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Current Retinitis Pigmentosa News and Events, Retinitis Pigmentosa News Articles.
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A new generation of artificial retinas based on 2D materials
Scientists report they have successfully developed and tested the world's first ultrathin artificial retina that could vastly improve on existing implantable visualization technology for the blind. The flexible 2-D material-based device could someday restore sight to the millions of people with retinal diseases. The researchers will present their results today at the 256th National Meeting & Exposition of the American Chemical Society. (2018-08-20)

Knockdown and replace: A gene therapy twofer to treat blindness
More than 150 different mutations in the light-sensing molecule rhodopsin can cause retinitis pigmentosa, characterized by a progressive loss of night and peripheral vision. A team from the University of Pennsylvania, together with University of Florida collaborators, have developed a treatment for the condition. Successful results in dogs set the stage for testing in humans. (2018-08-20)

Researchers find potential new gene therapy for blinding disease
Scientists funded by the National Eye Institute (NEI) report a novel gene therapy that halts vision loss in a canine model of a blinding condition called autosomal dominant retinitis pigmentosa (adRP). The strategy could one day be used to slow or prevent vision loss in people with the disease. (2018-08-20)

Mount Sinai researchers discover how to restore vision using retinal stem cells
Researchers at Mount Sinai have successfully restored vision in mice through activating retinal stem cells, something that has never been done before. (2018-08-15)

NIH-funded researchers reverse congenital blindness in mice
Researchers funded by the National Eye Institute have reversed congenital blindness in mice by changing supportive cells in the retina called Müller glia into rod photoreceptors. The findings advance efforts toward regenerative therapies for blinding diseases such as age-related macular degeneration and retinitis pigmentosa. (2018-08-15)

Lessons from flies: genetic diversity impacts disease severity
New research offers clues as to why some diseases are highly variable between individuals. The phenomenon is apparent in retinitis pigmentosa, a condition that causes the light-sensing cells in the eye to degenerate. By analyzing thousands of flies, scientists at University of Utah Health found that variation in a background gene, called Baldspot, can make a difference in severity of the disease. (2018-08-06)

Selective neural connections can be reestablished in retina after injury, study finds
The brain's ability to form new neural connections, called neuroplasticity, is crucial to recovery from some types of brain injury, but this process is hard to study and remains poorly understood. A new study of neural circuit repair in the retina shows that neurons can make new connections to the right types of photoreceptors to restore selective connectivity after an injury. (2018-05-24)

Scientists develop method to tweak tiny 'antenna' on cells
Scientists at Johns Hopkins Medicine and the National Tsing Hua University in Taiwan say they have found a fast way to manipulate a cell's cilia, the tiny, fingerlike protrusions that 'feel' and sense their microscopic environment. The experiments, performed in mouse cells, may advance scientists' efforts to not only understand how the nanosized antennae work, but also how to repair them. (2018-05-15)

Genome surgery for eye disease moves closer to reality
Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa. (2018-05-11)

Lab-on-a-chip device mimics eye damage due to intense light
Houston Methodist researchers developed a new lab-on-a-chip technology that could quickly screen possible drugs to repair damaged neuron and retinal connections, like what is seen in people with macular degeneration or who've had too much exposure to the glare of electronic screens. (2018-05-09)

Strategy prevents blindness in mice with retinal degeneration
New research published in Nature Communications outlines a strategy that in mouse models significantly delayed the onset of blindness from inherited retinal degeneration such as retinitis pigmentosa. (2018-05-01)

Immune cells in the retina can spontaneously regenerate
Immune cells called microglia can completely repopulate themselves in the retina after being nearly eliminated, according to a new study in mice from scientists at the National Eye Institute (NEI). (2018-03-21)

Mass. Eye and Ear performs first FDA-approved gene therapy procedure for inherited disease
Massachusetts Eye and Ear made medical history on Tuesday by performing the first post-FDA approval gene therapy for patients with a form of inherited blindness. The occasion marks the beginning of a new era in medicine, as it is the first time any FDA-approved gene therapy has been given to a patient for any inherited disease. (2018-03-20)

