Current Rheumatoid Arthritis News and Events

Current Rheumatoid Arthritis News and Events, Rheumatoid Arthritis News Articles.
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Exercising muscle combats chronic inflammation on its own
Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors. (2021-01-22)

Study finds especially high rates of lupus in certain racial/ethnic groups
The US prevalence of the autoimmune disease lupus is 72.8 cases per 100,000 individuals, according to an analysis of population-based registries. The analysis, which is published in Arthritis & Rheumatology, found that the rate is 9 times higher for females than males (128.7 vs. 14.6 per 100,000), and it's highest among American Indians/Alaska Natives and Black females. (2021-01-21)

Developmental origins of eczema and psoriasis discovered
Scientists have created a highly detailed map of skin, which reveals that cellular processes from development are re-activated in cells from patients with eczema and psoriasis inflammatory skin diseases. The study in Science offers potential new drug targets for treating these painful skin diseases and provides a new understanding of inflammatory disease. Part of the global Human Cell Atlas initiative, the research could also provide a template for regenerating healthy skin in the laboratory. (2021-01-21)

New tool removes chemotherapy drugs from water systems
'What goes in, must come out' is a familiar refrain. It is especially pertinent to the challenges facing UBC researchers who are investigating methods to remove chemicals and pharmaceuticals from public water systems. Cleaning products, organic dyes and pharmaceuticals are finding their ways into water bodies with wide-ranging negative implications to health and the environment, explains Dr. Mohammad Arjmand, an assistant professor of mechanical engineering at UBC Okanagan. (2021-01-18)

New England Journal of Medicine publishes COVID-19 treatment trial results
In a multicenter study funded by the National Institutes of Health, a combination of two drugs, baricitinib and remdesivir, reduced time to recovery in hospitalized COVID-19 patients. The results from sites including UT Health San Antonio and University Health were published Dec. 11 in the New England Journal of Medicine. (2021-01-14)

Low fitness linked to higher psoriasis risk later in life
In a major register-based study, scientists at University of Gothenburg, Sweden, have now demonstrated a connection between inferior physical fitness in young adults and elevated risk of the autoimmune disease psoriasis. For the male recruits to compulsory military training who were rated as the least fit, the risk of developing psoriasis later was 35 percent higher than for the fittest. (2021-01-12)

To understand periodontal disease, researchers examine the surprising behavior of T cells
In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone? In a paper published recently in Scientific Reports, researchers from the Forsyth Institute and the Universidad de Chile describe a mechanism that unlocks a piece of the puzzle. (2021-01-11)

Autoimmune diseases: similar molecular signatures in target tissues
A study conducted by Professor Decio L. Eizirik's group - ULB Center for Diabetes Research - and published in Sciences Advances shows that autoimmune diseases, including type 1 diabetes, must be studied in their entirety, taking into account not only the immune system but also the target tissues. Indeed, the key mechanisms induced by inflammation, potentially shared between type 1 diabetes, systemic lupus erythematosus, multiple sclerosis and rheumatoid arthritis, could generate similar molecular signatures at the target tissue level. (2021-01-07)

Hydroxychloroquine blood levels predict clotting risk in patients with lupus
A new study in Arthritis & Rheumatology shows that monitoring patients' blood levels of hydroxychloroquine can predict their clotting risk. (2021-01-06)

A new approach to study autoimmune diseases
A team of researchers led by the Indiana Biosciences Research Institute Diabetes Center's Scientific Director Decio L. Eizirik, MD, PhD, has found that identifying new treatments for autoimmune diseases requires studying together the immune system AND target tissues. This study, ''Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis and rheumatoid arthritis,'' is featured in the Jan. 6, 2021, edition of Science Advances. (2021-01-06)

Polysaccharides from red algae affect mice immune systems, say FEFU scientists
Carrageenans, biologically active polysaccharides isolated from red algae and widely used in the food industry as stabilizers, thickeners, or jelly agents have an express effect on the immune systems of mice, a study reports. The research was carried out by scientists from the School of Biomedicine of Far Eastern Federal University (FEFU), Far Eastern Branch of the Russian Academy of Sciences, and Vilnius University. A related article appears in the Journal of Biomedical Materials Research. (2020-12-29)

Despite recommendations, patients with treatment-resistant hypertension rarely tested for primary al
A retrospective cohort study found that testing for primary aldosteronism in patients with treatment-resistent hypertension was rare and also associated with higher rates of evidence-based treatment and better longitudinal blood pressure control. The findings are published in Annals of Internal Medicine. (2020-12-28)

