Current Prostate News and Events

Current Prostate News and Events, Prostate News Articles.
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Genetic tool improves estimation of prostate cancer risk in diverse ethnic/racial groups
Scientists at University of California San Diego School of Medicine validated a more inclusive and comprehensive genetic tool, known as a polygenic hazard score (PHS), for predicting age of onset of aggressive prostate cancer. (2021-02-23)

Targeting MAPK4 emerges as a promising therapy for prostate cancer
New research opens the possibility that targeting the enzyme MAPK4 in human prostate cancer might provide a novel therapeutic strategy for this disease that is the second leading cause of cancer death in American men. (2021-02-19)

Addressing the biological causes of racial disparities in prostate cancer
A new review published in Cancer Reports examines the biological differences in the development of prostate cancer across ethnicities. (2021-02-18)

Physical conditions linked to psychological distress in patients with cancer
Among patients with cancer, having additional physical comorbidities was linked with a higher risk of experiencing psychological distress. The finding comes from a Psycho-Oncology analysis of 2017 data from the National Health Survey of Spain. (2021-02-18)

How inflammatory signalling molecules contribute to carcinogenesis
A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signalling molecule and one of the main oncogenes. The study has been published in the leading journal 'Molecular Cancer'. (2021-02-17)

Toward a disease-sniffing device that rivals a dog's nose
A new system can detect the chemical and microbial content of an air sample with even greater sensitivity than a dog's nose. Researchers at MIT and elsewhere coupled this to a machine-learning process that can identify the distinctive characteristics of the disease-bearing samples. (2021-02-17)

Model helps predict which patients will benefit most from PSMA PET scan
A new study led by researchers at the UCLA Jonsson Comprehensive Cancer Center helps identify which patients with prostate cancer will benefit most from the use of prostate-specific membrane antigen PET imaging, PSMA PET, a novel imaging technique that recently was approved by the U.S. Food and Drug Administration. (2021-02-16)

Exercise now proven to have mental health benefits for prostate cancer
New Edith Cowan University (ECU) research has found that exercise not only has physical benefits for men with prostate cancer, it also helps reduce symptoms of depression and anxiety. (2021-02-15)

Genomic test helps estimate risk of prostate cancer metastasis, death
A commercially available genomic test may help oncologists better determine which patients with recurrent prostate cancer may benefit from hormone therapy, according to new research from the Johns Hopkins Kimmel Cancer Center and 15 other medical centers. (2021-02-11)

Study: New prostate cancer test could avoid unnecessary biopsies
A urine test based on University of Michigan Rogel Cancer Center research could have avoided one third of unnecessary prostate cancer biopsies while failing to detect only a small number of cancers, according to a validation study that included more than 1,500 patients. (2021-02-11)

Why Black men's prostate cancer may be more responsive to immunotherapy
Black men die more often of prostate cancer yet have greater survival benefits from immunotherapy treatment. A new study discovered the reason appears to be an increase of a surprising type of immune cell in the tumor. The findings could lead to immune-based precision medicine treatment for men of all races with localized aggressive and advanced prostate cancer. (2021-02-10)

Oncotarget: Melatonin increases overall survival of prostate cancer patients
'The results of the use of melatonin drugs in palliative treatment of patients with end-stage prostate cancer are shown' (2021-02-10)

Joint radionuclide therapy-immunotherapy approach effective in prostate cancer model
A combination of radionuclide therapy and immunotherapy has proven successful in slowing the progression of prostate cancer and increasing survival time, according to new research published in the February issue of The Journal of Nuclear Medicine. The results of the murine study indicate that radionuclide therapy promotes prostate cancer immunogenicity, provoking a cellular response that makes the tumors more receptive to immunotherapy. (2021-02-08)

HKBU and CUHK launch Spermine Risk Score for prostate cancer diagnosis
Researchers from Hong Kong Baptist University (HKBU) and the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) have jointly developed the Spermine Risk Score which, coupled with the use of a urine test, provides a non-invasive and more reliable method for the diagnosis of prostate cancer. In a study conducted by the researchers, about 37% of the patients, who were ultimately found to have no prostate cancer, can avoid undergoing a prostate biopsy procedure. (2021-02-08)

