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Current Photodynamic Therapy News and Events, Photodynamic Therapy News Articles.
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Fostamatinib in chronic immune thrombocytopenia: No comparison -- added benefit not proven
Fostamatinib in chronic immune thrombocytopenia: no comparison -- added benefit not proven The manufacturer conducted no direct or indirect comparison of its drug with an appropriate comparator therapy (eltrombopag or romiplostim). (2020-10-06)

Scientists propose immune cocktail therapy to boost cancer-immunity cycle in multiple aspects
A research team led by Prof. TIAN Huayu from the Changchun Institute of Applied Chemistry (CIAC) of the Chinese Academy of Sciences proposed an innovative immune cocktail therapy that combined ICT along with other therapeutic approaches. The cocktail therapy achieved multiple boosting of the cancer-immunity cycle by utilizing a nano-delivery system. (2020-09-30)

Quality over quantity in recovering language after stroke
New Edith Cowan University (ECU) research has found that intensive therapy is not necessarily best when it comes to treating the loss of language and communication in early recovery after a stroke. (2020-09-06)

Ultraviolet B exposure expands proenkephalin+ regulatory T cells with a healing function
Skin exposure to ultraviolet B (UVB) induces expansion of regulatory T (Treg) cells with immunosuppressive activity. Here researchers found that UVB-expanded skin Treg (UVB-skin Treg) cells had a tissue repair function. UVB-skin Treg cells expressed proenkephalin (PENK) and amphiregulin (AREG), which promoted keratinocyte outgrowth and skin wound healing. Their results provide a new implication in developing a therapy using UVB-skin Treg cells. (2020-09-01)

Hope for 500 000 insomniacs in Norway
Digital sleep therapy could offer help to people with sleep problems and enable many of them to reduce their sleep medication after treatment. (2020-09-01)

Nanomaterials based strategies for treatment of hypoxic tumor
Hypoxic tumor microenvironment restricts efficiency of tumor therapies and leads to serious results of tumor recurrence and high mortality. Different strategies to treat hypoxic tumors based on nanomaterials have been utilized to eliminate the side effects of hypoxia on tumor therapies. The strategies could be summarized into two classes, i) elevating oxygen level in tumor by nanomaterials and ii) diminishing oxygen dependence of nanomaterials for hypoxic tumor therapy. (2020-08-31)

Black children with cancer three times less likely to receive proton radiotherapy than White children
A retrospective analysis led by investigators from Brigham and Women's Hospital has found racial disparities in the use of the therapy for patients enrolled in trials. (2020-08-27)

Delaying prostate cancer radiation therapy offers room for flexibility in pandemic peak
A new study by investigators from Brigham and Women's Hospital found that for men with unfavorable intermediate-risk or high-risk localized prostate cancer, who are receiving radiation and hormone therapy, delaying radiation while remaining on hormone therapy is unlikely to impact survival. (2020-08-13)

Engineered capsids for efficient gene delivery to the eye
A rational design approach created novel variants of adeno-associated viral (AAV) capsids. These have improved transduction properties in the mouse retina and cornea. (2020-08-13)

Gene therapy targets inner retina to combat blindness
Batten disease is a group of fatal, inherited lysosomal storage disorders that predominantly affect children. The most prevalent form is CLN3 disease, for which there is no cure. Retinal degeneration and resulting vision loss is one of the symptoms. (2020-08-10)

Photodynamic therapy can combat secondary infections in COVID-19 patients
Researchers at the Optics and Photonics Research Center, supported by FAPESP, advocate the technique as an additional treatment for patients with the disease. (2020-08-04)

COVID-19 may cause deadly blood clots
COVID-19 may increase the risk of blot cots in women who are pregnant or taking estrogen with birth control or hormone replacement therapy, according to a new manuscript published in the Endocrine Society's journal, Endocrinology. (2020-07-29)

Fracture risk associated with bisphosphonate drug holidays
Bisphosphonates have been shown to reduce the risk of osteoporotic fractures. To avoid possible side effects of long-term therapy, many patients take a drug holiday after several years of bisphosphonate therapy. Researchers have examined the implications of such drug holidays on fracture risk. They found that in patients who had previously suffered a vertebral fracture, a longer bisphosphonate drug holiday was associated with an increase in the risk of so-called major osteoporotic fractures. (2020-07-29)

