Current Pharmaceutical News and Events

Current Pharmaceutical News and Events, Pharmaceutical News Articles.
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Chemists developed a simplified method for pharmaceutical compounds synthesizing
A team of chemists from Immanuel Kant Baltic Federal University and Saint Petersburg State University developed a simple and efficient method to synthesize tetrahydroisoquinolines--important organic molecules for drug discovery. The method consists of just three steps. (2021-02-09)

Insulin can be stored out of refrigeration in hot settings!
Patients with diabetes must keep a supply of insulin which must respect the cold chain. However not every household has a refrigerator. This forces people living with diabetes to go to hospital on a daily basis. MSF and UNIGE test insulin storage at temperatures ranging from 25°C to 37°C. The findings demonstrate that the stability of insulin stored under these conditions is the same as that of cold-stored insulin, with no impact on efficacy. (2021-02-03)

Age groups that sustain resurging COVID-19 epidemics in the United States
By late summer 2020, the resurgence of COVID-19 in the United States was largely driven by adults between the ages of 20 and 49, a new study finds. (2021-02-02)

Drugs used to treat HIV and flu can have detrimental impact on crops
Scientists from the UK and Kenya found that lettuce plants exposed to a higher concentration of four commonly-used antiviral and antiretroviral medicines could be more than a third smaller in biomass than those grown in a drug-free environment. (2021-01-28)

New tool removes chemotherapy drugs from water systems
'What goes in, must come out' is a familiar refrain. It is especially pertinent to the challenges facing UBC researchers who are investigating methods to remove chemicals and pharmaceuticals from public water systems. Cleaning products, organic dyes and pharmaceuticals are finding their ways into water bodies with wide-ranging negative implications to health and the environment, explains Dr. Mohammad Arjmand, an assistant professor of mechanical engineering at UBC Okanagan. (2021-01-18)

Bacterium produces pharmaceutical all-purpose weapon
For some years, an active substance from the leaves of an ornamental plant has been regarded as a possible forerunner of a new group of potent drugs. So far, however, it has been very laborious to manufacture it in large quantities. That could now change: Researchers at the University of Bonn (Germany) have identified a bacterium that produces the substance and can also be easily cultivated in the laboratory. The results are published in the journal Nature Communications. (2021-01-11)

Researchers develop new combined process for 3D printing
Chemists at Martin Luther University Halle-Wittenberg (MLU) have developed a way to integrate liquids directly into materials during the 3D printing process. This allows, for example, active medical agents to be incorporated into pharmaceutical products or luminous liquids to be integrated into materials, which allow monitoring of damage. The study was published in ''Advanced Materials Technologies''. (2020-12-16)

Molecular pores for thought
Ultrathin porous films that can pluck out specific nanoscopic molecules could refine oil purification and drug development. (2020-12-06)

RUDN University medics created a wound-healing gel with metabolic products of trichoderma
Researchers from the Department of Biochemistry of RUDN University developed a wound-healing gel based on a substance that is produced by Trichoderma fungi. (2020-12-04)

Wuhan mass screening identifies hundreds of asymptomatic cases
A mass screening programme of 10 million Wuhan residents identified 300 asymptomatic cases in May, but none were infectious - according to a new study. They found no 'viable' virus in the asymptomatic cases and the close contacts of these positive asymptomatic cases did not test positive. But these findings do not show that the virus can't be passed on by asymptomatic carriers. Rather mask-wearing, hand washing, social distancing and lockdown have helped reduce Covid-19 virulence. (2020-11-30)

Simple new testing method aims to improve time-release drugs
UC Riverside engineers filled a glass tube bent like a tuning fork, kept vibrating by a circuit at its resonance frequency, with simulated stomach and intestine contents and passed an over-the-counter time-release drug granule through the tube. They observed a brief change in the frequency. When plotted, they could compare the peaks of resonance frequency against the time to learn the buoyant mass of the drug granule at that moment. (2020-11-24)

Financial penalties imposed on large pharmaceutical firms for illegal activities
The UNC Charlotte study examined financial penalties imposed by government agencies using a sample of 26 large pharmaceutical firms over 13 years. Results indicated that 22 firms (85%) were penalized for illegal activities with most firms engaging in illegal activities for four or more years. Total penalties imposed during this period were $33 billion. The most common penalties were pricing violations, off-label marketing, and kickbacks. Four firms had no penalties assessed during the period. (2020-11-17)

