Current Retina News and Events

Current Retina News and Events, Retina News Articles.
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Improved vectors for ocular gene therapy
Strategies based on the use of gene therapy to mitigate the effects of mutations that cause blindness are undergoing rapid development. Novel gene vectors now achieve widespread gene delivery and reduce the risks associated with these approaches. (2021-02-22)

New therapeutic approach may help treat age-related macular degeneration effectively
Runt-related transcription factor 1 (RUNX1) has been linked to retinal neovascularization and the development of abnormal blood vessels, which result in vision loss in diabetic retinopathy. Now, scientists have found that RUNX1 inhibition presents a new therapeutic approach in the treatment of age-related macular degeneration (AMD), which is the leading cause of blindness in the elderly worldwide. Their results are reported in The American Journal of Pathology, published by Elsevier. (2021-02-22)

A sharper look at the interior of semiconductors
A research team at Friedrich Schiller University Jena (Germany) developed a high-resolution imaging method based on extreme short-wave UV light. It can be used to examine internal structures in semiconductors non-destructively, and with nanometre precision as the team reported in the current issue of the journal 'Optica'. (2021-02-16)

New research sheds light on vision loss in Batten disease
Progressive vision loss, and eventually blindness, are the hallmarks of juvenile neuronal ceroid lipofuscinosis (JNCL) or CLN3-Batten disease. New research shows how the mutation associated with the disease could potentially lead to degeneration of light sensing photoreceptor cells in the retina, and subsequent vision loss. (2021-02-05)

Synthesized very-long-chain polyunsaturated fatty acids improved retinal function in mice
A University of Utah ophthalmologist is investigating how lipids known as VLC-PUFAs could be used to prevent eye disease thanks to a new way to synthesize them for research. (2021-02-04)

Medicated drops may help close macular holes, helping some patients avoid surgery
Medicated drops may help close small macular holes over a two- to eight-week period, allowing some people to avoid surgery to fix the vision problem, a new study suggests. (2021-01-21)

A rift in the retina may help repair the optic nerve
In experiments in mouse tissues and human cells, Johns Hopkins Medicine researchers say they have found that removing a membrane that lines the back of the eye may improve the success rate for regrowing nerve cells damaged by blinding diseases. (2021-01-14)

Retinal cell transplant clears experimental hurdle toward treating blindness
Retinal cells derived from adult human eye stem cells survived when transplanted into the eyes of monkeys, an important early step in the validation of this approach for treating blindness, according to a study by Liu, et al recently published in Stem Cell Reports. The retinal pigment epithelium (RPE), a layer of pigmented cells in the retina, is essential for sustaining normal vision. Blindness due to RPE dysfunction, such as macular degeneration, affects about 200 million people worldwide. (2021-01-14)

Scientists take important step toward using retinal cell transplants to treat blindness
Latest discovery is promising step in use of cell therapy to treat retinal diseases (2021-01-14)

A niche for the eye
What if the degenerative eye conditions that lead to glaucoma, corneal dystrophy, and cataracts could be detected and treated before vision is impaired? Recent findings from the lab of Investigator Ting Xie, PhD, at the Stowers Institute for Medical Research point to the ciliary body as a key to unlocking this possibility. (2021-01-13)

Routine eye scans may give clues to cognitive decline in diabetes
As they age, people with diabetes are more likely to develop Alzheimer's disease and other cognitive disorders than are people without diabetes. Scientists at Joslin Diabetes Center now have shown that routine eye imaging can identify changes in the retina that may be associated with cognitive disorders in older people with type 1 diabetes. These results may open up a relatively easy method for early detection of cognitive decline in this population. (2021-01-05)

AI algorithms detect diabetic eye disease inconsistently
In a paper published Jan. 5 in Diabetes Care, researchers compared seven algorithms to detect diabetic retinopathy against the diagnostic expertise of retina specialists. (2021-01-05)

Tracing the many paths of vision
New study decodes the molecular diversity of neurons in the zebrafish retina. (2020-12-23)

AI-supported test predicts eye disease three years before symptoms
A pioneering new eye test, developed by scientists at UCL in collaboration with the Western Eye Hospital, London, may predict wet AMD, a leading cause of severe sight loss, three years before symptoms develop, finds a new study in Expert Review of Molecular Diagnostics. (2020-12-18)

