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Current Pulmonary Edema News and Events, Pulmonary Edema News Articles.
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Face masks unlikely to cause over-exposure to CO2, even in patients with lung disease
New research findings contradict statements linking wearing face masks to carbon dioxide poisoning by trapping CO2. During the COVID-19 pandemic the wearing of face masks has become a highly political issue with some individuals falsely claiming that wearing face masks may be putting people's health at risk. The study published in the Annals of the American Thoracic Society shows otherwise. (2020-10-02)

High risk of deep vein thrombosis and pulmonary embolism in patients with COVID-19
In a systematic review of the worldwide published data on ''Venous thromboembolism (VTE) in COVID-19 patients'', researchers from the Department of Medicine I (MedUni Vienna), provide an in-depth analysis on the risk of VTE in patients hospitalised for COVID-19. While hospitalized patients at general wards have a VTE risk between 5 and 11%, the risk of developing deep vein thrombosis or pulmonary embolism in critically ill patients is 18 to 28%. (2020-10-01)

Study finds lung transplant patients not given antifungal preventive drugs have higher risk of death
Antifungal preventive medications reduce mortality risk by half in the first year following lung transplantation, according to Mayo Clinic research involving 667 patients who received lung transplants from 2005 to 2018. (2020-09-23)

BU researchers discover how COVID-19 may trigger fatal levels of lung inflammation
Responding to the COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, requires models that can duplicate disease development in humans, identify potential targets and enable drug testing. Specifically, access to primary human lung in vitro model systems is a priority since a variety of respiratory epithelial cells are the proposed targets of viral entry. (2020-09-21)

New virtual screening tool eases, accelerates routine diagnosis of pulmonary hypertension
The COVID-19 pandemic has increasing numbers of doctors caring for patients virtually. While critical to protecting patient health during a pandemic, however, virtual care presents unique challenges, especially when it comes to diagnosis. Now, cardiologists at the Lewis Katz School of Medicine at Temple University, have come up with a virtual screening tool that greatly simplifies the process of diagnosing a complex form of heart failure known as pulmonary hypertension. (2020-09-17)

New treatments for deadly lung disease could be revealed by 3D modeling
A 3D bioengineered model of lung tissue built by University of Michigan researchers is poking holes in decades worth of flat, Petri dish observations into how the deadly disease pulmonary fibrosis progresses. (2020-09-14)

COPD program decreases 30-day hospital readmission, may increase mortality
The 30-day readmission rate for patients with chronic obstructive pulmonary disease has decreased but the mortality rate has increased. Hospitals, in seeking to avoid financial penalties by reducing readmissions, may inadvertently affect minority and disadvantaged patients. (2020-09-10)

Researchers draw more links between vaping, smoking, young people, and coronavirus
Vapers, smokers, and non-smokers with chronic conditions are all at higher risk for COVID-19. The scientific explanation behind this is complex and not yet certain -- but it may boil down to an enzyme known as ACE2, that lives on the surface of many cells in the lungs and serves as the entry point for the coronavirus. (2020-09-09)

Rutgers-led national survey uncovers doctors' misconceptions about nicotine risks
Most doctors misperceive the risks of nicotine, the addictive chemical in tobacco products, according to a Rutgers-led national survey. (2020-09-09)

Elevated clotting factor V levels linked to worse outcomes in severe COVID-19 infections
ICU patients on ventilators who had abnormally high factor V activity were at higher risk for blood clots, and when factor V was lower, the risk for death was increased. (2020-09-08)

COVID-19 patients suffer long-term lung and heart damage but it can improve with time
Two studies on COVID-19 to be presented at the European Respiratory Society International Congress show that 1) coronavirus patients can suffer long-term lung and heart damage but, for many, this tends to improve over time (findings from first, prospective follow-up of COVID-19 patients); 2) the sooner COVID-19 patients started a pulmonary rehabilitation programme after coming off ventilators, the better and faster their recovery. Embargoed press conference at 11.00 hrs CEST Friday 4 September. (2020-09-06)

Factors that raise the risk of mortality among children with several acute malnutrition
#AJCN review identifies independent predictors of inpatient mortality among children with severe acute malnutrition: HIV infection, diarrhea, pneumonia, shock, lack of appetite, and low weight-to-height ratio. The authors found that children with a low weight-to-height ratio at hospital admission were at highest risk of mortality. ''Early recognition of these prognostic factors within the community, alongside risk stratification at hospital admission, may help reduce inpatient mortality among children with severe acute malnutrition,'' said author Jonathan Sturgeon. (2020-09-04)

Trial clarifies which patients with acute pulmonary embolism can be managed at home
Patients with acute pulmonary embolism can be selected for home management using the sPESI score or the Hestia criteria, according to results of the HOME-PE trial presented in a Hot Line session today at ESC Congress 2020.1 Principal investigator Professor Pierre-Marie Roy of the University Hospital of Angers, France said: ''The pragmatic Hestia method was at least as safe as the sPESI score for triaging haemodynamically stable pulmonary embolism patients for outpatient care.'' (2020-08-31)

