Current Progesterone News and Events

Current Progesterone News and Events, Progesterone News Articles.
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How a gene called HAND2 may impact the timing of labor
Using new and existing datasets the team studied genes that were active in the uterine linings of different animals while pregnant or carrying eggs. Scientists also investigated the changing levels of HAND2 during gestation. (2021-02-22)

Imaging identifies breast cancer patients unlikely to benefit from hormone therapy
Hormone therapy can be very effective for so-called estrogen receptor-positive breast cancer. But it only works for a little more than half of women who receive the treatment. In a small study, researchers at Washington University School of Medicine in St. Louis found that women whose tumors did not respond to a one-day estrogen challenge did not benefit from hormone therapy. The findings could help doctors choose treatments most likely to help their patients. (2021-02-02)

Nanotechnology prevents premature birth in mouse studies
In a study in mice and human cells, Johns Hopkins Medicine researchers say that they have developed a tiny, yet effective method for preventing premature birth. (2021-01-13)

Identifying strategies to advance research on traumatic brain injury's effect on women
Analysis from a workshop convened by the National Institute of Neurological Disorders and Stroke (NINDS) in 2017 reveals gaps in and opportunities for research to improve understanding of the effects of traumatic brain injury (TBI) in women. A new paper in the Journal of Head Trauma Rehabilitation summarizes and updates the findings presented during the 'Understanding Traumatic Brain Injury in Women' workshop and provides strategies for advancing research efforts in this area. NINDS is part of the National Institutes of Health. (2021-01-06)

Surgery may offer survival advantage in certain metastatic breast cancers
Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to Penn State College of Medicine and Penn State Cancer Institute researchers. They studied nearly 13,000 stage four breast cancer patients and found that those who had surgery in addition to their other treatments had a survival advantage over those who had other treatments alone. (2020-12-22)

Promising treatment for premenstrual dysphoric disorder, PMDD
The mental symptoms of premenstrual dysphoric disorder improve following treatment with a progesterone receptor modulator, as demonstrated by SciLifeLab researcher Erika Comasco and Professor Inger Sundström-Poromaa, Uppsala University. The mechanism of action of the study drug provides insights into the potential molecular mechanisms underlying this psychiatric disorder and its treatment. (2020-12-10)

Study shows protective role sex steroids play in COVID-19
''Sex and Covid-19: A protective role for reproductive steroids,'' by Graziano Pinna, research associate professor in psychiatry, analyzes existing research to look at reasons why COVID-19 symptom severity and mortality are more frequent in men than in women and in older people. His paper suggests female reproductive steroids play a protective role. (2020-11-24)

Pregnancy complications linked to heightened risk of heart disease and stroke in later life
Pregnancy complications such as miscarriage, pre-eclampsia, diabetes in pregnancy (gestational diabetes) and pre-term birth are linked to a heightened risk of heart disease in later life, suggests an overarching (umbrella) analysis of data published by The BMJ today. (2020-10-07)

A better alternative to Phthalates?
In collaboration with the Medical University of South Carolina, researchers at the National Institute of Standards and Technology (NIST) analyzed urine samples from pregnant women to look for the presence of DINCH, which is short for di(isononyl)cyclohexane-1,2-dicarboxylate. They found concentrations of DINCH in most of the urine samples but no evidence of effects in lab assays on two hormones, progesterone and estrogen. (2020-09-25)

Web resources bring new insight into COVID-19
Two new web resources put at researchers' fingertips information about cellular genes whose expression is affected by coronavirus infection and place these data points in the context of the complex network of host molecular signaling pathways. (2020-09-22)

KKH's novel clinical triage protocol for threatened miscarriages saves pregnancies
A study conducted by clinicians from KK Women's and Children's Hospital (KKH) and researchers at the Nanyang Technological University, Singapore (NTU), which evaluated and demonstrated the safety and effectiveness of a KKH-developed novel clinical protocol to screen and triage women with threatened miscarriages, has been published in the journal, Scientific Reports. (2020-06-18)

WPI-led research team shrinks breast cancer tumors in mice with targeted therapy
A team of researchers led by Worcester Polytechnic Institute Provost Wole Soboyejo attached anti-cancer agents to the hormone LHRH to create drugs that targeted triple-negative breast cancer, which typically does not respond to conventional targeted cancer therapies. The researchers reported that the treatments reduced the size of tumors in mice with no signs of toxic side effects. (2020-05-28)

