Current Regeneration News and Events

Current Regeneration News and Events, Regeneration News Articles.
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Bioengineered hybrid muscle fiber for regenerative medicine
Scientists regenerate damaged muscle tissue using cell reprogramming technology and natural-synthetic hybrid scaffold. (2021-02-21)

New discovery could pave the way for improved treatments for diabetes
Monash University researchers have uncovered the barrier to β-cell (beta cell) regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage. (2021-02-12)

Novel protein could reverse severe muscle wasting in disease, aging and trauma
Muscle stem cells drive the tissue's growth and repair after such injuries. But growing these cells in the lab and using them to therapeutically replace damaged muscle has been frustratingly difficult. Australian researchers have discovered a factor that triggers these muscle stem cells to proliferate and heal. In a mouse model of severe muscle damage, injections of this naturally occurring protein led to the complete regeneration of muscle and the return of normal movement after severe muscle trauma. (2021-02-10)

A recipe for regenerating bioengineered hair
Scientists have recently developed ways to grow a variety of useful items in laboratories, from meat and diamonds to retinas and other organoids. At the RIKEN Center for Biosystems Dynamics Research in Japan, a team led by Takashi Tsuji has been working on ways to regenerate lost hair from stem cells. In an important step, a new study identifies a population of hair follicle stem cells in the skin and a recipe for normal cyclical regeneration in the lab. (2021-02-10)

Scientists switch on tissue repair in inflammatory bowel disease
Researchers have developed a method that instructs immune system cells to help repair damaged tissue in the intestine. The finding opens the way for more effective treatment of inflammatory bowel disease. (2021-02-08)

Meet the Smurfs: A bone metabolism family
Researchers from Osaka University and Ehime University have found that protein Smurf2 can regulate a cellular pathway that affects bone metabolism. Smurf2 can mark certain messenger proteins--specifically those that are part of the bone morphogenetic protein signaling pathway--for destruction to prevent the signals from going out of control. The BMP-induced bone in mice without Smurf2 had higher mass and formation rates. These findings improve our understanding of various bone defects. (2021-02-08)

Scientists discover a new promising target for diabetes treatment
Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission. (2021-01-27)

Cartilage matrix as natural biomaterial for cartilage regeneration
A working group at MedUni Vienna develops strategies for regeneration of articular cartilage and has found that natural cartilage matrix is suitable as a biomaterial for improved cartilage regeneration. (2021-01-20)

Parkinson's: Initial steps to show nerves their growth direction magnetically
One reason why nerve damage in the brain cannot regenerate easily is that the neurites do not know in which direction they should grow. A team of researchers from Ruhr-Universität Bochum (RUB), Sorbonne University Paris, and the Technische Universität Braunschweig is now working on showing them the direction using magnetic nanoparticles. (2021-01-18)

RUDN University and RLT scientists: Light, magnetic field, and ultrasound could help fight COVID-19
A team of researchers from RUDN University and RLT suggested restoring normal levels of lymphocytes in patients with COVID-19 and other viral diseases by subjecting them to the combined influence of light, magnetic field, and ultrasound. (2021-01-18)

A mathematical study describes how metastasis starts
A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumor invades the epithelial cells and automatically quantifies the progression of the tumor and the remaining cell islands after its progression. The model developed by these researchers could be used to better understand the biophysical characteristics of the cells involved when developing new treatments for wound healing, organ regeneration, or cancer progression. (2021-01-18)

Designer cytokine makes paralyzed mice walk again
To date, paralysis resulting from spinal cord damage has been irreparable. With a new therapeutic approach, scientists from the Department for Cell Physiology at Ruhr-Universität Bochum (RUB) headed by Professor Dietmar Fischer have succeeded for the first time in getting paralyzed mice to walk again. The keys to this are the protein hyper-interleukin-6, which stimulates nerve cells to regenerate, and the way how it is supplied to the animals. (2021-01-15)

A CNIO study links severe COVID-19 disease to short telomeres
The data show that telomeres are shorter in patients suffering more severe COVID-19 pathologies. The researchers propose that one of the consequences of the viral infection is shortening of the telomeres, which, in turn, hampers the regeneration of lung tissue and causes prolonged sequelae in some patients. The study, published in the journal 'Aging', suggests the usefulness of a possible therapy for patients with post-COVID pulmonary injury based on activation of the enzyme telomerase. (2021-01-11)

