Current Regenerative Medicine News and Events

Current Regenerative Medicine News and Events, Regenerative Medicine News Articles.
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'Walking' molecule superstructures could help create neurons for regenerative medicine
By discovering a new printable biomaterial that can mimic properties of brain tissue, Northwestern University researchers are now closer to developing a platform capable of conditions using regenerative medicine. (2021-02-22)

Organoids grown from bile duct cells repair human livers; may aid liver transplant processes
Organoids grown from bile duct epithelial cells can be used to repair damaged bile ducts in transplanted human livers, researchers report. (2021-02-18)

Phase I clinical trial shows promise of adipose-derived stem cells in treating lymphedema
Results of a phase I clinical trial released in STEM CELLS Translational Medicine shows there is a strong possibility that stem cells may alleviate lymphedema, a chronic debilitating condition affecting up to one in three women treated for breast cancer. (2021-02-17)

Unlocking the mystery behind skeletal aging
Researchers from the UCLA School of Dentistry have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million people worldwide. Findings, published online in the journal Cell Stem Cell, could hold an important key to developing more effective treatments for osteoporosis and improving the lives of an aging population. (2021-02-15)

New discovery could pave the way for improved treatments for diabetes
Monash University researchers have uncovered the barrier to β-cell (beta cell) regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage. (2021-02-12)

Novel protein could reverse severe muscle wasting in disease, aging and trauma
Muscle stem cells drive the tissue's growth and repair after such injuries. But growing these cells in the lab and using them to therapeutically replace damaged muscle has been frustratingly difficult. Australian researchers have discovered a factor that triggers these muscle stem cells to proliferate and heal. In a mouse model of severe muscle damage, injections of this naturally occurring protein led to the complete regeneration of muscle and the return of normal movement after severe muscle trauma. (2021-02-10)

New insights put a freeze on the mechanisms for safely cryopreserving biological materials
The ability to freeze cells and even whole organs without damaging them, known as cryoprotection, is of considerable interest to medical practitioners, and scientists have experimented with chemicals called polyampholytes as cryoprotectants. In an article recently published in Communications Materials, a team of Japanese scientists now describes the mechanisms by which polyampholytes act to enable cryoprotection. Their insights may aid efforts to develop improved chemical cryoprotection technologies. (2021-02-09)

Molecular sleuthing identifies and corrects major flaws in blood-brain barrier model
A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center. (2021-02-08)

New stem cell therapy in dogs -- a breakthrough in veterinary medicine
A team of scientists in Japan has developed a novel method to induce stem cell generation from the blood samples of dogs. Through this technique, the scientists hope to advance regenerative therapies in veterinary medicine. This would mean that, in the near future, veterinarians might be able to reverse conditions in dogs that were previously thought incurable. (2021-02-03)

Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases. (2021-01-27)

Titanium oxide nanotubes facilitate low-cost laser-assisted photoporation
Toyohashi University of Technology developed a nanosecond pulse laser-assisted photoporation method using titanium-oxide nanotubes (TNTs) for highly efficient and low-cost intracellular delivery. HeLa - human cervical cancer cells were cultured in the nanotubes and submerged in a solution of biomolecules. After cells were exposed to nanosecond pulse laser, we successfully delivered propidium iodide (PI) and fluorescent dextran into cells with high efficiency and cell viability. (2021-01-25)

Cartilage matrix as natural biomaterial for cartilage regeneration
A working group at MedUni Vienna develops strategies for regeneration of articular cartilage and has found that natural cartilage matrix is suitable as a biomaterial for improved cartilage regeneration. (2021-01-20)

Hope for children with rare heart condition: novel stem cell therapy to save the day
In a new study, scientists at Okayama University isolated cardiac stem cells and assessed their potential use as regenerative therapy in young patients with cardiac defects. They confirmed the safety and effectiveness of their proposed treatment in early-phase trials and even identified the mechanism through which the stem cells improved cardiac function. Based on these preliminary findings, they hope to proceed to larger clinical trials and move towards pharmaceutical approval in the future. (2021-01-12)

