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Current Prognosis News and Events, Prognosis News Articles.
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Scientists reveal comprehensive proteomic map of human lung adenocarcinoma
A team of Chinese scientists from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, National Center for Protein Sciences (Beijing), National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, and Shanghai Jiao Tong University, recently reported a comprehensive proteomic analysis based on 103 Chinese patients with lung adenocarcinoma (LUAD), a leading cause of death among all types of cancer worldwide. (2020-07-09)

Early clinical trial tests treatment strategy for pancreatic cancer
Pancreatic cancer carries a poor prognosis, and it often goes undetected until advanced stages. A new BJS (British Journal of Surgery) study indicates that a certain cocktail of chemotherapy drugs may be a safe and effective treatment option for patients with a metastatic form of the disease. (2020-07-08)

Great expectations: Patients overestimate success in IVF
Couples embarking on IVF to treat their infertility tend to overestimate their chance of success, according to a prospective study of 69 couples having at least their second treatment attempt. Such over-optimism, suggest the authors, may be a source of distress or even a reason to discontinue their IVF treatment. (2020-07-07)

Encouraging results from functional MRI in an unresponsive patient with COVID-19
A patient with severe COVID-19 who, despite prolonged unresponsiveness and structural brain abnormalities, demonstrated functionally intact brain connections and later recovered the ability to follow commands. (2020-07-06)

Identified the genetic landscape of myelodysplastic/myeloproliferative neoplasms
Researchers from the MDS Group of the Josep Carreras Leukaemia Research Institute and the Munich Leukemia Laboratory map the mutations that can ease and accelerate the diagnosis of Myelodysplastic/Myeloproliferative Neoplasms rare malignancies. (2020-07-01)

Cancer cells make blood vessels drug resistant during chemotherapy
Scientists have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance. Through mice experiment, the team also found that the combined usage of an inhibitor and anticancer drug makes chemotherapy more effective. (2020-07-01)

A novel radioisotope therapy for children with neuroblastoma
Researchers from Kanazawa University retrospectively analyzed children with refractory or relapsed high-risk neuroblastoma who were treated with high-dose 131I-metaiodobenzylguanidine at Kanazawa University Hospital. They showed that within a 5-year period, this therapy could provide a favorable prognosis without severe non-hematological side effects. These findings could provide new insights into a novel treatment option for patients with high-risk neuroblastoma. (2020-06-19)

Review: A good vitamin D status can protect against cancer
A good vitamin D status is beneficial both in cancer prevention and in the prognosis of several cancers, according to a new research review. The anti-cancer effects of vitamin D are especially pronounced in the prevention and treatment of colon cancer and blood cancers. In addition, high vitamin D responsiveness can be linked to a smaller cancer risk. Vitamin D responsiveness varies between individuals, affecting their need for vitamin D supplementation. (2020-06-10)

New method to identify genes that can drive development of brain tumors
Researchers at Uppsala University have developed a method for identifying functional mutations and their effect on genes relevant to the development of glioblastoma. The results show that a specific, evolutionarily conserved, mutation in the vicinity of SEMA3C disrupts the binding of certain proteins whose task is to bind genes and regulate their activity. (2020-06-09)

New treatment target verification for myelodysplastic syndrome
A Japanese research group analyzed the pathophysiology of myelodysplastic syndrome (MDS), a blood cancer that presents often in the elderly, and found the presence of transcription factor RUNX3, thereby revealing a cancer growth function for what had been considered be a tumor suppressor. Additional analyses of human MDS cells and model mice found an abnormal gene expression mechanism linked to the onset of cancer, and confirmed RUNX3 as a potential therapeutic target. (2020-06-08)

A new method for predicting the evolution of melanoma emerges
Research led by the UPV/EHU-University of the Basque Country estimates that determining the mutational load of the mutation of the BRAF (BRAF-V600E) gene could predict whether the melanoma will progress to metastasis (2020-05-27)

No evidence blanket 'do-not-resuscitate' orders for COVID-19 patients are necessary
It's inappropriate to consider blanket do-not-resuscitate orders for COVID-19 patients because adequate data is not yet available on US survival rates for in-hospital resuscitation of COVID-19 patients and data from China may not relate to US patients, according to a new article published today in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal. (2020-05-22)

