Current Polycystic Ovary Syndrome News and Events

Current Polycystic Ovary Syndrome News and Events, Polycystic Ovary Syndrome News Articles.
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First hybrid gene therapy shows early promise in treating long QT syndrome
In a new study published in Circulation, Mayo Clinic researchers provide the first preclinical, proof-of-concept study for hybrid gene therapy in long QT syndrome, a potentially lethal heart rhythm condition. (2021-01-28)

Concordia researchers find melatonin is effective against polycystic kidney disease
Melatonin, a hormone commonly associated with sleep-wake regulation, has been found to reduce cysts in fruit flies, according to Concordia researchers. It's a finding that may affect the way we treat some kidney diseases and reduce the need for kidney transplants. (2021-01-26)

Hypertension symptoms in women often mistaken for menopause
Pregnancy complications and early menopause increase women's future risk of heart disease. Cardiologists, gynaecologists and endocrinologists recommend how to help middle-aged women prevent later heart problems in a European Society of Cardiology (ESC) consensus document published today in European Heart Journal, a journal of the ESC. ''Physicians should intensify the detection of hypertension in middle-aged women,'' states the document. (2021-01-26)

Approximately half of AD dementia cases are mild, one-fifth are severe
What percent of patients with Alzheimer's Disease (AD) currently have severe dementia? Do more people have mild disease? Or are the majority suffering with moderate dementia? A new study using data from the Framingham Heart Study (FHS) sheds light on these trends. (2021-01-13)

Pillar-like molecules as biosensors for metabolites
Researchers at Kanazawa University report in Communications Chemistry that a molecule known as pillar[6]arene can form a host-guest compound with a cancer-associated metabolite. The phenomenon can be used to efficiently detect the metabolite in crude biological samples, which is important for preventing and treating metabolic syndrome and associated pathologies. (2021-01-11)

Study: New insights on the role of the MLL4 gene in Kabuki syndrome
Research suggests that MLL4 controls the production of neurons that secrete growth hormone-releasing hormone (GHRH) in a part of the brain called the hypothalamus. (2021-01-11)

Bats with white-nose syndrome prefer suboptimal habitats despite the consequences
Bats are mistakenly preferring sites where fungal growth is high and therefore their survival is low. (2021-01-08)

A subtle change in the DNA may predispose to polyneuropathy after gut infection
Researchers from Tokyo Medical and Dental University (TMDU) identified a novel genetic variant associated with Guillain-Barré syndrome (GBS). By analyzing the DNA sequence of patients with the disease, the researchers identified two novel variants of the ganglioside-binding protein Siglec-10 accumulated in the patients. They found that one of these variants impairs the function of the protein, predisposing carriers to the development of GBS. This study improves our understanding of the pathophysiology of GBS. (2021-01-07)

A brain mechanism underlying 'vision' in the blind is revealed
Researchers observed slow spontaneous fluctuations in the brain's visual centers that preceded visual hallucinations in blind people. (2021-01-07)

New research finds ginger counters certain autoimmune diseases in mice
The main bioactive compound of ginger root lowers autoantibody production and helps halt disease progression in mice with antiphospholipid syndrome and lupus. (2021-01-06)

Some English bulldogs thought to have cancer may have newly identified syndrome
Some English bulldogs diagnosed with a common cancer may instead have a newly described, non-cancerous syndrome called polyclonal B?cell lymphocytosis. The discovery was made by Morris Animal Foundation-funded researchers at Colorado State University during a study to better understand B-cell chronic lymphocytic leukemia (BCLL). The team published their findings in the Journal of Veterinary Internal Medicine. (2021-01-05)

Metabolic syndrome 'interacts' with COVID-19
Announcing a new publication for BIO Integration journal. In this review article the authors Zeling Guo, Shanping Jiang, Zilun Li and Sifan Chen from Sun Yat-Sen University, Guangzhou, China review how metabolic syndrome 'interacts' with COVID-19. (2020-12-23)

Scientists pinpoint molecular cause for severe disorder in children
A team of scientists from the University of Ottawa have opened a window into the cause of a rare genetic disorder that causes mortality in young children. (2020-12-22)

Researchers determine factors associated with ovary removal in patients with ovarian torsion
To determine the factors associated with an increased likelihood for ovary removal during the time of surgery for ovarian torsion, researchers from Boston University School of Medicine (BUSM), conducted a retrospective study of patients from a racially diverse, urban safety-net hospital with a diagnosis of ovarian torsion during a four-and-a-half-year period. (2020-12-18)

