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Current Risk Assessment News and Events, Risk Assessment News Articles.
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One in 4 patients with defibrillators experiences boost in heart function over time
A Johns Hopkins-led study of outcomes among 1,200 people with implanted defibrillators -- devices intended to prevent sudden cardiac death from abnormal heart rhythms -- shows that within a few years of implantation, one in four experienced improvements in heart function substantial enough to put them over the clinical threshold that qualified them to get a defibrillator in the first place. (2015-07-27)

Biomarkers higher in binge drinkers
A biomarker found in the blood of alcohol users is significantly higher in binge drinkers than in those who consume alcohol moderately, according to a study by researchers at the University of Illinois at Chicago. The biomarker, called phosphatidylethanol, could be used to screen young adults for harmful or heavy drinking such as binge drinking. (2015-07-23)

Hormesis hypothesis may be acknowledged by US regulatory action
When environmental toxicologist Edward Calabrese at UMass Amherst heard that the US National Regulatory Commission has opened a new docket on proposed rule changes and standards for radiation protection, he felt it as a vindication of his 30-year career. He has long argued that the LNT model has never been properly validated and current federal and international rules on human exposure to chemicals, drugs and low-dose radiation based on it were adopted without rigorous testing. (2015-07-23)

New checklist helps identify children, teens with bereavement disorder
An assessment tool developed jointly by psychiatrists at UCLA and the University of Texas, Houston will be the first to help identify maladaptive grief in youth between 8 and 18. (2015-07-22)

Questionnaire beats blood test in identifying at-risk drinking among ER patients
Emergency room physicians treating patients with alcohol-related trauma can better identify those at risk of future drinking-related trauma with a 10-point questionnaire rather than the standard blood alcohol content test, according to a study in The Journal of the American Osteopathic Association. (2015-07-21)

Study IDs traits of those who screen positive for dementia but refuse diagnostic testing
Two thirds of individuals 65 and older who screened positive for cognitive impairment refused subsequent evaluation according to the first study of its kind to examine older adults' willingness to undergo diagnostic assessment. The Indiana University Center for Aging Research, Regenstrief Institute and Eskenazi Health study of approximately 500 older adults found that individuals living alone were the least likely to agree to diagnostic assessment following a positive screening test for dementia. (2015-07-16)

Increased radiation offers no survival benefit for patients with low-risk prostate cancer
Increased radiation dose is associated with higher survival rates in men with medium- and high-risk prostate cancer, but not men with low-risk prostate cancer, according to a new study from Penn Medicine published this week in JAMA Oncology. (2015-07-16)

Iowa State analysis reveals needs for improvement in youth fitness
A new study provides a snapshot of health-related physical fitness levels for US schoolchildren in grades first through 12th. Iowa State University researchers analyzing data collected nationally through the NFL PLAY 60 FITNESSGRAM Partnership Project found that fitness levels sharply declined as students got older. (2015-07-15)

Anti-stress hormone may provide indication of breast cancer risk
A new study from Lund University in Sweden shows that women with low levels of an anti-stress hormone have an increased risk of getting breast cancer. The study is the first of its kind on humans and confirms previous similar observations from animal experiments. (2015-07-14)

Accuracy of newer cholesterol guidelines in identifying increased risk of CVD events
An examination of the 2013 guidelines for determining statin eligibility, compared to guidelines from 2004, indicates that they are associated with greater accuracy and efficiency in identifying increased risk of cardiovascular disease events and presence of subclinical coronary artery disease, particularly in individuals at intermediate risk, according to a study in the July 14 issue of JAMA. (2015-07-14)

Drinking alcohol while pregnant is common in UK, Ireland, and Australasia
Drinking alcohol while pregnant is common, ranging from 20 to 80 pecent among those questioned in the UK, Ireland, Australia and New Zealand, reveals a study of almost 18,000 women published in the online journal BMJ Open. (2015-07-06)

Restraint and confinement still an everyday practice in mental health settings
Providers of mental-health services still rely on intervention techniques such as physical restraint and confinement to control some psychiatric hospital patients, a practice which can cause harm to both patients and care facilities, according to a new study from the University of Waterloo. (2015-07-06)

