Current Regenerative Medicine News and Events

Current Regenerative Medicine News and Events, Regenerative Medicine News Articles.
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Hope for children with rare heart condition: novel stem cell therapy to save the day
In a new study, scientists at Okayama University isolated cardiac stem cells and assessed their potential use as regenerative therapy in young patients with cardiac defects. They confirmed the safety and effectiveness of their proposed treatment in early-phase trials and even identified the mechanism through which the stem cells improved cardiac function. Based on these preliminary findings, they hope to proceed to larger clinical trials and move towards pharmaceutical approval in the future. (2021-01-12)

Birmingham research paves the way for new anti-fibrotic therapy for glaucoma
Researchers showed that novel low molecular weight dextran-sulphate, ILB®, can normalise matrix deposition inside the eye and lower IOP in a pre-clinical model of human glaucoma, paving the way for new anti-fibrotic therapies to be developed for the disease. (2021-01-07)

Tracking the formation of the early heart, cell by cell
Richard Tyser and colleagues have mapped the origins of the embryonic mouse heart at single-cell resolution, helping to define the cell types that make up the heart in the earliest days of development. (2021-01-07)

Designer protein patches boost cell signaling
A new class of protein material that interacts with living cells without being absorbed by them can influence cell signaling, a new study shows. The material does this by binding and sequestering cell surface receptors. The discovery could have far-reaching implications for stem cell research and enable the development of new materials designed to modulate the behavior of living systems. (2021-01-06)

New strategy to fight botulinum toxin - expert available
Published research shows a new ''Trojan horse'' approach that produces strong antidotal efficacy in treating lethal botulism. (2021-01-06)

Mid-term clinical trial results show similar outcomes in promising cell therapies for CLI
Mid-term results of the first clinical trial designed specifically to evaluate the safety and effectiveness of two cell therapies that are showing early promise in treating angiitis-induced critical limb ischemia were released in STEM CELLS Translational Medicine. (2021-01-05)

Digging deep for differences in Duchenne muscular dystrophy
A UT Southwestern research team has catalogued gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic mutation that causes Duchene muscular dystrophy (DMD) in humans. The findings, published online recently in PNAS, could lead to new treatments for this devastating degenerative disease and insights into factors that affect muscle development. (2020-12-21)

Study in mice shows genes may be altered through drug repurposing
Researchers screened drugs that can enhance the PAX6 gene and found MEK inhibitors can stimulate PAX6 expression in the eye. They tested this drug in newborn PAX6 deficient mice and found that either topical or oral administration of the drug enhanced PAX6 and partially normalized their eye development. Mice treated with topical MEK inhibitor had clearer corneas (less scarring) and could see better. (2020-12-17)

Molecules derived from omega-3 can regenerate inflamed periodontal tissue
An in vitro study by a Brazilian researcher shows that maresin and resolvin synthesized from fatty acid stimulate periodontal ligament stem cells even in the presence of inflammation (2020-12-16)

Stem cell-derived extracellular vesicles ease brain bleeding in newborn rats
Murine study, by researchers at Sungkyunkwan University in Seoul, shows how extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) can ease IVH-induced brain injuries. (2020-12-15)

Research dispels fears human stem cells contain cancer-causing mutations
Pioneering new research has made a pivotal breakthrough that dispel concerns that human stem cells could contain cancer-causing mutations. (2020-12-14)

Scientists discover how COVID-19 virus causes multiple organ failure in mice
UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs. Using their model, the scientists discovered that the SARS-CoV-2 virus can shut down energy production in cells of the heart, kidneys, spleen and other organs. (2020-12-07)

Radicals seem to be good for the brain
Scientists of the German Center for Neurodegenerative Diseases (DZNE) report in the journal Cell Stem Cell that reactive oxygen molecules, also known as 'free radicals.' are important for the brain's ability to adapt -- at least in mice. (2020-12-04)

