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Current Radiation Therapy News and Events, Radiation Therapy News Articles.
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Biodistribution of AAV gene transfer vectors in nonhuman primate
The biodistribution of adeno-associated virus (AAV) gene transfer vectors can be measured in nonhuman primates using a new method. The method quantifies whole-body and organ-specific AAV capsids from 1 to 72 hours after administration (2021-01-15)

Discovery of a new approach to inhibiting a highly treatment-refractory liver cancer
Blocking placental growth factor (PlGF), a member of the vascular endothelial growth factor family, inhibits the progression of intrahepatic cholangiocarcinoma (ICC) and enhances the efficacy of chemotherapy in mouse models. This novel approach to targeting the connective tissue microenvironment of ICC, a rare but notoriously treatment-resistant form of liver cancer, could pave the way for combination therapies, including chemotherapy and immune checkpoint blockade. (2021-01-12)

Treatment for chronic pain must address both physical and social pain
Physical pain and social pain may be more closely related than previously thought. Social pain, which typically results from interpersonal rejection or abuse, has been viewed as a non-medical response to external factors. However, recent research suggests that some physical and social stress responses may arise because of shared processing in the brain. (2021-01-12)

New hard disk write head analytical technology can increase hard disk capacities
Using synchrotron radiation at SPring-8 - a large-scale synchrotron radiation facility - Tohoku University, Toshiba Corporation, and the Japan Synchrotron Radiation Research Institute (JASRI) have successfully imaged the magnetization dynamics of a hard disk drive (HDD) write head for the first time, with a precision of one ten-billionth of a second. The method makes possible precise analysis of write head operations, accelerating the development of the next-generation write heads and further increasing HDD capacity. (2021-01-07)

Ibrutinib with rituximab in previously untreated CLL: indication of added benefit over FCR
Ibrutinib with rituximab in previously untreated CLL: indication of added benefit over FCR. The new drug combination prolongs overall survival in patients in good general health. No study data are available for other patient groups. (2021-01-05)

Alpha-ray missile therapy: tumor cells attacked from intracellular region
Researchers from Osaka University have innovated a technique of irradiating cancer from within. They tagged α-methyl-L-tyrosine with 211Astatine, an α-emitter, to prepare 211At-AAMT; this radiopharmaceutical was effectively conveyed into cancer cells by the amino acid transporter LAT1. Alpha radiation combines high linear energy transfer with minimal tissue penetration, damaging cancer cells lethally while sparing surrounding normal tissue. This strategy may prove a breakthrough in the management of intractable or advanced cancers. (2021-01-04)

Study explains why patients with cancer spread to the liver have worse outcomes
A new study finds that tumors in the liver siphon off critical immune cells, rendering immunotherapy ineffective. But coupling immunotherapy with radiotherapy to the liver in mice restored the immune cell function and led to better outcomes. (2021-01-04)

Surgery may offer survival advantage in certain metastatic breast cancers
Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to Penn State College of Medicine and Penn State Cancer Institute researchers. They studied nearly 13,000 stage four breast cancer patients and found that those who had surgery in addition to their other treatments had a survival advantage over those who had other treatments alone. (2020-12-22)

Inverted fluorescence
Fluorescence usually entails the conversion of light at shorter wavelengths to light at longer wavelengths. Scientists have now discovered a chromophore system that goes the other way around. When excited by visible light, the fluorescent dyes emit light in the ultraviolet region. According to the study published in the journal Angewandte Chemie, such light upconversion systems could boost the light-dependent reactions for which efficiency is important, such as solar-powered water splitting. (2020-12-18)

For college students, skin cancer risk remains high in winter months
New research finds college students could be just as at risk for developing skin cancer in the dead of winter as they are in the middle of summer. (2020-12-17)

Change in global precipitation patterns as a result of climate change
The Earth's climate system is largely determined by the differences in temperature between the tropics and the poles. Global warming is likely to cause global atmospheric circulation to change and progressively revert to a situation similar to that of 5,000 to 10,000 years ago. This is the conclusion of a study published in Nature Communications. (2020-12-17)

Oral hormone therapy shown to significantly alter metabolome of menopausal women
Groundbreaking research led by a team of scientists including a University of Massachusetts Amherst biostatistician shows that oral hormone therapy (HT) significantly alters the metabolome of postmenopausal women. This finding, which examined blood specimens from the landmark Women's Health Initiative (WHI) study, may help explain the disease risks and protective effects associated with different regimens of hormone therapy. (2020-12-16)