Pharmacy dropboxes can help improve proper drug disposal, PSU study finds
Drug take-back boxes are a safe and secure way to dispose of unwanted medications, but a new Portland State University study shows awareness of these dropboxes as well as knowledge about risks of improper disposal remain low. (2020-11-16)

Biochar from agricultural waste products can adsorb contaminants in wastewater
Biochar -- a charcoal-like substance made primarily from agricultural waste products -- holds promise for removing emerging contaminants such as pharmaceuticals from treated wastewater. That's the conclusion of a team of researchers that conducted a novel study that evaluated and compared the ability of biochar derived from two common leftover agricultural materials -- cotton gin waste and guayule bagasse -- to adsorb three common pharmaceutical compounds from an aqueous solution. (2020-11-16)

New method shows great potential for the treatment of Alzheimer's disease
In Alzheimer's disease, a protein (peptide) forms clumps in the brain and causes sufferers to lose their memory. In a recently published article, a research group at Uppsala University described a new treatment method that increases the body's own degradation of the building blocks that lead to these protein clumps. (2020-11-03)

Identifying potential anti-COVID-19 pharmacological components of TCM
Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening https://doi.org/10.1016/j.apsb.2020.10.002 Lianhuaqingwen (LHQW) capsule, a herb medicine product, has been clinically proved to be effective in coronavirus disease 2019 (COVID-19) pneumonia treatment. (2020-10-27)

Crystal structure of SARS-CoV-2 papain-like protease
The pandemic of coronavirus disease 2019 (COVID-19) is changing the world like never before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine. The papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays essential roles in virus replication and immune evasion, presenting a promising drug target. (2020-10-27)

Study: 34% of older adults in the US are prescribed potentially inappropriate drugs
The prescription of potentially inappropriate medications to older adults is linked to increased hospitalizations, and it costs patients, on average, more than $450 per year, according to a new University at Buffalo study. (2020-10-23)

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. (2020-10-20)

D3Targets-2019-nCoV: a webserver for predicting drug targets and for target and multi-site based virtual screening against COVID-19
A highly effective drug therapy is urgently required to combat coronavirus disease 2019 (COVID-19). The authors of this article have developed a molecular docking based webserver, namely D3Targets-2019-nCoV, with two functions, one is for predicting drug targets for drugs or active compounds observed from clinic or in vitro/in vivo studies, the other is for identifying lead compounds against potential drug targets via docking. (2020-10-20)

A cancer shredder
Researchers at the universities of Würzburg and Frankfurt (Germany) have developed a new compound for treating cancer. It destroys a protein that triggers its development. (2020-09-29)

New live biotherapeutic products will require regulatory and scientific innovation
European regulatory expertise centre, the Pharmabiotic Research Institute (PRI), which supports the pharmaceutical development of microbiome-based drug products, a new field of biological medicine, has published a review of the regulatory and scientific requirements needed to properly develop live biotherapeutic products (LBPs). Similarly to other innovative medicinal products, demonstrating the quality, efficacy and safety of these living medicines will require an innovative regulatory and technical approach. (2020-09-17)

TV ads for psoriasis and eczema medications portray few people of color
Commercials from pharmaceutical companies advertising medication to treat psoriasis and eczema lack people from racial and ethnic minorities, according to research from the Perelman School of Medicine at the University of Pennsylvania. (2020-09-15)

Genetic study of proteins is a breakthrough in drug development for complex diseases
An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases. (2020-09-07)

Researchers develop a yeast-based platform to boost production of rare natural molecules
Researchers at Concordia University in Montreal and in Berkeley, California outline a method to synthesize complex bioactive molecules much more quickly and efficiently. Using cutting-edge synthetic biology approaches, They were able to produce a large amount of benzylisoquinoline alkaloid (BIA) to synthesize an array of natural and new-to-nature chemical structures in a yeast-based platform. This can provide a blueprint for the large-scale production of thousands of products, including the opioid analgesics morphine and codeine. (2020-08-27)

Analysis: Health sector, big pharma spent big on lobbying for COVID-19 funding
To date, Congress has authorized roughly $3 trillion in COVID-19 relief assistance -- the largest relief package in history. With more COVID relief money on the way, a new analysis in the Journal of General Internal Medicine finds these newly available funds led to a significant surge in health sector lobbying activity, especially within the pharmaceutical industry. (2020-08-12)

Coordination helps avoid continental COVID-19 resurgence, European modeling study shows
Coordinated lockdown strategies among countries is key to preventing resurgent COVID-19 outbreaks in continental Europe, a new modeling study shows. (2020-07-17)