Pre-treating progenitor cells with protein-activator slows progression of atherosclerosis
A new treatment for atherosclerosis, commonly known as hardening of the arteries, may be on the horizon, according to a study released in STEM CELLS Translational Medicine (SCTM). (2020-11-24)

World's first: Drug guides stem cells to desired location, improving their ability to heal
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy--a scientific first and major advance for the field of regenerative medicine. (2020-11-24)

Not just lizards - alligators can regrow their tails too
A team of researchers from Arizona State University and the Louisiana Department of Wildlife and Fisheries have uncovered that young alligators have the ability to regrow their tails up to three-quarters of a foot, or 18% of their total body length. (2020-11-23)

Researchers improve neuronal reprogramming by manipulating mitochondria
Researchers at Helmholtz Zentrum München and Ludwig Maximilians University Munich (LMU) have identified a hurdle towards an efficient conversion: the cell metabolism. By expressing neuron-enriched mitochondrial proteins at an early stage of the direct reprogramming process, the researchers achieved a four times higher conversion rate and simultaneously increased the speed of reprogramming. (2020-11-17)

Study reveals how smoking worsens COVID-19 infection in the airways
UCLA researchers using a model of airway tissue created from human stem cells have pinpointed how smoking cigarettes causes more severe infection by SARS-CoV-2, the virus that causes COVID-19, in the airways of the lungs. (2020-11-17)

Internal clocks drive beta cell regeneration
Our body can repair itself after a damage. This phenomenon describes how cells that are still functional start to proliferate to compensate for the loss. By studying diabetic mice, scientists from the University of Geneva and the University Hospitals of Geneva, observed that this regeneration mechanism was under the influence of circadian rhythms, allowing new perspectives to be envisaged to promote beta cell regeneration. (2020-11-11)

New study finds a link between sleep apnea and increased risk of dementia
A new study by Monash University has found that obstructive sleep apnea (OSA) has been linked to an increased risk of dementia. (2020-11-10)

WFIRM scientists create hybrid tissue construct for cartilage regeneration
Wake Forest Institute for Regenerative Medicine scientists have developed a method to bioprint a type of cartilage that could someday help restore knee function damaged by arthritis or injury. (2020-11-09)

Wound-healing biomaterials activate immune system for stronger skin
Researchers at Duke University and the University of California, Los Angeles, have developed a biomaterial that significantly reduces scar formation after a wound, leading to more effective skin healing. This new material, which quickly degrades once the wound has closed, activates an adaptive immune response that can trigger regenerative wound healing, leaving behind stronger and healthier healed skin. (2020-11-09)

Promising therapeutic approach against COPD
Chronic obstructive pulmonary disease (COPD) is one of the most common and deadliest diseases worldwide. Until today, COPD is not curable. Researchers at Helmholtz Zentrum München and at the German Cancer Research Center (DKFZ) have now succeeded in curing COPD in mice exposed to chronic cigarette smoke. Their goal is to test the novel therapeutic approach in human clinical trials over the next few years. (2020-11-04)

Stem cells: new insights for future regenerative medicine approaches
The study published in Open Biology unravels important data for a better understanding of the process of division in stem cells and for the development of safer ways to use them in medicine. (2020-10-28)

Identified a subgroup of stem cells that resists ageing and maintains muscle regeneration
For the first time the researchers have demonstrated in a study in mice that not all muscle stem cells age equally, and have identified a subgroup with greater regenerative capacity which is maintained until geriatric age. The finding provides a basis for mitigating the loss of muscle regenerative capacity in very elderly people. (2020-10-27)

Researchers create human airway stem cells from patients' cells
For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients. Given that airway basal cells are defined as stem cells of the airways because they can regenerate the airway epithelium in response to injury, this study may help accelerate research on diseases impacting the airway, including COVID-19, influenza, asthma and cystic fibrosis. (2020-10-23)

A study indicates that hair loss might be prevented by regulating stem cell metabolism
An international research group headed by Associate Professor Sara Wickstrom at the University of Helsinki has identified a mechanism that is likely to prevent hair loss. (2020-10-13)

