Current Sarcoma News and Events

Current Sarcoma News and Events, Sarcoma News Articles.
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Dartmouth-invented technology allows doctors to see beam field during radiation treatment
With the use of the BeamSite Cherenkov imaging camera system invented by DoseOptics, LLC., radiation oncologists at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center can capture real-time external beam delivery images during cancer patients' standard radiation therapy sessions. These images are used to verify that the beam is targeting the exact area intended, and make necessary adjustments to prevent unintentional exposure to patients. (2021-02-04)

Nixing bone cancer fuel supply offers new treatment approach, mouse study suggests
An innovative approach to treating bone tumors - starving cancer cells of the energy they need to grow - could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. (2021-01-26)

Study identifies distinct sub-types of aggressive tumours to allow for targeted treatment
- Angiosarcomas are clinically aggressive tumours that are more prevalent in Asian populations -Study led by Singapore clinician-scientists has found a way to classify angiosarcomas into three subtypes, allowing for more targeted treatment, better outcomes for patients and the development of new therapies - Findings were published in The Journal of Clinical Investigation this year (2020-12-28)

Anti-depressant repurposed to treat childhood cancer
A new study has found that a commonly prescribed anti-depressant may halt growth of a type of cancer known as childhood sarcoma, at least in mice and laboratory cell experiments. The findings, from researchers at Karolinska Institutet in Sweden and MD Anderson Cancer Centre in Texas, ignite hope of novel treatment strategies against this disease. The study is published in the journal Cancer Research. (2020-11-06)

Oncotarget: KDM5A and PHF2 positively control expression of pro-metastatic genes
The cover for Issue 43 of Oncotarget features Figure 6, ''(A) Following the experimental protocol of Franzetti et al. [11] A673-shA1c cells ?/+ Dox (EWS/Fli1high/EWS/Fli1low) were injected into the tail vein, and metastases were allowed to form in the absence of further Dox treatment (to allow recovery of cell growth in EWS/Fli1low cells),'' (2020-10-27)

Researchers uncover crucial gene for growth of Ewing sarcoma
Researchers have discovered a gene that is critical for the development of Ewing sarcoma, a rare type of developmental cancer that presents in bones and soft tissues. Exploring the pharmacological inhibition of RING1B as a clinical therapy to treat Ewing sarcoma could open the door for new treatments for the rare disease. (2020-10-23)

Immunotherapy combo halts rare, stage 4 sarcoma in teen
The patient, whose tumor responded within two weeks after receiving the combination, resumed normal activity and was in a complete remission at the time of the report. (2020-10-16)

The CNIO reprograms CRISPR system in mice to eliminate tumor cells without affecting healthy cells
CNIO researchers destroyed Ewing's sarcoma and chronic myeloid leukaemia tumor cells by using CRISPR to cut out the fusion genes that cause them. For the first time, fusion genes have been selectively and efficiently removed using CRISPR. These genes are attracting a great deal of interest from the research community because they are unique to the tumor cell and are therefore excellent targets for the development of future drugs that only attack the tumor and are harmless for healthy cells. (2020-10-08)

Oncotarget: Exosomes secreted under hypoxia enhance stemness in Ewing's sarcoma
The cover for issue 40 of Oncotarget features Figure 5, ''miR-210 silences the proapoptosis member CASP8AP2,'' by Kling, et al. which reported that hypoxic Ewing's sarcoma cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS cells by enhancing survival. (2020-10-08)

Genetic testing cost effective for newly diagnosed GIST
UC San Diego School of Medicine researchers reported that genetic testing is cost-effective and beneficial for newly diagnosed patients with metastatic gastrointestinal stromal tumors (GIST), a rare type of cancer. (2020-09-28)

New treatment developed by CHOP shows success in high-risk solid tumors
In a breakthrough study, researchers at Children's Hospital of Philadelphia (CHOP) have shown that an enhanced treatment developed in their lab leads to long-term remissions in 80% to 100% of mice with drug-resistant or high-risk solid tumors. The research, which could soon lead to clinical trials, is described in Cancer Research, a journal of the American Association for Cancer Research. (2020-08-24)

Extrachromosomal DNA is common in human cancer and drives poor patients outcomes
The multiplication of genes located in extrachromosomal DNA that have the potential to cause cancer drives poor patient outcomes across many cancer types, according to a Nature Genetics study published Aug. 17, 2020 by a Nature Genetics by a team of researchers including Professors Vineet Bafna and Dr.Paul Mischel of the University of California San Diego and Professor Roel Verhaak of Jackson Laboratories. (2020-08-17)

