Current Placenta News and Events

Current Placenta News and Events, Placenta News Articles.
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Placental function can illuminate future disease in adults and children
Researchers at the University of Colorado Anschutz Medical Campus have discovered a direct association between placental function in pregnant women and future metabolic disorders in children and adults, a finding that could lead to earlier intervention and diagnosis of disease. (2021-01-22)

Estrogen receptors in mom's placenta critical during viral infection
A team of Duke and Mt. Sinai researchers has found a mechanism that protects a fetus from harm when the mother's innate immune system responds to a viral infection. Inflammation that would harm the fetus is dampened by a cell-surface estrogen receptor called GPER1 that is especially abundant in the placenta and fetal tissues. (2021-01-21)

Important cause of preeclampsia discovered
New findings show that cholesterol crystals in the uterine wall are the villain that researchers have been looking for. These crystals cause intensified inflammation in people who become ill. (2021-01-21)

Prenatal BPA exposure may contribute to the male bias of autism spectrum disorder
Autism has a higher prevalence in males than females. Bisphenol A (BPA) is a common chemical found in plastics, our food, and even the human placenta. Higher prenatal exposure to BPA is thought to increase the risk of autism. Researchers have, for the first time, identified autism candidate genes that may be responsible for the sex-specific effects of BPA. (2021-01-19)

Can a mother's stress impact children's disease development?
A University of Cincinnati researcher finds that stress on an expectant mother could affect her baby's chance of developing disease -- perhaps even over the course of the child's life. (2021-01-11)

Research reveals compromised transfer of SARS-CoV-2-specific antibodies through placenta
Lower than expected levels of protective SARS-CoV-2 antibodies pass through the placenta from mothers who are infected in the third trimester with the virus that causes COVID-19. This low level of transfer from mother to fetus may be caused by altered attachments of carbohydrates to the SARS-CoV-2-specific antibodies. (2020-12-23)

Pregnant women in third trimester unlikely to pass SARS-CoV-2 infection to newborns
Pregnant women who are infected with SARS-CoV-2, the virus that causes COVID-19, during the third trimester are unlikely to pass the infection to their newborns, suggests a study funded by the National Institutes of Health. The study followed 127 pregnant women who were admitted to Boston hospitals during the spring of 2020. Among the 64 pregnant women who tested positive for SARS-CoV-2, no newborns tested positive for the virus. (2020-12-22)

Pregnant women with COVID-19 pass no virus but fewer-than-expected antibodies to newborns
Pregnant women may be especially vulnerable to developing more severe cases of COVID-19, but little is known about their anti-SARS-CoV-2 immune response or how it may affect their offspring. A new study provides new insights that could help improve care for these women and their newborns and emphasizes the need for pregnant women to be considered in vaccine rollout plans. (2020-12-22)

Gene therapy for placental insufficiency moves toward the clinic
A new study identified an adenovirus gene therapy vector carrying a VEGF isoform. It can improve uterine blood flow in placental insufficiency. (2020-12-15)

Small and large birth weight linked to genetics of mother and baby -- except in tiniest babies
Genetics of mother and baby contribute to most cases where babies are born very large or very small, according to new research. (2020-12-02)

Protein commonly screened for in pregnancy is linked to gestational diabetes
Laboratory research and analysis of epidemiological data by Silvia Corvera, MD, and Tiffany Moore Simas, MD, MPH, MEd, and colleagues show that low levels of a protein commonly seen in screening tests for chromosomal disorders during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes mellitus in pregnant women. (2020-11-30)

How will COVID-19 affect our next generation?
Exposure to COVID-19 could pose a risk to the health and aging of individuals who aren't even born yet, according to a newly published analysis. By the end of 2020, approximately 300,000 infants could be born to mothers infected by SARS-CoV-2, the virus that causes COVID-19. Millions more will be born into families who have experienced tremendous stress and upheaval due to the pandemic even if they haven't been infected themselves. (2020-11-12)