Prenatal testing has halved the number of babies born with Down syndrome in Europe
For the first time, a study has aggregated data on the number of babies born with Down syndrome in each European country. Researchers estimate the number of people with Down syndrome alive each year between 1950 and 2015. It is critical to have accurate estimates of the prevalence of Down syndrome so each country can evaluate the impact of prenatal testing on its population and to allocate appropriate resources to its citizens with Down syndrome. (2020-12-18)

Water may be an effective treatment for metabolic syndrome
Researchers at the University of Colorado Anschutz Medical Campus have discovered that fructose stimulates the release of vasopressin, a hormone linked to obesity and diabetes. They also found that water can suppress the hormone and alleviate these conditions in mice. (2020-12-15)

How poor oral hygiene may result in metabolic syndrome
Researchers from TMDU identified a novel mechanism by which periodontal disease may cause metabolic syndrome. By studying patients with metabolic syndrome, the researchers demonstrated high antibody titers against Porphyromonas gingivalis, the bacterium causing periodontal disease. In a mouse model, the researchers then showed that infection with this bacterium causes systemic insulin resistance and metabolic dysfunction in skeletal muscle by altering the gut microbiome. This study shows the effect periodontal disease can have on the entire body. (2020-12-08)

Rutgers reports first instance of COVID-19 triggering recurrent Guillain-Barré Syndrome
Researchers at Rutgers Robert Wood Johnson Medical School have reported the first instance of COVID-19 triggering a recurrence of Guillain-Barré Syndrome - a rare disorder where the body's immune system attacks nerves and can lead to respiratory failure and death. (2020-12-08)

The gut microbiome in polycystic ovary syndrome and its association with metabolic traits
University of Tartu researchers and their collaborators from Finland and Spain investigated the relationship between the gut microbiome and polycystic ovary syndrome. Their study revealed that women with polycystic ovary syndrome in their late reproductive years have significant microbial changes in gut-related to their metabolic health. (2020-12-08)

Gestational age linked to ADHD in children with Down syndrome
A new study by the UC Davis MIND Institute finds a connection between gestational age and ADHD in children with Down syndrome. An earlier gestational age is linked to higher ADHD symptoms later in childhood. (2020-12-04)

New childhood dementia insight
Is the eye a window to the brain in Sanfilippo syndrome, an untreatable form of childhood-onset dementia, Australian researchers ask in a new publication. The findings of the NHMRC-funded project, just published in international journal Acta Neuropathologica Communications, highlight the potential for using widely available retinal imaging techniques to learn more about brain disease and monitor treatment efficacy. (2020-12-01)

How thyroid function affects stress-related heart problems
Chest pain, shortness of breath, heart flutter and palpitations: these symptoms are not only characteristic of a heart attack, but can also be caused by another, as yet little researched condition. So-called Takotsubo cardiomyopathy is a rare but life-threatening disease of the heart that can occur during extreme stress events. Heart and hormone research teams in Bochum and Mannheim have now shown that there is apparently a strong link between the occurrence of Takotsubo syndrome and impaired thyroid function in patients. (2020-12-01)

Breakthrough in studying the enzyme that ultimately produces fish odour syndrome
Fish odour syndrome (trimethylaminuria) is a debilitating disease, in which the liver cannot break down the smelly chemical trimethylamine which is produced by enzymes from bacteria residing in the gut leaving people with a fish like odour. Researchers from the University of Warwick are paving the way to prevent the syndrome after a breakthrough in studying the enzyme in the gut which produces trimethylamine. (2020-11-23)

Early signs of Alzheimer's disease in people with Down's syndrome
Researchers at Karolinska Institutet in Sweden have studied the incidence and regional distribution of Alzheimer's disease biomarkers in the brains of people with Down's syndrome. The results can bring new possibilities for earlier diagnosis and preventive treatment of dementia. The study is published in Molecular Neurodegeneration. (2020-11-22)

Maraxilibat reduces debilitating itching in children with Alagille syndrome
On behalf of Childhood Liver Disease Research Network (ChiLDReN), Texas Children's Hospital and Baylor College of Medicine researchers report that prolonged treatment with Maraxilibat resulted in clinically meaningful improvements in debilitating itching (pruritus) and related quality of life outcomes in children with Alagille syndrome. The novel pharmacological approach addresses a major unfulfilled therapeutic need to control severe and relentless itching in pediatric patients with Alagille syndrome. (2020-11-19)

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy. (2020-11-18)

A patented solution for dry mouth relief and food product development
A team of scientists from the University of Leeds have developed a new hydrogel that has significant potential for oral care products that can help with dry mouth relief. (2020-11-17)