Overlooked cell key player in preventing age-related vision loss
Researchers have pinpointed a new therapeutic target for macular degeneration, an eye disease that affects over 10 million Americans and is the leading cause of blindness in adults over 60. The findings show that tree-shaped retinal cells called Müller glia play a key role in preventing degenerative vision loss in rats. (2018-03-06)

The CRISPR Journal debuts with articles by Rodolphe Barrangou, Fyodor Urnov, et al.
The CRISPR Journal, a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers announces the publication of its groundbreaking inaugural issue. (2018-02-15)

The CRISPR Journal inaugural issue published, with content from Rodolphe Barrangou, et al
The CRISPR Journal, a groundbreaking new peer-reviewed journal from Mary Ann Liebert, Inc., publishers, announces the publication of its inaugural issue. (2018-02-15)

Commonalities in late stages of inherited blinding diseases suggest targets for therapy
In studying the late stages of disease in two different canine models of retinitis pigmentosa, a group of progressive and inherited blinding diseases, University of Pennsylvania researchers found commonalities, specifically involving the innate immune system. The findings point to potential new treatment options for the conditions. (2017-12-20)

Genetic treatment for blindness may soon be reality
Patients who had lost their sight to an inherited retinal disease could see well enough to navigate a maze after being treated with a new gene therapy, according to research presented today at AAO 2017, the 121st Annual Meeting of the American Academy of Ophthalmology. (2017-11-10)

Gene therapy shows promise for reversing blindness
Most causes of untreatable blindness occur due to loss of the millions of light sensitive photoreceptor cells that line the retina, similar to the pixels in a digital camera. (2017-10-02)

Blindness study shows how gene causes middle-age sight loss
Chemical changes in the eye that can lead to blindness have been identified by scientists, a conference has heard. (2017-09-06)

Using omega 3 fatty acids to treat Alzheimer's & other diseases?
Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer's disease, age-related macular degeneration, Parkinson's disease and other retinal and neurodegenerative diseases. The key is to be able to intervene during the early stages of the disease. (2017-07-18)

Immune system found to control eye tissue renewal in zebrafish
Researchers at Johns Hopkins Medicine report evidence that zebrafishes' natural ability to regenerate their eyes' retinal tissue can be accelerated by controlling the fishes' immune systems. Because evolution likely conserved this mechanism of regenerative potential in other animals, the new findings may one day advance efforts to combat degenerative eye disease damage in humans. (2017-07-17)

Gene mutation linked to retinitis pigmentosa in Southwestern US Hispanic families
Thirty-six percent of Hispanic families in the U.S. with a common form of retinitis pigmentosa got the disease because they carry a mutation of the arrestin-1 gene, according to a new study from researchers at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health. (2017-06-26)

Oxford student creates first synthetic retina for the visually impaired
A synthetic, soft tissue retina developed by an Oxford University student could offer fresh hope to visually impaired people. Until now, all artificial retinal research has used only rigid, hard materials. The new research, by Vanessa Restrepo-Schild, a 24 year old D.phil student and researcher at the Oxford University, Department of Chemistry, is the first to successfully use biological, synthetic tissues, developed in a laboratory environment. (2017-05-04)

Using CRISPR to reverse retinitis pigmentosa and restore visual function
Using the gene-editing tool CRISPR/Cas9, researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China, have reprogrammed mutated rod photoreceptors to become functioning cone photoreceptors, reversing cellular degeneration and restoring visual function in two mouse models of retinitis pigmentosa. (2017-04-21)

New nano-implant could one day help restore sight
A team of engineers at the University of California San Diego and La Jolla-based startup Nanovision Biosciences Inc. have developed the nanotechnology and wireless electronics for a new type of retinal prosthesis that brings research a step closer to restoring the ability of neurons in the retina to respond to light. The researchers demonstrated this response to light in a rat retina interfacing with a prototype of the device in vitro. (2017-03-14)

Volker Busskamp receives prize for application-oriented neurobiological research
The young researcher has been awarded for his contribution to a gene therapy approach to treat retinitis pigmentosa and for the development of artificial neuronal circuits. Retinitis pigmentosa is an inherited eye disease that leads to blindness. (2017-03-14)