Women with Neandertal gene give birth to more children
One in three women in Europe inherited the receptor for progesterone from Neandertals -- a gene variant associated with increased fertility, fewer bleedings during early pregnancy and fewer miscarriages. This is according to a study published in Molecular Biology and Evolution by researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institutet in Sweden. (2020-05-26)

Fine-tuning treatment for triple-negative breast cancer
Researchers at the University of Queensland may have found a way to improve treatment of triple-negative breast cancer. (2020-05-26)

New therapy for triple negative breast cancer
Researchers at the Principe Felipe Research Center (CIPF), the Universitat Politècnica de València (UPV), CIBER-BBN and the Institute for Research in Biomedicine (IRB) of Barcelona have inhibited tumor growth and reduced metastasis, as well as the toxicity of the antitumor drug Navitoclax in preclinical animal models of triple negative breast cancer (TNBC). (2020-05-25)

Conservation research on lynx
Scientists at the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) and the Leibniz Institute for Molecular Pharmacology (Leibniz-FMP) discovered that selected anti-oxidative enzymes, especially the enzyme superoxide dismutase (SOD2), may play an important role to maintain the unusual longevity of the corpus luteum in lynxes. It is highly likely that SOD2 not only detoxifies the reactive oxygen radicals in the cells, but also inhibits programmed cell death. (2020-04-23)

Human pregnancy is weird -- new research adds to the mystery
University at Buffalo and University of Chicago scientists set out to investigate the evolution of a gene that helps women stay pregnant: the progesterone receptor gene. The results come from an analysis of the DNA of 115 mammalian species. (2020-04-21)

BU engineers make breakthrough that could open doors to continuous health-monitoring devices
BU biomedical engineers say a new breakthrough could open doors to continuous health-monitoring devices and wearables. (2020-04-15)

Possible treatment for breast cancer patients could roll out to clinical trial immediately
A worldwide collaborative study involving scientists at the University of Sussex has proposed a new treatment strategy for patients with a rare but aggressive subtype of cancer known as triple negative breast cancer. (2020-03-10)

High sugar diet may impair metabolic health & maternal care after pregnancy
Rats on a high sugar diet during pregnancy have altered levels of sex steroid hormones and dopamine in their brains, which may lead to behavioural changes that can affect care of offspring and motivation, as well as increasing the risk of diabetes and liver disease, according to a study published in the Journal of Endocrinology. (2020-02-28)

A better pregnancy test for whales
To determine whale pregnancy, researchers have relied on visual cues or hormone tests of blubber collected via darts, but the results were often inconclusive. Research from the National Institute of Standards and Technology (NIST) points to a weakness of previous testing and evaluation methods and provides a new hormone testing regime that offers better results. (2020-02-20)

A new way to assess male fertility
Current tests for male fertility include measuring the concentration and motility of spermatozoa. However, other characteristics of sperm, such as their ability to follow a chemical trail to the egg, can influence the likelihood of fertilization. Now, researchers reporting in Analytical Chemistry have devised a quick and convenient microfluidic chip to assess this chemotactic response of spermatozoa, which could help provide a more complete picture of a man's fertility. (2020-02-19)

Acid reflux drug is a surprising candidate to curb preterm birth
Lansoprazole, an over-the-counter acid reflux drug that is often taken by pregnant women, may be a promising therapy to reduce preterm birth, according to a computational drug repurposing study that also tested several of the drugs in mice. (2020-02-13)

Giving some pregnant women progesterone could prevent 8,450 miscarriages a year -- experts
Researchers at the University of Birmingham and Tommy's National Centre for Miscarriage Research say giving progesterone to women with early pregnancy bleeding and a history of miscarriage could lead to 8,450 more babies being born each year. (2020-01-30)

Progesterone from an unexpected source may affect miscarriage risk
Progesterone signaling is key to a healthy pregnancy. An Austrian team's research suggests a link between recurrent miscarriage and disrupted progesterone synthesis. (2020-01-06)

Corpus luteum cells of cats successfully cultivated and comprehensively characterized
The reproduction of lynxes is highly mysterious. Unlike other wild cats, most lynxes are only receptive for a few days once a year. The Berlin team has now achieved another breakthrough in solving the puzzle: they were able to isolate several cell types of corpus luteum from domestic cat tissue and characterise their function with the help of cell cultures. The new method can also be applied to endangered felids such as the Iberian lynx. (2019-12-20)