Birmingham research paves the way for new anti-fibrotic therapy for glaucoma
Researchers showed that novel low molecular weight dextran-sulphate, ILB®, can normalise matrix deposition inside the eye and lower IOP in a pre-clinical model of human glaucoma, paving the way for new anti-fibrotic therapies to be developed for the disease. (2021-01-07)

Tracking the formation of the early heart, cell by cell
Richard Tyser and colleagues have mapped the origins of the embryonic mouse heart at single-cell resolution, helping to define the cell types that make up the heart in the earliest days of development. (2021-01-07)

Designer protein patches boost cell signaling
A new class of protein material that interacts with living cells without being absorbed by them can influence cell signaling, a new study shows. The material does this by binding and sequestering cell surface receptors. The discovery could have far-reaching implications for stem cell research and enable the development of new materials designed to modulate the behavior of living systems. (2021-01-06)

New strategy to fight botulinum toxin - expert available
Published research shows a new ''Trojan horse'' approach that produces strong antidotal efficacy in treating lethal botulism. (2021-01-06)

Mid-term clinical trial results show similar outcomes in promising cell therapies for CLI
Mid-term results of the first clinical trial designed specifically to evaluate the safety and effectiveness of two cell therapies that are showing early promise in treating angiitis-induced critical limb ischemia were released in STEM CELLS Translational Medicine. (2021-01-05)

Digging deep for differences in Duchenne muscular dystrophy
A UT Southwestern research team has catalogued gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic mutation that causes Duchene muscular dystrophy (DMD) in humans. The findings, published online recently in PNAS, could lead to new treatments for this devastating degenerative disease and insights into factors that affect muscle development. (2020-12-21)

Study in mice shows genes may be altered through drug repurposing
Researchers screened drugs that can enhance the PAX6 gene and found MEK inhibitors can stimulate PAX6 expression in the eye. They tested this drug in newborn PAX6 deficient mice and found that either topical or oral administration of the drug enhanced PAX6 and partially normalized their eye development. Mice treated with topical MEK inhibitor had clearer corneas (less scarring) and could see better. (2020-12-17)

Molecules derived from omega-3 can regenerate inflamed periodontal tissue
An in vitro study by a Brazilian researcher shows that maresin and resolvin synthesized from fatty acid stimulate periodontal ligament stem cells even in the presence of inflammation (2020-12-16)

Stem cell-derived extracellular vesicles ease brain bleeding in newborn rats
Murine study, by researchers at Sungkyunkwan University in Seoul, shows how extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) can ease IVH-induced brain injuries. (2020-12-15)

Research dispels fears human stem cells contain cancer-causing mutations
Pioneering new research has made a pivotal breakthrough that dispel concerns that human stem cells could contain cancer-causing mutations. (2020-12-14)

Scientists discover how COVID-19 virus causes multiple organ failure in mice
UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs. Using their model, the scientists discovered that the SARS-CoV-2 virus can shut down energy production in cells of the heart, kidneys, spleen and other organs. (2020-12-07)

Radicals seem to be good for the brain
Scientists of the German Center for Neurodegenerative Diseases (DZNE) report in the journal Cell Stem Cell that reactive oxygen molecules, also known as 'free radicals.' are important for the brain's ability to adapt -- at least in mice. (2020-12-04)

Pre-treating progenitor cells with protein-activator slows progression of atherosclerosis
A new treatment for atherosclerosis, commonly known as hardening of the arteries, may be on the horizon, according to a study released in STEM CELLS Translational Medicine (SCTM). (2020-11-24)

World's first: Drug guides stem cells to desired location, improving their ability to heal
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy--a scientific first and major advance for the field of regenerative medicine. (2020-11-24)