Behavioral disorders more common in children exposed to maternal antenatal corticosteroids
Maternal antenatal corticosteroid treatment is standard care when there is a risk for preterm delivery. The treatment improves the prognosis of babies born preterm. However, a new study conducted by experts from the University of Helsinki, University of Oulu and THL Finnish Institute for Health and Welfare shows that children exposed to maternal antenatal corticosteroid treatment have higher rates of emotional, behavioral and psychological development disorders than nonexposed children. (2020-05-20)

AI successfully used to identify different types of brain injuries
Researchers have developed an AI algorithm that can detect and identify different types of brain injuries. (2020-05-14)

Insulin resistance contributes to racial disparities in breast cancer prognosis in US women, Mount Sinai researchers reveal
New study identifies that differences in insulin resistance can explain in part the disparities in breast cancer survival between black and white women. (2020-05-11)

New tool helps predict risk of death, admission to long-term care for people with dementia
A new tool that predicts risk of death and admission to a long-term care facility for patients with dementia may help conversations between health care providers, patients and their families, according to new research in CMAJ. (2020-04-20)

Newborns infected with COVID-19 in China experienced mild symptoms
Researchers have identified a total of four cases of newborn babies with COVID-19 infection in China. In all cases the babies experienced only mild symptoms with none requiring intensive care or mechanical ventilation according to research published in in the European Respiratory Journal today (Thursday). (2020-04-08)

Brief entrance test can predict academic success within first year of study in economics
German researchers at Johannes Gutenberg University Mainz (JGU) and Humboldt-Universität zu Berlin found that even a short test can reliably predict students' success within their first year of study in economics -- much better than an intelligence test or predictions based on school grades. (2020-03-13)

Biomarker tests for decision-making on chemotherapy for breast cancer: No evidence of transferability
Biomarker tests for decision-making on chemotherapy for breast cancer: No evidence of transferability 27.02.2020 The tests assign different women to the group 'low risk of recurrence.' It thus remains unclear who could omit chemotherapy. (2020-03-06)

PET imaging offers new insights into post-transplant care for heart patients
Myocardial blood flow (MBF) and myocardial flow reserve (MFR) have been identified as accurate indicators for graft failure after cardiac transplantation, according to research published in The Journal of Nuclear Medicine. (2020-03-05)

Finding new clues to brain cancer treatment
Researchers at Case Western Reserve University School of Medicine and Cleveland Clinic new discovered a more accurate way to determine the relative life expectancy of glioblastoma victims and identify who could be candidates for experimental clinical drug trials by blending information from Artificial Intelligence (AI)--in this case, computer image analysis of the initial MRI scans taken of brain cancer patients--and genomic research. (2020-02-20)

Protein could offer therapeutic target for breast cancer metastasis
A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a protein known as heat shock protein 47 could be key for suppressing breast cancer metastasis. (2020-02-05)

Chromothripsis in human cancer
Newly discovered mutational phenomenon chromothripsis is prevalent across more cancers than previously thought. (2020-02-05)

NCRI data shows increase in cancer research funding following five years of growth
Analysis of the NCRI's 18 partner organizations shows that cancer research funders in the UK have increased their collective spend, for the first time spending over £700 million in the year 2018/19. This follows five years of spending increases and the highest level of funding since NCRI started collecting data in 2002. (2020-02-04)

Bringing the 'sticky' back to pancreatic cancer
A multidisciplinary team of researchers at Japan's Tohoku University has found that a gene regulator, called BACH1, facilitates the spread of pancreatic cancer to other parts of the body. The scientists, who published their findings in the journal Cancer Research, say drugs that control BACH1 could improve disease prognosis. (2020-02-03)

B cells linked to effective cancer immunotherapy
Cancer patients responded better to immunotherapy and had a better prognosis if their melanoma tumors contained specific clusters of B cells, according to new research from Lund University in Sweden. The study is published in Nature. (2020-01-16)

Antipsychotic medications linked to brain injuries in individuals with Alzheimer's disease
New findings published in the Journal of the American Geriatrics Society reveal that use of antipsychotic medications was associated with an increased risk of head injuries in a study of individuals with Alzheimer's disease. (2020-01-08)

Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy
To establish a molecular signature of this resistance in ovarian cancer, the authors developed preclinical tumor models of adaptive resistance to chronic anti-VEGF treatment. (2020-01-08)

Discoveries detail role of stem cell in deadly gastric cancer
A Cornell study provides important new insights into a common and deadly type of gastric cancer. (2020-01-07)

Gastric cancer susceptibility marker discovered
Gastric cancer is often associated with a poor prognosis because it tends to be diagnosed at an advanced stage. To reduce the death rate, it is essential to identify a biomarker enabling early diagnosis of this cancer. In pursuit of this goal, scientists analyzed the mechanisms involved in the development of gastric cancer during infection by the bacterial pathogen Helicobacter pylori. As a result, they were able to identify a potential susceptibility marker. (2019-12-17)

Residual cancer burden after neoadjuvant therapy can accurately predict breast cancer survival
Researchers from The University of Texas MD Anderson Cancer Center today reported results from a pooled analysis of more than 5,100 breast cancer patients that found residual cancer burden (RCB) continuous index and classification were independently and strongly prognostic for all breast cancer phenotypes. (2019-12-13)

Standard pathology tests outperform molecular subtyping in bladder cancer
While trying to develop a comparatively easy, inexpensive way to give physicians and their patients with bladder cancer a better idea of likely outcome and best treatment options, scientists found that sophisticated new subtyping techniques designed to do this provide no better information than long-standing pathology tests. (2019-12-13)

Research revises classification of acute myeloid leukemia & myelodysplastic syndrome
Findings presented as a late-breaking abstract at the American Society of Hematology annual meeting by St. Jude Children's Research Hospital showcase the power and potential of combining genomic and transcriptomic data. (2019-12-10)

Bile duct biomarker? Protein found to pinpoint patients with a lethal cancer
Patients with intrahepatic cholangiocarcinoma (ICC), a form of bile duct cancer, have a poor prognosis. Researchers at Tokyo Medical and Dental University (TMDU) identified a protein called ARID1A that contributes to poor outcomes in ICC. Loss of ARID1A enhances the malignancy of ICC tumor cells and can predict worse survival outcomes. The findings could eventually form the basis of a prognostic biomarker for ICC and new treatment options for ARID1A-negative patients. (2019-12-05)

New methodology developed at UPV to monitor patients with glioblastoma
The UPV methodology helps medical doctors know the patients' situation with greater precision; it allows them to obtain several vascular biomarkers directly linked to their survival. (2019-12-04)

Researchers identify a process responsible for therapeutic resistance in breast cancer
Researchers at the Lady Davis Institute have identified a key protein that is required for resistance to chemotherapy in the most aggressive form of breast cancer. This holds the promise of opening the door to new therapies for overcoming drug resistance. (2019-12-02)

More children survive neuroblastoma
Both the survival rate and the incidence of neuroblastoma have increased in the last decennia in the Netherlands, as was shown by a study from the Princess Máxima Center. The improved chance of survival and the increase in the number of patients has been greatest in the high risk group; children older than 18 months with a stage 4 neuroblastoma. (2019-11-18)

Advances in the detection of the postoperative progress of abdominal aortic aneurysm
A study published in Frontiers in Bioengineering and Biotechnology by a team of researchers from BCN MedTech with the VICOMTech Foundation in San Sebastian, the BioDonostia Health Research Institute and Donostia University Hospital, offers a promising methodology for post-operative CTA time-series registration and subsequent aneurysm biomechanical strain analysis, which correlates with the patient's long-term prognosis. (2019-11-14)

New tool predicts five-year risk of chronic kidney disease
A new risk calculator tool that uses a mix of variables including age, hypertension, and diabetes status can be used to predict accurately whether someone is likely to develop chronic kidney disease within five years. (2019-11-08)

Published a clinical guide for the genomic diagnosis of Myelodysplastic Syndromes and Chronic Myelomonocytic leukaemia
A collective work between researchers from 8 research centres and hospitals in Spain, coordinated by Francesc Solé of the Josep Carreras Leukaemia Research Institute (IJC), and Esperanza Such, of the University and Polytechnic Hospital de la Fe describes the recommendations of use of the Next Generation genome Sequencing (NGS) in the diagnosis of Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML). (2019-11-04)

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