Current Prognosis News and Events

Current Prognosis News and Events, Prognosis News Articles.
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Cancer control: Non-DNA changes induce metabolism variations in hepatocellular carcinomas
Mechanisms underlying metabolic variations in hepatocellular carcinoma (HCC), a fast growing and invasive cancer, remain unclear. Now, researchers from Fudan University, China identified signatures of ''m6A,'' the most abundant ''post-transcriptional RNA modification,'' that segregate HCC into sub-types with distinct metabolic characteristics. They have also developed a novel m6A score that can quantify such modifications and aid risk assessment, prediction of prognosis, and response to treatment in patients with HCC. (2021-02-22)

Dr. Frederick Boop presents at the ISPN 2020 Virtual Meeting
Understanding the molecular biology of brain tumors is key to prognosis and treatment said Le Bonheur Neuroscience Institute Co-Director Frederick Boop, MD, in his presentation ''How Molecular Biology Impacts Clinical Practice'' at the International Society for Pediatric Neurosurgery (ISPN) 2020 Virtual Meeting. (2021-02-17)

Oncotarget: Melatonin increases overall survival of prostate cancer patients
'The results of the use of melatonin drugs in palliative treatment of patients with end-stage prostate cancer are shown' (2021-02-10)

The genetic susceptibility of people with Down's syndrome to COVID-19
A study reveals the genetic factors that may expose or protect people with Down syndrome from SARS-CoV-2. TMPRSS2, a gene that codes for an enzyme critical for aiding the entry of SARS-CoV-2 in human cells, had 60% higher levels of expression in Down syndrome. The researchers also found higher expression levels for CXCL10, a gene that can trigger cytokine storms. The authors call to vaccinate people with Down syndrome against COVID-19 as a priority. (2021-02-08)

Gene mutations linked to worse outcomes from leukemia in Hispanic and Latino children
A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers. They said a novel therapeutic drug combination - as well as testing for these mutations - may help address the disparity. (2021-02-02)

New approach emerges to better classify, treat brain tumors
A look at RNA tells us what our genes are telling our cells to do, and scientists say looking directly at the RNA of brain tumor cells appears to provide objective, efficient evidence to better classify a tumor and the most effective treatments. (2021-01-19)

Poor gut health connected to severe COVID-19, new review shows
In a review published this week in mBio, researchers examined emerging evidence suggesting that poor gut health adversely affects COVID-19 prognosis. (2021-01-12)

Liver cancer cells manipulate stromal cells involved in fibrosis to promote tumor growth
Researchers led by Osaka University have found that liver cancer cells induce autophagy in hepatic stellate cells, causing them to produce a growth factor called GDF15 that promotes tumor growth. GDF15 was more highly expressed in tumor tissue than normal liver tissue, and patients with higher levels of GDF15 had a poorer prognosis. New therapies targeting GDF15 may help prevent the development and proliferation of hepatocellular carcinoma. (2021-01-06)

The immunomodulatory activity of a drug would improve the efficacy of immunotherapy in breast cancer
* The team of Eva González-Suarez, from the CNIO and IDIBELL, and the team of Christos Sotiriou, from the Jules Bordet Institute, demonstrate that a drug already used to treat osteoporosis promotes the infiltration of immune cells in breast tumours * These findings propose a new target to increase the antitumor immune response and make breast cancer more sensitive to immunotherapy (2020-12-10)

Circulating tumor DNA indicates risk of relapse after transplant in DLBCL patients
Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse. (2020-12-07)

β-AR agonist therapy puts the brakes on oral cancer progression
Oral cancer has a high mortality rate that is mainly attributed to metastasis. Researchers from Tokyo Medical and Dental University (TMDU) screened a panel of small chemical compounds for their ability to inhibit metastasis in oral cancer, identifying β2?AR-agonist isoxsuprine as a potential candidate. Treatment of various oral cancer cells with isoxsuprine suppressed their motility, while tumor size was significantly decreased in isoxsuprine-treated mice, suggesting that β-AR-agonist therapy could be an effective new treatment for oral cancer. (2020-12-03)

