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No hot flashes? Then don't count on hormones to improve quality of life
Hormones at menopause can help with sleep, memory, and more, but only when a woman also has hot flashes, find researchers at Helsinki University in Finland. (2013-11-13)
Kidney Week 2013: New clinical trials reveal insights on treating patients with kidney disease
An investigational drug called ZS-9 demonstrated promising Phase 2 clinical trial results for treating abnormally high potassium levels in patients with chronic kidney disease. (2013-11-09)
Calcium and vitamin D improve bone density in patients taking antiepileptic drugs
A recent prospective, randomized, placebo-controlled clinical trial reports that calcium and vitamin D supplementation improves bone density in a group of male veterans with epilepsy who were treated chronically with antiepileptic drugs. (2013-11-07)
Natura Therapeutics product shown to improve decision making skills in older adults
A human clinical study of older adults has demonstrated that participants who took NutraStem Cardio, a natural dietary supplement created by Natura Therapeutics, Inc., showed a significant increase in cognition when compared to age-matched individuals taking a placebo. (2013-11-06)
Common diabetes drug fails to fulfill promise of improving cardiovascular risk in people without diabetes
Despite high expectations for the commonly used diabetes drug metformin to improve risk factors for heart disease in people without diabetes, few beneficial effects have been found in a randomised trial of patients with established cardiovascular disease, published in The Lancet Diabetes & Endocrinology. (2013-11-06)
Clinical trial indicates gabapentin is safe and effective for treating alcohol dependence
The generic drug gabapentin, which is already widely prescribed for epilepsy and some kinds of pain, appears to be safe and effective in the treatment of alcohol dependence. (2013-11-04)
New drug could offer first safe and effective treatment for psychotic symptoms
Up to 10 million people worldwide have Parkinson's disease and more than 50 percent of them will experience psychosis (mainly hallucinations and delusions) at some time. (2013-10-31)
New study shows promise for first effective medicine to treat cocaine dependence
New research published in JAMA Psychiatry reveals that topiramate, a drug approved by the US Food and Drug Administration to treat epilepsy and migraine headaches, also could be the first reliable medication to help treat cocaine dependence. (2013-10-25)
Flu vaccine associated with lower risk of cardiovascular events
Receiving an influenza vaccination was associated with a lower risk of major adverse cardiovascular events such as heart failure or hospitalization for heart attack, with the greatest treatment effect seen among patients with recent acute coronary syndrome (ACS; such as heart attack or unstable angina), according to a meta-analysis published in the October 23/30 issue of JAMA. (2013-10-22)
Intranasal application of hormone appears to enhance placebo response
Simon Kessner, of the University Medical Center Hamburg-Eppendorf, Hamburg, Germany, and colleagues conducted a study to test whether oxytocin enhances the placebo response in an experimental placebo analgesia model. (2013-10-22)
Shining the soothing light
Low-level laser therapy reduces the occurrence of oral mucositis, known as the common canker sore, and improves quality of life in head and neck squamous cell cancer patients. (2013-10-20)
ADHD drug effective for people with dependency
People with ADHD and dependency rarely respond as they should to ADHD drugs. (2013-10-14)
Use of statin does not improve survival among adults with ventilator-associated pneumonia
Laurent Papazian, M.D., Ph.D., of Hopital Nord, Marseille, France, and colleagues conducted a study to determine whether statin therapy decreased day-28 mortality among intensive care unit patients with ventilator-associated pneumonia. (2013-10-09)
Boston University researchers test effectiveness of treatments for alcoholism and anxiety
Domenic Ciraulo, M.D., chair of psychiatry at Boston University School of Medicine and David H. (2013-10-07)
New class of drugs lowers cholesterol in first human trial
A new class of cholesterol-lowering drugs that target a recently discovered regulator of harmful cholesterol could be an alternative or complementary treatment for the 30 million people who take statins, after the first trial in humans confirms the technique's feasibility and safety. (2013-10-02)
What works for women doesn't work for men
Flushed face, sweating, a sudden rush of heat. The hot flash, the bane of menopausal women, also can affect men who are undergoing hormone therapy for prostate cancer. (2013-09-30)
Testosterone promotes reciprocity in the absence of competition
Boosting testosterone can promote generosity, but only when there is no threat of competition, according to new research published in Psychological Science. (2013-09-30)
Novel drug prevents common viral disease in stem-cell transplant patients, study finds
A common, sometimes severe viral disease in patients receiving a transplant of donated stem cells can be prevented by a new drug given shortly after transplant, according to findings from a clinical trial led by researchers at Dana-Farber Cancer Institute and Brigham and Women's Hospital. (2013-09-25)
Cheap dextrose gel could help prevent cause of brain damage in newborns
A cheap and easy-to-administer dextrose gel should be used to treat low blood sugars in newborns, a common problem that affects up to 15% of otherwise healthy babies, and a preventable cause of brain damage, according to new research published in The Lancet. (2013-09-24)
Mayo-led study: Drug fails to reduce diarrhea in patients receiving radiation therapy
Sulfasalazine, a drug commonly prescribed to reduce diarrhea in patients with inflammatory bowel disease, does not reduce diarrhea in patients receiving radiation therapy for cancers in the pelvic area a Mayo Clinic-led study has found. (2013-09-24)
