Current Sepsis News and Events | Page 2

Current Sepsis News and Events, Sepsis News Articles.
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MMR vaccine could protect against the worst symptoms of COVID-19
Administering the MMR (measles, mumps, rubella) vaccine could serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection, say a team of experts in this week's mBio, a journal of the American Society for Microbiology. (2020-06-19)

Antihypotensive agent disrupts the immune system in sepsis
Patients who go into shock caused by sepsis (septic shock) are treated with the antihypotensive agent norepinephrine. Researchers from Radboud university medical center published results in today's American Journal of Respiratory and Critical Care Medicine revealing that its use is not without drawbacks: the drug disrupts the immune system and increases susceptibility to infections. This may have negative consequences for patients. Research into alternatives is therefore justified. (2020-06-11)

Small protein, big impact
In meningococci, the RNA-binding protein ProQ plays a major role. Together with RNA molecules, it regulates processes that are important for pathogenic properties of the bacteria. (2020-06-04)

New testing system predicts septic shock outcomes
PME professor Savas Tay and his collaborators have developed a new, extremely sensitive method that can quantify bacteria, an antibiotic resistant gene, and immune molecule levels within sepsis patients, far more rapidly than current protocols. (2020-05-26)

The cardiac depressant factor DPP3 is predicting organ failure in burn patients
High DPP3 blood concentrations are indicating multiple organ failure and poor outcomes. sphingotec commercializes a rapid CE-IVD test for DPP3 on its proprietary point-of-care platform Nexus IB10. (2020-05-14)

Indicators of infection response do not predict severity of pneumonia in children
Blood biomarkers that reflect the body's response to infection -- including white blood cell count, absolute neutrophil count, C-reactive protein (CRP) and procalcitonin -- are generally not useful in predicting the overall severity of community-acquired pneumonia in children, according to a study published in Pediatrics. (2020-05-13)

Better antibiotic dosing could save lives in ICU
More lives could be saved in intensive care units around the world if new antibiotic guidelines designed by The University of Queensland are adopted. (2020-05-08)

Researchers unlock TB vaccine puzzle in findings that could save millions of newborns
An international research team has identified the mechanism behind one of science's most enduring mysteries: what makes the 100-year-old tuberculosis (TB) vaccine so effective at preventing newborn deaths from diseases other than TB? (2020-05-06)

To prevent antimicrobial resistance, vaccinate the world's kids
Childhood vaccination may be a powerful tool in the fight against antimicrobial resistance in low- and middle-income countries, finds a new analysis led by researchers University of California, Berkeley. The study found that immunization with two common vaccines -- the pneumococcal conjugate and rotavirus vaccines -- significantly reduces the rates of acute respiratory infections and diarrhea among small children in these settings. And, with fewer children getting sick or severely sick, fewer are receiving antibiotic treatment. (2020-04-29)

Protein produced in sepsis lowers blood pressure, treatment identified to reverse effects
Temple scientists show that when a molecule known as c-Jun N-terminal kinase (JNK) becomes active in sepsis, it increases the production of a protein called B-type natriuretic peptide (BNP) -- the more BNP that is produced in sepsis, the greater the deterioration of cardiovascular function. But perhaps more significantly, in mice, the researchers show that JNK and BNP activity can be halted, reversing cardiovascular damage and reducing the risk of death from sepsis. (2020-04-23)

Milestone for the early detection of sepsis
Researchers from Graz, Austria, are developing a ground-breaking method that uses biomarkers to detect sepsis 2 to 3 days before the first clinical symptoms appear. This can significantly increase the chances of survival in cases of blood poisoning by bacteria or fungi. (2020-04-21)

Study of sewage finds link between different rates of sepsis in UK and presence of E. coli in the community
A study to be presented at European Congress on Clinical Microbiology and Infectious Diseases (ECCMID) shows that rates of Escherichia coli related sepsis in different regions of the UK could be directly linked to the levels of pathogenic (disease-causing) E. coli in the community, as determined by its presence in sewage in that area. (2020-04-17)

An antibody treatment combats life-threatening sepsis in rodents
Sepsis -- the body's extreme and organ-damaging response to severe infections -- is a major contributor to death in patients battling infectious disease. (2020-04-15)