WeChat group of chest pain center for patients with acute ST-segment elevation myocardial infarction
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0590, Liu Yue, Qin Zhu-Yun, Yang Xin, Tang Rong and Gao Ling-Yun from the The First Affiliated Hospital of Chongqing Medical University, Chongqing, China consider the use of a social media platform (WeChat) to provide faster treatment and improve prognoses for a group of patients with acute ST-segment Elevation Myocardial Infarction. (2020-11-19)

Prostate cancer: CRYM protein inhibits tumour growth
Prostate cancer is caused by elevated hormone levels, and tumours are generally treated using hormone therapy. A research team headed by Lukas Kenner of MedUni Vienna in collaboration with David Heery from the University of Nottingham/UK and Sarka Pospisilova and Suzanne Turner of the University of Brno/Czech Republic have shown that the protein μ-crystallin (CRYM) plays a significant part in tumour growth. The higher the levels of this protein that are present, the better the prognosis. (2020-11-18)

Breakthrough in childhood brain cancer will save lives
A scientific breakthrough has enabled experts to predict relapse in a common childhood cancer and means doctors can tailor treatment for each individual child and improve prognosis. (2020-11-17)

The lung microbiome may affect lung cancer pathogenesis and prognosis
Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association for Cancer Research. (2020-11-11)

Protein in blood may predict prognosis, recovery from stroke
Researchers at Mayo Clinic in Florida and collaborators have found that a biomarker in the blood may determine the extent of brain injury from different types of strokes and predict prognosis in these patients. Their findings are reported in Science Translational Medicine. (2020-11-11)

Changes in subcellular traffic increase invasiveness of radioresistant cancer cells
Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy. (2020-10-29)

A study has demonstrated that omega-3 rich foods improve post-heart attack prognosis
A team of researchers from the Germans Trias i Pujol Hospital and Research Institute (IGTP) and the Hospital del Mar Medical Research Institute (IMIM) has shown that regularly consuming foods rich in omega-3 fatty acids, from both animal and vegetable origins, strengthens the heart's membranes and helps improve the prognosis in the event of a myocardial infarction. To arrive at these conclusions, they used data from 950 patients. (2020-10-27)

Oncotarget: An integrative microenvironment approach for follicular lymphoma
Oncotarget Volume 11, Issue 33 features Figure 8, ''Haplotype estimates in follicular lymphoma patients,'' by Assis-Mendonça, et al. which reported that the authors tested associations between SNPs, clinicopathological features and TME composition, and proposed survival models in R-CHOP/R-CVP-treated patients. (2020-10-26)

Study shows how exercise stalls cancer growth through the immune system
People with cancer who exercise generally have a better prognosis than inactive patients. Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth in mice: Physical activity changes the metabolism of the immune system's cytotoxic T cells and thereby improves their ability to attack cancer cells. The study is published in the journal eLife. (2020-10-26)

Cholesterol medications linked to lower cancer-related deaths in women
Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology. (2020-10-21)

Serum creatinine-to- cystatin C ratio predicts mortality
In patients initiating continuous renal replacement therapy for acute kidney injury, higher serum creatinine-to-cystatin C ratios were associated with lower mortality. (2020-10-21)

CNIO team finds how melanoma 'deceives' the immune system, increasing resistance to immunotherapy
* The CNIO researchers have identified how melanoma redirects the immune system, preventing it from attacking the tumour and transforming it into an ally in cancer development * A key element in this 'deception' is MIDKINE, a protein that modifies the function of several components of the immune system. By blocking MIDKINE, the researchers managed to rewire immune cells to resume the attack against the tumour * This finding can lead to the development of optimised immunotherapy, which is only partly effective in some tumours today (2020-10-19)

The number and clonality of TCRs are associated with the prognosis of colorectal cancer
This study has used a new technique called 'T-cell receptor (TCR) immuno-sequencing', which allows us to obtain both the number of T lymphocytes that infiltrate the tumor and their clonality index. (2020-10-06)

Promising treatment for aggressive childhood cancer
A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine. (2020-10-06)

COVID-19 may deplete testosterone, helping to explain male patients' poorer prognosis
For the first time, data from a study with patients hospitalized due to COVID-19 suggest that the disease might deteriorate men's testosterone levels. (2020-09-28)

New analytical model detects mutations in breast cancer
Researchers at Lund University in Sweden have developed a computational model which is effective in detecting and identifying genetic mutations in breast tumours. The study, the largest of its kind in the world, includes results from over 3 200 patients with breast cancer. (2020-09-24)