Surgical and drug treatment options lead to similar outcomes for diabetic eye disease
Surgical and injectable drug approaches are equally effective for treatment of bleeding inside the eye from proliferative diabetic retinopathy (PDR), according to a National Eye Institute (NEI)-supported clinical study from the DRCR Retina Network (DRCR.net). (2020-12-15)

Development of the first biohybrid artificial retina built with silk fibroin and retinal cells.
An international research led by the Complutense University of Madrid has taken a further step to solve Age-related Macular Degeneration (AMD)-derived blidness problem with the development of the first biohybrid artificial retina built with silk fibroin and retinal cells. (2020-12-11)

A matter of balance: asymmetric divisions are crucial to form a functional retina
Researchers at the Instituto Gulbenkian de Ciência and the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, have discovered that in the developing retina, and important part of the central nervous system, the divisions leading to the first differentiating neurons are asymmetric and that this asymmetry is necessary to generate the correct types of neurons in the right numbers and proportions. (2020-12-11)

New insights about age-related macular degeneration could spur better treatments
Experiments in a mouse model have uncovered mechanisms involved in abnormal blood vessel formation in ''wet'' age-related macular degeneration. Certain inflammatory pathways and proteins may be attractive therapeutic targets for the disease. (2020-12-11)

Brain clears the way for binocular vision even before eyes are open
The brain architecture of binocular vision is laid down even before a young mouse's eyes are open. About half of the chandelier cells, so-named because they have many long extensions that control the firing of hundreds of excitatory pyramidal neurons, are selectively pruned from the developing mouse visual cortex by a process of programmed cell death called apoptosis. (2020-12-07)

Problems with depth perception caused by too many cells
The connections that integrate information from the left and right eyes are set up early in development, but visual experiences are important for fine-tuning the circuits. Without pruning the proper cells, an adult may lack full use of their visual system. (2020-12-07)

Researchers use genomics to identify diabetic retinopathy factors
In the paper, ''Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes,'' published in eLife, researchers identified genes that respond differently in response to high glucose in individuals with and without diabetic retinopathy. (2020-12-07)

Reconstruction of eye tissue gives new insight into outer retina
Researchers used a newly developed imaging technique called serial block face scanning electron microscopy, to produce a digital reconstruction of eye tissues from the outer retina, at very high resolution. This is the first time this technology has been used to fully reconstruct cells from the retina and could provide new insights into the causes of irreversible blinding diseases. (2020-12-02)

New childhood dementia insight
Is the eye a window to the brain in Sanfilippo syndrome, an untreatable form of childhood-onset dementia, Australian researchers ask in a new publication. The findings of the NHMRC-funded project, just published in international journal Acta Neuropathologica Communications, highlight the potential for using widely available retinal imaging techniques to learn more about brain disease and monitor treatment efficacy. (2020-12-01)

Retinal transplant boost opens door to treat eyesight loss
Researchers have identified two cell signals - Ccr5 and Cxcr6 - that are sent out by dying retinal cells to recruit stem cells and repair eye damage. When genetically engineered stem cells with an overabundance of Ccr5 and Cxcr6 cell receptors were transplanted into human and mouse models, they displayed a significantly higher rate of migration to degenerating retinal tissue, rescuing them from death and preserving their function. (2020-12-01)

LSU Health New Orleans discovers drug development target for retinal dystrophies
A team of LSU Health New Orleans researchers reports for the first time that deleting one of the inhibitors of the RPE65 gene in a mouse model that carries a human disease mutation prevents degeneration of cone photoreceptors that are used for daytime high-resolution color vision. (2020-12-01)

UB study identifies new functions in the Machado-Joseph genetic disease
Ataxia is a minority disease with genetic origins, known for its neuromuscular alterations due to the selective loss of neurons in the cerebellum. University of Barcelona researchers have identified new functions in the ataxin 3 gene (ATXN3) -which causes Machado-Joseph disease, the most common type of ataxia- in the development of retina photoreceptors. These results are relevant also to understand other diseases, such as macular degenerations. (2020-11-25)

