Current Proteomics News and Events

Current Proteomics News and Events, Proteomics News Articles.
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Finding coronavirus's helper proteins
A group of scientists led by EMBL's Mikhail Savitski, Nassos Typas, and Pedro Beltrao, and collaborator Steeve Boulant at Heidelberg University Hospital, have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication. (2021-02-16)

Aggressive brain tumor mapped in genetic, molecular detail
A new study led by Washington University School of Medicine in St. Louis has revealed a detailed map of the genes, proteins, infiltrating cells and signaling pathways that play key roles in driving glioblastoma. The study, of 99 tumors from patients, is the largest and most detailed schematic of this deadly brain tumor. (2021-02-11)

Male sex, BMI, smoking and depression all increase biological age
A 'biological age' score predicts that being male, overweight, a smoker and having depression all contribute to biological aging, a study published today in eLife reports. (2021-02-09)

TGen-led study results suggest more accurate diagnostic for breast cancer
Patrick Pirrotte, Ph.D., an Assistant Professor and Director of TGen's Collaborative Center for Translational Mass Spectrometry, and an international team of researchers developed a test that can detect infinitesimally small breast cancer biomarkers that are shed into the bloodstream from cells surrounding cancer known as extracellular matrix (ECM), according to the findings of their study recently published in the scientific journal Breast Cancer Research. (2021-01-26)

New study connects religiosity in US South Asians to cardiovascular disease
The Study on Stress, Spirituality and Health (SSSH), a cutting-edge proteomics analysis, suggests that religious beliefs modulate protein expression associated with cardiovascular disease in South Asians in the United States. (2021-01-15)

Scientists pinpoint molecular cause for severe disorder in children
A team of scientists from the University of Ottawa have opened a window into the cause of a rare genetic disorder that causes mortality in young children. (2020-12-22)

Proteogenomics enhances the identification of therapeutic vulnerabilities in breast cancer
Applying powerful proteogenomics approaches to breast cancer, researchers propose more precise diagnostics, identify new tumor susceptibilities for translation into treatments and implicate new mechanisms involved in breast cancer treatment resistance. (2020-11-18)

Research reveals infertile spikelets contribute to yield in sorghum and related grasses
A team of scientists at the Donald Danforth Plant Science Center, in laboratories led by Elizabeth (Toby) Kellogg PhD, member and Robert E. King Distinguished Investigator, and Doug Allen, PhD, associate member and USDA research scientist, set out to answer the questions; could this apparently useless floral structure capture and move photosynthetic carbon to the seed? And, ultimately, if removed, would we notice a difference in yield? (2020-11-05)

Study identifies how infection by Zika virus during pregnancy can affect the fetal brain
The study by more than 30 Brazilian scientists investigated tens of thousands of genomic, transcriptomic and proteomic variables, discovering several alterations caused by the vírus. (2020-09-03)

How to spot patients most likely to die from blood infections
Unprecedented analysis of proteins and metabolites in patient serum provides new biomarkers associated with a patient's risk of dying from Staphylococcus aureus bacteremia. (2020-09-03)

Duchenne: "Crosstalk" between muscle and spleen
Duchenne muscular dystrophy (DMD) is the most common muscle disease in children and is passed on by X-linked recessive inheritance. Characteristic is a progressive muscular atrophy. The disease often results in death before the third decade of life. Researchers of the Universities of Maynooth (Ireland) and Bonn have found a connection between dystrophic muscles and the lymphatic system in mice with Duchenne disease. The results have now been published in the journal ''iScience''. (2020-08-27)

Recipe for success -- interaction proteomics become a household item
A research team from University of Helsinki introduces a new optimised and integrated interaction proteomics protocol that combines two state-of-the art methods to allow rapid identification of protein-protein interactions and more. (2020-08-11)

Identified a new regulatory mechanism of response to metabolic stress
The Chromatin Biology group, led by Dr. Alex Vaquero has identified a new enzymatic activity in SIRT7, involved in stress response, aging and hematopoiesis, which plays a key role in metabolic stress and aging. (2020-07-27)

Advancing knowledge on archaea
An open-source data platform for researchers studying archaea is paving the way for new insights and educational opportunities. (2020-07-20)

