Current Radiotherapy News and Events

Current Radiotherapy News and Events, Radiotherapy News Articles.
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High energy radiotherapy could 'paint' tumours to avoid harming healthy tissue
A radiotherapy technique which 'paints' tumours by targeting them precisely, and avoiding healthy tissue, has been devised in research led by the University of Strathclyde. (2021-02-23)

Combination therapy with radiation shows promise in treating glioblastoma
In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma (2021-02-09)

Dartmouth-invented technology allows doctors to see beam field during radiation treatment
With the use of the BeamSite Cherenkov imaging camera system invented by DoseOptics, LLC., radiation oncologists at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center can capture real-time external beam delivery images during cancer patients' standard radiation therapy sessions. These images are used to verify that the beam is targeting the exact area intended, and make necessary adjustments to prevent unintentional exposure to patients. (2021-02-04)

First images of muon beams
A new technique has taken the first images of muon particle beams. Nagoya University scientists designed the imaging technique with colleagues in Osaka University and KEK, Japan. They plan to use it to assess the quality of these beams, which are being used more and more in advanced imaging applications. (2021-02-03)

Reduced-dose RT with Cisplatin improves outcomes for HPV-associated oropharyngeal carcinoma
A combination of reduced-dose radiotherapy using intensity-modulated radiotherapy (IMRT) combined with concurrent cisplatin met the threshold for disease control and quality of life compared to the standard of care for good-risk patients with HPV-associated oropharyngeal squamous cell carcinoma on the NRG Oncology clinical trial NRG-HN002. (2021-01-29)

Ludwig Cancer Research study reveals how certain gut bacteria compromise radiotherapy
A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients. (2021-01-26)

Study finds shorter radiation regimen safe, effective for men with advanced prostate cancer
UCLA researchers found shortening a traditional 45-day course of radiation to a five-day course delivered in larger doses is safe and as effective as conventional radiation for men with high-risk forms of prostate cancer. (2021-01-25)

Dramatic changes to radiotherapy treatments due to COVID-19
Dramatic changes were seen in the delivery of radiotherapy treatments for cancer during the first wave of the coronavirus pandemic in England. Much shorter radiotherapy courses were delivered, treatments were delayed where it was safe to do so and some increases were seen in order to compensate for reduced surgical capacity. Experts believe the changes reflect an impressive adaption of services by the NHS, and that the overall impact on cancer outcomes is likely to be modest. (2021-01-22)

COVID-19's impact on cancer prevention and control in Africa
When the COVID-19 pandemic reached Africa, the continent was already struggling to deal with another public health crisis - a growing cancer epidemic characterized by more than one million new cancer cases and nearly 700,000 deaths per year. (2020-12-31)

New treatment could spare early-stage rectal cancer patients life-altering side effects
A new and less invasive treatment developed by Cancer Research UK researchers is safer than standard major surgery for early-stage rectal cancer, giving patients a better quality of life with fewer life-altering side effects, results from a pilot study show. (2020-12-10)

Under-recognition of symptoms may be common in breast cancer patients receiving radiation
Among patients with breast cancer treated with radiotherapy, under-recognition of symptoms was common in reports of pain, pruritus, edema, and fatigue, with younger patients and Black patients having significantly increased odds of symptom under-recognition. (2020-12-09)

Predicting breast cancer recurrences
A new tool combining traditional pathology with machine learning could predict which breast cancer patients actually need surgery. The technology, reported in the November issue of American Journal of Physiology -- Cell Physiology (vol. 319: C910-C921; https://doi.org/10.1152/ajpcell.00280.2020), could spare women from unnecessary treatments, reduce medical expenses, and lead to a new generation of drugs to stop breast cancer recurrences. (2020-12-03)

Surrey's new hybrid X-ray detector goes toe-to-toe with state-of-the-art rivals
A new hybrid X-ray detector developed by the University of Surrey outperforms commercial devices - and could lead to more accurate cancer therapy. (2020-11-26)

Survival protein may prevent collateral damage during cancer therapy
Australian researchers have identified a protein that could protect the kidneys from 'bystander' damage caused by cancer therapies. The 'cell survival protein', called BCL-XL, was required in laboratory models to keep kidney cells alive and functioning during exposure to chemotherapy or radiotherapy. Kidney damage is a common side effect of these widely used cancer therapies, and the discovery has shed light on how this damage occurs at the molecular level. (2020-11-25)