When it comes to arthritic bone spurs, stem cells hurt instead of heal
The same stem cells that heal broken bones can also generate arthritic bone spurs called osteophytes, according to a new study in the Annals of Rheumatic Diseases. By resolving the cellular origins of osteophytes, the research provides clues for how to target these painful bone spurs that develop at the edge of joints in many arthritis patients. (2020-10-09)

Terahertz zaps alter gene activity in stem cells
Terahertz light pulses change gene expression in stem cells, report researchers from Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and Tokai University in Japan in the journal Optics Letters. The findings come thanks to a new tool, with implications for stem cell research and regenerative therapy development. (2020-10-08)

Amniotic fluid may yield new, better treatment for ischemic stroke
A study released in STEM CELLS Translational Medicine points the way to a possible new avenue of treatment for ischemic stroke. (2020-10-07)

Mammals share gene pathways that allow zebrafish to grow new eyes
Working with fish, birds and mice, Johns Hopkins Medicine researchers report new evidence that some animals' natural capacity to regrow neurons is not missing, but is instead inactivated in mammals. (2020-10-07)

Excess folic acid during pregnancy harms brain development of mice
A study of pregnant mice found high levels of folic acid were associated with significant changes in brain development of offspring. (2020-10-05)

Survey finds American support for human-animal chimera research
In September 2015, the US National Institutes of Health placed a funding moratorium on research that involves introducing human pluripotent stem cells into animal embryos. To assess attitudes on human-animal chimeric embryo research, investigators conducted a survey among 430 Americans. The results of the survey, which found that 82% of people are supportive of at least some parts of this research, appear October 1 in the journal Stem Cell Reports. (2020-10-01)

Latent lineage potential in neural stem cells enables spinal cord repair in mice
Spinal stem cells in mice can be reprogrammed to generate protective oligodendrocytes after spinal cord injury, enhancing neural repair, according to a new study. (2020-10-01)

Discovery of cells that heal cardiac damage after infarction
Researchers at Cima and the Clinica Universidad de Navarra (Spain) have led an international study identifying the cardiac cells responsible for repairing the damage to this organ after infarction. These ''restorative'' cells are a subpopulation of cardiac fibroblasts that play a fundamental role in the creation of the collagen scar needed to avoid the rupture of the ventricular wall. The research also reveals the molecular mechanisms involved in the activation of these cells and the regulation of their function. (2020-09-29)

Fine-tuning stem cell metabolism prevents hair loss
An international research team has shown in mice that Rictor, a protein that helps to regulate the growth, energy, and oxygen consumption of cells, plays a key role in the cellular metabolism and longevity of hair follicle stem cells / publication in 'Cell Metabolism' (2020-09-28)

Bioelectronic device achieves unprecedented control of cell membrane voltage
Every living cell maintains a voltage across the cell membrane that results from differences in the concentrations of charged ions inside and outside the cell. In an impressive proof-of-concept demonstration, an interdisciplinary team of scientists has developed a bioelectronic system driven by a machine learning algorithm that can shift the membrane voltage in living cells and maintain it at a set point for 10 hours. (2020-09-24)

Breakthrough for tomorrow's dentistry
New knowledge on the cellular makeup and growth of teeth can expedite developments in regenerative dentistry - a biological therapy for damaged teeth - as well as the treatment of tooth sensitivity. The study, which was conducted by researchers at Karolinska Institutet, is published in Nature Communications. (2020-09-23)

BU researchers discover how COVID-19 may trigger fatal levels of lung inflammation
Responding to the COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, requires models that can duplicate disease development in humans, identify potential targets and enable drug testing. Specifically, access to primary human lung in vitro model systems is a priority since a variety of respiratory epithelial cells are the proposed targets of viral entry. (2020-09-21)

Tail regeneration in lungfish provides insight into evolution of limb regrowth
Researchers at UChicago find that the molecular mechanisms underlying tail regeneration in West African lungfish are similar to those seen in amphibians, suggesting the trait evolved in a common ancestor. (2020-09-16)

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