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Current Psoriasis News and Events, Psoriasis News Articles.
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Psoriasis: Towards a novel therapeutic approach
Researchers at the Université libre de Bruxelles (ULB) and the Department of Dermatology of the Erasme hospital uncover the importance of VEGFA signaling in the epidermis to mediate psoriasis development. (2020-01-09)

Insights into psoriasis suggest a new treatment target
Investigators from Brigham and Women's Hospital and the Harvard Stem Cell Institute have uncovered a novel pathway that may explain why skin thickens in psoriasis and suggests new strategies for developing therapies for the condition. (2019-12-11)

Study examines sex differences in potential link between psoriasis and metabolic disorders
An analysis published in the Journal of the European Academy of Dermatology and Venereology revealed considerable sex differences when considering links between psoriasis and metabolic disorders. (2019-12-04)

Researchers uncover critical metabolic switch for inflammatory diseases
A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases. (2019-11-21)

Psoriasis onset determines if psoriatic arthritis patients develop arthritis or psoriasis first
In a new study presented at the 2019 ACR/ARP Annual Meeting, researchers found the age of psoriasis onset determines whether arthritis or psoriasis starts first in people with psoriatic arthritis. Additionally, they found that pustular psoriasis is associated with arthritis onset two years earlier than the intercept interval; and there is an increased delay for nail involvement, plaque psoriasis or family history of psoriasis from psoriasis to arthritis by approximately two years for each characteristic. (2019-11-09)

Increased depression, suicidal thoughts and stress are reported in patients with chronically itchy skin
Itch is a very common symptom in patients suffering from skin diseases. In a new multicenter cross-sectional study on the psychological burden of itch in the Journal of Investigative Dermatology, published by Elsevier, investigators report that the presence of itch in dermatological patients was significantly associated with clinical depression, suicidal ideation and stress. They recommend providing patients with access to a multidisciplinary team to prevent and manage problems associated with itch. (2019-10-29)

How do ketogenic diets affect skin inflammation?
Not all fats are equal in how they affect our skin, according to a new study in the Journal of Investigative Dermatology, published by Elsevier. The investigators found that different ketogenic diets impacted skin inflammation differently in psoriasiform-like skin inflammation in mice. Ketogenic diets heavy in medium-chain triglycerides (MCTs) such as coconut, especially in combination with omega-3 fatty acids from fish oil and plant sources like nuts and seeds, exacerbated psoriasis. (2019-10-17)

Psoriasis appears associated with increased risk of developing, dying of cancer
The risk of developing and dying of cancer among people with psoriasis was examined in this study (called a systematic review and meta-analysis) that combined the results of 58 observational studies. (2019-10-16)

Psoriasis drug target offers potential for osteosarcoma
Research reveals a new therapeutic target for the treatment of osteosarcoma. (2019-09-18)

Prolonged antibiotic treatment may alter preterm infants' microbiome
Treating preterm infants with antibiotics for more than 20 months appears to promote the development of multidrug-resistant gut bacteria, suggests a study funded by the National Institutes of Health. The research appears in Nature Microbiology. (2019-09-09)

Danish-American research presents new ways of developing treatment of chronic inflammation
Researchers from Aarhus University Hospital and Aarhus University in Denmark in collaboration with researchers from Colorado in the United States have found a new way to treat the inflammation involved in chronic diseases such as psoriasis, asthma and HIV. A group of transmitter substances (cytokines) in the immune system, the so-called IL-1 family, has been shown to play an important role in many of these diseases by regulating the body's immune responses. (2019-08-30)

Once considered rare, an itchy dermatologic skin disorder is more common than thought
Johns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be associated with other inflammatory skin disorders as well as systemic and mental health disorders. Compared with other skin diseases, however, not much is known about PN. While symptoms of PN can be managed, no cures exist. Researchers were looking to determine associated conditions that are more common in patients with PN, compared with similar patients without PN. (2019-08-21)

Shedding light on the reaction mechanism of PUVA light therapy for skin diseases
Together with their Munich-based colleagues, a team of physical chemists from Heinrich Heine University Düsseldorf (HHU) has clarified which chemical reactions take place during PUVA therapy. The therapy involves light-induced damage to the DNA of diseased cells. The team working under Prof. Dr. Peter Gilch has now published its findings in the Journal of the American Chemical Society. (2019-08-20)

