Current Pharmaceutical Sciences News and Events

Current Pharmaceutical Sciences News and Events, Pharmaceutical Sciences News Articles.
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Chemists developed a simplified method for pharmaceutical compounds synthesizing
A team of chemists from Immanuel Kant Baltic Federal University and Saint Petersburg State University developed a simple and efficient method to synthesize tetrahydroisoquinolines--important organic molecules for drug discovery. The method consists of just three steps. (2021-02-09)

Use of goldenseal may compromise glucose control in diabetics on metformin
Diabetic patients taking the natural product goldenseal while taking the prescription drug metformin may be unwittingly sabotaging their efforts to maintain healthy blood glucose levels. Metformin--the world's most-prescribed oral glucose-lowering medication--was included in a cocktail of selected drugs given to participants in a clinical study led by scientists at Washington State University. The study found that after six days of taking goldenseal, participants had about 25 percent less metformin in their bodies. (2021-02-08)

Insulin can be stored out of refrigeration in hot settings!
Patients with diabetes must keep a supply of insulin which must respect the cold chain. However not every household has a refrigerator. This forces people living with diabetes to go to hospital on a daily basis. MSF and UNIGE test insulin storage at temperatures ranging from 25°C to 37°C. The findings demonstrate that the stability of insulin stored under these conditions is the same as that of cold-stored insulin, with no impact on efficacy. (2021-02-03)

Age groups that sustain resurging COVID-19 epidemics in the United States
By late summer 2020, the resurgence of COVID-19 in the United States was largely driven by adults between the ages of 20 and 49, a new study finds. (2021-02-02)

Drugs used to treat HIV and flu can have detrimental impact on crops
Scientists from the UK and Kenya found that lettuce plants exposed to a higher concentration of four commonly-used antiviral and antiretroviral medicines could be more than a third smaller in biomass than those grown in a drug-free environment. (2021-01-28)

New tool removes chemotherapy drugs from water systems
'What goes in, must come out' is a familiar refrain. It is especially pertinent to the challenges facing UBC researchers who are investigating methods to remove chemicals and pharmaceuticals from public water systems. Cleaning products, organic dyes and pharmaceuticals are finding their ways into water bodies with wide-ranging negative implications to health and the environment, explains Dr. Mohammad Arjmand, an assistant professor of mechanical engineering at UBC Okanagan. (2021-01-18)

Bacterium produces pharmaceutical all-purpose weapon
For some years, an active substance from the leaves of an ornamental plant has been regarded as a possible forerunner of a new group of potent drugs. So far, however, it has been very laborious to manufacture it in large quantities. That could now change: Researchers at the University of Bonn (Germany) have identified a bacterium that produces the substance and can also be easily cultivated in the laboratory. The results are published in the journal Nature Communications. (2021-01-11)

Majority of biotech companies completing an IPO from 1997-2016 achieved product approvals
A large scale study from Bentley University of the biotechnology companies that completed Initial Public Offerings from 1997-2016 estimates that 78% of these companies are associated with products that reach phase 3 trials and 52% are associated with new product approvals. The article, titled 'Late-stage product development and approvals by biotechnology companies after IPO, 1997-2016,' shows that these emerging, public biotechnology companies continue to have a role in initiating new product development, but are no longer distinctively focused on novel, biological products. (2021-01-06)

HKU chemists develop a new drug discovery strategy for "undruggable" drug targets
A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells. (2020-12-28)

Gene biomarkers indicate liver toxicity quickly and accurately
When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval. This testing usually involves lengthy and expensive animal studies. A research team at University of Illinois has developed a gene biomarker identification technique that cuts the testing process down to a few days while maintaining a high level of accuracy. (2020-12-18)

Researchers develop new combined process for 3D printing
Chemists at Martin Luther University Halle-Wittenberg (MLU) have developed a way to integrate liquids directly into materials during the 3D printing process. This allows, for example, active medical agents to be incorporated into pharmaceutical products or luminous liquids to be integrated into materials, which allow monitoring of damage. The study was published in ''Advanced Materials Technologies''. (2020-12-16)

Molecular pores for thought
Ultrathin porous films that can pluck out specific nanoscopic molecules could refine oil purification and drug development. (2020-12-06)

RUDN University medics created a wound-healing gel with metabolic products of trichoderma
Researchers from the Department of Biochemistry of RUDN University developed a wound-healing gel based on a substance that is produced by Trichoderma fungi. (2020-12-04)

