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Two studies point to an unrecognized avenue for anti-viral therapies against COVID-19
Helping to explain what makes SARS-CoV-2 so capable of infecting human cells, researchers in two independent studies discovered that the virus's spike protein recognizes and binds a protein on the human cell surface called neuropilin-1. (2020-10-20)

Old methods prove true for studying proteins
A decades-old technique for probing protein motions proves more accurate than current practices. (2020-10-17)

New technology diagnoses sickle cell disease in record time
Researchers have developed a new way to diagnose diseases of the blood like sickle cell disease with sensitivity and precision and in only one minute. (2020-10-15)

A new protein discovered that repairs DNA
Our cells have DNA repair systems to defend themselves against this sort of damage. One of these systems is based on a protein, photolysis, which uses blue light to repair DNA damage before it leads to mutations. (2020-10-14)

Scientists detect long-lived antibodies in both blood and saliva of patients with COVID-19
Two separate studies have documented the persistence of antibodies that target SARS-CoV-2 in hundreds of patients with COVID-19 at least 3 months after symptom onset. (2020-10-08)

Taking sides - factors that influence patterns in protein distribution
A new paper, published in Current Biology has found that even cells in isolation can become polarised to create the head to tail pattern, and that this polarity can orient how the cell grows. (2020-10-08)

Breaking the coupling process
Real-time observation of signal transmission in proteins provides new insights for drug research. (2020-10-06)

Rapeseed instead of soy burgers: researchers identify a new source of protein for humans
Rapeseed has the potential to replace soy as the best plant-based source of protein for humans. In a current study, nutrition scientists at the Martin Luther University Halle-Wittenberg (MLU), found that rapeseed protein consumption has comparable beneficial effects on human metabolism as soy protein. The glucose metabolism and satiety were even better. Another advantage: The proteins can be obtained from the by-products of rapeseed oil production. The study was published in the journal ''Nutrients''. (2020-09-30)

A Sudoku-solving algorithm holds promise for protein medicine
Computational biologists from the University of Toronto have developed an artificial intelligence algorithm that has the potential to design novel protein molecules as finely tuned therapeutics. (2020-09-23)

new alteration in the brain of people with Alzheimer's discovered
New research led by Spanish scientists suggest that the altered glycosylation could determine that the Amyloid Precursor Protein (APP) is processed by the amyloidogenic (pathological) pathway, giving rise to the production of the beta-amyloid, a small protein with a tendency to cluster forming the amyloid plaques characteristic of Alzheimer's disease. (2020-09-18)

Parkinson's patient skin samples provide clues to disease mechanism and clinical test
A recent study from Finland reports that a protein kinase called LRRK2 is hyperactive in skin samples from Parkinson's disease patients which leads to a decrease in protein synthesis. This new finding could help in the development of new treatments for Parkinson's disease. (2020-09-15)

Designed antiviral proteins inhibit SARS-CoV-2 in the lab
Computer-designed miniproteins have now been shown to protect lab-grown human cells from SARS-CoV-2, the coronavirus that causes COVID-19. The lead antiviral candidate rivals the best-known SARS-CoV-2 monoclonal antibodies in its protective actions. The synthetic antiviral candidates were designed to prevent infection by interfering with the mechanism that coronaviruses use to break into and enter cells. (2020-09-09)

Finding a handle to bag the right proteins
A method that lights up tags attached to selected proteins can help to purify the proteins from a mixed protein pool. (2020-09-09)

Cashing in on marine byproducts
As exploitation of wild fisheries and marine environments threaten food supplies, Flinders University scientists are finding sustainable new ways to convert biowaste, algal biomass and even beached seaweed into valuable dietary proteins and other products. In one of several projects under way at the Flinders Centre for Marine Bioproducts Development, researchers are looking to extract value from crayfish shells and other marine waste via a 'green' fluidic processing machine developed at the University. (2020-09-08)