NIH scientists deploy CRISPR to preserve photoreceptors in mice
Silencing a gene called Nrl in mice prevents the loss of cells from degenerative diseases of the retina, according to a new study. The findings could lead to novel therapies for preventing vision loss from human diseases such as retinitis pigmentosa. The study was conducted by researchers at the National Eye Institute (NEI), part of the National Institutes of Health, and was published online today in Nature Communications. (2017-03-14)

Fish eyes may hold key to regenerating human retinas
Research into retinal regeneration in zebrafish has identified a signal that appears to trigger the self-repair process, raising the possibility that human retinas can also be induced to regenerate, naturally repairing damage caused by degenerative retinal diseases and injury, including age-related macular degeneration and retinitis pigmentosa. (2017-03-09)

FASEB Science Research Conference: The Biology of Cilia and Flagella
Research on the biology of the cilium has seen explosive growth as its essential roles in cell signaling and human disease are now well recognized. Sensory cilia act as cellular (2017-02-28)

GARP2 accelerates retinal degeneration in a mouse model
Researchers show that GARP2 accelerates retinal degeneration in mice, and have made an important step toward creating a standardized nomenclature between mice and humans for a measurement of retinal degeneration. (2017-02-16)

A new path to fixing genes in living organisms
A gene-editing method shows promise for using targeted gene-replacement therapy in living organisms. (2017-01-30)

Improving the view on the genetic causes of retinitis pigmentosa
Scientists have discovered that mutations in REEP6 -- a gene that until now had not been associated with a human disease -- can explain some of the cases of retinitis pigmentosa that lacked a genetic diagnosis. (2017-01-13)

Stem cell therapy reverses blindness in animals with end-stage retinal degeneration
A stem cell-based transplantation approach that restores vision in blind mice moves closer to being tested in patients with end-stage retinal degeneration, according to a study published Jan. 10 in Stem Cell Reports. The researchers showed that retinal tissue derived from mouse induced pluripotent stem cells (iPSCs) established connections with neighboring cells and responded to light stimulation after transplantation into the host retina, restoring visual function in half of mice with end-stage retinal degeneration. (2017-01-10)

New gene-editing technology partially restores vision in blind animals
Salk researchers have discovered, for the first time, how to place DNA in specific locations in non-dividing cells. (2016-11-16)

Retinitis pigmentosa may be treated by reprogramming sugar metabolism
Columbia University researchers slowed vision loss in mice with a form of retinitis pigmentosa by reprogramming the metabolism of photoreceptors in the retina. (2016-11-14)

After blindness, the adult brain can learn to see again
More than 40 million people worldwide are blind, and many of them reach this condition after many years of slow and progressive retinal degeneration. Little is known about whether the brain of blind people retains residual capacity to process restored or artificial visual inputs. A new study publishing Oct. 25 in the open-access journal PLOS Biology investigates the brain's capability to process visual information after many years of total blindness, by studying blind patients. (2016-10-25)

Experimental drug, implanted in eye, could fight glaucoma
An experimental drug, consisting of cells manufactured and implanted in the eye to stimulate optic nerve growth and activity, could be an entirely new way of fighting glaucoma, according to BrightFocus Foundation. (2016-10-14)

A first glimpse into disc shedding in the human eye
This glimpse into the inner workings of the eye will help scientists better understand, prevent and manage major eye diseases that affect photoreceptors like age-related macular degeneration and retinitis pigmentosa. (2016-10-13)

Nanoscope Technologies awarded Audacious Goal Initiative grant by National Eye Institute
Nanoscope Technologies has been awarded an Audacious Goal Initiative grant by the National Eye Institute for exploring novel laser based therapeutic gene delivery to the eye. Nanoscope has developed laser based gene delivery and imaging platform to analyze expression of highly-photosensitive Opsin. This will allow retinal stimulation for vision-restoration in patients with RP and other genetic retinal photo-degenerative diseases. RP-patients loose vision in the periphery and laser delivery can accurately treat these peripheral areas. (2016-08-26)

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