Wuhan mass screening identifies hundreds of asymptomatic cases
A mass screening programme of 10 million Wuhan residents identified 300 asymptomatic cases in May, but none were infectious - according to a new study. They found no 'viable' virus in the asymptomatic cases and the close contacts of these positive asymptomatic cases did not test positive. But these findings do not show that the virus can't be passed on by asymptomatic carriers. Rather mask-wearing, hand washing, social distancing and lockdown have helped reduce Covid-19 virulence. (2020-11-30)

Simple new testing method aims to improve time-release drugs
UC Riverside engineers filled a glass tube bent like a tuning fork, kept vibrating by a circuit at its resonance frequency, with simulated stomach and intestine contents and passed an over-the-counter time-release drug granule through the tube. They observed a brief change in the frequency. When plotted, they could compare the peaks of resonance frequency against the time to learn the buoyant mass of the drug granule at that moment. (2020-11-24)

Financial penalties imposed on large pharmaceutical firms for illegal activities
The UNC Charlotte study examined financial penalties imposed by government agencies using a sample of 26 large pharmaceutical firms over 13 years. Results indicated that 22 firms (85%) were penalized for illegal activities with most firms engaging in illegal activities for four or more years. Total penalties imposed during this period were $33 billion. The most common penalties were pricing violations, off-label marketing, and kickbacks. Four firms had no penalties assessed during the period. (2020-11-17)

Pharmacy dropboxes can help improve proper drug disposal, PSU study finds
Drug take-back boxes are a safe and secure way to dispose of unwanted medications, but a new Portland State University study shows awareness of these dropboxes as well as knowledge about risks of improper disposal remain low. (2020-11-16)

Biochar from agricultural waste products can adsorb contaminants in wastewater
Biochar -- a charcoal-like substance made primarily from agricultural waste products -- holds promise for removing emerging contaminants such as pharmaceuticals from treated wastewater. That's the conclusion of a team of researchers that conducted a novel study that evaluated and compared the ability of biochar derived from two common leftover agricultural materials -- cotton gin waste and guayule bagasse -- to adsorb three common pharmaceutical compounds from an aqueous solution. (2020-11-16)

New method shows great potential for the treatment of Alzheimer's disease
In Alzheimer's disease, a protein (peptide) forms clumps in the brain and causes sufferers to lose their memory. In a recently published article, a research group at Uppsala University described a new treatment method that increases the body's own degradation of the building blocks that lead to these protein clumps. (2020-11-03)

UMass Amherst research compares sensitivity of all genes to chemical exposure
A University of Massachusetts Amherst environmental health scientist has used an unprecedented objective approach to identify which molecular mechanisms in mammals are the most sensitive to chemical exposures. (2020-10-29)

Identifying potential anti-COVID-19 pharmacological components of TCM
Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening https://doi.org/10.1016/j.apsb.2020.10.002 Lianhuaqingwen (LHQW) capsule, a herb medicine product, has been clinically proved to be effective in coronavirus disease 2019 (COVID-19) pneumonia treatment. (2020-10-27)

Crystal structure of SARS-CoV-2 papain-like protease
The pandemic of coronavirus disease 2019 (COVID-19) is changing the world like never before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine. The papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays essential roles in virus replication and immune evasion, presenting a promising drug target. (2020-10-27)

Study: 34% of older adults in the US are prescribed potentially inappropriate drugs
The prescription of potentially inappropriate medications to older adults is linked to increased hospitalizations, and it costs patients, on average, more than $450 per year, according to a new University at Buffalo study. (2020-10-23)

RUDN University chemist suggested synthesizing bioactive substances using a copper catalyst
A chemist from RUDN University used a copper catalyst in the click reaction of triazole synthesis. Triazoles are bioactive substances that are used to treat fungal diseases and synthesize pharmaceutical drugs and also play a role in polymer chemistry. The catalyst not only accelerated the reaction several times but also helped perform it at room temperature and without any bases or solvents. The reaction turned out to be almost 100% effective and had no by-products. (2020-10-22)

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. (2020-10-20)

D3Targets-2019-nCoV: a webserver for predicting drug targets and for target and multi-site based virtual screening against COVID-19
A highly effective drug therapy is urgently required to combat coronavirus disease 2019 (COVID-19). The authors of this article have developed a molecular docking based webserver, namely D3Targets-2019-nCoV, with two functions, one is for predicting drug targets for drugs or active compounds observed from clinic or in vitro/in vivo studies, the other is for identifying lead compounds against potential drug targets via docking. (2020-10-20)

Removal of synthetic estrogen from water
Synthetic estrogens from pharmaceuticals contaminate rivers and threaten the health of humans and fish. An effective and cost-efficient method for removing synthetic estrogen from bodies of water (2020-10-20)