Eye exam could lead to early Parkinson's disease diagnosis
A simple eye exam combined with powerful artificial intelligence (AI) machine learning technology could provide early detection of Parkinson's disease, according to research being presented at the annual meeting of the Radiological Society of North America (RSNA). (2020-11-23)

An acebuchin-oil-enriched diet helps to reduce hypertension
The acebuche, also know as the wild olive tree, is a variety of tree widely found throughout Spain and covering almost nine million hectares in Andalusia. However, little data is available on the composition and therapeutic potential of acebuchin oil. The studies mainly focus on the composition and pharmacological effects of olive tree leaves and extra virgin olive oil. (2020-11-17)

Retinas: New potential clues in diagnosing, treating Alzheimer's
A study led by the Cedars-Sinai Department of Neurosurgery has identified certain regions in the retina - the lining found in the back of the eye - that are more affected by Alzheimer's disease than other areas. The findings may help physicians predict changes in the brain as well as cognitive deterioration, even for patients experiencing the earliest signs of mild impairment. (2020-11-17)

Researchers from CSIC identify the genetic program that allows us to see in 3D
A group of researchers from the Institute of Neurosciences UMH-CSIC, in Alicante, led by Dr. Eloísa Herrera, has discovered a genetic program essential for the formation of bilateral circuits, such as the one that makes possible 3D vision or the one enabling motor coordination. The finding, carried out in mice, is published today in Science Advances. (2020-11-13)

Scientists speed up artificial organoid growth and selection
The method currently used to produce stem cell-derived tissues has a very limited throughput. By semi-automating tissue differentiation, researchers from MIPT and Harvard have made the process nearly four times faster, without compromising on quality.The new algorithm is also useful for analyzing the factors that affect cell specialization. (2020-11-10)

Diabetes epidemic detected among Xavante indigenous community in Central Brazil
Researchers examine retinas and find high prevalence of type 2 diabetes as well as ocular problems caused by the disease. (2020-11-10)

Technique to regenerate optic nerve offers hope for future glaucoma treatment
Scientists have used gene therapy to regenerate damaged nerve fibres in the eye, in a discovery that could aid the development of new treatments for glaucoma, one of the leading causes of blindness worldwide. (2020-11-05)

Detect with PKAchu
Researchers use genetically engineered mice that fluoresce during PKA activation -- PKAchu -- to observe its activation in retina cells. They found prolonged PKA activates in darkness, after a subsequent light-on mode. Moreover, the activation was seen only in rod cells. The group hopes the results will lead to a better understanding of how our eyes see at night. (2020-10-27)

New strategy for treating common retinal diseases shows promise
Scientists at Scripps Research have uncovered a potential new strategy for treating eye diseases that affect millions of people around the world, often resulting in blindness. (2020-10-27)

Regeneration of eye cells: Warning lights discovered
Moving around in the half-light is difficult but not impossible. To help us in this undertaking we have the rods, a type of photoreceptors present in the retina of vertebrates, capable of detecting very low lights. They are the protagonists of the new study published in PNAS by a team of researchers of SISSA and CNR-Iom which reveals new and essential details of how the retina works and in particular photoreceptors. (2020-10-23)

Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year. (2020-10-21)

Therapy using immune system cells preserves vision in mice implanted with rare eye cancer
A treatment that uses immune system T cells, combined with an immune-boosting drug packaged in an injectable gel, was found to preserve the vision of mice implanted with retinoblastoma tissue. The cancer, which is most commonly diagnosed in infants and young children, is treatable in early stages but can still lead to the loss of vision in about 5% of cases. (2020-10-12)

Mammals share gene pathways that allow zebrafish to grow new eyes
Working with fish, birds and mice, Johns Hopkins Medicine researchers report new evidence that some animals' natural capacity to regrow neurons is not missing, but is instead inactivated in mammals. (2020-10-07)

Researchers identify process for regenerating neurons in the eye and brain
A team of researchers from the University of Notre Dame, Johns Hopkins University, Ohio State University and the University of Florida has identified networks of genes that regulate the process responsible for determining whether neurons will regenerate in certain animals, such as zebrafish. (2020-10-05)

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