Virtual patients and in silico clinical studies improve blue light treatment for psoriasis
A new study supports the use of virtual patients and in silico clinical studies to evaluate the effectiveness of blue light to reduce the symptoms of psoriasis. (2019-08-07)

Psoriasis therapy linked to reduced coronary inflammation in patients with skin condition
Researchers have found that anti-inflammatory biologic therapies used to treat moderate to severe psoriasis can significantly reduce coronary inflammation in patients with the chronic skin condition. Scientists said the findings are particularly notable because of the use of a novel imaging biomarker, the perivascular fat attenuation index (FAI), that was able to measure the effect of the therapy in reducing the inflammation. (2019-07-31)

Vaccinations not a risk factor for multiple sclerosis
Data from over 12,000 multiple sclerosis (MS) patients formed the basis of a study by the Technical University of Munich (TUM) which investigated the population's vaccination behavior in relation to MS. It showed that five years before their diagnosis, MS patients were statistically less likely to receive vaccinations than comparator groups. Consequently, there was no positive correlation between vaccinations and the development of MS. (2019-07-31)

Mice with a human immune system help research into cancer and infections
Researchers from Aarhus University and Aarhus University Hospital have succeeded in using mice with a transplanted human immune system to study functions in the immune system which are otherwise particularly difficult to study. The method could turn out to be important in further research into e.g. cancer, HIV and autoimmune diseases. (2019-06-25)

Psoriasis patients turn to alternative medicine when traditional treatments fail
A recent survey from the GW School of Medicine and Health Sciences found patients with psoriasis frequently use complementary or alternative therapies to treat their symptoms when traditional treatments fail. (2019-06-20)

Tildrakizumab shows promising efficacy and safety in psoriatic arthritis
The results of a phase 2B study presented today at the Annual European Congress of Rheumatology (EULAR 2019) demonstrate superior efficacy and comparable safety of tildrakizumab versus placebo in patients with psoriatic arthritis. (2019-06-14)

Imaging tests help reveal heart risks in patients with psoriatic disease
Patients with psoriasis and psoriatic arthritis -- collectively termed psoriatic disease -- face increased heart risks. A new study published in Arthritis & Rheumatology indicates that ultrasound imaging of the carotid arteries can reveal the extent to which patients' arteries are clogged and also indicate their risk of experiencing future cardiovascular events. (2019-06-05)

Phosphorylation of Regnase-1 lets IL-17 run amok
A research team led by Osaka University found that the cytokine interleukin (IL)-17 triggers the phosphorylation of mRNA-degrading enzyme Regnase-1, resulting in excessive inflammation. By blocking this phosphorylation, novel therapies may be able to prevent the development or severity of IL-17-associated autoimmune diseases such as inflammatory bowel disease, multiple sclerosis, and psoriasis. (2019-06-03)

Newly identified bacteria-killing protein needs vitamin A to work
UT Southwestern researchers identified a previously unknown bacteria-killing protein on the epidermis that requires vitamin A to work. (2019-05-14)

Study: Some biologic treatments for psoriasis may be safer for patients
In the largest study of its kind, Erica D. Dommasch, M.D., M.P.H., a dermatologist in the Department of Dermatology at BIDMC, and colleagues found a decreased risk of infection in patients with psoriasis using some of the newer, more targeted medications compared to those taking methotrexate, a drug widely used since the 1960s as a first line treatment for moderate-to-severe psoriasis. (2019-05-10)

Articles focus on psoriasis, risk of mental health disorders
Two related articles and an editorial focus on the chronic inflammatory skin disorder psoriasis and the risk of mental health disorders. (2019-05-08)

Higher weight increases risk of psoriasis
The higher a person's BMI, the greater the chance of getting psoriasis. But researchers are still uncertain as to why. (2019-04-26)

Dermatology students improve Wikipedia entries on skin disease
A group of medical students recruited to improve Wikipedia articles on skin-related diseases, saw millions more views of those stories following their editing, highlighting the value of expert input on the popular web encyclopedia. (2019-04-03)

Topical immunotherapy keeps skin cancer risk at bay
A combination of two topical creams already shown to clear precancerous skin lesions from sun-damaged skin also lowers the risk that patients will later develop squamous cell carcinoma of the skin. The study, from Washington University School of Medicine in St. Louis, Massachusetts General Hospital, and Harvard Medical School, appears March 21 in JCI Insight. (2019-03-21)

