Current Pulmonary Fibrosis News and Events

Current Pulmonary Fibrosis News and Events, Pulmonary Fibrosis News Articles.
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Measuring hemoglobin levels with AI microscope, microfluidic chips
A complete blood count can help ascertain the health of a patient and typically includes an estimate of the hemoglobin concentration, which can indicate several conditions, including anemia, polycythemia, and pulmonary fibrosis. In AIP Advances, researchers describe a AI-powered imaging-based tool to estimate hemoglobin levels. The setup was developed in conjunction with a microfluidic chip and an AI-powered automated microscope that was designed for deriving the total as well as differential counts of blood cells. (2021-02-23)

Cytoglobin: key player in preventing liver disease
Researchers have discovered that the use of Cytoglobin (CYGB) as an intravenous drug could delay liver fibrosis progression in mice. CYGB, discovered in 2001 by Professor Norifumi Kawada, is present in hepatic stellate cells, the cells that produce fibrotic molecules such as collagens when the liver has acute or chronic inflammation induced by different etiologies. The enhancement of CYGB on these cells or the injection of recombinant CYGB has the effect of suppressing liver damage and cirrhosis. (2021-02-16)

Epigenetic mechanisms allow native Peruvians to thrive at high altitudes
Scientists reveal the epigenetic mechanisms that enable humans to survive at extremely high altitudes in the Andes (2021-02-15)

Arizona economic burden of valley fever totals $736 million
Expenses for the fungal disease endemic to the Southwest can skyrocket for people whose diagnosis is delayed, leading to more serious infection or death. (2021-02-09)

Bernese researchers create sophisticated lung-on-chip
In collaboration with clinical partners from the Inselspital, researchers from the ARTORG Center for Biomedical Research of the University of Bern have developed a second-generation lung-on-chip model with life-size dimension alveoli in a stretchable membrane, made of purely biological material. The new model reproduces key aspects of the lung tissue architecture not found in previous lungs-on-chip. This opens up new possibilities for basic pneumological research, understanding lung pathologies, drug screening and precision medicine. (2021-02-08)

CU offers plan for improving mental health care for resident physicians
A pilot program to offer mental health services offered resident physicians at the University of Colorado School of Medicine provides a model for confidential and affordable help, according to an article published today by the journal Academic Medicine. (2021-02-04)

Minority patients miss out on cystic fibrosis drugs due to genetic test limitations
There is an impassioned debate taking place in medicine on whether race-based considerations should be a factor in research, diagnoses, or treatments. (2021-02-02)

NIH study shows hyaluronan is effective in treating chronic lung disease
Researchers at the National Institutes of Health and their collaborators found that inhaling unfragmented hyaluronan improves lung function in patients suffering from severe exacerbation of chronic obstructive pulmonary disease (COPD). Hyaluronan, a sugar secreted by living tissue that acts as a scaffold for cells, is also used in cosmetics as a skin moisturizer and as a nasal spray to moisturize lung airways. Utilized as a treatment, hyaluronan decreased the number of days in the hospital. (2021-02-01)

Melatonin produced in the lungs prevents infection by novel coronavirus
The hormone acts as a barrier against SARS-CoV-2, blocking the expression of genes that encode proteins in cells serving as viral entry points, according to a study by researchers at the University of São Paulo. (2021-01-27)

CT identifies patients with high-risk nonalcoholic fatty liver disease (NAFLD)
According to ARRS' American Journal of Roentgenology, Fibrosis-4 and multiple CT findings can identify patients with high-risk nonalcoholic fatty liver disease--advanced fibrosis or cirrhosis, that is--though the presence of nonalcoholic steatohepatitis remains elusive on CT. (2021-01-22)

Inflammation caused by scorpion venom should be blocked immediately, study shows
In an article published in Nature Communications, Brazilian researchers show for the first time that in severe cases of scorpion envenomation it is the neuroimmune reaction triggered by the venom that leads to death. (2021-01-20)

CU Anschutz scientists reverse deadly impacts of asthma in mice
Excess mucus in the lungs can be fatal for asthma patients, but scientists at the University of Colorado Anschutz Medical Campus have broken up those secretions at the molecular level and reversed their often deadly impacts. (2021-01-13)

