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Current Peripheral Neuropathy News and Events, Peripheral Neuropathy News Articles.
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High cholesterol levels affect mobilization of cells from the bone marrow
Researchers in Portugal show that high levels of cholesterol can affect the microenvironment of the bone marrow, so that more cells move from the bone marrow to peripheral, circulating blood. These findings, by Sergio Dias and his team, an external group of the Instituto Gulbenkian de Ciencia, have implications for transplantation and further understanding bone marrow malignancies, are to appear in the next issue of the journal Blood. (2010-05-10)

$1.9 million grant to help UCF find multiple sclerosis 'nerve-ana'
Stephen Lambert, an associate professor in the College of Medicine and a member of UCF's Hybrid Systems Laboratory, will study the breakdown of myelin, a substance that coats and protects nerves inside the brain and spinal cord, enabling electrical signals to reach distant nerve cells and muscles. The goal is for the research to ultimately lead to new drugs that reverse the damage caused by these diseases and help patients lead longer, healthier lives. (2010-05-10)

High-res US: First-line imaging choice for the evaluation of patients with foot drop?
High resolution ultrasound should be the imaging test of choice when evaluating patients with foot drop (an inability or difficulty in moving the ankle and toes causing uncontrolled slapping of the foot while taking a step), according to a study to be presented at the ARRS 2010 Annual Meeting in San Diego, Calif. Ultrasound imaging is noninvasive and involves exposing part of the body to high-frequency ultrasound waves to produce pictures of inside the body. (2010-05-06)

Mayo researchers find candidate gene culprits for chronic pain
Chronic pain severely limits patients' quality of life and is among the cost drivers in US health care. (2010-05-06)

Gymnastic training improves bone health in girls
According to a new study accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism, long-term elite rhythmic gymnastics exerts positive effects on volumetric bone density and bone geometry in adolescent girls. (2010-05-05)

Changing 'channels' to eliminate chronic pain
Dr. Joel Hirsch of Tel Aviv University is developing new computer-derived models of drugs that might affect chronic pain -- such as pain from backaches, sore limbs and arthritis -- which are targeted for calcium channels. (2010-04-26)

New studies reveal that age-related nerve decline is associated with inflammation, differs by gender
New research investigating neurological decline in a population of (2010-04-14)

A push makes neuron longer
Some neurons from spinal cord have quite long neurites, but the molecular mechanism of long-neurite outgrowth has been still mysterious. The research team led by Assistant Professor Koji Shibasaki in Gumma University and Professor Makoto Tominaga in National Institute for Physiological Sciences in Japan, reported that TRPV2 receptor can act as mechanical stretch-sensor in developing neurons to help their neurites grow much longer. They report their finding in Journal of Neuroscience published on March 31, 2010. (2010-03-30)

Inflammation research opens route to better pain relief
An international group of scientists led by Dr. Nikita Gamper of the University's Faculty of Biological Sciences has discovered how two proteins play a key role in the way we feel pain, offering new targets on which drug development can be focused. The findings are published online today in the Journal of Clinical Investigation. (2010-03-24)

Potent radiation treatment provides tumor control for patients with inoperable lung cancer
Early findings suggest a radiation therapy that involves numerous highly focused and potent radiation beams provides targeted tumor control in nearly all patients, reduces treatment-related illness, and may ultimately improve survival for patients with inoperable non-small cell lung cancer, according to a study in the March 17 issue of JAMA, a theme issue on cancer. (2010-03-16)

Stem cells build new blood vessels to treat peripheral arterial disease
Bone marrow stem cells suspended in X-ray-visible microbubbles dramatically improve the body's ability to build new blood vessels in the upper leg -- providing a potential future treatment for those with peripheral arterial disease or PAD, say researchers at the Society of Interventional Radiology's 35th Annual Scientific Meeting in Tampa, Fla. (2010-03-16)

Interventional radiologists examine simple test that might predict heart attacks
The prevalence of abnormal ankle-brachial index test results among individuals tested for peripheral arterial disease -- and who are not considered at high risk of a coronary heart event by Framingham-based risk factors -- is high and provides another way to identify those who may be at risk for future heart attacks, say researchers at the Society of Interventional Radiology's 35th Annual Scientific Meeting in Tampa, Fla. (2010-03-15)

Brain Science Institute announces license agreement to develop treatments for neurological disease
Johns Hopkins University's newly formed Brain Science Institute's NeuroTranslational Program has entered into a licensing agreement with pharmaceutical company Eisai Inc. to discover and develop small molecule glutamate carboxypeptidase II (GCPII) inhibitors. (2010-03-12)