Clinical trial: Using MRI for prostate cancer diagnosis equals or beats current standard
The results of a Phase III randomized clinical trial have shown that when it comes to detecting clinically significant prostate cancer, Magnetic Resonance Imaging (MRI) with targeted biopsies (MRI-TBx) matches the current standard and brings a multitude of advantages. The PRostate Evaluation for Clinically Important Disease: MRI vs Standard Evaluation Procedures (PRECISE) study will help to make prostate cancer diagnosis more accurate and less invasive. (2021-02-04)

Ultrasound technique treats prostate cancer with minimal side effects
A technique that delivers high-intensity focused ultrasound to targeted tissue under MRI guidance effectively treats intermediate-risk prostate cancer with minimal side effects, according to a new study. (2021-02-02)

Prostate drug associated with lower risk of Parkinson's disease
Taking a particular type of medication to treat enlarged prostate is associated with a reduced risk of developing Parkinson's disease, according to a large observational study by researchers at the University of Iowa, and colleagues in Denmark and China. The findings, published in JAMA Neurology, suggest that terazosin, and similar medications, might have potential to prevent or delay the development of Parkinson's disease. (2021-02-01)

Oncotarget: Drug-resistant cells grow exponentially in metastatic prostate cancer
The Oncotarget authors show that the drug-resistant, metastasis-causing cells are capable of producing drug-resistant, exponentially growing tumors, responsible for tumor growth as a patient receives different treatments (2021-01-25)

Study finds shorter radiation regimen safe, effective for men with advanced prostate cancer
UCLA researchers found shortening a traditional 45-day course of radiation to a five-day course delivered in larger doses is safe and as effective as conventional radiation for men with high-risk forms of prostate cancer. (2021-01-25)

Cancer can be precisely diagnosed using a urine test with artificial intelligence
The Korea Institute of Science and Technology(KIST) announced that the collaborative research team led by Dr. Kwan Hyi Lee from the Biomaterials Research Center and Professor In Gab Jeong from Asan Medical Center developed a technique for diagnosing prostate cancer from urine within only twenty minutes with almost 100% accuracy. The research team developed this technique by introducing a smart AI analysis method to an electrical-signal-based ultrasensitive biosensor. (2021-01-21)

Cancer-related suicide declined in the US during the past two decades
Despite increases in overall suicide rates in the United States during the past two decades, cancer-related suicides declined by 2.8% per year, according to a new study by the American Cancer Society. (2021-01-19)

An unexpected, and novel, target for prostate cancer - our biological clock
Researchers find that CRY-1, a regulator of circadian rhythms, promotes tumor progression by altering DNA repair. (2021-01-15)

Record drop in cancer mortality for second straight year due to improved lung cancer treatment
Overall cancer death rates in the United States dropped continuously from 1991 through 2018 for a total decrease of 31%, including a 2.4% decline from 2017 to 2018. (2021-01-12)

Killing cancer by unleashing the body's own immune system
The body's immune system is the first line of defense against infections like bacteria, viruses or cancers. Some cancers, however, have developed the art of molecular deception to avoid destruction by the body's immune system. Now, a University of Missouri researcher might have found a new way to help the body's immune system get past that deception and destroy the cancer. (2021-01-12)

Mediterranean diet may decrease risk of prostate cancer progression
In a study to examine a Mediterranean diet in relation to prostate cancer progression in men on active surveillance, researchers from The University of Texas MD Anderson Cancer Center found that men with localized prostate cancer who reported a baseline dietary pattern that more closely follows the key principles of a Mediterranean-style diet fared better over the course of their disease. (2021-01-07)

MRI frequently underestimates tumor size in prostate cancer
Improving imaging processes will lead to more successful treatments and help reduce morbidity in men with the disease. (2021-01-07)

New clues to prostate cancer
Australian research has identified a new mechanism in which prostate cancer cells can 'switch' character and become resistant to therapy. These findings, just published in Cell Reports, are an important development in unravelling how an aggressive subtype of prostate cancer, neuroendocrine prostate cancer (NEPC), develops after hormonal therapies. (2021-01-05)