Novel biomarker technology for cancer diagnostics
A new way of identifying cancer biomarkers has been developed by researchers at Lund University in Sweden. The new technology allows very sensitive, quick and cost-effective identification of cancer biomarkers. The research is published in Nature Communication Biology. (2020-07-15)

Scientists reveal comprehensive proteomic map of human lung adenocarcinoma
A team of Chinese scientists from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, National Center for Protein Sciences (Beijing), National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, and Shanghai Jiao Tong University, recently reported a comprehensive proteomic analysis based on 103 Chinese patients with lung adenocarcinoma (LUAD), a leading cause of death among all types of cancer worldwide. (2020-07-09)

Researchers have found a promising therapy for cardiac regeneration
New research gives information in order to understand safety, efficacy and mechanisms of action of a new cardiac therapy. (2020-06-30)

University of Arizona researchers identify potential pathway to make opioids safer, more effective
Researchers from the UArizona College of Medicine -- Tucson Department of Pharmacology found that inhibiting heat shock protein 90 in the spinal cord enhanced the efficacy of morphine -- a finding that could be used decrease the adverse side effects of opioid therapy. (2020-05-05)

Spanish scientists identify a biomarker that detects atherosclerosis before the appearance of symptoms
Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD) in Madrid have demonstrated that a proteins present in early atheroma plaques -- accumulations of cholesterol in the wall of arteries -- could be used as a biomarker to detect atherosclerosis in the subclinical phase, before the appearance of symptoms. (2020-04-21)

Technologies converge on interacting surfaces in protein complexes
Researchers at the Stowers Institute for Medical Research have fine-tuned a method to pinpoint surfaces within large multi-protein complexes that are close to, and likely to be directly interacting with, one another. (2020-04-14)

A molecular map for the plant sciences
Plants are essential for life on earth. They provide food for essentially all organisms, oxygen for breathing, and they regulate the climate of the planet. Proteins play a key role in controlling all aspects of life including plants. Under the leadership of the Technical University of Munich (TUM), a team of scientists has now mapped around 18,000 of all the proteins found in the model plant Arabidopsis thaliana. (2020-03-12)

Technology provides a new way to probe single molecules
A new technology called individual ion mass spectrometry, or I2MS, can determine the exact mass of a huge range of intact proteins. (2020-03-02)

Study surveys molecular landscape of endometrial cancer
The most comprehensive molecular study of endometrial cancer to date has further defined the contributions of key genes and proteins to the disease. (2020-02-13)

Study reveals missing link in mechanisms underlying fight-or-flight response
Scientists map the molecular cascade behind heart function during fight-or-flight state. Findings solve longstanding biological puzzle. Results yield critical insights in adrenaline physiology that may inform other fields. Newly identified pathway can set stage for better targeted therapies to regulate heart muscle function. (2020-01-23)

Melting reveals drug targets in a living organism
Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team led by researchers at the European Molecular Biology Laboratory and Cellzome, a GSK company, has developed a technology to systematically identify drug targets in living animals. In their results, published in Nature Biotechnology on Jan. 20, the scientists mapped protein-drug interactions in rat organs and blood. Their research opens pathways in drug discovery, fundamental biology, and personalized medicine. (2020-01-20)

New point-of-care diagnostic test may revolutionize early diagnosis of Mediterranean rickettsiosis spotted fever
Rickettsiae are bacteria that cause severe, potentially lethal human infections, including Mediterranean spotted fever (MSF) and Rocky Mountain spotted fever. Delays in diagnosing and treating MSF can cause significant morbidity and mortality, due in part to the lack of a test for early detection. A new study in The American Journal of Pathology reports the discovery of a sensitive and specific marker that may enable early diagnosis, treatment, and accurate public health notification of spotted fever rickettsial infections including MSF. (2020-01-16)

Stage is set to develop clinically relevant, senescence-based biomarkers of aging
Biomarkers are essential in order to develop clinically-approved interventions for human aging and age-related diseases. We live too long to wait for results to be validated in traditional methods. The stage is now set to develop senescence-based biomarkers of aging. Senescent cells are long-recognized drivers of multiple diseases of aging. The Proteomic Atlas of Senescence-Associated Secretomes, developed at the Buck Institute, is available to the research community to speed translation of therapeutics to clinical use. (2020-01-16)