Metabolic syndrome linked to worse outcomes for COVID-19 patients
Patients hospitalized with COVID-19 who had a combination of high blood pressure, obesity and diabetes were over three times more likely to die from the disease, according to a new Tulane University study published in Diabetes Care. (2020-08-25)

Mount Sinai study finds COVID patients were most commonly readmitted to hospital for respiratory complications
Study describes characteristics of patients with COVID-19 who returned to the ER or required readmission to the hospital within 14 days of being discharged (2020-08-21)

Dilated blood vessels in the lung may explain low oxygen levels in severe cases of COVID-19
A new pilot study from the Icahn School of Medicine at Mount Sinai suggests that COVID-19 is causing significant dilation of the blood vessels of the lung, specifically the capillaries. (2020-08-20)

Hypoxia in hospitalized COVID-19 patients may be treatable
Covid-19 patients with hypoxia respond positively to icatibant treatment, Radboud university medical center researchers wrote in JAMA Network Open. These findings have led to a follow-up study at ten Dutch hospitals into a drug that may be even more effective. The current study has been funded by ZonMw. (2020-08-19)

New practice guidelines on non-invasive ventilation in chronic stable Hypercapnic COPD
A subcommittee of the American Thoracic Society Assembly in Sleep and Respiratory Neurobiology has released new clinical practice guidelines to help advise clinicians on the optimal management of patients with chronic obstructive pulmonary disease (COPD) and chronic hypercapnia. Hypercapnia is the buildup of carbon dioxide in the bloodstream. (2020-08-17)

Novateur Ventures explores new strategy to reduce hyperinflammatory response caused by COVID-19
Novateur's research proposes simple treatment paradigm using two generic drugs, directed to blocking inflammation in airways of patients with asthma, to target hyper-inflammatory response insevere COVID-19. This will be accomplished by combination of leukotriene biosynthesis blocker zileuton (Zyflo® controlled release formulation) and inhibitor of cysteinyl leukotriene 1 receptor montelukast (Singulair®). Both these agents have been on market for many years, and their activity and side effects in humans are well known. (2020-08-12)

Improving treatment of spinal cord injuries
A group led by UC Riverside bioengineering professor Victor G. J. Rodgers and UC Riverside School of Medicine professor Devin Binder has created an osmotic therapy device that gently removes fluid from the spinal cord to reduce swelling in injured rats with good results. The device can eventually be scaled up for testing in humans. (2020-08-12)

The CNIO pave the way for a future gene therapy to reverse pulmonary fibrosis associated with ageing
''Our results indicate that a new therapy may be developed to prevent the development of pulmonary fibrosis associated with ageing,'' says CNIO's Maria Blasco, principal investigator of the study * Lung tissue of patients with pulmonary fibrosis does not regenerate because the cells involved in lung generation have damaged telomeres, the ends of the chromosomes. The new study describes a gene therapy that activates the enzyme that repairs telomeres (2020-08-10)

COVID-19 - The virus and the vasculature
In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that activated immune cells and blood platelets play a major role in these pathologies. (2020-08-07)

Adding another dimension to a cell culture model for pulmonary arterial hypertension
Pulmonary arterial hypertension is a rare disease in which excessive proliferation of the cells of pulmonary arterial walls obstructs the blood flow in the lungs. A group of scientists based in Okayama, Japan, has now used 3D cell culture technology to recapitulate the pathogenetic process involved in pulmonary arterial hypertension in the laboratory, with potential applications in drug testing. (2020-08-07)

Treatment option improves chances of survival for babies with rare cerebrovascular disorder
Endovascular treatment of vein of Galen aneurysmal malformation (VGAM) in babies with severe pulmonary hypertension can improve chances of survival, according to a study released today at the Society of NeuroInterventional Surgery's (SNIS) 17th Annual Meeting. The study, Outcomes of Endovascular Treatment of Vein of Galen Aneurysmal Malformation in Neonates, evaluated data from 52 surgery patients with VGAMs at the Meshalkin National Medical Research Center. Eleven of these patients were younger than 10 days when surgery was performed. (2020-08-07)

Pulmonary fibrosis treatment shows proof of principle
A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF). (2020-08-06)

Lung-specific risk factors may increase hip fracture risk in individuals who smoke
Smoking has been linked to a higher risk of bone fractures. Researchers have now identified certain lung-related factors that may help to predict an individual smoker's fracture risk. The findings are published in the Journal of Bone and Mineral Research. (2020-08-05)

Reducing the adverse impact of water loss in cells
A University of Houston College of Medicine researcher has found how a protein inside the body reduces the adverse effects of hypertonicity, an imbalance of water and solutes inside cells, which leads to cell death. (2020-08-04)