Genetic analysis links obesity to higher rheumatoid arthritis risk
An analysis of genetic data collected from more than 850,000 individuals of European ancestry has found a link between obesity-related genes and rheumatoid arthritis. (2020-09-23)

The Josep Carreras Institute identifies a marker of poor evolution in Hodgkin's lymphoma
Dr. Manel Esteller, director of the Josep Carreras Leukemia Research Institute, published today in Blood journal, the discovery of a marker that allows predicting which patient with Hodgkin's lymphoma will present the aggressive clinical course, and will therefore be a case of special risk. (2020-09-15)

Novel insights of how prostate cancer causes secondary tumors
An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long run provide new opportunities for treatment of aggressive prostate cancer. This according to a new study by researchers at Umeå University, Sweden, in collaboration with researchers in Uppsala and Tokyo. (2020-09-03)

Link between cognitive impairment and worse prognosis in heart failure patients
Heart failure is an endemic disease affecting 250 000 Swedes. Despite new treatments such as modern medicines and defibrillators, the mortality rate is still high and the prognosis worse than for certain cancers. A new study from Lund University in Sweden now shows a link between cognitive impairment and an increased risk for rehospitalisation, or an early death, in heart failure patients. (2020-08-26)

NUS researchers develop new system for accurate telomere profiling in less than 3 hours
The novel STAR assay developed by NUS researchers can be used to rapidly determine telomere dysregulation in cancers and age-related diseases in clinical settings. This helps clinicians to make faster diagnosis and plan targeted treatments for patients. (2020-08-25)

Key molecule responsible for poor prognosis of breast cancer identified
Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer. (2020-08-21)

Tumour gene test could help to predict ovarian cancer prognosis
A global team of medical researchers led by UNSW have developed a test that could help to predict survival for women diagnosed with ovarian cancer, and pave the way towards personalised treatment. (2020-08-17)

New diagnostic criteria shine light on early dementia mimics
Experts estimate up to one third of people attending specialist memory clinics in the UK could have a condition that is commonly mistaken for early dementia. In a paper published in the journal, Brain, UK academics and clinicians have collaborated to develop a diagnostic definition of the widely recognised but poorly understood condition, Functional Cognitive Disorder (FCD). (2020-08-16)

Increased breast cancer risk in obesity linked to fat cell chemicals
Obesity increases the release of tumour-promoting molecules from fat tissue and is associated with an increased risk of breast cancer, according to a study published in Endocrine-Related Cancer. The study found that fat tissue from people with obesity released increased amounts of extracellular vesicles (EV's) enriched in harmful and inflammatory molecules into the blood stream, which can alter breast cancer cells to become more aggressive and invasive. (2020-08-11)

Identified gene mutations impact on the severity of a type of hematologic cancer
Researchers from Josep Carreras Leukemia Research Institute participate in an international study that confirms for the first time that mutation of the two TP53 gene's copies is associated with a worse prognosis in myelodysplastic syndromes, a group of blood cancers a more frequent in elderly population. The results of this study have been published in Nature Medicine journal and represent an advance in the diagnosis and treatment of this type of hematological cancer. (2020-08-04)

Pathological regression of lymph nodes better predicts esophageal cancer survival
A team of researchers led by Osaka University established a new pathological grading system to evaluate the therapeutic effect of neoadjuvant chemotherapy (NAC) for metastatic lymph nodes (LNs) removed in esophageal cancer (EC) surgery, demonstrating that the system predicts recurrence and prognosis in EC patients better than conventional systems. Their findings will enable 'tailor-made' treatment according to the pathological assessment of all metastatic LNs, eventually improving treatment performance of EC. (2020-07-27)

The first mouse model of human pancreas cancer subtypes
Organoids power the first mouse model of two pancreas cancer subtypes, identifying genes influencing a lethal transformation of one subtype to the other. (2020-07-23)

Leukemia drug shows the potential to treat aggressive pediatric brain câncer
When tested in vitro, arsenic trioxide killed tumor cells and prevented the formation of new colonies. This leukemia drug also boosted the effect of radiation therapy on medulloblastoma, a type of central nervous system tumor most common in children. (2020-07-21)

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