Researchers characterize stem cell function
Northwestern University researchers are the first to fully characterize a special type of stem cell, endothelial progenitor cells (EPCs) that exist in circulating blood, to see if they can behave as endothelial cells in the body when cultured on a bioengineered surface. (2010-03-11)

Crowded houses: Why our peripheral vision may not be as random as we think
As you read this, you may notice that the word directly in front of you is clear, but all the surrounding words are hard to make out. For most people, this effect is not a problem. However, for millions of people worldwide with eye disease, it can make everyday tasks such as reading or recognizing friends a challenge. Wellcome Trust-funded researchers have made new insights into this process. (2010-03-04)

Aspirin use does not significantly reduce events among those identified by certain screening method
Individuals who were identified as being at increased risk of cardiovascular or cerebrovascular events based on screening for low ankle brachial index, a type of pressure measurement used in the diagnosis of peripheral artery disease, did not significantly reduce their risk of these events with the use of aspirin, according to a study in the March 3 issue of JAMA. (2010-03-02)

AAN guideline evaluates treatments for muscle cramps
A new guideline from the American Academy of Neurology recommends that the drug quinine, although effective, should be avoided for treatment of routine muscle cramps due to uncommon but serious side effects. The guideline is published in the Feb. 23, 2010, issue of Neurology, the medical journal of the American Academy of Neurology. (2010-02-22)

Stanford review finds painfully few surefire treatments for muscle cramps
A thorough literature review conducted by researchers at the Stanford University School of Medicine, to be published Feb. 23 in Neurology, confirms the FDA's concerns. The resulting guidelines urge caution in the use of quinine, suggest the exploration of other possible treatments and encourage patients and physicians to pay closer attention to the manifestation of muscle cramps, which are usually benign but can sometimes signal more significant medical problems. (2010-02-22)

Rapid breathing, parental concern, and doctor's instinct among the red flags warning of serious infection in children in developed countries
A systematic review of published research shows that a number of factors have value in confirming or excluding the possibility of serious infection in children presenting to general practice or other outpatient care. These include rapid breathing, poor peripheral circulation, and -- in one primary care study -- parental concern and doctor's instinct. The findings are reported in an article published online first and in an upcoming edition of the Lancet. (2010-02-02)

No difference in survival between leukaemia patients 10 years after undergoing stem-cell or marrow transplant
Patients transplanted with peripheral blood stem cells have no difference in survival compared with patients given bone marrow after 10 years, according to the largest randomized study comparing the effect of type of transplant on survival, published online first in the Lancet Oncology. (2010-01-31)

Can blocking a frown keep bad feelings at bay?
Your facial expression may tell the world what you are thinking or feeling. But it also affects your ability to understand written language related to emotions, according to research that was presented today to the Society for Personal and Social Psychology in Las Vegas, and will be published in the journal Psychological Science. (2010-01-29)

Fat tissue may be a source of valuable blood stem cells, study says
Bone marrow is a leading source of adult stem cells, which are increasingly used for research and therapeutic interventions, but extracting the cells is an arduous and often painful process. Now, researchers have found evidence that fat tissue, known as adipose tissue, may be a promising new source of valuable and easy-to-obtain regenerative cells called hematopoietic stem and progenitor cells, according to a study prepublished online in Blood, the official journal of the American Society of Hematology. (2010-01-27)

Press registration open for Society of Interventional Radiology's 35th Annual Scientific Meeting
Nearly 5,300 physicians, scientists and allied health professionals are expected to attend the Society of Interventional Radiology's 35th Annual Scientific Meeting March 13-18 at the Tampa Convention Center. Scientific press conferences are scheduled for 9-10:30 a.m. on both Monday, March 15, and Tuesday, March 16. (2010-01-26)

Guideline: Widely used device for pain therapy not recommended for chronic low back pain
A new guideline issued by the American Academy of Neurology finds that transcutaneous electric nerve stimulation, a widely used pain therapy involving a portable device, is not recommended to treat chronic low-back pain -- pain that has persisted for three months or longer -- because research shows it is not effective. The guideline is published in the Dec. 30, 2009, online issue of Neurology, the medical journal of the American Academy of Neurology. (2009-12-30)

Novel detection method unmasks circulating breast cancer cells
Circulating metastatic breast cancer cells can lose their epithelial receptors, a process that enables them to travel through the bloodstream undetected, according to research from the University of Texas M. D. Anderson Cancer Center. (2009-12-11)

Drug shows positive responses, low side-effects in multiple myeloma
The second-generation proteasome inhibitor carfilzomib is showing noteworthy response rates and low levels of adverse side effects among multiple myeloma patients in a phase II clinical trial, researchers report. (2009-12-07)