Robot jaws shows medicated chewing gum could be the future
Medicated chewing gum has been recognised as a new advanced drug delivery method but currently there is no gold standard for testing drug release from chewing gum in vitro. New research by the University of Bristol has shown a chewing robot with built-in humanoid jaws could provide opportunities for pharmaceutical companies to develop medicated chewing gum. (2020-07-14)

Using electricity to break down pollutants left over after wastewater treatment
Pesticides, pharmaceutical products, and endocrine disruptors are some of the emerging contaminants often found in treated domestic wastewater, even after secondary treatment. Professor Patrick Drogui of the Institut national de la recherche scientifique (INRS) and his team have tested the effectiveness of a tertiary treatment process using electricity in partnership with the European Membrane Institute in Montpellier (IEM) and Université Paris-Est. (2020-07-09)

New pharmaceuticals: public research combines efficiency with contained costs
Is the basic research that goes into the development of new drugs more efficiently conducted by public-sector scientists, pharmaceutical firms, or independent private laboratories? What role do each of these groups play in determining prices of innovative pharmaceuticals, which have risen steeply over the last years? To answer these questions, economists Francesca Barigozzi, of the University of Bologna, and Izabela Jelovac, of the CNRS, designed and studied a model inspired by game theory. (2020-06-29)

The impact of disclosure laws on prescription patterns from companies that pay them
It's not uncommon for U.S. pharmaceutical companies to pay medical doctors to promote their medications. Questions over possible conflicts of interest have led to introduction of laws that require payment disclosure so that the public can see which pharmaceutical companies are paying which doctors. (2020-06-08)

Solubilizer Captisol enables body to absorb authorized COVID-19 drug therapy
Remdesivir's formulation includes the solubilizer Captisol, developed at the University of Kansas, which allows remdesivir be administered to the patient. Captisol was invented and patented by Valentino Stella, University Distinguished Professor Emeritus, and Roger Rajewski, research professor in the Department of Pharmaceutical Chemistry. (2020-06-01)

Chemistry breakthrough could speed up drug development
Scientists have successfully developed a new technique to reliably grow crystals of organic soluble molecules from nanoscale droplets, unlocking the potential of accelerated new drug development. (2020-05-08)

Study reveals pharmacy-level barriers to treatment for opioid use disorder in Appalachian Kentucky
A new study led by University of Kentucky researcher April Young and Emory University researcher Hannah Cooper shows that a number of pharmacies in the Appalachian region of Kentucky are limiting the dispensing of buprenorphine, a medication used to treat opioid use disorder (OUD). (2020-04-28)

A new way to deliver drugs in MOFs
Scientists from the Institute of Physical Chemistry of the Polish Academy of Sciences (IPC PAS) in cooperation with the Faculty of Chemistry of the Warsaw University of Technology (WUT) have developed a new, solvent-free method for the encapsulation of drug molecules in MOF (Metal-Organic Framework) porous materials. (2020-04-05)

Pharma's potential impact on water quality
When people take medications, these drugs and their metabolites can be excreted and make their way to wastewater treatment plants. From there, the compounds can end up in waterways. Wastewater from pharmaceutical companies could start off with even larger amounts of these substances. In ACS' Environmental Science & Technology, researchers report that a single pharmaceutical manufacturing facility could be influencing the water quality of one of Europe's most important rivers. (2020-03-25)

Lung cancer trials supported by drug industry stronger
Lung cancer clinical trials supported by the pharmaceutical industry demonstrate no more bias compared to studies funded by other sources, according to a study published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer. (2020-03-25)

Scientists proposed a way of producing water-soluble fullerene compounds for medicine
Scientists developed a single-step method to obtain water-soluble fullerene compounds with remarkable biological properties, such as the ability to effectively suppress the human immunodeficiency virus (HIV). (2020-03-17)

GARDP partners with Japanese pharmaceutical in pursuit of new antibiotics
The Global Antibiotic Research and Development Partnership (GARDP) has today announced an agreement with Daiichi Sankyo for GARDP to access and screen the Daiichi Sankyo chemical library. (2020-03-12)

A hidden electronic transition 'S0 → Tn' in heavy-atom-containing molecules
Researchers in Japan have discovered S0 → Tn, a previously overlooked electronic transition in photoreactions occurring in heavy atom-containing molecules exposed to visible light. The study was published online in Angewadte Chemie International Edition on March 9, 2020. (2020-03-11)

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