Not just lizards - alligators can regrow their tails too
A team of researchers from Arizona State University and the Louisiana Department of Wildlife and Fisheries have uncovered that young alligators have the ability to regrow their tails up to three-quarters of a foot, or 18% of their total body length. (2020-11-23)

Researchers improve neuronal reprogramming by manipulating mitochondria
Researchers at Helmholtz Zentrum München and Ludwig Maximilians University Munich (LMU) have identified a hurdle towards an efficient conversion: the cell metabolism. By expressing neuron-enriched mitochondrial proteins at an early stage of the direct reprogramming process, the researchers achieved a four times higher conversion rate and simultaneously increased the speed of reprogramming. (2020-11-17)

Study reveals how smoking worsens COVID-19 infection in the airways
UCLA researchers using a model of airway tissue created from human stem cells have pinpointed how smoking cigarettes causes more severe infection by SARS-CoV-2, the virus that causes COVID-19, in the airways of the lungs. (2020-11-17)

Internal clocks drive beta cell regeneration
Our body can repair itself after a damage. This phenomenon describes how cells that are still functional start to proliferate to compensate for the loss. By studying diabetic mice, scientists from the University of Geneva and the University Hospitals of Geneva, observed that this regeneration mechanism was under the influence of circadian rhythms, allowing new perspectives to be envisaged to promote beta cell regeneration. (2020-11-11)

New study finds a link between sleep apnea and increased risk of dementia
A new study by Monash University has found that obstructive sleep apnea (OSA) has been linked to an increased risk of dementia. (2020-11-10)

WFIRM scientists create hybrid tissue construct for cartilage regeneration
Wake Forest Institute for Regenerative Medicine scientists have developed a method to bioprint a type of cartilage that could someday help restore knee function damaged by arthritis or injury. (2020-11-09)

Wound-healing biomaterials activate immune system for stronger skin
Researchers at Duke University and the University of California, Los Angeles, have developed a biomaterial that significantly reduces scar formation after a wound, leading to more effective skin healing. This new material, which quickly degrades once the wound has closed, activates an adaptive immune response that can trigger regenerative wound healing, leaving behind stronger and healthier healed skin. (2020-11-09)

Promising therapeutic approach against COPD
Chronic obstructive pulmonary disease (COPD) is one of the most common and deadliest diseases worldwide. Until today, COPD is not curable. Researchers at Helmholtz Zentrum München and at the German Cancer Research Center (DKFZ) have now succeeded in curing COPD in mice exposed to chronic cigarette smoke. Their goal is to test the novel therapeutic approach in human clinical trials over the next few years. (2020-11-04)

Stem cells: new insights for future regenerative medicine approaches
The study published in Open Biology unravels important data for a better understanding of the process of division in stem cells and for the development of safer ways to use them in medicine. (2020-10-28)

Identified a subgroup of stem cells that resists ageing and maintains muscle regeneration
For the first time the researchers have demonstrated in a study in mice that not all muscle stem cells age equally, and have identified a subgroup with greater regenerative capacity which is maintained until geriatric age. The finding provides a basis for mitigating the loss of muscle regenerative capacity in very elderly people. (2020-10-27)

Researchers create human airway stem cells from patients' cells
For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients. Given that airway basal cells are defined as stem cells of the airways because they can regenerate the airway epithelium in response to injury, this study may help accelerate research on diseases impacting the airway, including COVID-19, influenza, asthma and cystic fibrosis. (2020-10-23)

A study indicates that hair loss might be prevented by regulating stem cell metabolism
An international research group headed by Associate Professor Sara Wickstrom at the University of Helsinki has identified a mechanism that is likely to prevent hair loss. (2020-10-13)

When it comes to arthritic bone spurs, stem cells hurt instead of heal
The same stem cells that heal broken bones can also generate arthritic bone spurs called osteophytes, according to a new study in the Annals of Rheumatic Diseases. By resolving the cellular origins of osteophytes, the research provides clues for how to target these painful bone spurs that develop at the edge of joints in many arthritis patients. (2020-10-09)

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