Skin cancer treatments could be used to treat other forms of the disease
The creation of a silica nanocapsule could allow treatments that use light to destroy cancerous or precancerous cells in the skin to also be used to treat other types of cancer. Such are the findings of a study by INRS (Institut national de la recherche scientifique) professors Fiorenzo Vetrone and Federico Rosei, in collaboration with an international research team. (2020-07-21)

New nano drug candidate kills aggressive breast cancer cells
Researchers at the University of Arkansas have developed a new drug candidate that kills triple negative breast cancer cells. The discovery will help clinicians target breast cancer cells directly, while avoiding the adverse, toxic side effects of chemotherapy. (2020-07-20)

Traditional PTSD therapy doesn't trigger drug relapse
Johns Hopkins researchers have now demonstrated that behavior therapy that exposes people to memories of their trauma doesn't cause relapses of opioid or other drug use, and that PTSD severity and emotional problems have decreased after the first therapy session. (2020-07-20)

Therapy delivered electronically more effective than face to face: Hamilton researchers
In this evidence review, researchers identified 17 randomized control trials comparing therapist-supported cognitive behavioural therapy delivered electronically to face to face cognitive behavioural therapy. The studies were conducted between 2003 and 2018 in the United States, Australia, Netherlands, Switzerland, Sweden and the United Kingdom (2020-07-08)

New Human Gene Therapy editorial: Concern following gene therapy adverse events
Response to the recent report of the deaths of two children receiving high doses of a gene therapy vector (AAV8) in a Phase I trial for X-linked myotubular myopathy (MTM). The news ''is a tragic reminder of how difficult it is to predict outcomes in first-in-human studies (2020-07-02)

Existing drugs may limit damage caused by HIV
Yale researchers have identified four drugs that may help minimize the long-term health effects of HIV infection, they report June 23 in the Journal of Clinical Investigation. (2020-06-23)

Rice lab turns fluorescent tags into cancer killers
Fluorophores with one oxygen atom replaced by a sulfur atom can be triggered with light to create reactive oxygen species within cancer cells, killing them. (2020-06-11)

Fewer complications after organ transplantation
A large international study coordinated by University Hospital Regensburg and Charité - Universitätsmedizin Berlin has demonstrated the safety of new cell therapy approaches for use in kidney transplant recipients. Transplant recipients were shown to require lower levels of immunosuppression in order to prevent organ rejection. This reduces the risk of side effects such as viral infections. Results from this study have been published in The Lancet.* (2020-06-10)

Phenothiazine derivatives may find use in photodynamic therapy
A group on organic compounds under Professor Ivan Stoikov's guidance has been working on phenothiazine derivatives at Kazan Federal University since 2016. Probably the most well-known derivative among the general public is methylene blue - a dye with antiseptic properties. (2020-06-09)

Photodynamic therapy used to treat ovarian cancer
Photodynamic therapy (PDT) is one of the most promising methods of treating localized tumors. PDT can be used for treatment in almost all major locations as an independent method or in combination with traditional types of treatment (surgery, radiation, and chemotherapy). (2020-06-08)

A Genethon team has succeeded in inhibiting the immune response linked to AAV
A research team from Genethon, in collaboration with teams from CNRS/Inserm and from the biotechnology company Spark Therapeutics, announced today in Nature Medicine that it has succeeded in inhibiting the immune response induced by AAV antibodies present as a result of natural immunity or following gene therapy, thanks to the IdeS enzyme. This result opens up new therapeutic prospects and the possibility of treating more patients. (2020-06-05)

Thyroid dysfunction in pregnancy being overdiagnosed, overtreated
The current practice of testing most pregnant women for thyroid stimulating hormone (TSH) may be leading to overdiagnosis and overtreatment, according to new research in CMAJ (Canadian Medical Association Journal). http://www.cmaj.ca/lookup/doi/10.1503/cmaj.191664 (2020-06-01)

New study sheds light on IBD patients with COVID
The researchers conclude that increasing age, comorbidities, and corticosteroids are associated with severe COVID-19 among IBD patients. Notably, TNF antagonists do not appear to be associated with severe COVID-19. (2020-05-18)

Arthritis clinical trial shows support for dextrose injection to alleviate knee pain
A randomized controlled trial conducted by a research team at a primary care clinic at the Chinese University of Hong Kong indicates that intra-articular-only injection therapy with hypertonic dextrose is safe and effective for alleviating symptoms of knee osteoarthritis. (2020-05-12)