Calculating early warning scores before they reach hospital can help the sickest patients
Recording National Early Warning Scores (NEWS) when a patient is urgently referred to hospital can improve the process of care for the sickest patients and reduce the time taken to get to hospital, according to a NIHR- funded study at the University of Bristol published in the BJGP today [7 April]. National Early Warning Scores help clinicians recognise when patients are at risk of deterioration, for example as a result of infection such as sepsis. (2020-04-07)

An affordable and fast clinical test that can save human lives and spares at-risk population
LAL is an essential biotech resource for sterility testing of medical devices, but harvesting horseshoe crabs from the ocean to produce it puts pressure on vulnerable animal populations. In a new study, researchers have developed an animal-friendly, sustainable aquaculture method that yields an extra-potent LAL that can check for sepsis-causing bacteria and fungi in human blood. (2020-04-01)

Guidelines on caring for ICU patients with COVID-19
An international team including McMaster University researchers has come together to issue guidelines for health-care workers treating intensive care unit (ICU) patients with COVID-19. (2020-04-01)

New guidelines on caring for ICU patients with COVID-19
An international team including McMaster University researchers has come together to issue guidelines for health-care workers treating intensive care unit (ICU) patients with COVID-19. (2020-04-01)

Destroying DNA to save the genome -- study offers new insights into sepsis and its treatment
Sepsis is a life-threatening condition that kills millions annually; it is poorly understood and has no specific treatment. Now, researchers from Tata Memorial Centre, India, led by Prof. Dr Indraneel Mittra, have uncovered an important molecular mechanism underlying different aspects of sepsis--chromatin released by dying host cells after infection or injury. The scientists also put forth a novel treatment strategy for sepsis, which targets cell-free chromatin. (2020-03-26)

New research shows promise to treat female group A streptococcus genital tract infections
Puerperal sepsis, also known as childbed fever, is the leading cause of maternal deaths. In this novel study in The American Journal of Pathology, published by Elsevier, scientists report on the discovery of group A streptococcus (GAS) surface proteins involved in female reproductive tract infections such as puerperal sepsis that may pave the way to developing vaccines and more effective treatments. (2020-03-19)

Breast milk may help prevent sepsis in preemies
Researchers at Washington University School of Medicine in St. Louis and Mayo Clinic in Rochester, Minn., have found -- in newborn mice -- that a component of breast milk may help protect premature babies from developing life-threatening sepsis. (2020-03-16)

Sensing infection, suppressing regeneration
UIC researchers describe an enzyme that blocks the ability of blood vessel cells to self-heal. By studying mice with sepsis they found that removal of the enzyme allows cells to fully regenerate. (2020-03-11)

The Lancet: First study identifies risk factors associated with death in adults hospitalised with new coronavirus disease in Wuhan
Being of an older age, showing signs of sepsis, and having blood clotting issues when admitted to hospital are key risk factors associated with higher risk of death from the new coronavirus (COVID-19), according to a new observational study of 191 patients with confirmed COVID-19 from two hospitals in Wuhan, China, published in The Lancet. (2020-03-09)

New next-generation sequencing technique dramatically shortens diagnosis of sepsis
A report in The Journal of Molecular Diagnostics, published by Elsevier, describes a new technique that uses real-time next-generation sequencing (NGS) to analyze tiny amounts of microbial cell-free DNA in the plasma of patients with sepsis, offering the possibility of accurate diagnosis of sepsis-causing agents within a few hours of drawing blood. Current diagnostic tests are neither fast nor specific enough to provide timely, critically important information. (2020-03-05)

Sphingotec's endothelial function biomarker bio-ADM® improves risk stratification of sepsis patients at ICUs
New study data show that monitoring blood levels of sphingotec's endothelial function biomarker bio-ADM® on top of guideline parameter lactate improves risk stratification of sepsis patients admitted to intensive care units. (2020-03-05)

Novel sepsis treatment enhances bacterial capture by neutrophil 'traps'
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a novel treatment for sepsis - one of the leading causes of hospital death - that enhances the body's bacteria-capturing neutrophil extracellular traps (NETs) so that they more effectively capture infectious bacteria, resist degradation, and improve sepsis outcomes and survival. (2020-03-05)