Arthritis drug may treat immunotherapy-related heart complication
A drug typically prescribed for rheumatoid arthritis may also be effective in treating a rare but potentially deadly heart complication some cancer patients experience after taking immunotherapies, according to a study published in Cancer Discovery and co-led by investigators at Vanderbilt University Medical Center (VUMC). (2020-12-21)

Developing new classification criteria for improving antiphospholipid syndrome research
An international team of more than 80 collaborators led by Hospital for Special Surgery (HSS) investigators is developing new classification criteria for clinical research of antiphospholipid syndrome (APS), a life-threatening autoimmune clotting disorder. In a paper published online in Arthritis Care & Research, the investigators reported on the first two of four phases of criteria development. (2020-12-17)

New therapeutic target pinpointed for stomach cancer
WEHI researchers have identified a key molecular regulator, TNF, which is involved in the progression and spread of stomach cancer, suggesting a potential new approach to treat this devastating disease. (2020-12-16)

Compound derived from thunder god vine could help pancreatic cancer patients
The results of a pre-clinical study led by researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest how a compound derived from the thunder god vine -- an herb used in China for centuries to treat joint pain, swelling and fever -- is able to kill cancer cells and potentially improve clinical outcomes for patients with pancreatic cancer. (2020-12-14)

Baricitinib plus Remdesivir shows promise for treating COVID-19
The combination of baricitinib, an anti-inflammatory drug, and remdesivir, an antiviral, reduced time to recovery for people hospitalized with COVID-19, according to clinical trial results published in The New England Journal of Medicine. The study was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (2020-12-11)

Life expectancy and healthcare costs for patients with rheumatoid arthritis
A new study published in Arthritis & Rheumatology suggests that recent advances in the treatment of rheumatoid arthritis have prolonged patients' lives but also increased healthcare costs. (2020-12-09)

Higher body temperatures still a factor in patients in remission from rheumatoid arthritis
A pioneering study carried out among patients in remission from Rheumatoid Arthritis has determined that they display significantly higher temperatures than healthy individuals. The work, published in PLOSONE and undertaken by University of Malta and Staffordshire University, compares thermographic patterns of patients with Rheumatoid Arthritis (RA) in remission with healthy individuals. (2020-12-09)

The impact of Neandertal DNA on human health
A researcher at the University of Tartu described new associations between Neandertal DNA and autoimmune diseases, prostate cancer and type 2 diabetes. (2020-12-03)

New breakthrough in the treatment of rheumatoid arthritis
People with Rheumatoid Arthritis (RA) could soon benefit from a new drug treatment, otilimab, that not only suppresses inflammation but also significantly reduces patient reported pain scores. (2020-11-25)

TTUHSC scientist takes next step in search for bone disease treatment
For more than a decade, TTUHSC's Hiranmoy Das, Ph.D., has been investigating how KLF2 influences the development of bone and musculoskeletal diseases. Most recently, Das attempted to determine if inducing KLF2 levels in dental pulp derived stem cells will promote osteoblast and the building of new bone. His study, ''KLF2 regulates dental pulp-derived stem cell differentiation through the induction of mitophagy and altering mitochondrial metabolism,'' was published in the September issue of Redox Biology. (2020-11-20)

Link between periodontitis and cardiovascular disease in individuals with rheumatoid arthritis
Rates of both periodontal disease and cardiovascular disease are elevated in individuals with rheumatoid arthritis. New research published in Arthritis & Rheumatology suggests that immune responses to certain bacteria that cause periodontal disease may play a role in patients' higher cardiovascular disease risk. (2020-11-18)

Metabolic signaling plays a crucial role in regulating specialized T cells
Scientists at St. Jude Children's Research Hospital have identified how metabolic signaling pathways influence key immune cells with implications for treating autoimmune disorders and cancer. (2020-11-17)

Study explores sleep apnea, autoimmune disease link
New research by University of Georgia scientists sheds light on why people with obstructive sleep apnea may have associated autoimmune disorders. The results could lead to better approaches to treatment and possibly new drug therapies. (2020-11-17)

Novel technique 'stuns' arthritis pain in shoulder and hip
A novel outpatient procedure offers lasting pain relief for patients suffering from moderate to severe arthritis in their hip and shoulder joints, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA). Researchers said the procedure could help reduce reliance on addictive opiates. (2020-11-16)

Study pinpoints target for managing inflammation, promoting tissue repair
Drugs that can manage the activity of a protein called BCAP could help the body repair IBD-related tissue damage caused by inflammation, according to experts at Cincinnati Children's. (2020-11-16)