Stem cell transplantation: undesirable rejection mechanism identified
In the treatment of leukaemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions - especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A team of researchers in Vienna has now identified an immune mechanism that is partially responsible for this. (2020-11-19)

Is proton therapy the silver bullet for children with brain cancer?
How safe is proton therapy for children with brain cancer compared to the conventional x-ray radiation delivered post-surgery? (2020-11-11)

Every month delayed in cancer treatment can raise risk of death by around 10%
People whose treatment for cancer is delayed by even one month have in many cases a 6 to 13% higher risk of dying - a risk that keeps rising the longer their treatment does not begin - suggests research published online in The BMJ. (2020-11-04)

Microbes in the gut could be protective against hazardous radiation exposure
A study by scientists at UNC Lineberger Comprehensive Cancer Center and colleagues showed that mice exposed to potentially lethal levels of total body radiation were protected from radiation damage if they had specific types of bacteria in their gut. They demonstrated that the bacteria mitigated radiation exposure and enhanced the recovery of blood cell production as well as repair of the gastrointestinal tract. (2020-10-30)

Changes in subcellular traffic increase invasiveness of radioresistant cancer cells
Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy. (2020-10-29)

Outcomes of salvage low dose RT brachytherapy after EBRT for prostate cancer
Researchers involved in the phase II NRG Oncology RTOG 0526 trial studying low dose rate (LDR) prostate brachytherapy (BT) following local recurrence (LR) after external beam radiotherapy (EBRT) for patients with low-to-intermediate risk prostate cancer reported late Grade 3 gastrointestinal and genitourinary adverse events (AEs) occurring in 14% of trial participants. (2020-10-28)

MFS Is a strong surrogate endpoint for OS for men receiving salvage RT for recurrent prostate cancer
An analysis of the phase III NRG Oncology clinical trial RTOG 9601 on men receiving salvage radiotherapy (SRT) following prostatectomy for recurrent prostate cancer indicated that, while biochemical failure (BF) was not a strong surrogate endpoint to determine overall survival (OS), metastasis-free survival (MFS) was in this patient population. (2020-10-26)

Photon IMRT treatment group displays no significant survival difference between arms
A preliminary analysis of photon therapy treatment group 1 from the phase II NRG Oncology clinical trial NRG-BN001 indicates that there is no statistically significant overall survival (OS) or toxicity differences between dose-intensification radiation therapy (DI-RT) using intensity-modulated radiation therapy (IMRT) and standard-dose radiation therapy (SD-RT) with temozolomide treatments for patients with newly diagnosed glioblastoma (GBM). (2020-10-26)

ASTRO highlights Winship study showing increased failure-free survival in prostate cancer
The EMPIRE-1 trial is the first randomized trial of men with prostate cancer with recurring cancer to show that treatment based on advanced molecular imaging can improve disease-free survival rates. (2020-10-23)

Radiation oncology research and clinical trials to be featured at ASTRO's Annual Meeting
The American Society for Radiation Oncology (ASTRO) announced today the press program for its 2020 Annual Meeting, which will feature studies on cancer treatment advances and discussions of topical issues including COVID-19. Researchers will present their findings via live webcasts on October 26 and 27. Register for press access at www.astro.org/annnualmeetingpress. (2020-10-14)

Treating DCIS with surgery and radiotherapy lowers cancer risk but benefits drop over time
A major study of women with DCIS - a breast condition that can become invasive cancer - has shown that surgery to remove the tissue followed by radiotherapy offers better protection compared to surgery alone. The study, presented at the 12th European Breast Cancer Conference, followed patients for up to 27 years. Although it shows that the benefit of radiotherapy and surgery over surgery alone persists, it also suggests that this benefit reduces over time. (2020-10-03)

Risk of heart disease in breast cancer patients can be predicted from routine scans
Automated analysis of breast cancer patients' routine scans can predict which women have a greater than one in four risk of going on to develop cardiovascular disease, according to research presented at the 12th European Breast Cancer Conference. (2020-10-01)