New algorithm tracks pediatric sepsis epidemiology using clinical data
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a novel computational algorithm to track the epidemiology of pediatric sepsis, allowing for the collection of more accurate data about outcomes and incidence of the condition over time, which is essential to the improvement of care. (2020-02-27)

sphingotec's biomarker penKid® shows best representation of true glomerular filtration rate and has utility in patients with severe burns two studies show
In-depth method comparison by Dutch group shows that sphingotec's proprietary kidney function biomarker penKid® is currently the most accurate surrogate marker for true glomerular filtration rate in patients with renal impairment (2020-02-19)

Low folate levels can indicate malnutrition in hospital patients
About 10% of patients who come to complex care hospitals may have low levels of folate and other indicators of malnutrition, investigators say. (2020-02-18)

Empty SV40 capsids increase survival of septic rats by eliciting numerous host signaling networks
The cover for issue 6 of Oncotarget features Figure 3, 'The effect of NCs treatments on routine lab results during disease and recovery progress,' by Ben-Nun-Shaul, et al. (2020-02-12)

Pioneering SFU research customizes vaccines to reduce bacterial disease
The invention of vaccines for disease prevention is often cited as one of the miracles of modern medicine. New research from Simon Fraser University suggests that tailoring vaccines based on geography and other factors could substantially reduce overall rates of bacterial disease. (2020-02-03)

Portable device helps doctors diagnose sepsis faster
EPFL researchers have developed a highly sensitive and portable optical biosensor that stands to accelerate the diagnosis of fatal conditions like sepsis. It could be used by ambulances and hospitals to improve the triage process and save lives. (2020-01-23)

Novel approach to immune system could lead to personalized therapy against sepsis
Two mechanisms could afford an alternative approach to studying and treating severe conditions such as sepsis. A combination of resistance to pathogens by means of fever; and temporary tolerance promoted by controlled hypothermia. (2020-01-23)

Study quashes controversial vitamin C treatment for sepsis with global trial
A paper published today in the Journal of the American Medical Association by Monash researchers comprehensively quashes the idea that the vitamin C-based cocktail has any positive impact on patients with sepsis. (2020-01-17)

Sepsis associated with 1 in 5 deaths globally, double previous estimate
Twice as many people as previously believed are dying of sepsis worldwide, according to an analysis published today in The Lancet and announced at the Critical Care Reviews annual meeting in Belfast. Among them are a disproportionately high number of children in poor areas. Led by researchers at the University of Pittsburgh and University of Washington schools of medicine, the study revealed 48.9 million global cases of sepsis in 2017 and 11 million deaths, representing 1 in 5 deaths worldwide. (2020-01-16)

Finding a new way to fight late-stage sepsis
Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body's extreme reaction to infection. (2020-01-06)

New research uncovers improvements in vaccines against meningitis
New research from experts at the University of Nottingham could lead to an improved vaccine to protect against the bacterium, Neisseria meningitides that causes sepsis and meningitis. (2019-12-20)

Sphingotec's biomarker penKid® predicts septic acute kidney injury
Sphingotec reports study data demonstrating that its proprietary renal function biomarker penKid® (Proenkephalin) predicts acute kidney injury (AKI), multi-organ failure and mortality in sepsis patients presenting to the emergency department (ED). (2019-12-20)

sphingotec's endothelial function biomarker bio-ADM® predicts need for organ support in general ICU patient population
Data from more than 2,000 patients enrolled in the FROG-ICU study demonstrate that high levels of bioactive adrenomedullin (bio-ADM®) predict the need for organ support, ionotropes, and vasopressors in the general patient population at admission to the intensive care unit (ICU). (2019-12-20)

Muscle weakness after sepsis linked to mitochondrial dysfunction
Damage to energy-producing mitochondria may underlie prolonged muscle weakness following a sepsis-like condition in mice, according to a new study published today in eLife. (2019-12-10)

Medicine against bone disease found in the leaves of saussurea
Bacterial bone infections are quite resistant to antibiotics and require new therapeutic approaches. A team of researchers from Kant Baltic Federal University discovered the ability of an extract from the leaves of Saussurea controversa to considerably reduce inflammatory processes and increase immune response in cases of osteomyelitis (2019-12-03)

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