Psoriasis drug shows promising results for treating type 1 diabetes
A drug formerly used to treat the skin disorder psoriasis has shown encouraging results in a phase 2 trial to assess its effectiveness in treating type 1 diabetes, according to new research published in The Lancet Diabetes and Endocrinology. (2013-09-22)
Sulfasalazine does not reduce diarrhea for patients receiving pelvic radiation therapy
Sulfasalazine does not reduce diarrhea, according to research presented today at the American Society of Radiation Oncology's 55th Annual Meeting. (2013-09-22)
Targeting memory T-cells in Type 1 diabetes
Encouraging results from the T1DAL study (Targeting effector memory T cells with alefacept in new onset type 1 diabetes) are published today in The Lancet Diabetes & Endocrinology. (2013-09-22)
Need steroids? Maybe not for lower back pain
New research from Johns Hopkins suggests that it may not be the steroids in spinal shots that provide relief from lower back pain, but the mere introduction of any of a number of fluids, such as anesthetics and saline, to the space around the spinal cord. (2013-09-17)
Copper bracelets and magnetic wrist straps fail to help rheumatoid arthritis, says York research
Copper bracelets and magnet wrist straps have no real effect on pain, swelling, or disease progression in rheumatoid arthritis, according to new findings from a study conducted at the University of York. (2013-09-16)
Varenicline helps smokers with depression to quit smoking
About half of smokers seeking treatment for smoking cessation have a history of depression. (2013-09-16)
Arginine therapy shows promise for sickle cell pain
Arginine therapy may be a safe and inexpensive treatment for acute pain episodes in patients with sickle cell disease, according to results of a recent clinical study. (2013-09-16)
Exposure/ritual prevention therapy boosts antidepressant treatment of OCD
Scientists have demonstrated that a form of behavioral therapy can augment antidepressant treatment of obsessive compulsive disorder (OCD) better than an antipsychotic. (2013-09-12)
Drug treatment means better, less costly care for children with sickle cell disease
The benefits of hydroxyurea treatment in people with sickle cell disease are well known -- fewer painful episodes, fewer blood transfusions and fewer hospitalizations. (2013-09-11)
Combination therapy for severe alcoholic hepatitis does not result in improved survival
Four weeks of treatment with a combination of the drug pentoxifylline and the corticosteroid prednisolone did not improve 6-month survival compared with prednisolone alone in 270 patients with severe alcoholic hepatitis, according to a study in the September 11 issue of JAMA. (2013-09-10)
First trial to compare e-cigarettes with nicotine patches shows comparable success in helping smokers to quit
The first ever clinical trial to compare e-cigarettes with nicotine patches has found that both methods result in comparable success in quitting, with roughly similar proportions of smokers who used either method remaining abstinent from smoking for six months after a 13 week course of patches or e-cigarettes. (2013-09-07)
First trial to compare e-cigarettes with nicotine patches
First trial to compare e-cigarettes with nicotine patches shows comparable success in helping smokers to quit. (2013-09-07)
Cleveland Clinic research finds no benefit over placebo in ASSURE trial
Patients with coronary artery disease and low levels of (2013-09-03)
Despite missing primary efficacy endpoint, ATOMIC-AHF identifies positive trends
Omecamtiv mecarbil, a cardiac myosin-activator, did not achieve its primary efficacy endpoint in reducing shortness of breath in patients with acute heart failure, according to the results of the phase II Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure study. (2013-09-03)
Hot Line IV: Late-breaking trials on heart failure and acute coronary syndrome
The blood pressure lowering drug aliskiren did not improve coronary artery disease when given to patients who had prehypertension, results of the Aliskiren Quantitative Atherosclerosis Regression Intravascular Ultrasound study reveal. (2013-09-03)
Medication does not slow progression of coronary disease in patients with prehypertension
Among patients with prehypertension and coronary artery disease, use of the renin (an enzyme secreted by the kidneys) inhibitor aliskiren, compared with placebo, did not result in improvement or slowing in the progression of coronary atherosclerosis, according to a study published by JAMA. (2013-09-03)
ASSURE study of experimental agent to raise HDL yields 'disappointing and surprising' results
The search continues for an agent that increases high-density lipoprotein and reduces arterial plaque, after the experimental apolipoprotein A1 (apoA1) inducer, RVX-208 failed to do so in the ApoA1 Synthesis Stimulation and Intravascular Ultrasound for Coronary Atheroma Regression Evaluation study. (2013-09-02)
Treatment with the anti-diabetic drug alogliptin does not increase CV risk in patients with ACS
Patients with Type 2 diabetes and high cardiovascular risk due to recent acute coronary syndromes had similar rates of cardiovascular events when treated with the anti-diabetic agent alogliptin compared to placebo according to results of the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care trial presented at the European Society of Cardiology Congress. (2013-09-02)
Rheumatoid arthritis: Biologics in second-line therapy show benefit
All 9 biotechnologically produced drugs for the treatment of adult patients with rheumatoid arthritis in whom prior pharmacological treatment failed to show a benefit for at least one outcome criterion. (2013-08-30)
T-cell targeted therapy tested in type 1 diabetes study
Results from the START clinical study, led by Dr. Steve Gitelman, University of California, San Francisco, and sponsored by the Immune Tolerance Network, are published today in The Lancet Diabetes & Endocrinology. (2013-08-27)
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