New computational tool enables prediction of key functional sites in proteins based on structure
A new technology that uses a protein's structure to predict the inner wiring that controls the protein's function and dynamics is now available for scientists to utilize. The tool, developed by researchers at Penn State, may be useful for protein engineering and drug design. (2020-09-03)

Finding cortisone alternatives with fewer side effects
Many people use cortisone of a regular basis. It is used for treating rheumatism, asthma, multiple sclerosis, or even COVID-19. Steroidal medication such as cortisone is highly effective but also possesses severe side effects. Henriette Uhlenhaut, professor at Technical University of Munich (TUM), and her team are examining the beneficial effects of cortisone in order to lay the groundwork for the development of similar drugs with fewer side effects. (2020-09-02)

Study finds insect shows promise as a good, sustainable food source
With global food on the rise, a study led by IUPUI scientists has found new evidence that the yellow mealworm shows promise as alternative source of nutritional protein. (2020-08-31)

Decoded: The structure of the barrier between three cells
Organs in animals and in humans have one thing in common: they are bounded by so-called epithelial cells. Researchers at the Institute of Animal Physiology at the University of Munster have found out how two proteins called Anakonda and M6 interact in epithelial cells in fruit flies in order to produce a functioning barrier at corner points between three of those cells. The study has been published in the journal 'Current Biology'. (2020-08-27)

A ribosome odyssey in mitochondria
The ciliate mitoribosome structure provides new insights into the diversity of translation and its evolution. (2020-08-26)

Unique protein structures could hold the key to treatment for Parkinson's disease
Scientists at the University Bath have discovered a series of protein structures that are thought to be highly relevant to the onset of Parkinson's disease. It is hoped that further analysis of these structures will open up a new avenue for potential treatment for a disease that is the fastest growing neurological condition in the world, with no cure currently available. (2020-08-20)

Improving protein digestibility in sorghum
Improving protein digestibility in sorghum (2020-08-19)

How protein protects against fatty liver
Non-alcoholic fatty liver disease is the most common chronic liver disease in the world, with sometimes life-threatening consequences. A high-protein, calorie-reduced diet can cause the harmful liver fat to melt away - more effectively than a low-protein diet. A new study by DIfE/DZD researchers published in the journal 'Liver International' shows which molecular and physiological processes are potentially involved. (2020-08-18)

Study shows frequently used serology test may not detect antibodies that could confirm protection against reinfection of COVID-19
Two different types of detectable antibody responses in SARS-CoV-2 (COVID-19) tell very different stories and may indicate ways to enhance public health efforts against the disease, according to researchers at The University of Texas MD Anderson Cancer Center. Antibodies to the SARS-CoV-2 spike protein receptor binding domain (S-RBD) are speculated to neutralize virus infection, while the SARS-CoV-2 nucleocapsid protein (N-protein) antibody may often only indicate exposure to the virus, not protections against reinfection. (2020-08-14)

How a protein stops cells from attacking their own DNA
Scientists at EPFL have demonstrated the mechanism that allows cells to fight off viral DNA without triggering an immune response against their own genetic material. (2020-08-13)

Researchers identify a protein that may help SARS-CoV-2 spread rapidly through cells
Eric Ross and Sean Cascarina, biochemistry and molecular biology researchers at Colorado State University, have released a research paper identifying a protein encoded by SARS-CoV-2, the virus that causes COVID-19, that may be associated with the quick spread of the virus through cells in the human body. Through powerful application of the foundational sciences and bioinformatic analysis their research highlights key characteristics of the virus that could one day be important in the development of a treatment for COVID-19. (2020-08-12)

Recipe for success -- interaction proteomics become a household item
A research team from University of Helsinki introduces a new optimised and integrated interaction proteomics protocol that combines two state-of-the art methods to allow rapid identification of protein-protein interactions and more. (2020-08-11)

Research exposes new vulnerability for SARS-CoV-2
Using nanometer-level simulations, the researchers discovered a positively charged site (known as the polybasic cleavage site) located 10 nanometers from the actual binding site on the spike protein. The positively charged site allows strong bonding between the virus protein and the negatively charged human-cell receptors. (2020-08-11)