First of its kind study seeks to answer whether effects of 'abortion pill' can be reversed
Women who initiate medical abortion but opt to stop in the middle of treatment may be at risk for serious blood loss, a UC Davis Health study finds. Researchers found this is true even for women who use an experimental treatment that claims to 'reverse' the effects of the abortion pill. The study, published today in Obstetrics and Gynecology, provides important insights into the safety of using high doses of progesterone during early pregnancy to try to stop a medical abortion. (2019-12-05)

New insights into cause and treatments for aggressive form of breast cancer
Potential environmental risk factors and new targets for treating an aggressive form of breast cancer have been identified, according to new data presented at the Society for Endocrinology annual conference in Brighton. The study suggests that exposure to common chemicals in our everyday environment may increase the risk of developing a difficult to treat type of breast cancer and highlights strategies for new treatment using combination therapy. (2019-11-11)

Why young females with obesity are at early risk for cardiovascular disease
In the face of obesity, the sex hormone progesterone that helps females get and stay pregnant appears to also put them at increased, early risk for cardiovascular disease, investigators report. (2019-09-11)

Fat-absorbing XX chromosomes raise heart disease risk in women
New research in mice at the University of Kentucky has confirmed that the presence of XX sex chromosomes increases the amount of fat circulating in the blood, which leads to narrowing of the arteries and ultimately a higher risk of heart attacks and coronary artery disease. (2019-09-03)

The Lancet: New analyses of the worldwide epidemiological evidence demonstrate link between different forms of menopausal hormone therapy and breast cancer incidence, and find that some risk persists for many years
The findings, published in The Lancet, suggest that all types of MHT, except topical vaginal estrogens, are associated with increased risks of breast cancer, and that the risks are greater for users of estrogen-progestagen hormone therapy than for estrogen-only hormone therapy. For estrogen-progestagen therapy, the risks were greater if the progestagen was included daily rather than intermittently (e.g., for 10-14 days per month). (2019-08-29)

Is diabetes keeping you up at night?
Hormone changes are known to alter insulin sensitivity and glucose metabolism, as well as interfere with women's sleep patterns. But little was known about the association between diabetes and sleep disturbances during the menopause transition until now, as a new study concludes that women with diabetes are at greater risk for sleep disturbances. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2019-08-14)

Does marital status affect prognosis after breast cancer diagnosis?
In a Cancer Medicine study of 298,434 patients diagnosed with breast cancer between 2004 and 2012, married patients had a better prognosis than patients who were single, who in turn had a better prognosis than those who were divorced, separated, or widowed. (2019-07-03)

Up to 30% of children carry a gene variant that may increase susceptibility to methylmercury
A study with 2,147 children explored the association between prenatal exposure to methylmercury, intellectual coefficient at 8 years of age, and genotype (2019-07-03)

Triple-negative breast cancer among black women in the US varies by birthplace
A new study finds substantial variation in the prevalence of triple-negative breast cancer among black women with breast cancer by birthplace in the United States. (2019-06-13)

Snout dated: Slow-evolving elephant shark offers new insights into human physiology
Slow-evolving elephant shark reveals hormonal adaptation and offers new insights into human physiology. (2019-06-04)

Progesterone could increase births in women with early pregnancy bleeding and previous miscarriage
Research led by the University of Birmingham suggests that giving progesterone to pregnant women with early pregnancy bleeding and a history of miscarriage could increase their chances of having a baby. (2019-05-08)

New study proves for the first time that intestinal bacteria grow in pregnant women
In a new study, published in Cell Reports, researchers at the Azrieli Faculty of Medicine of Bar-Ilan University found that progesterone regulates the microbial composition during pregnancy in a way that may facilitate appropriate transmission of beneficial species to the newborn. (2019-04-16)

VA study evaluates quality indicators for hormone therapy in menopausal women
Improvements are needed in VA's prescribing of hormone therapy for menopausal women veterans, concludes a study in the Journal for Healthcare Quality, the peer-reviewed journal of the National Association for Healthcare Quality. The journal is published in the Lippincott portfolio by Wolters Kluwer. (2019-03-07)

The sneaky way estrogen drives brain metastasis in non-estrogen-dependent breast cancers
University of Colorado Cancer Center study shows that while estrogen doesn't directly affect triple-negative breast cancer cells, it can affect surrounding brain cells in ways that promote cancer cell migration and invasiveness (2019-03-01)

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