Molecules responsible for radio-resistant glioblastoma identified
Scientists have identified key molecules that mediate radioresistance in glioblastoma multiforme; these molecules are a potential target for the treatment of this brain cancer. (2020-09-30)

High-fibre diet, low level inflammation: sidestepping the effects of radiation
Loved or hated, the humble oat could be the new superfood for cancer patients as international research shows a diet rich in fibre could significantly reduce radiation-induced gut inflammation. (2020-09-29)

Prostate cancer: immunotherapy offers hope
An antibody for treating advanced prostate cancer improves progression-free survival in patients with metastasised, castration-resistant prostate cancer. This is the finding of the long-term analyses of an international phase 3 clinical trial, recently published in the leading journal ''European Urology''. The study showed that overall survival was 2 - 3 times higher than in the placebo arm. (2020-09-29)

No benefit for post-operative radiotherapy in non-small-cell lung cancer
Post-operative radiotherapy (PORT) used in patients with non-small-cell lung cancer (NSCLC) following complete resection and after (neo) adjuvant chemotherapy shows no statistically significant difference in 3-year disease-free survival (DFS), according to data presented at ESMO 2020. These results give the oncology community a long-awaited answer. (2020-09-20)

Genomic analysis predicts survival benefit of adjuvant chemotherapy following radiotherapy over radiotherapy alone in low-grade gliomas in NRG Oncology clinical trial
A practice-changing study, NRG Oncology clinical trial NRG-RTOG 9802, has demonstrated, for the first time, a survival benefit of adjuvant chemotherapy following radiotherapy over radiotherapy alone in certain subgroups of patients with high-risk, low-grade glioma (WHO classification: LGG, grade II), a type of brain tumor that originates from glial cells. (2020-08-31)

Black children with cancer three times less likely to receive proton radiotherapy than White children
A retrospective analysis led by investigators from Brigham and Women's Hospital has found racial disparities in the use of the therapy for patients enrolled in trials. (2020-08-27)

Discovery of new genes that influence the success of cancer treatment
One of the great mysteries of cancer research is why certain patients respond better to radiation therapy than others. Researchers at the University of Bern have now discovered which genes play an important role in this. This results in new findings for cancer treatment. (2020-08-25)

Sortilin may hold the key to combat pancreatic cancer more effectively
Pancreatic cancer has an extremely poor prognosis; it is the third most common cause of cancer deaths in the United States. In a novel study published in The American Journal of Pathology, published by Elsevier, scientists report the discovery of an increased level of the neuroprotein sortilin in pancreatic cancer cells that may open up the way to developing more effective treatment. (2020-08-20)

Radiotherapy, androgen deprivation timing and implications for prostate cancer treatment during COVID-19
National Cancer Database data from 2004 to 2014 were used to examine the association between overall survival and timing of radiotherapy relative to androgen deprivation therapy in patients with prostate cancer. (2020-08-13)

Racial disparities in high-cost cancer treatment for children
This observational study looked at whether race and socioeconomic factors were associated with children enrolled in national clinical trials receiving high-cost proton radiotherapy for treatment of cancer. (2020-08-06)

Outcomes in radiotherapy-treated patients with cancer during COVID-19
The delivery of radiotherapy in 209 patients with cancer during the COVID-19 outbreak in Wuhan, China, is evaluated in this case series. (2020-07-30)

Reprogramming of immune cells enhances effects of radiotherapy in preclinical models of brain cancer
A Ludwig Cancer Research study has dissected how radiotherapy alters the behavior of immune cells known as macrophages found in glioblastoma (GBM) tumors and shown how these cells might be reprogrammed with an existing drug to suppress the invariable recurrence of the aggressive brain cancer (2020-07-15)

Long-term safety of radiotherapy in fewer doses for patients with early breast cancer
A lower total dose of radiotherapy delivered in fewer but larger doses is as safe in the long term as breast cancer radiotherapy courses giving multiple small doses, according to the final results of a 10-year study. (2020-07-14)

Adherence to oral diabetes drugs may improve survival in diabetics with colorectal cancer
Among patients with both colorectal cancer and diabetes in Korea, those who had a high adherence to their oral diabetes medication had a significantly reduced risk of overall mortality compared with those with lower adherence. (2020-06-01)

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