Current Resveratrol News and Events

Current Resveratrol News and Events, Resveratrol News Articles.
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Compounds from apples may boost brain function
Natural compounds found in apples and other fruits may help stimulate the production of new brain cells, which may have implications for learning and memory, according to a new study in mice published in Stem Cell Reports. (2021-02-11)

Novel Drosophila-based disease model to study human intellectual disability syndrome
The researchers from the TalTech molecular neurobiology laboratory headed by professor Tõnis Timmusk used the fruit fly, Drosophila melanogaster to develop a novel disease model for Pitt-Hopkins syndrome (PTHS). Their study was reported in the July issue of Disease Models and Mechanisms. (2020-09-29)

Destroying DNA to save the genome -- study offers new insights into sepsis and its treatment
Sepsis is a life-threatening condition that kills millions annually; it is poorly understood and has no specific treatment. Now, researchers from Tata Memorial Centre, India, led by Prof. Dr Indraneel Mittra, have uncovered an important molecular mechanism underlying different aspects of sepsis--chromatin released by dying host cells after infection or injury. The scientists also put forth a novel treatment strategy for sepsis, which targets cell-free chromatin. (2020-03-26)

Extract from seeds of the Melinjo tree may improve obesity and diabetes
In Southeast Asia, the fruit, flowers, and leaves of Indonesia's 'Melinjo' tree are traditional foods. Researchers from Kumamoto University, Japan who study plants from around the world for useful medicinal properties have found that Melinjo seed extract (MSE) stimulates the production of adiponectin, a beneficial hormone that improves obesity and diabetes. They also discovered that individual genotype differences were responsible for variations in its efficacy. (2020-03-23)

University of Minnesota researchers discover Mediterranean diet ingredient may extend life
Researchers at the University of Minnesota Medical School discover a potential new way in which diet influences aging-related diseases. (2020-02-21)

Eelgrass acid and resveratrol produced by cell factories for the first time
Scientists are now able to produce a wide range of sulfated aromatic compounds such as antifouling eelgrass acid, resveratrol and vanillic acid derivatives using microbial production hosts. This pioneering work could lead to new environmentally friendly anti-fouling paint for ships, as well as improved and sustainable nutraceuticals and medicine. (2019-11-04)

Exploring the effect of fasting on age-related diseases
There are many indications that fasting promotes longevity. In recent years, much attention has been devoted to so-called caloric restriction mimetics (CMRs), substances that simulate the health-promoting effects of fasting without the need of life-style change. A study published in EMBO Molecular Medicine reports the identification of a novel candidate CRM. The substance may prove useful in the further research for the treatment of age-related diseases. (2019-10-21)

When added to gene therapy, plant-based compound may enable faster, more effective treatments
Today's standard process for administering gene therapy is expensive and time-consuming--a result of the many steps required to deliver the healthy genes into the patients' blood stem cells to correct a genetic problem. In a discovery that appears in the journal Blood, scientists at Scripps Research believe they have found a way to sidestep some of the current difficulties, resulting in a more efficient gene delivery method that would save money and improve treatment outcomes. (2019-10-17)

New survey confirms muscadine grapes are affected by parasitic nematodes
Muscadines are also known for being hearty grapes, with a tough skin that protects them from many fungal diseases. Bunch grapes are highly susceptible to damage from plant-parasitic nematodes (PPNs), which affect their health, quality, production, and maintenance. Now, thanks to a combined effort between scientists at the University of Georgia and North Carolina State University, we know that PPNs also affect muscadines. (2019-10-15)

Temple scientists solve mystery underlying heart toxicity caused by diabetes drugs
For new diabetes medications, in which one drug aims to address the excess of lipids and glucose in the blood, the therapeutic benefits, while great, frequently are accompanied by dangerous toxic effects to the heart. Why and how these drugs, known as dual PPARα/γ agonists cause heart dysfunction in diabetes patients has been unclear. Now, Temple scientists show that dual PPARα/γ diabetes drugs have a profound toxic effect on the generation and function of mitochondria. (2019-09-25)

Pitt first to grow genetically engineered mini livers to study disease and therapeutics
In a proof-of-concept paper, Pitt researchers chronicle how they transformed genetically engineered human cells into functional, 3D liver tissue that mimics non-alcoholic fatty liver disease (NAFLD) - a condition involving fat buildup in the liver, which can lead to cirrhosis or even liver failure. (2019-08-06)

Compound found in red wine opens door for new treatments for depression, anxiety
A new University at Buffalo-led study has revealed that the plant compound resveratrol, which is found in red wine, displays anti-stress effects by blocking the expression of an enzyme related to the control of stress in the brain. (2019-07-26)

Red wine's resveratrol could help Mars explorers stay strong, says Harvard study
Mars is about 9 months from Earth with today's tech, NASA reckons. As the new space race hurtles forward, Harvard researchers are asking: how do we make sure the winners can still stand when they reach the finish line? Published in Frontiers in Physiology, their study shows that resveratrol substantially preserves muscle mass and strength in rats exposed to the wasting effects of simulated Mars gravity. (2019-07-18)