New insight into a placental gene pathway and its association with vitamin D
Vitamin D status during pregnancy has multifaceted effects on maternal health. In an article in Pregnancy Hypertension, researchers at the Medical University of South Carolina found that vitamin D sufficiency lowered the expression of placental genes related to preeclampsia - a severe, and sometimes fatal, condition. Their findings shed new light on the development of preeclampsia during pregnancy and how it may correlate with maternal vitamin D status. (2020-11-09)

Mothers pass on allergies to offspring, Singapore preclinical study shows
Maternal antibodies primed to react to specific allergens can cross the placenta, passing on transiently allergic reactions to offspring, according to new preclinical research from a collaborative study by the Agency for Science, Technology and Research, KK Women's and Children's Hospital, and Duke-NUS Medical School in Singapore. The finding hints at why infants exhibit allergies so early in life and suggests possible targets for intervention. (2020-10-29)

Study reveals factors that can make placenta less capable of protecting fetus from zika
Findings reported by Brazilian researchers in PLOS Neglected Tropical Diseases help explain why only some babies whose mothers are infected during pregnancy are born with microcephaly and other anomalies. (2020-10-27)

Happiness and the evolution of brain size
Serotonin can act as a growth factor for the stem cells in the fetal human brain that determine brain size. (2020-10-23)

Fish exposed to even small amounts of estrogen produce fewer males
UC assistant professor Latonya Jackson conducted experiments with North American freshwater fish called least killifish. She found that fish exposed to estrogen in concentrations of 5 nanograms per liter in controlled lab conditions had fewer males and produced fewer offspring. Scientists have found estrogen at as much as 16 times that concentration in streams adjacent to sewage treatment plants. (2020-10-23)

Blood tests could be developed to help predict pregnancy complications new study suggests
UCLA researchers say a blood test commonly used to detect fetal genetic abnormalities may help predict complications associated with pregnancy before symptoms develop. Their preliminary study, appearing in Epigenetics, links certain cell-free DNA signatures to adverse outcomes in pregnancy, including ischemic placental disease and gestational diabetes. (2020-10-13)

Pregnant women with severe COVID-19 face additional risks and early delivery
Pregnant women with severe or critical COVID-19 and their unborn infants face increased health risks before and after delivery but those with mild cases had similar outcomes compared to those who were uninfected, a Rutgers Robert Wood Johnson Medical School study finds. (2020-10-07)

Researchers create artificial lung to support pre-term babies in distress
An international team led by current and former McMaster University researchers has developed an artificial lung to support pre-term and other newborn babies in respiratory distress. (2020-09-29)

Placenta is initiated first, as cells of a fertilised egg divide and specialise
The first stages of placental development take place days before the embryo starts to form in human pregnancies. The finding highlights the importance of healthy placental development in pregnancy, and could lead to future improvements in fertility treatments such as IVF, and a better understanding of placental-related diseases in pregnancy. (2020-09-24)

First evidence that air pollution particles and metals are reaching the placenta
Pollution particles, including metals, have been found in the placentas of fifteen women in London, according to research led by Queen Mary University of London. (2020-09-23)

A new discovery in regenerative medicine
An international collaboration involving Monash University and Duke-NUS researchers have made an unexpected world-first stem cell discovery that may lead to new treatments for placenta complications during pregnancy. (2020-09-16)

Detection of PCBs and their metabolites (OH-PCBs) in the fetal brain of a Japanese macaque
This study selected the Japanese macaque (Macaca fuscata) as a model animal for the fetal transfer of OH-PCBs in humans, and revealed OH-PCB concentrations and their relationships in the maternal and fetal brains. The key finding from this study is that OH-PCBs can reach the developing brain of the fetus as early as the first trimester of pregnancy. These OH-PCBs may exceed the levels that induce adverse effects on neurodevelopment. (2020-09-14)

'One size fits all' medication approach doesn't work in pregnancy
New research led by the University of South Australia shows that a blanket approach to prescribing medication during pregnancy may put low birth weight babies at risk for the rest of their lives. (2020-09-08)

Cellular roadmaps predict body's coronavirus vulnerability
New research from Cornell University developed potential roadmaps for how the coronavirus infects organs and identifies what molecular factors could help facilitate or restrict infection. (2020-09-03)