Heat treatment may make chemotherapy more effective
The study, published in the Journal of Materials Chemistry B, found that ''loading'' a chemotherapy drug on to tiny magnetic particles that can heat up the cancer cells at the same time as delivering the drug to them was up to 34% more effective at destroying the cancer cells than the chemotherapy drug without added heat. (2021-01-05)

Largest, most diverse ever study of prostate cancer genetics brings disparities into focus
The largest, most diverse study of genetic variations related to prostate cancer shows evidence that genetics play some part in health disparities among different racial groups. The analysis includes 269 genetic variations that increase risk, 86 of them newly discovered by the researchers. Assessing risk based on a model incorporating these genetic factors researchers showed that men of African ancestry inherit about twice the prostate cancer risk on average compared to men of European ancestry. (2021-01-04)

Inflammation from ADT may cause fatigue in prostate cancer patients
Moffitt Cancer Center researchers are investigating whether inflammation in the body, a side effect of ADT, contributes to these symptoms in prostate cancer patients. In a new study published in the journal Cancer, they pinpoint a specific inflammation marker that is associated with increased fatigue in this group of patients. (2021-01-04)

Prostate cancer regulator plays role in COVID-19, providing a promising treatment lead
By taking a lesson from prostate cancer, researchers now have a promising lead on a treatment for COVID-19. They found that, just like in prostate cancer, TMPRSS2 is regulated by the androgen receptor in the lungs. And notably, blocking the androgen receptor led to lower expression of TMPRSS2, which led to decreased coronavirus infection in mice and cellular models. (2020-12-21)

Moffitt identifies genomic and immune indicators that predict lethal outcomes in prostate cancer
Moffitt Cancer Center researchers conducted studies to determine if genomic heterogeneity in tumors from grade 4/5 prostate cancer patients can be exploited to identify patient subsets that are at higher risk for lethal outcomes and that may benefit from targeted treatment strategies. Their results were published in the journal European Urology. (2020-12-15)

Uniquely human gene may drive numerous cancers
A new study published in FASEB BioAdvances reveals a human-specific connection between advanced carcinomas and a gene called SIGLEC12. (2020-12-09)

Glyphosate can create biomarkers predicting disease in future generations
Exposure to the widely used weed-killer glyphosate makes genetic changes to rats that can be linked to increased disease in their grandchildren and great-grandchildren. These glyphosate-induced changes to sperm from exposed rats could be used as biomarkers for determining propensity in subsequent generations for prostate and kidney diseases as well as obesity and incurring multiple diseases at once. (2020-12-09)

Researchers create framework to help determine timing of cancer mutations
UCLA researchers studying cancer evolution have created a framework to help determine which tool combinations are best for pinpointing the exact timing of DNA mutations in cancer genomes. (2020-12-07)

The impact of Neandertal DNA on human health
A researcher at the University of Tartu described new associations between Neandertal DNA and autoimmune diseases, prostate cancer and type 2 diabetes. (2020-12-03)

'Financial toxicity' of prostate cancer treatment: Radiation therapy has the greatest impact on patient finances
For men with early-stage prostate cancer, choices about initial treatment carry varying risks of 'financial toxicity,' reports a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer. (2020-11-30)

Gene donors at high risk for cancer received feedback
Researchers at the Estonian Genome Center at the University of Tartu studied how people at high risk for breast, ovarian or prostate cancer responses to the feedback of genetic findings. Gene donors who chose to receive results appreciated being contacted and considered the information provided to be valuable. Authors find that knowing more about people's genetic traits will significantly expand the chances of early detection of breast-, ovarian- and prostate cancer in the future. (2020-11-25)

For African American men with prostate cancer, decision regret linked to medical mistrust
Medical mistrust is one reason why African American patients are more likely to have regrets about their choice of treatment for prostate cancer, suggests a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer. (2020-11-24)

New findings speed progress towards affordable gene therapy
In a promising advance for affordable, personalised medicine, researchers have used metal-organic frameworks to successfully deliver the genetic snipping tool CRISPR/Cas9 into human cancer cells. (2020-11-20)

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