Multiple myeloma patients experience high response rate with new 3-drug combination
A new three-drug combination has shown in a phase 1/2 clinical trial that it is a (2009-12-05)

Glial cells can cross from the central to the peripheral nervous system
Glial cells, which help neurons communicate with each other, can leave the central nervous system and cross into the peripheral nervous system to compensate for missing cells, according to new research in the Dec. 2 issue of the Journal of Neuroscience. The animal study contributes to researchers' basic understanding of how the two nervous systems develop and are maintained, which is essential for the effective treatment of diseases such as multiple sclerosis. (2009-12-01)

Wistar-led research team discovers genetic pattern that indicates early stage lung cancer
Wistar Institute researchers and collaborators from the University of Pennsylvania and New York University have identified immune system markers in the blood which indicate early stage lung tumors in people at high risk for developing lung cancer. (2009-12-01)

News brief: Long-term testicular cancer survivors at high risk for neurological side effects
Long-term survivors of testicular cancer who were treated with cisplatin-based chemotherapy had more severe side effects, including neurological side effects and Raynaud-like phenomena, than men who were not treated with chemotherapy, according to a new study published online Nov. 25 in the Journal of the National Cancer Institute. (2009-11-25)

New drug regimen shows promising results for treating advanced biliary-tract cancers
Bevacizumab given in addition to the combined chemotherapy regimen of gemcitabine and oxaliplatin (GEMOX-B) is well tolerated and shows promising antitumour activity in patients with advanced biliary-tract cancers. The survival and tumor response reported in an article published online first in the Lancet Oncology compare favourably with previous studies in patients treated with GEMOX alone and require further investigation in randomized trials. (2009-11-22)

November/December 2009 Annals of Family Medicine tip sheet
This tip sheet features new research highlights from the Nov/Dec issue of Annals of Family Medicine research journal. (2009-11-09)

Excitation pattern peak is more important determinant of vowel quality
Vowel perception is a central problem of speech research, and by far no compelling explanation has been proposed for all phenomena in speech perception. As a kind of inner representative of peripheral auditory system, is the excitation pattern closer to the solution? This paper investigates the perceptions of five Chinese vowel -- u, o, a, y, i -- on basis of the excitation pattern, and the results show a determinant relation between phonetic qualities and the peak positions of excitation pattern. (2009-11-05)

Kidney function decline increases risk of heart failure and premature death
Declining kidney function is linked to a higher risk of heart failure, heart attack, peripheral arterial disease, and early death in individuals with or without kidney disease, according to a pair of studies appearing in an upcoming issue of the Journal of the American Society Nephrology. (2009-11-05)

Circadian surprise: Mechanism of temperature synchronization in drosophila
New research reveals a pathway that links peripheral sensory tissues with a (2009-10-28)

Medical food reduces medical costs and use of anti-convulsant medication
Diabetic patients diagnosed with peripheral neuropathy had lower medical costs and reduced use of anti-convulsant medications when treated with a folate-enriched prescription medical food, according to data presented today at the International Society for Pharmacoeconomics and Outcomes Research 12th Annual European Congress. (2009-10-27)

No such thing as a break in a curveball?
Simple animation developed by USC and American University suggests break in curveball is a visual illusion. (2009-10-27)

Henry Ford study: Drug used for neuropathic pain relieves discomfort from abdominal adhesions
Pregabalin, FDA-approved for neuropathic pain (pain caused by shingles and peripheral neuropathy), effectively reduced abdominal pain and improved sleep in women with adhesions, according to a Henry Ford study. Adhesion pain, a common complication after abdominal or pelvic surgery, currently lacks effective therapy. Adhesions can also form after infections in the bowel such as diverticulitis. (2009-10-26)

Lifestyle changes remain important in fighting peripheral arterial disease
Modifying the risk of peripheral arterial disease (or PAD) -- with healthy lifestyle changes -- remains vital to one's health, note researchers in a recent issue of the Journal of Vascular and Interventional Radiology. And while PAD can progress and worsen over time, there is not enough evidence yet to advocate minimally invasive treatment in patients who have had a narrowing or blockage of a leg artery but showing no signs or symptoms of the disease. (2009-10-21)

Diagnosis of cardiovascular disease associated with risk of subsequent hip fracture
A study that includes twins finds that the risk of hip fracture was significantly increased following a diagnosis of cardiovascular disease (CVD), with analysis also suggesting a genetic predisposition to the development of CVD and fractures, according to a study in the Oct. 21 issue of JAMA. (2009-10-20)

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