New Fred Hutch-led trial shows no benefits of dairy foods for blood sugar regulation
Results from a new trial published by a team led by researchers at Fred Hutchinson Cancer Research Center suggests lower dairy intake may be beneficial for people with metabolic syndrome. (2020-11-16)

New drug can improve fertility in women with reproductive health problems
A drug that acts via the natural 'kisspeptin' hormone system in the body has the potential to treat reproductive health problems in women, according to a new study. (2020-11-16)

Best practices for mechanical ventilation in patients with ARDS, COVID-19
A team from pulmonary and critical care medicine at Michigan Medicine outlines 20 evidence-based practices shown to reduce time spent on a ventilator and death in patients with acute respiratory failure and acute respiratory distress -- conditions that have many overlaps with severe COVID-19. (2020-11-13)

Single institution study finds high rates of cardiac complications in MIS-C
During the height of the COVID-19 pandemic, researchers at Children's National Hospital discovered that as many as one half of children diagnosed with multisystem inflammatory disease in children (MIS-C) at the hospital developed cardiac complications including coronary artery abnormalities, even when diagnosed and treated promptly. (2020-11-13)

Model helps predict which infants may develop NAS
A new Vanderbilt-designed prediction model may make it easier to determine which infants will go on to develop neonatal abstinence syndrome (NAS), a drug withdrawal syndrome in newborns that occurs after exposure to opioids during pregnancy. (2020-11-12)

Fish give insight on sound sensitivity in autism
Scientists at The University of Queensland used zebrafish that carry the same genetic mutations as humans with Fragile X syndrome and autism, and discovered the neural networks and pathways that produce the hypersensitivities to sound in both species. (2020-11-10)

Tracking down the causes of heart attack
Heart attacks strike suddenly and have a range of different triggers. Researchers from Charité - Universitätsmedizin Berlin and the German Centre for Cardiovascular Research (DZHK) were able to uncover a further underlying cause. Studying arterial deposits (plaque) in patients with acute coronary syndrome, the researchers found that, in some patients, these were characterized by activated immune cells which, as a result of altered flow conditions within the vessel, had accumulated on the interior arterial wall, causing damage to the arterial lining. (2020-11-10)

A novel finding on Kabuki syndrome, a rare genetic disease
It has a long time since the cause of the disease has been identified: mutations of KMT2D gene codify for MLL4, a protein involved in the regulation of chromatin, which is the complex of proteins and nucleic acids contained in the nucleus of cells. However, research still has a long way to go to identify therapeutic approaches. An Italian team, coordinated by the University of Trento, has taken a step forward in this direction (2020-11-09)

Attending an HBCU may protect Black students from later health problems
African Americans who attend Historically Black Colleges or Universities (HBCUs) may be at lower risk for health problems later in adulthood compared to African Americans who attend predominantly white institutions, a new study suggests. (2020-11-09)

Down Syndrome-associated gene suppresses age-related corneal clouding
Down syndrome and hypercholesterolemia mouse models suggest that the DSCR-1 gene protects against abnormal cornea vascularization and associated blindness by suppressing oxidized LDL cholesterol production and downstream angiogenic signaling during chronic high cholesterol. While the neurological pathology of Down syndrome patients worsens with age, they are less susceptible to age-related vascular diseases. The responsible genes and mechanisms are not yet clear, but DSCR-1 is a strong candidate for a wide range of vascular diseases. (2020-11-05)

Delirium could be an early marker of COVID-19
Delirium accompanied by fever could be an early symptom of COVID-19. This is the main conclusion drawn by a scientific research review carried out by researchers from the Universitat Oberta de Catalunya (UOC) and published in the open access Journal of Clinical Immunology and Immunotherapy, which highlights the fact that, together with the loss of the senses of taste and smell and headaches that occur in the days prior to the manifestation of coughing and breathing difficulties, some patients also develop delirium. (2020-11-04)

Possible triggers of autism symptoms and motor issues identified for several rare diseases
* Study identifies possible genetic triggers for debilitating symptoms of several rare diseases * These conditions, including Prader-Willi and Angelman syndromes, have few treatments * The results could eventually lead to more effective and personalised therapies (2020-10-29)

Plant compound reduces cognitive deficits in mouse model of Down syndrome
The plant compound apigenin improved the cognitive and memory deficits usually seen in a mouse model of Down syndrome, according to a study by researchers at the National Institutes of Health and other institutions. Apigenin is found in chamomile flowers, parsley, celery, peppermint and citrus fruits. The findings raise the possibility that a treatment to lessen the cognitive deficits seen in Down syndrome could one day be offered to pregnant women whose fetuses have been diagnosed with Down syndrome through prenatal testing. (2020-10-23)

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