Fingolimod in RRMS: Indication of added benefit in certain patients
Based on new analyses conducted by the drug manufacturer, an advantage can be determined in two instead of only one patient group. There are now indications instead of a hint. (2015-07-03)

Simple classroom measures may reduce the impact of ADHD
A systematic review has concluded that non-drug interventions in schools may be effective in improving outcomes such as performance in standardized tests for children with ADHD. However, the research also found so many different types of strategies, often combined in different ways and so many different ways of measuring whether they worked, that it was that it was impossible to clearly identify what works best. (2015-07-01)

Vision screening in preschool-aged children: Benefit and harm still unclear
No new screening studies were identified in an update search. The only new treatment study provided no evidence for a benefit of an earlier start of treatment. (2015-06-30)

Hospital-wide program for delirium, alcohol withdrawal and suicide/harm impacts readmission rates
In a new report, clinicians at Brigham and Women's Hospital describe the implementation and effectiveness of a hospital-wide clinical improvement initiative for acute care patients at risk for delirium, alcohol withdrawal and suicide harm and demonstrate its effectiveness in reducing readmission rates. (2015-06-30)

Multiple pathways progressing to Alzheimer's disease
UC San Diego School of Medicine researchers report that the amyloid cascade hypothesis, long believed to describe the pathology of Alzheimer's disease, is not a fixed and invariable sequence of events. Rather, early indicators or biomarkers of the neurodegenerative condition vary by individual, making preclinical diagnoses more challenging. (2015-06-25)

Low scores on memory and thinking tests may signal Alzheimer's earlier than thought
A new study suggests that errors on memory and thinking tests may signal Alzheimer's up to 18 years before the disease can be diagnosed. The research is published in the June 24, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology. (2015-06-25)

Aflibercept in macular oedema after BRVO: No hint of added benefit
No added benefit can be derived from the dossier because the drug manufacturer presented no relevant data. This is the fourth assessment according to AMNOG that IQWiG has conducted of this drug. (2015-06-23)

Smoking may impact survival after a breast cancer diagnosis
Researchers have found that smoking may increase the risk of dying early in premenopausal women with breast cancer. (2015-06-23)

SAMT project: Identifying best practices for evaluating sustainability in the process industry
The SAMT project of the European Union will work together with leading industrial actors from the cement, oil, metal, water, waste and chemical industries and review the latest scientific developments within the field of sustainability assessment. (2015-06-16)

Active clinician support and assistance are critical to successfully quitting smoking
A new study from a Massachusetts General Hospital research team finds that, while primary care providers' simply asking patients with high-risk smoking histories about their smoking status did not increase patients' likelihood of quitting, providing more direct assistance -- such as talking about how to quit, recommending or prescribing nicotine replacement or pharmaceutical aids, and following up on recommendations -- significantly improved patients' success in becoming smoke-free. (2015-06-15)

New web tool allows public to compare quality of long-term care homes
The public can now make a more informed choice about long-term care thanks to a new online tool launched today that compares facilities across Canada based on nine indicators such as safety, quality of life and general health of residents. (2015-06-10)

Ultrasound screening for abdominal aortic aneurysms: Advantages for men, but not for women
Men benefit from one-time screening. They live longer because a rupture of the abdominal aorta can be avoided. No such evidence is available for women. (2015-06-10)

Tool can accurately predict risk of death within 1 year after admission to hospital
A recently developed tool can accurately predict the risk of death for patients within one year after admission to hospital using routinely collected data, reports a study in CMAJ. (2015-06-08)

Insulin degludec: No hint of added benefit in children and adolescents
No added benefit for adolescents and children with diabetes mellitus can be derived from the drug manufacturer dossier. In girls with type 1 diabetes, severe side effects were more frequent. (2015-06-01)

Recommendations address how to manage seizures in infants
New recommendations offer insights on strategies for treating infants with seizures. (2015-06-01)

The Lancet Diabetes & Endocrinology: 2015 ERA-EDTA Congress media alert
The Lancet Diabetes & Endocrinology is pleased to announce that the following paper will be published to coincide with presentation at the 52nd ERA-EDTA Congress, taking place in London, UK, May 28-31, 2015. (2015-05-29)