Predictive placentas: Using artificial intelligence to protect mothers' future pregnancies
After a baby is born, doctors sometimes examine the placenta for features that indicate health risks in any future pregnancies. Most placentas go unexamined after the birth. A team of researchers from Carnegie Mellon University (CMU) and the University of Pittsburgh Medical Center (UPMC) report the development of a machine learning approach to examine placenta slides in The American Journal of Pathology so more women can be informed of their health risks. (2020-09-02)

Researchers identify proteins that prevent COVID-19 transmission through the placenta
Researchers from Boston Medical Center's Maxwell Finland Laboratory for Infectious Diseases have identified properties in placenta tissue that may play an important role in preventing the transmission of COVID-19 from a mother with the virus to her fetus. (2020-09-02)

Unravelling mother to baby transmission of Zika virus
Researchers have discovered that when a pregnant mother is infected by Zika virus, it can remain in the placenta for months, causing damage that can be dangerous to the fetus. These findings advance our understanding of mother to baby transmission and provide the groundwork for the future development of drugs and vaccines. (2020-09-01)

Placenta can indicate how body responds to opioids during pregnancy
Scientists at the University of Missouri have discovered possible biological markers that they hope could one day help identify the presence of an opioid use disorder during human pregnancy. (2020-08-26)

Mother transmitted COVID-19 to baby during pregnancy, UTSW physicians report
A pregnant mother who tested positive for COVID-19 transmitted the virus causing the disease to her prematurely born baby, UT Southwestern physicians report. Both were treated and recovered. (2020-08-24)

Prevention of heart disease can start before birth
Babies that experience low oxygen levels in the womb due to pregnancy complications often go on to develop heart disease in adulthood. A study using sheep has discovered that a specialised antioxidant called MitoQ can prevent heart disease at its very onset. The results are published today in the journal Science Advances. (2020-08-19)

Who's your daddy? Male seahorses transport nutrients to embryos
New research by Dr Camilla Whittington and her team at the University of Sydney has found male seahorses transport nutrients to their developing babies during pregnancy. This discovery provides an opportunity for further comparative evolutionary research. (2020-08-13)

Human coagulation factor XIIIa expressed in pichia pastoris as fXIIIa hemostatic agent
In this study, recombinant pPICZ╬▒C-FXIIIa was expressed in Pichia pastoris, purified as well as its biological activity was determined. (2020-07-28)

Experimental drug reduces replication of zika and prevents microcephaly in mice
No adverse effects were observed in the mice treated with the AHR inhibitor, but before the treatment is tested in human volunteers the experiment must be replicated in monkeys. (2020-07-20)

Simple twist of DNA determines fate of placenta
The development of the mammalian placenta depends upon an unusual twist that separates DNA's classic double helix into a single-stranded form, Yale researchers report July 15 in the journal Nature. (2020-07-15)

Researchers found a link between genes and preeclampsia
Researchers have showed that HLA-G gene regulates male-to-female ratio at birth. The study strengthens earlier findings of the vulnerability of male fetuses to preeclampsia. (2020-07-14)

COVID-19 can be transmitted in the womb, reports pediatric infectious disease journal
A baby girl in Texas -- born prematurely to a mother with COVID-19 -- is the strongest evidence to date that intrauterine (in the womb) transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur, reports The Pediatric Infectious Disease Journal, the official journal of The European Society for Paediatric Infectious Diseases. The journal is published in the Lippincott portfolio by Wolters Kluwer. (2020-07-10)

Novel biomarker discovery could lead to early diagnosis for deadly preeclampsia
Preeclampsia is a dangerous condition that worldwide kills over 70,000 women and 500,000 babies each year. The discovery of two new biomarkers has the potential to predict key underlying causes of the disease and could lead to the early diagnosis and prevention of severe preeclampsia, and associated complications, researchers say. (2020-07-03)

Tibetan antelope thrive at high altitudes using a juvenile form of blood oxygen transport
Adult Tibetan antelope have overcome oxygen deprivation on the high-altitude Tibetan Plateau through an unusual adaptation in which they permanently express a form of hemoglobin (the iron-containing oxygen transport protein in red blood cells) that other members of the cattle family only express as juveniles or when under extreme oxygen deprivation. (2020-06-17)

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