Challenges in diagnosing hypersensitivity pneumonitis addressed in latest guidelines
More than 30 years after the last guidance on the clinical evaluation of hypersensitivity pneumonitis (HP), the American Thoracic Society - in collaboration with the Asociación Latinoamericana de Tórax or ALAT and the Japanese Respiratory Society- has developed new guidelines for clinicians. The guidelines are available online ahead of print in the American Journal of Respiratory and Critical Care Medicine. (2020-08-03)

COPD underdiagnosed in older adults, but can be managed
''Recognizing and Treating COPD in Older Adults'' the latest issue of the What's Hot newsletter from The Gerontological Society of America, addresses what is known about the prevalence, incidence, and impact of chronic obstructive pulmonary disease (COPD) in older adults. (2020-08-03)

Broad antivirals kill SARS-CoV-2, the MERS virus, and other coronaviruses in cells and mice
A team of scientists has engineered antiviral compounds that can kill several types of coronaviruses, including SARS-CoV-2, the virus that causes COVID-19. (2020-08-03)

COVID-19: Lower incidence at high altitudes?
Despite recent reports of lower COVID-19 incidence among high-altitude populations, current data is insufficient to conclude that high altitude is protective against the SARS-CoV-2 virus. (2020-08-03)

LSU health pathologists publish first report on likely MIS involving the heart
A team of LSU Health New Orleans pathologists published what is believed to be the first case report on pathologic findings of vasculitis of the small vessels of the heart, which likely represents multisystem inflammatory syndrome (MIS). (2020-07-30)

Researchers find increase in comorbidities among hospitalized patients with heart failure
Melissa Caughey, PhD, instructor in the UNC/NC State Joint Department of Biomedical Engineering, is the senior author of a recently published study that shows an increase in comorbidities and mortality risk among hospitalized patients with acute decompensated HFpEF and HFrEF. (2020-07-30)

Casting a wider net to catch more cases of pulmonary hypertension
Investigators took an evidence-based approach to determine the lower end of the risk spectrum for PH based on pulmonary vascular resistance (PVR), which is resistance against blood flow from the pulmonary artery to the lungs. (2020-07-28)

Lung ultrasound shows duration, severity of coronavirus disease (COVID-19)
According to an open-access article published in ARRS' American Journal of Roentgenology (AJR), lung ultrasound was highly sensitive for detecting abnormalities in patients with coronavirus disease (COVID-19), with B-lines, a thickened pleural line, and pulmonary consolidation the most commonly observed features. Additionally, the authors of this AJR article found that lung ultrasound features can be used to reflect both the infection duration and disease severity. (2020-07-23)

Study suggests increased risks for COVID-19 patients who smoke, vape
TTUHSC's Luca Cucullo, Ph.D., has for years studied the effects smoking and vaping have on the cerebrovascular and neurological systems. He recently led an effort to review the effect smoking and vaping may have on the cerebrovascular and neurological systems of COVID-19 patients. The study, ''Cerebrovascular and Neurological Dysfunction under the Threat of COVID-19: Is There a Comorbid Role for Smoking and Vaping?'' was published May 30 by the International Journal of Molecular Sciences. (2020-07-22)

Nitric oxide may slow progression of COVID-19
Researchers at the George Washington University and Albert Einstein College of Medicine published a review in the journal Nitric Oxide suggesting that nitric oxide treatment can be pivotal in the fight against SARS-CoV-2. (2020-07-21)

Fusion protein holds promise for treating pulmonary arterial hypertension
In a paper published in Science Translational Medicine, researchers illuminate the underlying biological pathways that may lead to vessel destruction in pulmonary arterial hypertension. Their results provide a biological explanation for why proteins called activins and growth and differentiation factors (GDFs) might contribute to pulmonary vascular disease, and provide an explanation of how the activin/GDF-blocking drug sotatercept, currently in clinical trials, may help treat patients with pulmonary arterial hypertension. (2020-07-21)

ATS publishes new guidance on safely restoring elective pulmonary and sleep services
An American Thoracic Society-led international task force has released a guidance document to help guide clinicians on restoring elective in-person pulmonary and sleep services as COVID-19 incidence decreases in their communities. The new guidance, published online in the Annals of the American Thoracic Society, is titled ''Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens.'' (2020-07-16)

Experts strongly recommend varenicline over the patch for adult smokers hoping to quit
Smoking cessation initiatives notwithstanding, along with provocative public health campaigns and clinical guidance, quitting tobacco has remained elusive for many smokers. The American Thoracic Society's new clinical practice guideline on treatment for tobacco dependence in adults addresses how clinicians may deal with patients' reluctance to quit, one of a number of issues not previously assessed in the older guidelines. (2020-07-15)

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