (2020-06-24)

Tracking down cryptic peptides
Using a newly developed method, researchers from the University of Würzburg, in cooperation with the University Hospital of Würzburg, were able to identify thousands of special peptides on the surface of cells for the first time. They were able to show that these so-called cryptic peptides mark a significant proportion of tumor cells. These findings could provide a new starting point for cancer immunotherapy. (2020-06-23)

Which came first?
What did the very first proteins look like -- those that appeared on Earth around 3.7 billion years ago? Prof. Dan Tawfik of the Weizmann Institute of Science and Prof. Norman Metanis of the Hebrew University of Jerusalem have reconstructed protein sequences that may well resemble those ancestors of modern proteins, and their research suggests a way that these primitive proteins could have progressed to forming living cells. (2020-06-21)

Renewed hope for treatment of pain and depression
Researchers at the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) developed LIH383, a novel molecule that binds to and blocks a previously unknown opioid receptor in the brain, thereby modulating the levels of opioid peptides produced in the central nervous system (CNS) and potentiating their natural painkilling and antidepressant properties. These findings were published on June 19th in the prestigious international journal 'Nature Communications'. (2020-06-19)

Memory impairment in mice reduced by soy derivate that can enter the brain intact
Researchers from Japan have found that a soy-derived protein fragment that reaches the brain after being ingested reduces memory degradation in mice with an induced cognitive impairment, providing a new lead for the development of functional foods that help prevent mental decline. (2020-06-19)

Cyclosporin study may lead to novel ways of approaching mitochondrial dysfunction
Fungi producing cyclosporins exist as two reproducing stages: asexual -- soil fungi from which cyclosporin was initially extracted, and sexual -- parasitic fungi close to a popularly known genus Cordyceps. Unlike most polypeptides synthesized on ribosomes following the information directly encoded in nucleic acid, cyclosporins are produced on a special enzyme, cyclosporin synthetase. (2020-06-18)

NJIT researchers develop easier and faster way to quantify, explore therapeutic proteins
Researchers at New Jersey Institute of Technology in collaboration with Ohio University and Merck & Co. Inc. recently developed a new efficient method for targeted protein analysis -- one they say could speed up processes for disease testing, drug discovery and vaccine development. (2020-06-17)

Molecules that reduce 'bad' gut bacteria reverse narrowing of arteries in animal study
Scientists at Scripps Research have developed molecules that can remodel the bacterial population of intestines to a healthier state. They also have shown--through experiments in mice--that this approach reduces cholesterol levels and strongly inhibits the thickened-artery condition known as atherosclerosis. (2020-06-15)

We're not all equal in the face of the coronavirus
HLA genes, responsible for the adaptive immune system, differ between individuals. Thousands of possible variants have been identified. Not all of them are equally effective in fighting new viruses. The frequency of these variants varies from one population to another. In a study to be published in the journal HLA, scientists have pinpointed those that are potentially the most effective against the SARS-CoV-2 coronavirus. They have also brought to light significant differences between populations. (2020-06-10)

New antivirals for influenza and Zika
Leuven researchers have deployed synthetic amyloids to trigger protein misfolding as a strategy to combat the influenza A and Zika virus. (2020-06-09)

Novel computer-assisted chemical synthesis method cuts research time and cost
Hokkaido University scientists have succeeded in synthesizing an α,α-difluoroglycine derivative, a type of α-amino acid, based on a reaction path predicted by quantum chemical calculations. This novel method, combining experimental chemistry and computational chemistry, could innovate the development of new chemical reactions. (2020-06-08)

A boost for cancer immunotherapy
MIT engineers have found a way to boost the effectiveness of cancer immunotherapy drugs called checkpoint inhibitors. They showed that if they treated mice with these drugs along with new nanoparticles that stimulate the immune system, the therapy became more powerful than checkpoint inhibitors given alone. (2020-06-01)

New technology enables fast protein synthesis
MIT chemists have developed a protocol to rapidly produce protein chains up to 164 amino acids long. The flow-based technology could speed up drug development and allow scientists to design novel protein variants incorporating amino acids that don't occur naturally in cells. (2020-05-28)

Synthesis of prebiotic peptides gives clues to the origin of life on Earth
Coordination Compounds Lab of Kazan Federal University started researching prebiotic peptide synthesis in 2013 with the use of the ASIA-330 flow chemistry system. Many lab projects are devoted to the problem of selectivity and specificity of processes in living nature. (2020-05-25)

Direct control of dendritic cells for tracking and immune modulation
Dendritic cells patrol the body for invaders and activate T cells and natural killer cells to attack them, making them crucial players in keeping cancer and other diseases at bay. A new biomaterial-based technique now allows dendritic cells to be tagged, tracked, and controlled within the body for the first time. When deployed in mice, this system both treated and prevented lung cancer tumors, and shows promise for other immune conditions as well. (2020-05-18)

Detailed analysis of immune response to SARS-CoV-2 bodes well for COVID-19 vaccine
A new study documents a robust antiviral immune response to SARS-CoV-2 in a group of 20 adults who had recovered from COVID-19. The findings show that the body's immune system is able to recognize SARS-CoV-2 in many ways, dispelling fears that the virus may elude ongoing efforts to create an effective vaccine. (2020-05-14)

Peptides that can be taken as a pill
Peptides represent a billion-dollar market in the pharmaceutical industry, but they can generally only be taken as injections to avoid degradation by stomach enzymes. Scientists at EPFL have now developed a method to generate peptides that resist enzymatic degradation and can be taken orally. (2020-05-11)

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