Stem cell therapy corrects skull, brain function in mouse model of childhood disorder
Using stem cells to regenerate parts of the skull, scientists corrected skull shape and reversed learning and memory deficits in young mice with craniosynostosis, a condition estimated to affect 1 in every 2,500 infants born in the United States, according to the Centers for Disease Control and Prevention. (2021-01-07)

Researchers regenerate deactivated catalyst in methanol-to-olefins process
Researchers from DICP regenerated deactivated catalyst in industrially important methanol-to-olefins (MTO) process by directly transforming the coke deposited on the zeolite catalyst to active intermediates rather than burning off to carbon oxide. (2021-01-04)

Researchers identify a rare genetic bone disorder through massive sequencing methods
Researchers of the Cell Biology and Physiology-LABRET group of the University of Malaga (UMA), together with the Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), have described a new genetic skeletal disorder based on a precision medicine strategy. (2020-12-21)

New study: available drugs can prevent rejection and tissue injury after transplantation
Controlling inflammation after transplantation of organs, cells, or tissues is critical for graft survival; however, it can be difficult. Continuing injuries due to chronic rejection can be particularly problematic. Now, a team of researchers from Albert Einstein College of Medicine report that neutralizing the cell signaling molecule, tumor necrosis factor (TNF), can prevent cascades of injurious molecules and signals after cell transplantation in The American Journal of Pathology, published by Elsevier. (2020-12-21)

Stem cell treatment for vascular diseases can be predicted through real-time observation
The Korea Institute of Science and Technology(KIST) recently announced that the collaborative research team led by Dr. Kwangmeyung Kim from Center for Theragnosis and Sung-Hwan Moon from Stem Cell Research Institute, T&R Biofab Co. Ltd developed a method that can predict the therapeutic efficacy based on the distribution of the initial transplantation of hEPCs by tracking the initial distribution and migration of the transplanted cells using fluorescence romographic images. (2020-12-18)

Identifying where to reforest after wildfire
Forest managers can now look to a newly enhanced, predictive mapping tool to learn where forests are likely to regenerate on their own and where replanting efforts may be beneficial. This study also indicates a not-so-evergreen future of fewer conifers. (2020-12-18)

Neuroregenerative gene therapy
Spinal cord injury (SCI) often causes disability and seriously compromises quality of life. The major reasons for the difficulty of treatment for SCI might be due to the fact that many neurons are lost during the injury, leading to permanent loss of neural functions. An innovative gene therapy approach regenerated functional new neurons using local glial cells in the injured spinal cord, bringing new hope to millions of SCI patients worldwide. (2020-12-16)

Researchers discover clue to how to protect neurons and encourage their growth
Researchers have identified a family of enzymes whose inhibition both protects neurons and encourages their growth, a pathway to potential new treatments for neurodegenerative diseases from Alzheimer's to glaucoma. (2020-12-14)

Not just lizards - alligators can regrow their tails too
A team of researchers from Arizona State University and the Louisiana Department of Wildlife and Fisheries have uncovered that young alligators have the ability to regrow their tails up to three-quarters of a foot, or 18% of their total body length. (2020-11-23)

Discovery illuminates how cell growth pathway responds to signals
A basic science discovery by researchers at the Johns Hopkins Bloomberg School of Public Health reveals a fundamental way cells interpret signals from their environment and may eventually pave the way for potential new therapies. (2020-11-20)

Internal clocks drive beta cell regeneration
Our body can repair itself after a damage. This phenomenon describes how cells that are still functional start to proliferate to compensate for the loss. By studying diabetic mice, scientists from the University of Geneva and the University Hospitals of Geneva, observed that this regeneration mechanism was under the influence of circadian rhythms, allowing new perspectives to be envisaged to promote beta cell regeneration. (2020-11-11)

Printable ink guides cell growth, offers nerve injury hope
New research has cracked a major challenge in the emerging field of nerve engineering. The ink can concentrate neuron growth where it is needed, meticulously guiding cells to regrow in lines between the broken ends of a nerve. (2020-11-10)

Scientists use bacteria as micro-3D printers
A team at Aalto University has used bacteria to produce intricately designed three-dimensional objects made of nanocellulose. With their technique, the researchers are able to guide the growth of bacterial colonies through the use of strongly water repellent -- or superhydrophobic -- surfaces. (2020-11-10)

Technique to regenerate optic nerve offers hope for future glaucoma treatment
Scientists have used gene therapy to regenerate damaged nerve fibres in the eye, in a discovery that could aid the development of new treatments for glaucoma, one of the leading causes of blindness worldwide. (2020-11-05)