A CNIO study links severe COVID-19 disease to short telomeres
The data show that telomeres are shorter in patients suffering more severe COVID-19 pathologies. The researchers propose that one of the consequences of the viral infection is shortening of the telomeres, which, in turn, hampers the regeneration of lung tissue and causes prolonged sequelae in some patients. The study, published in the journal 'Aging', suggests the usefulness of a possible therapy for patients with post-COVID pulmonary injury based on activation of the enzyme telomerase. (2021-01-11)

Why COVID-19 pneumonia lasts longer, causes more damage than typical pneumonia
COVID pneumonia is significantly different from pneumonia caused by other causes, reports a new study in Nature. It shows how hijacks the lungs' own immune cells and uses them to spread across the lung over weeks. The infection leaves damage in its wake and fuels the fever, low blood pressure and damage to the kidneys, brain, heart and other organs in patients with COVID-19. Scientists discovered a target for treating COVID pneumonia and a clinical trial is underway at Northwestern. (2021-01-11)

Singapore and US scientists uncover the structure of Wnt, Wntless proteins
Preventing Wnt from hitching a ride may offer new avenue for novel treatments for cancer and fibrosis. (2021-01-11)

Initial severity of COVID-19 not associated with later respiratory complications
A new study published online in the Annals of the American Thoracic Society examines the recovery of lung function and overall wellness in individuals who had varying degrees of COVID-19 severity. Little is known about lung health following infection with SARS-CoV-2, the virus that causes COVID-19, and whether later respiratory problems, fatigue and ill health are associated with the disease's initial severity. (2021-01-08)

Birmingham research paves the way for new anti-fibrotic therapy for glaucoma
Researchers showed that novel low molecular weight dextran-sulphate, ILB®, can normalise matrix deposition inside the eye and lower IOP in a pre-clinical model of human glaucoma, paving the way for new anti-fibrotic therapies to be developed for the disease. (2021-01-07)

Study: e-cigarettes trigger inflammation in the gut
Chemicals used for vaping break down zipper-like junctions between cells in the gut, leading to chronic inflammation and potential for other health concerns. (2021-01-07)

Increased meat consumption associated with symptoms of childhood asthma
Substances present in cooked meats are associated with increased wheezing in children, Mount Sinai researchers report. (2020-12-22)

Pneumolysis: High altitude specialists explain lung destruction caused by COVID-19
According to the scientific paper, COVID-19's hypoxemia (low oxygen tension in the blood) can hardly be handled by ventilators and should not be considered as pneumonia or treated as a SARS (severe acute respiratory syndrome). (2020-12-21)

Antifungal drug improves key cystic fibrosis biomarkers in clinical study
A drug widely used to treat fungal infections improved key biomarkers in lung tissue cultures as well as in the noses of patients with cystic fibrosis, a clinical study by researchers at the University of Illinois Urbana-Champaign and the University of Iowa found. (2020-12-17)

Protein linked to progressive lung scarring in scleroderma patients
Osteopontin is discovered as the culprit behind systemic sclerosis patients' main cause of death: lung fibrosis. However, a repurposed immunosuppressive drug may combat the pro-inflammatory protein. (2020-12-17)

Physicians say non-contact infrared thermometers fall short as COVID-19 screeners
While a fever is one of the most common symptoms for people who get sick with COVID-19, taking one's temperature is a poor means of screening who is infected with the SARS-CoV-2 virus that causes the disease, and more importantly, who might be contagious. (2020-12-15)

The un-appeal of banana: liquid e-cigarette flavorings measurably injure lungs
UC San Diego researchers report chemicals used for flavor in e-cigarette liquid negatively affect specialized proteins that support immune system. (2020-12-14)

Inhaled vaccine induces fast, strong immune response in mice and non-human primates
Researchers demonstrate in a study publishing December 10 in the journal Med that a phage-based inhalation delivery system for vaccines generates potent antibody responses in mice and non-human primates, without causing lung damage. The findings suggest that a safe and effective lung delivery system could one day be used for vaccines and therapeutics against respiratory diseases. (2020-12-10)

Study connects diabetes, air pollution to interstitial lung disease
People with pre-diabetes or diabetes who live in ozone-polluted areas may have an increased risk for an irreversible disease with a high mortality rate. These findings are especially important today in the midst of the COVID-19 pandemic, where there is a heightened concern for the convergence of health effects from air pollution and SARS-CoV-2 in susceptible populations. (2020-12-09)

Coronavirus pneumonia and pulmonary thromboembolism
Announcing a new publication for BIO Integration journal. In this article the authors Mingkang Yao; Phei Er Saw and Shanping Jiang from Sun Yat-Sen University, Guangzhou, China review Coronavirus Pneumonia and Pulmonary Thromboembolism. (2020-12-08)