How viral infections associated with cancer become persistent?
A new study led by Pedro Simas, group leader at Instituto de Medicina Molecular (iMM; Portugal) and Kenneth M. Kaye, Professor at Harvard Medical School (HMS; USA), discovered a region of viral protein LANA that is key for viral latency and persistent infection inside human cells. These findings published today in the prestigious journal PNAS, can potentially be used to develop therapy for KSHV tumors since blocking the function of this LANA region is expected to abolish virus persistence, which would eliminate the cancer cells. (2020-08-17)

Immunotherapy-resistant cancers eliminated in mouse study
In a mouse study, researchers at Washington University School of Medicine in St. Louis have found that an antibody that targets the protein TREM2 empowers tumor-destroying immune cells and improves the effectiveness of cancer immunotherapy. (2020-08-11)

Chemotherapy is used to treat less than 25% of people with localized sarcoma
UCLA researchers have found that chemotherapy is not commonly used when treating adults with localized sarcoma, a rare type of cancer of the soft tissues or bone. In a nationwide analysis of nearly 20,000 patients whose cancer had not yet spread to other organs, the scientists learned that only 22% were treated with some form of chemotherapy. (2020-08-06)

Dana-Farber study advances understanding of rare sarcoma
In this study, scientists discover how abnormal protein disrupts gene expression in synovial sarcoma. For the first time, scientists discover the molecular basis for the cancer-specific targeting properties of the culprit fusion protein found in synovial sarcoma (2020-08-03)

A mouse model was used to determine the personalized treatment for a cancer patient
A team from IDIBELL and ICO, using a mouse orthotopic model, conducted a real-time personalized oncology study to test the best therapeutic option to treat a type of relapse sarcoma. (2020-07-23)

Finding hints at novel target for Ewing sarcoma therapy
A genetic code-reading machine that is overactive in the pediatric cancer Ewing sarcoma causes cell structures called nucleoli to break up, researchers found. A team at UT Health San Antonio's Greehey Children's Cancer Research Institute will study how to take advantage of this finding therapeutically. (2020-07-16)

Researchers have found a molecular explanation to a longstanding enigma in viral oncology
The oncogenic herpesvirus (HHV8 or KSHV) causes a cancer known as Kaposi's Sarcoma. An international team of scientists led by the University of Helsinki has discovered key factors that control the genome maintenance and replication of a virus responsible for lymphatic vascular cancer. (2020-06-09)

Adoptive T-cell therapy ADP-A2M4 targeting MAGE-A4 shows early activity in patients with advanced solid tumors
The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center. (2020-05-29)

Osteosarcoma profiling reveals why immunotherapy remains ineffective
Comprehensive profiling of tumor samples taken from patients with osteosarcoma shows that multiple factors contribute to the traditionally poor responses observed from treatment with immune checkpoint inhibitors, according to new research from The University of Texas MD Anderson Cancer Center. (2020-02-21)

A potential new weapon against deadly brain and soft tissue cancers
Researchers at the USC Viterbi School of Engineering have designed a new drug cocktail that kills some types of brain and soft tissue cancers by tricking the cancer cells to behave as if they were starving for their favorite food -- glucose. The researchers' findings were recently published in the Journal of Biological Chemistry and may pave the way for targeted cancer treatments with greater efficacy and less harmful side effects. (2020-02-20)

Much shorter radiation treatment found to be safe, effective for people with soft tissue sarcoma
A new study led by researchers at UCLA found that treating soft tissue sarcoma with radiation over a significantly shorter period of time is safe, and likely just as effective, as a much longer conventional course of treatment. (2020-02-13)

Identified a determinant protein for tumor progression and metastasis in Rhabdomyos
LOXL2 increases the metastatic capacity of tumors from Rhabdomyoarcoma, a childhood cancer. The metastasic activity of LOXL2 is inside the cells and is independent of its classical function. (2020-01-29)

B cells linked to effective cancer immunotherapy
Cancer patients responded better to immunotherapy and had a better prognosis if their melanoma tumors contained specific clusters of B cells, according to new research from Lund University in Sweden. The study is published in Nature. (2020-01-16)

B-cell enrichment predictive of immunotherapy response in melanoma, sarcoma and kidney cancer
Multiple studies out in Nature indicate that a patient's response to immune checkpoint blockade may depend on B cells located in special structures within the tumor. (2020-01-15)