Researchers find new potential treatment for prion diseases
A new study in Nucleic Acids Research suggests a possible effective treatment strategy for patients suffering from prion disease. (2020-08-10)

Success in promoting plant growth for biodiesel
Scientists of Waseda University in Japan succeeded in promoting plant growth and increasing seed yield by heterologous expression of protein from Arabidopsis (artificially modified high-speed motor protein) in Camelina sativa, which is expected as a useful plant for biodiesel. The study is expected to apply to other plant resources for biodiesel, such as corn, rice, and sugar cane. (2020-08-07)

Locking down shape-shifting spike protein aids development of COVID-19 vaccine
Publishing in the journal Nature, researchers from the Univ. of Texas at Austin, Moderna and the NIH explain how they developed the COVID-19 vaccine candidate mRNA-1273 and report strong positive results on its effectiveness in mice. (2020-08-05)

Better at binding SARS-CoV-2: A variant of the human receptor for the virus as a powerful decoy
By exploring variants of a soluble version of the receptor that SARS-CoV-2 uses to binds human cells - which are being considered as therapeutic candidates that neutralize COVID-19 infection by acting as a decoy - researchers identified one that binds the virus's spike protein tightly enough to compete with spike binding by monoclonal antibodies. (2020-08-04)

Identification of a new mechanism in the immune system provides knowledge about diseases
A recently identified mechanism in the immune system reveals a previously unknown protein that could provide an opening to a better understanding of infections and autoimmune diseases. This is shown by a new basic research study from Aarhus University, Denmark. (2020-08-04)

Researchers describe structure of SARS-CoV-2 proteins suitable for design of new drugs
Group of researchers at IOCB Prague determined and analyzed the precise structure of the Nsp16 and Nsp10 protein complex of the new coronavirus SARS-CoV-2. They identified several fundamental characteristics, which can be targeted by inhibitors that suppress the activity of the Nsp16 and Nsp10 protein complex and may, in the future, serve as drugs to combat many coronaviruses. (2020-07-30)

Studying COVID-19's envelope protein
A likeness between genes of the SARS and COVID-19 viruses could inform research into potential treatments. (2020-07-27)

Engineered SARS-CoV-2 protein offers better stability and yields for vaccine researchers
A team of scientists has engineered the spike protein of the SARS-CoV-2 virus - a critical component of potential COVID-19 vaccines - to be more environmentally stable and generate larger yields in the lab. (2020-07-23)

Diets high in protein, particularly plant protein, linked to lower risk of death
Diets high in protein, particularly plant protein, are associated with a lower risk of death from any cause, finds an analysis of the latest evidence published by The BMJ today. (2020-07-22)

Influenza virus-induced oxidized DNA activates inflammasomes
In this study, a research group at The Institute of Medical Science, The University of Tokyo (IMSUT) observed nucleus- and mitochondria-derived double-stranded DNA (dsDNA) in extracellular web-like structures in the cytoplasm and extracellular space around influenza virus-infected macrophages. (2020-07-21)

Scientists present pre- and postfusion cryo-em structures of SARS-CoV-2 spike protein
Scientists report two new cryo-EM structures representing the pre- and postfusion conformations of the full-length SARS-CoV-2 spike (S) protein, an essential viral component responsible for host cell entry and the spread of infection. (2020-07-21)

COVID-19: Viral shutdown of protein synthesis
Researchers from Munich and Ulm have determined how the pandemic coronavirus SARS-CoV-2 inhibits the synthesis of proteins in infected cells and shown that it effectively disarms the body's innate immune system (2020-07-17)

Close-up of SARS-CoV-2 protein shows how it interferes with host anti-viral immunity
A detailed study of a SARS-Cov-2 protein, Nsp1, with a central role in weakening the host anti-viral immune response shows that it effectively shuts down production ofproteins in the host. (2020-07-17)

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