Baricitinib treatment linked to reduced mortality in COVID-19 patients
The rheumatoid arthritis drug baricitinib can block viral entry and reduce mortality in patients with moderate to severe COVID-19, according to translational research by an international team coordinated by researchers from Karolinska Institutet in Sweden. The findings, published in the journal Science Advances, support the continuation of ongoing randomized clinical trials. (2020-11-13)

Approved JAK inhibitor baricitinib shows promise against cytokine storm in COVID-19 clinical study
A clinical study involving 601 patients in Italy and Spain suggests that the JAK inhibitor drug baricitinib may enhance survival rates of patients (2020-11-13)

COVID-19 survival among elderly patients could be improved by arthritis drug
A type of arthritis drug may reduce the risk of dying for elderly patients with COVID-19. (2020-11-13)

Scientists pinpoint two new potential therapeutic targets for rheumatoid arthritis
A collaborative team of scientists has pinpointed two new potential therapeutic targets for rheumatoid arthritis - a painful inflammatory disease that affects an estimated 350 million people worldwide. (2020-11-12)

HSS presents innovative research at 2020 ACR Annual Meeting
At this year's American College of Rheumatology virtual meeting, Hospital for Special Surgery (HSS) presented exciting research related to rheumatology and orthopedic surgery. The research focuses on the diagnosis of renal disorders, the risk of venous thromboembolism after total knee replacement (TKR), and the care of pediatric and young adult patients with rheumatologic diseases. There are also studies related to the care of rheumatology patients during the COVID-19 pandemic. (2020-11-09)

Investigators discover unique immune cells in patients with checkpoint inhibitor-induced arthritis
A study from investigators at Hospital for Special Surgery (HSS) and Brigham and Women's Hospital in Boston has found that the synovial fluid and blood of people experiencing checkpoint inhibitor-induced arthritis is populated by a type of T cells rarely seen in people with other types of inflammatory arthritis. The findings are being presented at the virtual American College of Rheumatology annual meeting. (2020-11-08)

Kids with arthritis in less affluent families report longer period of morning stiffness
Children with arthritis affecting five or more joints, called polyarticular juvenile idiopathic arthritis (polyarticular JIA), living in less affluent families were twice as likely to report more than an hour of morning joint stiffness, compared to their counterparts from more affluent families, according to a study by investigators at Hospital for Special Surgery (HSS). Parents and physicians should be aware that morning joint stiffness may indicate early disease symptoms of polyarticular JIA and serve as a more reliable indicator than pain. (2020-11-07)

Black patients with RA less likely to receive biologic, more likely to get glucocorticoids
A new study reveals that Black patients with rheumatoid arthritis (RA) were less likely to be prescribed a biologic treatment and more likely to use glucocorticoids, which carry a risk of serious long-term side effects. This study highlights ongoing racial disparities in the care of patients with rheumatic disease. Details of the study was shared at ACR Convergence, the ACR's annual meeting. (2020-11-06)

Hydroxychloroquine not linked to longer heart rhythm intervals in RA or lupus patientsti
New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, discovers that use of hydroxychloroquine, a generic drug, does not cause any significant differences in QTc length or prolonged QTc, key measures of heart rate, in people with rheumatoid arthritis (RA) or systemic lupus erythematosus. (2020-11-06)

Patients reported international hydroxychloroquine shortages due to COVID-19
A new study shows that patients with rheumatic diseases across Africa, Southeast Asia, the Americas and Europe had trouble filling their prescriptions of antimalarial drugs, including hydroxychloroquine, during the 2020 global coronavirus pandemic, when antimalarials were touted as a possible COVID-19 treatment. Patients who could not access their antimalarial drugs faced worse physical and mental health outcomes as a result. (2020-11-06)

COVID-19 infection rates low in people with rheumatic diseases, most report mild illness
A new study shows that the COVID-19 infection incidence has been low in people with rheumatic diseases, and most of those infected experience a mild course of illness. Additionally, fatalities have been low among rheumatic disease patients infected with COVID-19. Details of this research was presented at ACR Convergence, the American College of Rheumatology's annual meeting. (2020-11-06)

Therapeutic drug monitoring does not improve remission for patients starting infliximab
New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care. (2020-11-06)

Minority patients with rheumatic diseases have worse COVID-19 outcomes
New research at ACR Convergence, the American College of Rheumatology's annual meeting, reveals that people of color with rheumatic disease have worse health outcomes from COVID-19 infection, are more likely to be hospitalized to treat their coronavirus infection, and are more likely to require invasive ventilator treatment. (2020-11-06)

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