A first-in-human clinical trial shows microbubbles augments radiation in liver cancer patients
Bursting gas-filled microbubbles using ultrasound waves sensitizes tumors to targeted radiation, reducing tumor growth and improving overall survival after treatment. (2020-12-15)

Moffitt identifies genomic and immune indicators that predict lethal outcomes in prostate cancer
Moffitt Cancer Center researchers conducted studies to determine if genomic heterogeneity in tumors from grade 4/5 prostate cancer patients can be exploited to identify patient subsets that are at higher risk for lethal outcomes and that may benefit from targeted treatment strategies. Their results were published in the journal European Urology. (2020-12-15)

Gene therapy for placental insufficiency moves toward the clinic
A new study identified an adenovirus gene therapy vector carrying a VEGF isoform. It can improve uterine blood flow in placental insufficiency. (2020-12-15)

Everything you want to know about sunscreen
From safety and effectiveness to who should use sunscreen and how to apply it, Canadian dermatologists review the latest evidence and guidelines on use of sunscreen. The review, published in CMAJ (Canadian Medical Association Journal), recommends that everyone older than six months of age should use sunscreen to protect against skin cancer (2020-12-14)

Gene could help predict response to cervical cancer treatment
UCLA researchers have identified a potential diagnostic marker that could help predict how likely someone with cervical cancer is to respond to the standard treatment of chemotherapy and radiation. (2020-12-11)

Immunotherapy improves responses w/o reducing quality of life in early breast cancer
Adding an immune checkpoint inhibitor to the standard chemotherapy regimen for patients with early-stage breast cancer places no greater burden on patients' ability to perform day-to-day activities than chemotherapy alone, new research by Dana-Farber/Brigham and Women's Cancer Center investigators shows. (2020-12-10)

Robots could replace real therapy dogs
Robotic animals could be the 'pawfect' replacement for our real-life furry friends, a new study published today by the University of Portsmouth has found. (2020-12-10)

Phase 1 trial assesses whether fecal microbiota transplant impacts cancer patients resistant to immu
In one of the first in-human studies to investigate whether modifying the gut microbiome by a fecal microbiota transplant could make cancer immunotherapy more effective, researchers analyzing this in ten cancer patients with refractory melanoma suggest the treatment can improve patient outcomes. (2020-12-10)

AAV capsid-promoter interactions in the non-human primate brain
The phenomenon of AAV capsid-promoter interaction recently seen in the rat central nervous system has now been shown to occur in the non-human primate brain. This interaction can directly determine cell-specific transgene expression (2020-12-10)

Physicians don't always recognize patients' radiation therapy side effects
Physicians did not recognize side effects from radiation therapy in more than half of breast cancer patients who reported a significant symptom, a new study finds. (2020-12-09)

Under-recognition of symptoms may be common in breast cancer patients receiving radiation
Among patients with breast cancer treated with radiotherapy, under-recognition of symptoms was common in reports of pain, pruritus, edema, and fatigue, with younger patients and Black patients having significantly increased odds of symptom under-recognition. (2020-12-09)

Omitting radiation therapy after breast-conserving surgery may not impact 10-year survival rates for older patients with HR-positive breast cancer
Older patients with hormone receptor-positive breast cancer who did not receive radiation therapy after breast-conserving surgery had higher rates of local recurrence but similar 10-year survival rates when compared to patients who received postoperative radiation therapy, according to updated 10-year data from the PRIME II study, presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Single-eye gene therapy improves vision in both eyes of patients with inherited eye disorder
A gene therapy for an inherited eye disorder can ameliorate vision loss in both eyes despite only being injected into one, according to a phase 3 clinical trial involving 37 patients. (2020-12-09)

Cervical cancer survival may improve by targeting senescent "zombie" cells
How well women with cervical cancer respond to treatment and survive correlates with the level of 10 proteins in their blood that also are associated with a ''zombie'' cell state called senescence, Medical College of Georgia scientists report. (2020-12-07)

Aluminium alloy research could benefit manned space missions
Manned space missions in spacecraft made of aluminium that is light yet resistant to radiation could be a step nearer following research involving a world-leading facility at the University of Huddersfield. (2020-12-07)