Research sheds new light on cause of deadly lung disease
New research could shed light on the mystery cause of a lung disease that is a major killer, and potentially unlock new treatments (2020-12-08)

Disrupting the cellular process that promotes pancreatic cancer's deadly growth
Researchers say they've identified a way to disrupt a process that promotes the growth of pancreatic cancers -- one of the most difficult and deadly cancers to treat. (2020-12-08)

Johns Hopkins develops potential antibiotic for drug-resistant pathogen
Scientists from Johns Hopkins University and Medicine have developed a possible new antibiotic for a pathogen that is notoriously resistant to medications and frequently lethal for people with cystic fibrosis and other lung ailments. (2020-12-08)

Synthetic llama antibodies rescue doomed proteins inside cells
Columbia researchers created a new technology using synthetic llama antibodies to protect endangered proteins inside cells. The technology could treat dozens of diseases. (2020-12-07)

Lung tissue from COVID-19 patients and others reveals promising target to treat lung fibrosis
An analysis of lung tissues from patients with different types of pulmonary fibrosis - including cases triggered by COVID-19 - has revealed a promising molecular target to ameliorate the chronic and irreversible disease. Experiments in mouse models of lung fibrosis showed that administering blockers of (2020-12-04)

Healthy muscles are a carrot on a string for healthy lungs
Scientists show effectiveness of carrot-based Japanese herbal medicine called ''Ninjin'yoeito'' in improving muscle atrophy in the hind legs of mice exposed to cigarette smoke through an increased expression of PGC-1α, positioning the medicine as a potential treatment for sarcopenia frailty-related complications with chronic obstructive pulmonary disease (COPD). Their findings were published online in the international scientific journal ''International Journal of Chronic Obstructive Pulmonary Disease'' on November 27, 2020. (2020-12-02)

Researchers determine how the SARS-CoV-2 virus hijacks and rapidly causes damage to human lung cells
In a multi-group collaborative involving the National Emerging Infectious Disease Laboratories (NEIDL), the Center for Regenerative Medicine (CReM), and the Center for Network Systems Biology (CNSB), scientists have reported the first map of the molecular responses of human lung cells to infection by SARS-CoV-2. (2020-12-02)

Sensor can detect scarred or fatty liver tissue
MIT engineers have now developed a diagnostic tool, based on nuclear magnetic resonance (NMR), that could be used to detect both fatty liver disease and liver fibrosis. (2020-12-02)

Repurposed mouse model sheds light on loss of smell in COVID-19
A repurposed mouse model can develop symptoms of both severe COVID-19 (lung damage, blood clots, abnormal blood vessels, and death) and also of milder disease, including loss of the sense of smell, according to a recent University of Iowa study published in Nature. (2020-12-01)

Why long-suffering hosts grow a thick skin
Researchers from the University of Tsukuba have shown that the skin fibrosis seen in chronic graft-versus-host disease is mediated by transforming growth factor-β1 expressed by epidermal cells undergoing programmed death when they are stimulated by interferon-γ. Further investigations elucidate the sclerodermatous changes characteristic of autoimmune and inflammatory conditions such as systemic sclerosis, discoid lupus erythematosus and toxic epidermal necrolysis, thus opening up research avenues in pharmacotherapeutics based on targeting apoptosis and interferon-γ. (2020-12-01)

Mild electrical stimulation with heat shock ameliorates kidney disease
The combination of mild electrical stimulation and heat shock at 42 °C (MES+HS) exerts anti-inflammatory and anti-fibrotic effects in a mouse model of nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells. Clinical data have shown that the medical device used for this therapeutic approach is safe in humans. Researchers believe that it can be applied clinically to control the pathologies of NS. (2020-11-30)

Insulators in Alberta at higher risk of chest infections, COPD: study
Construction workers in Alberta, Canada who work with hazardous insulation materials are much more likely to be affected by repeated chest infections and chronic obstructive pulmonary disease (COPD), according to new research published in the International Journal of Environmental Research and Public Health. (2020-11-26)

New therapy for flu may help in fight against COVID-19
A new therapy for influenza virus infections that may also prove effective against many other pathogenic virus infections, including HIV and COVID-19, has been developed by Purdue University scientists. The Purdue team's approach uses a targeted therapy approach against the virus infections. (2020-11-24)

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