Ombitasvir/paritaprevir/r in hepatitis C: Indication of added benefit in certain patients
The new drug combination showed an advantage in three of a total of 16 patient groups, particularly regarding virologic response. The extent of added benefit remains unclear, however. (2015-05-28)

Aftershock assessment
Earthquakes kill, but their aftershocks can cause the rapid collapse of buildings left standing in the aftermath of the initial quake. Research published in the International Journal of Reliability and Safety offers a new approach to predicting which buildings might be most susceptible to potentially devastating collapse due to the ground-shaking aftershock tremors. (2015-05-28)

The safe use of flavorings in e-cigarettes
Flavorings typically used are food grade, which means that are usually ingested rather than inhaled. 'The data available is oral, but safe to eat is not the same as safe to inhale,' says Sandra Costigan, Principle Toxicologist at Nicoventures, a nicotine company owned by BAT. 'There are data gaps, but the meantime, what are the kinds of scientific rationale that will allow us to determine if we can use a flavor and at what level? (2015-05-27)

Cannabis use can be prevented, reduced or delayed
Contrary to some popular beliefs, marijuana is harmful to adolescent brains. Researchers have found that targeting at-risk youth through school programmes can limit their use of this drug (2015-05-26)

Frailer older patients at higher risk of readmission or death after discharge from hospital
Frailer older patients are at higher risk of readmission to hospital or death within 30 days after discharge from a general internal medicine ward, but health care professionals can assess who is at risk using the Clinical Frailty Scale, according to a study in CMAJ. (2015-05-25)

Ledipasvir plus sofosbuvir: Hint of added benefit in further patient group
The documents subsequently submitted by the manufacturer show an advantage in sustained virologic response also for hepatitis C infection of genotype 1 with HIV coinfection without cirrhosis of the liver. (2015-05-22)

Personalized care during eye visits didn't lower HbA1c levels for diabetics
Providing personalized education and risk assessment for patients with diabetes when they visit the ophthalmologist did not improve glycemic control as measured by hemoglobin A1c levels compared with patients who received usual care, according to a study published online by JAMA Ophthalmology. (2015-05-21)

Dasabuvir in hepatitis C: Indication of added benefit in certain patients
The new drug combination showed an advantage in three of a total of 10 patient groups, particularly regarding virologic response. The extent of added benefit remains unclear, however. (2015-05-20)

DATECAN initiative publishes guidelines for time-to-event end point definitions in breast cancer trials
The DATECAN initiative, Definition for the Assessment of Time-to-event Endpoints in CANcer trials, has published guidelines for time-to-event end point definitions in breast cancer trials in a recent issue of the Annals of Oncology. Standardized definitions can help researchers to more easily compare the results of clinical trials. The guidelines developed by the DATECAN initiative can help researchers to have a more uniform usage of key endpoints in the design, conduct, and reporting of clinical trials for patients with breast cancer. (2015-05-19)

Apremilast in plaque psoriasis and psoriatic arthritis: No added benefit can be derived
The dossiers contained neither data from studies of direct comparisons nor indirect comparisons. The manufacturer itself also did not claim an added benefit for its new drug. (2015-05-19)

RAND study finds association between teen sleep patterns and alcohol or marijuana use
Studying adolescents in Southern California, researchers found that the link between sleep and alcohol/marijuana use was consistent even after controlling for other known risk factors, such as depression. For every 10 minutes later that teens went to bed, there was a 6 percent increased risk of alcohol or marijuana use in the previous month. In addition, teens who reported significant trouble sleeping were 55 percent more likely to have used alcohol in the past month. (2015-05-18)

Adding genetic information to risk profile of smokers improves adherence to lung cancer screening
Researchers have found that adding genetic information to a former or current smoker's clinical risk profile results in a reclassification of their risk for lung cancer in about one in four patients. Preliminary findings from their lung cancer screening feasibility study also suggests that those whose genetic and clinical risk placed them in the highest risk category were more likely to adhere to follow-up computed tomography scans during screening. (2015-05-18)

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