CAR T cell therapy effective as first-line treatment for high-risk large B-cell lymphoma
A study led by researchers at The University of Texas MD Anderson Cancer Center found that axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy, is a safe and effective first-line therapy for patients with high-risk large B-cell lymphoma (LBCL), a group with an urgent need for new and effective treatments. (2020-12-06)

Secukinumab in children with plaque psoriasis: Study unsuitable for benefit assessment
Secukinumab in children with plaque psoriasis: study unsuitable for benefit assessment The comparator group was not treated appropriately. Firstly, therapy in this group remained unchanged despite non-response, and secondly, it was continued for longer than approved. (2020-12-04)

AI predicts which drug combinations kill cancer cells
A machine learning model developed in Finland can help us treat cancer more effectively. (2020-12-01)

Warbler coloration shaped by evolution via distinct paths
Two genes that are important for the diverse colors and patterns of warbler plumage have evolved through two very different processes, according to a new study led by Penn State researchers. These evolutionary processes could help explain the rapid evolution of these songbirds into so many unique species. (2020-11-30)

Penn researchers unlock the door to tumor microenvironment for CAR T cells
Combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack solid tumors, leading to significantly enhanced survival in mice. (2020-11-30)

Combination therapy might improve outcomes in treatment-resistant liver cancer
A combination cancer therapy that is effective against treatment-resistant hepatocellular carcinoma (HCC) by inhibiting tumor growth and increasing survival has been identified by researchers at Massachusetts General Hospital. The dual therapy -- which combines the multikinase inhibitor drug regorafenib to ''reprogram'' the tumor immune microenvironment, and programmed cell death 1 antibodies to stimulate anti-tumor immunity -- improved survival in mouse models of HCC beyond what each therapy could have achieved alone. (2020-11-30)

'Financial toxicity' of prostate cancer treatment: Radiation therapy has the greatest impact on patient finances
For men with early-stage prostate cancer, choices about initial treatment carry varying risks of 'financial toxicity,' reports a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer. (2020-11-30)

Safe ultraviolet light could be used to sterilise high-risk COVID-19 environments
Research at Cranfield University is paving the way for a new solution to kill aerosolised COVID-19 in enclosed environments such as hospitals and long-term care facilities. Computational modelling has shown that low dose far-ultraviolet C (UVC) lighting can be used to disinfect in-room air, increasing disinfection rates by 50-85% compared to a room's ventilation alone. (2020-11-26)

Survival protein may prevent collateral damage during cancer therapy
Australian researchers have identified a protein that could protect the kidneys from 'bystander' damage caused by cancer therapies. The 'cell survival protein', called BCL-XL, was required in laboratory models to keep kidney cells alive and functioning during exposure to chemotherapy or radiotherapy. Kidney damage is a common side effect of these widely used cancer therapies, and the discovery has shed light on how this damage occurs at the molecular level. (2020-11-25)

Space travel can adversely impact energy production in a cell
Studies of both mice and humans who have traveled into space reveal that critical parts of a cell's energy production machinery, the mitochondria, can be made dysfunctional due to changes in gravity, radiation exposure and other factors. These findings are part of an extensive research effort across many scientific disciplines to look at the health effects of travel into space. (2020-11-25)

Scientists propose to make a laser scalpel with a 'curved' blade
Scientists from Tomsk Polytechnic University and Saratov State University teamed up with colleagues from Taiwan and proposed to make a laser 'blade' for a medical scalpel with a specified curved shape using a photonic 'hook'. (2020-11-20)

In-stent thrombosis after antiplatelet therapy conversion while awaiting coronary bypass
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0589, Nathan Burke, Tawanna Charlton, Hussam Hawamdeh, and Ki Park from the University of Florida College of Medicine, Gainesville, Florida, USA consider a case study of in-stent thrombosis after antiplatelet therapy conversion while awaiting coronary bypass. (2020-11-19)

Immunotherapy for lung and other cancers may also be beneficial for rare skin cancer
New research from the University of North Carolina School of Medicine and the Lineberger Comprehensive Cancer Center found immunotherapies effective against lung cancer and melanoma may work against cutaneous angiosarcoma, a rare, highly aggressive skin tumor found primarily on the scalps of older White people. The researchers report tumor-infiltrating lymphocytes and the surface protein markers PD-1 and PD-L1 could help guide the choice of immunotherapy to fight cutaneous angiosarcomas. (2020-11-18)

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