Chinese researchers uncover link between phase separation and human developmental disorders
Researchers from the Shanghai Institute of Organic Chemistry (SIOC) of the Chinese Academy of Sciences have uncovered the mechanism that underlies the pathogenesis of Noonan syndrome and Noonan syndrome with multiple lentigines. (2020-09-30)

A cancer shredder
Researchers at the universities of Würzburg and Frankfurt (Germany) have developed a new compound for treating cancer. It destroys a protein that triggers its development. (2020-09-29)

Research on emerging COVID-19 (target, mechanism, and therapeutics)
Acta Pharmaceutica Sinica B publishes special issue on 'Research on Emerging COVID-19 (Target, Mechanism, and Therapeutics)' edited by Hai-Bin Luo, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Shilin Chen, Institute of Chinese Materia Medica, Beijing, China and Peiqing Liu, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China. (2020-09-28)

October issue of SLAS Discovery now available
The October edition of SLAS Discovery features the cover article, 'A Critical and Concise Review of Mass Spectrometry Applied to Imaging in Drug Discovery' by Richard J. A. Goodwin Ph.D. (AstraZeneca), Zoltan Takats Ph.D. (Imperial College London), and Josephine Bunch, Ph.D. (National Physical Laboratory). (2020-09-21)

New live biotherapeutic products will require regulatory and scientific innovation
European regulatory expertise centre, the Pharmabiotic Research Institute (PRI), which supports the pharmaceutical development of microbiome-based drug products, a new field of biological medicine, has published a review of the regulatory and scientific requirements needed to properly develop live biotherapeutic products (LBPs). Similarly to other innovative medicinal products, demonstrating the quality, efficacy and safety of these living medicines will require an innovative regulatory and technical approach. (2020-09-17)

Increase in alcohol-industry funded research is a cause for concern, study suggests
A study by the University of York has found that since 2009, there has been a 56% increase in research funded by alcohol companies or affiliated organisations - with some studies making claims about the health benefits of alcohol. (2020-09-16)

TV ads for psoriasis and eczema medications portray few people of color
Commercials from pharmaceutical companies advertising medication to treat psoriasis and eczema lack people from racial and ethnic minorities, according to research from the Perelman School of Medicine at the University of Pennsylvania. (2020-09-15)

Decreased MIR2911 absorption in human with SIDT1 polymorphism fails to inhibit SARS-CoV-2
In a new study in Cell Discovery, Liang Li and Chen-Yu Zhang's group at Nanjing University and two other groups report that SIDT1 polymorphism remarkably decreases HD-MIR2911 absorption in human. Exosome isolated from volunteers that carry SIDT1 polymorphism has lower level of HD-MIR2911 and fails to inhibit of SARS-CoV-2 replication. (2020-09-11)

Genetic study of proteins is a breakthrough in drug development for complex diseases
An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. (2020-09-07)

Researchers develop a yeast-based platform to boost production of rare natural molecules
Researchers at Concordia University in Montreal and in Berkeley, California outline a method to synthesize complex bioactive molecules much more quickly and efficiently. Using cutting-edge synthetic biology approaches, They were able to produce a large amount of benzylisoquinoline alkaloid (BIA) to synthesize an array of natural and new-to-nature chemical structures in a yeast-based platform. This can provide a blueprint for the large-scale production of thousands of products, including the opioid analgesics morphine and codeine. (2020-08-27)

Stomach SIDT1 mediates dietary microRNA absorption: ending of the 10-year debate
In a new study published in Cell Research, Chen-Yu Zhang's group at Nanjing University School of Life Sciences, China, reports that SIDT1 in the mammalian stomach mediates host uptake of dietary and orally administered microRNAs (miRNAs), thus exerting biological functions in the host. (2020-08-17)

Analysis: Health sector, big pharma spent big on lobbying for COVID-19 funding
To date, Congress has authorized roughly $3 trillion in COVID-19 relief assistance -- the largest relief package in history. With more COVID relief money on the way, a new analysis in the Journal of General Internal Medicine finds these newly available funds led to a significant surge in health sector lobbying activity, especially within the pharmaceutical industry. (2020-08-12)

Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19
Effective antivirals with safe clinical profile are urgently needed to improve the overall COVID-19 prognosis. In an analysis of a randomly collected cohort of 124 patients with COVID-19, the authors found that hypercoagulability as indicated by elevated concentrations of D-dimers was associated with disease severity. By virtual screening of a U.S. FDA approved drug library, the authors identified an anticoagulation agent dipyridamole (DIP) in silico, which suppressed SARS-CoV-2 replication in vitro. (2020-07-26)

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