An out-of-the-box attack on diabetes
A protein newly identified as important in type 1 diabetes can delay onset of the disease in diabetic mice, providing a new target for prevention and treatment in people, according to research led by scientists at the US Department of Energy's Pacific Northwest National Laboratory and Indiana University School of Medicine. (2020-01-09)

Mason scientists invent new technology to streamline drug discovery
George Mason University researchers have discovered the exact location where two proteins responsible for hiding cancer cells from the immune system bind using a transformative protein painting technology. This discovery provides a novel approach to developing new cancer immunotherapy medicines that can be administered as a pill, compared to existing intravenous therapeutics. The findings were published in July 2019 in the Journal of Biological Chemistry. (2019-10-07)

Researchers alter mouse gut microbiomes by feeding good bacteria their preferred fibers
Humans choose food based on the way it looks, smells, and tastes. But the microbes in our guts use a different classification system -- one that is based on the molecular components that make up different fibers. In a study published Sept. 19, 2019 in the journal Cell, investigators found particular components of dietary fiber that encourage growth and metabolic action of beneficial microbes in the mouse gut. (2019-09-19)

Protein mapping pinpoints why metastatic melanoma patients do not respond to immunotherapy
Tel Aviv University and Sheba Medical Center researchers say they have discovered why more than half of patients with metastatic melanoma do not respond to immunotherapy cancer treatments. (2019-09-09)

Novel paradigm in drug development
Targeted protein degradation (TPD) is a new paradigm in drug discovery that could lead to the development of new medicines to treat diseases such as cancer more effectively. A recent study by researchers at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences reveals global and drug-specific cellular effectors needed for TPD. The results have now been published in the scientific journal Molecular Cell. (2019-08-23)

BAFfling cancer growth strategies
More than one-fifth of all human cancers harbor mutations in one of the members of the BAF chromatin remodeling complex. Deep biochemical and epigenomic characterization of a cell line panel comprehensively representing all these mutations enabled researchers at the CeMM Research Center for Molecule Medicine of the Austrian Academy of Sciences to identify new approaches to target BAF mutant cancers. The study describing these findings has now been published in the journal Nature Genetics. (2019-08-20)

New proteomics technique gives insights into ubiquitin signalling
Australian researchers are among the first in the world to have access to a new approach to understand intricate changes that control how proteins function in our cells in health and disease. The new proteomics technique called 'ubiquitin clipping' allows researchers to create high-definition maps of how proteins are modified by a process called ubiquitination. (2019-08-14)

What can you do with two omes that you can't do with one?
In an issue on multiomics, researchers report new approaches to study the microbiome, cancer and other diseases by combining proteomics, genomics, transcriptomics and other high-throughput ways to collect data. (2019-08-06)

Scientists identified a new signaling component important for plant symbiosis
A proteomics-based protein-protein interaction study has led to the discovery of proteins that interact with a legume receptor that mediates signal transduction from the plasma membrane to the nucleus. This shows how symbiotic signals from symbiotic bacteria are transmitted upon perception, ultimately leading to their accommodation within the host plant. (2019-08-01)

Goat milk kefir is proven to be good for your health
A University of Cordoba research team, for the first time, applied a protein identification technique to this product on a massive scale and found activity of healthy compounds (2019-06-25)

New biomarker test improves diagnosis of ovarian cancer
The majority of women who undergo surgery for suspected ovarian cancer do not have cancer. A novel blood test developed by researchers at Uppsala University and the Sahlgrenska Academy, University of Gothenburg, now offers the possibility of more precise diagnostics without the need for surgery. This could lead to a reduction in unnecessary surgery and to earlier detection and treatment for affected women. The study was recently published in Communications Biology. (2019-06-20)

A new tool makes it possible to adapt treatment for patients with cardiogenic shock
Cardiogenic shock is a possible complication of serious heart attack involving an associated mortality rate of approximately 50% of all cases. The combination of this new tool with existing methods renders precise and patient-specific decision-making possible. The research is being led by Dr. Antoni Bayés at Germans Trias and the Proteomics Unit of the CRG and UPF, under Dr. Eduard Sabidó. (2019-06-17)

Artificial intelligence boosts proteome research
Using artificial intelligence, researchers at the Technical University of Munich (TUM) have succeeded in making the mass analysis of proteins from any organism significantly faster than before and almost error-free. This new approach is set to provoke a considerable change in the field of proteomics, as it can be applied in both basic and clinical research. (2019-05-29)

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