Cognitive therapy can help treat anxiety in children with autism
Cognitive behavioural therapy and other psychosocial interventions are effective for treating anxiety in school-aged children with autism spectrum disorder, according to an analysis of all relevant studies published in 2005-2018. The findings are published in Campbell Systematic Reviews. (2020-05-06)

Gas nanomedicine: An emerging cutting-edge field
Several therapeutic gases are quite helpful for treatment of many inflammation-related diseases including cancer, but also exhibit some shortcomings such as limited therapy efficacy. Gas nanomedicine appears as an emerging cutting edge of nanomaterials and gas medicine, raising urgent demand on nanomaterials to address the issues of gas medicine. Scientists based in China propose a series of strategies of engineering advanced gas-releasing nanomedicines, and envisage current trends and future directions of gas-releasing nanomedicines for anticancer. (2020-05-06)

Killing 'sleeper cells' may enhance breast cancer therapy
The anti-cancer medicine venetoclax could improve the current therapy for estrogen receptor-positive (ER+) breast cancer - the most common form of breast cancer in Australia - according to preclinical studies led by Walter and Eliza Hall Institute researchers. The promising preclinical results for this 'triple therapy' have underpinned a phase 1 clinical trial in Melbourne, Australia, that is combining venetoclax with hormone therapy and CDK4/6 inhibitors in patients with ER+ breast cancer. (2020-05-06)

/LAMA combination therapy more effective for COPD patients with exercise intolerance
Clinicians grappling with the pharmacologic management of COPD in patients complaining of exercise intolerance or dyspnea now have new guidance. The American Thoracic Society has published an official clinical practice guideline in which a panel of experts strongly recommended LABA/LAMA combination therapy over LABA or LAMA alone. The complete guideline detailing all the recommendations was posted online ahead of print in the American Journal of Respiratory and Critical Care Medicine. (2020-04-14)

Illuminating the future of renewable energy
A new chemical compound created by researchers at West Virginia University is lighting the way for renewable energy. (2020-04-13)

Therapy dogs may help lower emergency clinicians' stress
New research published in Academic Emergency Medicine indicates that for physicians and nurses working evening shifts in the emergency department, interacting with a therapy dog for several minutes may help lower stress. (2020-04-08)

Film photosensitizer: High efficient singlet oxygen generation
A new non-polypyrrole-based photosensitizer (LW-PBI) was developed via introducting a nonplanar spirofluorene into a derivative of perylene bisimide (PBI) containing two long-alkyl chains. Photophysical studies demonstrated that the compound shows good solubility in common organic solvents, great photochemical stability, and high absorption efficiency in the visible light region. Further studies revealed that effective photo-production of singlet oxygen can be also realized via utilization of a tiny and low-price LED lamp as a light source and as a film support. (2020-04-08)

Managing negative thoughts helps combat depression in Parkinson's patients
People with Parkinson's disease who engage in cognitive behavioral therapy -- a form of psychotherapy that increases awareness of negative thinking and teaches coping skills -- are more likely to overcome depression and anxiety, according to a Rutgers study. (2020-04-01)

Lung cancer therapy may improve outcomes of metastatic brain cancer
A medication commonly used to treat non-small cell lung cancer that has spread, or metastasized, may have benefits for patients with metastatic brain cancers, suggests a new review and analysis led by researchers at St. Michael's Hospital of Unity Health Toronto and Harvard Medical School. (2020-03-25)

One drug, three action modes
Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action. Such a single-drug therapy would increase the chances of killing all cancer cells, the authors state in the journal Angewandte Chemie. (2020-03-13)

Study finds music therapy helps stroke patients
New research has found that music therapy sessions have a positive effect on the neurorehabilitation of acute stroke patients, as well as their mood. (2020-03-05)

Scientists discover new compound which could improve photodynamic therapy for cancer
Researchers at the University of Sheffield have synthesized a new compound which could improve the success rate of photodynamic therapy when treating cancer. (2020-02-26)

Study shows dietitians are an effective part of weight loss
A new study in the journal Family Practice indicates that intensive behavioral therapy from dietitians may be a very effective ways for older Americans to lose weight. (2020-02-20)

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