B cells: New allies in sarcoma immunotherapy?
How can we improve and better personalize the treatment of soft tissue sarcomas, these particularly resistant and aggressive forms of cancer? An international team led by Wolf Hervé Fridman with researchers from Inserm, Sorbonne Université and Université de Paris, has shown that B cells also play a major role in predicting of patient's response to immunotherapy. Their findings, to be published in Nature, pave the way for the personalization of treatments for patients with soft tissue sarcomas. (2020-01-15)

Combination of chemo and diabetes drugs shows potential for treating Ewing sarcoma
Houston Methodist researchers propose a combination of two well-known drugs as a new treatment option for Ewing sarcoma -- one of them typically used to treat diabetes. (2019-12-16)

Turning key metabolic process back on could make sarcoma more susceptible to treatment
Soft tissue sarcoma cells stop a key metabolic process which allows them to multiply and spread, and so restarting that process could leave these cancers vulnerable to a variety of treatments (2019-11-26)

Scientists reveal novel oncogenic driver gene in human gastrointestinal stromal tumors
A team led by Prof. WANG Yuexiang of the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences, together with Prof. Jonathan Fletcher from Brigham and Women's Hospital and Harvard Medical School, described a novel druggable driver gene in gastrointestinal stromal tumors (GISTs). (2019-10-24)

A new route to blocking children's bone cancer
A study in mice showed that reducing a particular hormone signal keeps the cancer from growing and spreading. (2019-10-02)

Markey researchers discover role of nuclear glycogen in non-small cell lung cancers
Researchers at the University of Kentucky Markey Cancer Center have made a breakthrough discovery that solves a mystery long forgotten by science and have identified a potentially novel avenue in pre-clinical models to treat non-small cell lung cancers. (2019-09-12)

Breaking the 'stalemate' in the most common soft tissue sarcoma in children
Rhabdomyosarcoma is the most common soft tissue sarcoma in children. A phase II clinical trial, led by Leo Mascarenhas, M.D., at Children's Hospital Los Angeles, is the first to show improved outcomes in rhabdomyosarcoma in 45 years. (2019-09-12)

Cancer research -- The genetic context is crucial
An Ludwig-Maximilians-Universitaet (LMU) in Munich team has uncovered a mechanism behind the variability in the clinical course of Ewing sarcoma. The interaction between the acquired driver mutation and the germline genetic context in which it occurs determines the course of the disease. (2019-09-11)

Discovered a molecule that regulates the development of cancer in a variety of tumors
Researchers from the Josep Carreras Leukemia Research Institute (IJC), discover that a non-coding region of the genome originates a key molecule for the proliferation of tumors in breast cancer and some types of sarcoma. (2019-09-04)

Chemical screening suggests a two-pronged treatment for pediatric Ewing sarcoma
For children with Ewing sarcoma, an aggressive bone cancer, a combination of two different classes of drugs may work synergistically to turn off the drivers fueling this disease, finds a new study. The combination appears to be more powerful than relying on either treatment alone. (2019-08-14)

Cancer genes and the tumor milieu
In a recent study published in Cancer Research, researchers demonstrate the role of an oncogene in altering the immediate environment of tumors. (2019-07-08)

Scientists identify interactions that stabilize a neurodegeneration-associated protein
A team of researchers led by Nicolas Fawzi, an associate professor in the Department of Molecular Pharmacology, Physiology and Biotechnology at Brown University, used a combination of techniques to determine the atomic interactions that stabilize the liquid, yet 'condensed' phase of FUS, which is found in a a 'solid' or aggregate phase in some people with severe cases of amyotrophic lateral sclerosis (ALS) and a type of dementia called frontotemporal dementia. (2019-07-01)

Cancer survival rates in the young show inconsistent progress
A new study in JNCI Cancer Spectrum finds that dramatic increases in cancer survival in adolescents and young adults are undermined by continuing disparities by race, ethnicity, and socioeconomic status. The patterns here suggest that most of the recent survival increases in this age group were driven by improvements in treatments for HIV/AIDS and related cancers. (2019-06-12)

Immunotherapy drug found safe in treating cancer patients with HIV
The results of a study led by physicians at Fred Hutchinson Cancer Research Center showed that patients living with HIV and one of a variety of potentially deadly cancers could be safely treated with the immunotherapy drug pembrolizumab, also known by its brand name, KEYTRUDA. (2019-06-03)

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