Drinking red wine on the red planet
BIDMC researchers report that a daily moderate dose of resveratrol significantly preserved muscle function and mitigated muscle atrophy in an animal model mimicking Mars' partial gravity. Novel model innovated by BIDMC researchers will help scientists fill in the blanks about the little understood physiological consequences of partial gravity. (2019-07-18)

Study highlights anti-tumor activity of curcumin on stomach cancer
A review article authored by Brazilian researchers evaluated several compounds with therapeutic potential against gastric tumors. (2019-04-22)

Improved understanding of the pathology of dwarfism may lead to new treatment targets
Pseudoachondroplasia (PSACH) is a severe inherited dwarfing condition In PSACH, a genetic mutation leads to abnormal retention of cartilage oligomeric matrix protein (COMP) within the endoplasmic reticulum (ER) of cartilage-producing cells (chondrocytes), which interferes with function and cell viability. In a report in The American Journal of Pathology, investigators describe how this protein accumulation results in 'ER stress' and initiates a host of pathologic changes. These findings may open up new ways to treat PSACH and other ER-stress-related conditions. (2018-12-12)

Statins vs. nutraceutical (Longevinex®) for vision threatening cholesterol deposits
Drusen deposits approached the visual center (fovea) of the patient's only functional eye. Use of the National Eye Institute AREDS antioxidant dietary supplement and then two successive statin drugs increased the drusen-free area from ~1500 to ~5000 pixels but were not able to eradicate visual distortions on a home vision test. A weight-loss diet and use of a resveratrol-based dietary supplement (Longevinex®) doubled the drusen-free area from 5074 to 9064 pixels and resolved visual aberrations. (2018-10-08)

Root extract of Chinese medicinal plant makes worms to live longer
A root extract of the Fallopia multiflora, or Chinese knotweed, has special properties: it enables the nematode C. elegans to live longer and protects it from oxidative stress. This has been demonstrated in a new study by nutritional scientists at Martin Luther University Halle-Wittenberg (MLU). The researchers provide scientifically substantiated evidence for the effectiveness of this extract.They also have identified molecular signalling pathways that could be responsible for the extract's effect. (2018-10-08)

A grape constituent protects against cancer
Lung cancer is the deadliest form of cancer, and 80 percent of death are related to smoking. In addition to tobacco control, effective chemoprevention strategies are therefore needed. A team of scientists from the University of Geneva, Switzerland, studied a well-known natural product, resveratrol, which is found in grapes and in red wine. It had so far shown no effect on lung cancers. Thanks to nasal administration, the UNIGE team obtained very promising results. (2018-10-03)

Is resveratrol an effective add-on to NSAIDS to treat knee osteoarthritis?
In what researchers state is the first pilot clinical trial to assess the effects of resveratrol on pain severity and levels of inflammatory biomarkers in patients with mild to moderate knee osteoarthritis, the scientists compared treatment with a nonsteroidal anti-inflammatory drug (NSAID) combined with either resveratrol or placebo over 90 days. (2018-09-17)

Scientists develop alternative treatment for peripheral artery disease
Cristina Sabliov, LSU Biological and Agricultural Engineering professor, and Tammy Dugas, professor in the LSU School of Veterinary Medicine's Department of Comparative Biomedical Sciences, have joined forces to fight peripheral artery disease, or PAD, an ailment affecting 8 million Americans. (2018-08-28)

Substance found in grapes prevents agglomeration of a mutant protein that leads to cancer
A novel Brazilian study published in Oncotarget is the first to show the action of resveratrol, a bioactive compound present in grapes and red wine, on the inhibition of aggregates of the mutant p53 protein. Because they are found in more than half of human malignant tumors, these amyloid aggregates are considered strategic targets in the fight against cancer. (2018-06-26)

Calorie restriction trial in humans suggests benefits for age-related disease
One of the first studies to explore the effects of calorie restriction on humans showed that cutting caloric intake by 15 percent for two years slowed aging and metabolism and protected against age-related disease. The study, which will appear March 22 in the journal Cell Metabolism, found that calorie restriction decreased systemic oxidative stress, which has been tied to age-related neurological conditions such as Alzheimer's and Parkinson's diseases, as well as cancer, diabetes, and others. (2018-03-22)

A neuron can cause a domino effect
If the sense of smell disappears, this can indicate a disease such as Alzheimer's or Parkinson's disease. However, unlike previously assumed, general degenerations in the nervous system do not play a leading role in the loss of the sense of smell with increasing age, but individual nerve cells or classes of nerves are decisive. (2018-03-01)

Red wine proves good for the heart (again)
Antioxidant compounds found in red wine are advancing the treatment of heart disease -- the leading cause of death for both men and women in the US Researchers have developed drug-eluting stents with red wine antioxidants. (2018-02-01)

Boosting Sirt4 gene activity extends healthy lifespan in fruit flies
Results from study led by Brown University researchers illustrate that Sirt4, also found in humans, may be an important factor in age-related metabolic decline and healthy lifespan. (2018-01-29)