New potential approach to treat atopic dermatitis
How does the immune system respond to fungi on our skin? Researchers at the University of Zurich have demonstrated that the same immune cells that protect us against skin fungi also encourage the inflammatory symptoms of atopic dermatitis. An antibody therapy could alleviate this chronic inflammatory skin disease. (2019-03-18)

Could genetic breakthrough finally help take the sting out of mouth ulcers?
A large breakthrough has been made in the genetic understanding of mouth ulcers which could provide potential for a new drug to prevent or heal the painful lesions. Mouth ulcers affect up to 25 percent of young adults and a higher proportion of children. Previous research has shown that mouth ulcers are partially heritable, but until now there has been little evidence linking specific genes or genomic regions to mouth ulcers. (2019-03-05)

When good cells go bad: Regulating the ms-causing properties of Th17 cells
Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a mouse model of MS, a team led by researchers from Osaka University identified a major regulator of Th17 cell-associated pathogenic inflammatory processes. The protein, Satb1, enhances the expression of genes promoting inflammation and suppresses genes needed to prevent autoimmunity. By targeting this protein, novel therapies may be able to attenuate inflammatory autoimmune diseases. (2019-02-13)

Study links psoriasis treatment and improvement in heart artery disease
Researchers have found that treating psoriasis, a chronic inflammatory skin disease, with biologic drugs that target immune system activity can reduce the early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke. The findings highlight how immunotherapies that treat inflammatory conditions might play a role in the reduction of cardiovascular disease risks. (2019-02-05)

Psoriasis medication may improve heart disease in patients with the skin condition
Anti-inflammatory biologic drugs used to treat severe psoriasis have the potential to prevent heart disease in patients with the skin condition, according to research published today in Cardiovascular Research, a journal of the European Society of Cardiology (ESC). During one year of treatment, biologic therapy improved coronary artery plaque similar to the effect of a low-dose statin. (2019-02-05)

Molecule discovery holds promise for gene therapies for psoriasis
Scientists at the University of Birmingham have discovered a protein that could hold the key to novel gene therapies for skin problems including psoriasis - a common, chronic skin disease that affects over 100 million people worldwide. (2018-12-20)

Skin game
Medical University of Vienna professor Leopold Eckhart and colleagues have performed one of the largest comparative genomic studies to help determine the key molecular and evolutionary origins of mammalian adaptations seen in skin proteins. ''The results of the present study provide important new data on the evolution of keratins that control the mechanical stability of the epidermis, the outermost layer of the skin,'' said Eckhart. (2018-12-13)

Providers show interest in prescribing therapeutic cannabinoids
A team from the GW School of Medicine and Health Sciences found many dermatologists are interested in learning more about and recommending therapeutic cannabinoids to their patients. (2018-12-10)

National rheumatology and psoriasis organizations release joint guideline for psoriatic arthritis
The American College of Rheumatology (ACR) and National Psoriasis Foundation (NPF) have released a joint treatment guideline for psoriatic arthritis (PsA) that provides evidence-based pharmacologic and non-pharmacologic recommendations on caring for treatment-naïve patients with active PsA and patients who continue to have active PsA despite treatment. (2018-12-03)

Balneo-phototherapy: Studies now show greater benefit also in atopic eczema
For psoriasis, it has been known since 2007 that UV light therapy should be combined with brine baths. New data have now shown this also for atopic eczema. (2018-11-29)

Lipid that aids normal skin turnover may help psoriasis
Topical application of the lipid phosphatidylglycerol, or PG, on a mouse model of psoriasis reduced inflammation as well as characteristic, raised skin lesions, they report in the Journal of Investigative Dermatology. (2018-11-27)

Link between autoimmune, heart disease explained in mice
Autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis more than double the risk of cardiovascular disease. A new study shows that immune cells that arise during autoimmune disease cause cholesterol to become trapped inside blood vessels. (2018-11-08)

New insight into the mechanism of the drug against sclerosis and psoriasis
A multidisciplinary research team at Aarhus University has provided fundamental new insight into the mechanism of the medical drug dimethyl fumarate, which is the active component of important treatments for multiple sclerosis and psoriasis. The results contribute to the development of new strategies for drug discovery. (2018-10-31)

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