Promising therapeutic approach against COPD
Chronic obstructive pulmonary disease (COPD) is one of the most common and deadliest diseases worldwide. Until today, COPD is not curable. Researchers at Helmholtz Zentrum München and at the German Cancer Research Center (DKFZ) have now succeeded in curing COPD in mice exposed to chronic cigarette smoke. Their goal is to test the novel therapeutic approach in human clinical trials over the next few years. (2020-11-04)

Molecular compass for cell orientation
Plants have veins that transport nutrients through their body. These veins are highly organized. The hormone auxin travels directionally from cell-to-cell and provides cells with positional information, coordinating them during vein formation and regeneration. Scientists at IST Austria now discovered how cells translate auxin signals into forming a complex system of veins. This phenomenon also applies to wound healing and might lead to more mechanically resistant plants and further agricultural implications. (2020-10-29)

Brazilian researchers discover how muscle regenerates after exercise
Adaptation of muscle tissue to aerobic exercise alters the metabolism of muscle stem cells, helping them recover from injury. Findings may contribute to treatment of cachexia, sarcopenia and other conditions associated with lean mass loss. (2020-10-28)

Identified a subgroup of stem cells that resists ageing and maintains muscle regeneration
For the first time the researchers have demonstrated in a study in mice that not all muscle stem cells age equally, and have identified a subgroup with greater regenerative capacity which is maintained until geriatric age. The finding provides a basis for mitigating the loss of muscle regenerative capacity in very elderly people. (2020-10-27)

Innovative surgery restores movement in patients with Parsonage-Turner syndrome
Orthopedic surgeons at Hospital for Special Surgery performed successful microsurgery to repair damaged nerves and restore muscle strength and movement to patients experiencing paralysis from Parsonage-Turner Syndrome, according to a study published online ahead of print in The Journal of Hand Surgery. (2020-10-27)

Lineage tracing of direct astrocyte-to-neuron conversion for brain repair
A research team led by Prof. Gong Chen at Jinan University (Guangzhou, China) published a work on October 9th in Neural Regeneration Research, providing unambiguous data that brain internal astrocytes are directly converted into neurons through lineage tracing studies. Using brain internal astrocytes, a type of supporting cells to neurons, to directly convert into new neurons is an innovative brain repair technology that may benefit millions of patients worldwide. (2020-10-16)

University of South Carolina research finds trigger that leads to faster nerve healing
Damaged nerves regenerate faster when protein clusters are broken apart, releasing mRNAs that can be used to rebuild the nerve. University of South Carolina scientists have found the trigger that could be used to accelerate regrowth more. (2020-10-15)

Tissue grafts of both bone and cartilage could regenerate damage to a crucial jaw joint
Scientists have engineered tissue grafts that, in pigs, regenerated both bone and cartilage in the temporomandibular joint (TMJ), a part of the jaw that can cause debilitating pain and disability when damaged. (2020-10-14)

Skeletal muscle development and regeneration mechanisms vary by gender
Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice. This was not observed in male mice that lacked the ERβ gene, suggesting that estrogen and its downstream signals may be a female-specific mechanism for muscle growth and regeneration. (2020-10-12)

Damaged muscles don't just die, they regenerate themselves
Researchers building a model of muscle damage in a cultured system found that components leaking from broken muscle fibers activate ''satellite cells,'' which are muscle stem cells. While attempting to identify the activating proteins, they found that metabolic enzymes, such as GAPDH, rapidly activated quiescent satellite cells and accelerated muscle injury regeneration. This is a highly rational and efficient regeneration mechanism, in which the damaged muscle itself activates satellite cells for regeneration. (2020-10-12)

When it comes to arthritic bone spurs, stem cells hurt instead of heal
The same stem cells that heal broken bones can also generate arthritic bone spurs called osteophytes, according to a new study in the Annals of Rheumatic Diseases. By resolving the cellular origins of osteophytes, the research provides clues for how to target these painful bone spurs that develop at the edge of joints in many arthritis patients. (2020-10-09)

Light stimulation makes bones heavier
Tokyo Medical and Dental University (TMDU) researchers showed that laser ablation of bone inhibits expression of the osteogenesis inhibitor protein sclerostin without causing inflammation, unlike the conventional bur-drilling technique. Further investigations confirmed that this beneficial bio-stimulation works by inducing mechanical stress. These findings help advance research into the treatment of osteoporosis as well as specific enhancement of bone regrowth in orthopedic and dental surgery. (2020-10-08)

Stem cell sheets harvested in just two days
POSTECH and Pohang Semyung Christianity Hospital joint research team develops a thermoresponsive nanotopography cell culture platform. (2020-10-08)

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