Berry gives boost to cervical cancer therapy
According to the Centers for Disease Control and Prevention, approximately 12,000 women in the United States are diagnosed with cervical cancer each year. One of the most common treatments for cervical cancer is radiation. While radiation therapy destroys cancer cells, it also destroys nearby healthy cells. University of Missouri School of Medicine researchers studied in vitro human cancer cells to show that combining blueberry extract with radiation can increase the treatment's effectiveness. (2017-12-29)

How forest fires spoil wine
If wine is cultivated where forest fires occur more often, such as in Australia or Italy, aromas that make the alcoholic drink unpalatable can develop in the finished product. Until now, it wasn't known why this is so and what happens at the molecular level. A team at Technical University Munich is describing why the smoke aromas are stored in grapes and is thus showing the way for growers to eliminate this degradation in quality. (2017-09-26)

Getting fat to 'talk' again could lower blood glucose and weight
Researchers are exploring a novel approach to treating diabetes: implanting a polymer sponge into fat tissue. Their study has shown that in obese mice with symptoms resembling Type 2 diabetes, the implant reduced weight gain and blood-sugar levels -- by getting the fat to 'talk' again. The researchers are presenting their results at the 254th National Meeting & Exposition of the American Chemical Society. (2017-08-22)

Modeling Gulf War illness: Knowing the cause of brain dysfunction is key to finding a cure
When hundreds of thousands of American troops deployed to the Persian Gulf in 1990 and 1991 in the First Gulf War, they were exposed to a variety of chemicals. These chemicals -- especially when coupled with war-related stress -- seem to still be affecting nearly 200,000 Gulf War veterans -- or 25 to 32 percent of those who served--more than 25 years later, and the constellation of resulting symptoms has been termed Gulf War illness . (2017-06-20)

Grape-based compounds kill colon cancer stem cells in mice
Compounds from grapes may kill colon cancer stem cells both in a petri dish and in mice, according to a team of researchers. (2017-06-19)

Starving prostate cancer with what you eat for dinner
When you dine on curry and baked apples, enjoy the fact that you are eating something that could play a role starving -- or even preventing -- cancer. New research from The University of Texas at Austin identifies several natural compounds found in food, including turmeric, apple peels and red grapes, as key ingredients that could thwart the growth of prostate cancer. (2017-06-06)

Nutraceutical (Longevinex) reduces time it takes older eyes to adapt to the dark
For the first time eye researchers have been able to reduce the time it takes for older eyes to adapt to the dark with use of an oral nutraceutical (Longevinex). Prolonged dark adaptation time is a marker of the future onset of a dreaded vision problem -- macular degeneration. The dark adaptation test can predict vision loss 4 years before it occurs. (2017-05-08)

4 exciting advances in food and nutrition research
New discoveries tied to how food affects our body and why we make certain food choices could help inform nutrition plans and policies that encourage healthy food choices. The Experimental Biology 2017 meeting (EB 2017) will showcase groundbreaking research in food policy, nutrition and the biochemistry of food. (2017-04-22)

UNSW scientists unveil a giant leap for anti-aging
UNSW researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars. (2017-03-23)

Metabolites of Resveratrol (Longevinex) pass through blood-ocular barriers in humans
On the heels of a study published last year that showed the red wine molecule resveratrol and its metabolites are found in human cerebrospinal fluid and therefore penetrate the blood-brain barrier, for the first time metabolites of the red wine molecule resveratrol have been detected in ocular tissues of humans as well. [Neurology Oct 2015; Journal Ophthalmology March 20, 2017] (2017-03-22)

University of Alberta research may provide solutions for the future treatment of diabetes
In a study published in the journal Diabetes, researchers at the University of Alberta found that feeding resveratrol to obese mice over a period of 6 weeks altered the makeup of the bacteria in their intestines, improving glucose tolerance. A second experiment, involving fecal transplant from resveratrol fed mice to obese mice with insulin resistance, led to much more dramatic and rapid effects. (2017-03-09)

Can we reverse aging by tweaking our biological machinery?
Humans have been looking for ways to cheat death for centuries. And while we've succeeded in extending our life span, many people suffer ill health in their later years. Now researchers have pivoted to study ways to improve our 'health span' to allow us to enjoy our longevity. The cover story in Chemical & Engineering News, the weekly news magazine of the American Chemical Society, explores whether this could finally unlock the secrets of youth. (2017-03-08)

Resveratrol preserves neuromuscular synapses, muscle fibers in aging mice
red wine, and metformin, a drug often prescribed to fight type 2 diabetes, have many of the neuroprotective benefits of a low-calorie diet and exercise. (2017-03-07)

Resveratrol may be an effective intervention for lung aging
In a study led by Barbara Driscoll, Ph.D., of The Saban Research Institute of Children's Hospital Los Angeles, researchers demonstrate, for the first time that inhaled resveratrol treatments slow aging-related degenerative changes in mouse lung. Lung aging, characterized by airspace enlargement and decreasing lung function, is a significant risk factor for chronic human lung diseases. The study is published online in the journal Thorax. (2017-02-22)

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