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Targeted delivery of highly toxic anti-cancer drug to brain tumors
University of Houston biomedical researcher Sheeren Majd is reporting the development and testing of a new nano-carrier as a potential treatment to deliver highly toxic medicine to glioblastomas, the most common and aggressive form of primary brain tumors. (2021-02-23)

Cytoglobin: key player in preventing liver disease
Researchers have discovered that the use of Cytoglobin (CYGB) as an intravenous drug could delay liver fibrosis progression in mice. CYGB, discovered in 2001 by Professor Norifumi Kawada, is present in hepatic stellate cells, the cells that produce fibrotic molecules such as collagens when the liver has acute or chronic inflammation induced by different etiologies. The enhancement of CYGB on these cells or the injection of recombinant CYGB has the effect of suppressing liver damage and cirrhosis. (2021-02-16)

How healthy lifestyle behaviours can improve cholesterol profiles
Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife. (2021-02-16)

Radioactive bone cement found to be safer in treating spinal tumors
A radioactive bone cement that's injected into bone to provide support and local irradiation is proving to be a safer alternative to conventional radiation therapy for bone tumors, according to a study led by University of California, Irvine researchers. (2021-02-16)

Research highlights ways to protect astronaut cardiovascular health from space radiation
In the inky blackness of space an invisible threat is ever present - radiation. It can have a huge array of negative effects on astronaut health, including cardiovascular disease. However, if we are ever to journey to the red planet, we will need to understand and reduce this risk. A new review charts a course through what we know about the cardiovascular risks of space radiation, and the best ways to protect space travelers. (2021-02-12)

Get a load of ZIF! Better delivery of cancer immunotherapy
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone. (2021-02-11)

Exercise caution after working out in virtual reality
Virtual 'exergaming' has become a popular way to exercise - especially among younger people - since the release of virtual reality (VR) fitness games on consoles such as Nintendo and Playstation. But while VR is undoubtedly raising fitness games to a whole new level, researchers at the University of South Australia are cautioning players about the potential side effects of VR, particularly in the first hour after playing. (2021-02-04)

When rhinos fly: Upside down the right way for transport
When it comes to saving endangered species of a certain size, conservationists often have to think outside the box. (2021-02-01)

Not too big, not too small: Goldilocks analogy found in maze navigation
Research from the Okinawa Institute of Science and Technology Graduate University has taken a close look at how fluids navigate around mazes and obstacles and has found a surprising randomness in how they choose their path. (2021-02-01)

Genetic screening before prescribing could benefit millions
New research finds that millions of UK patients could benefit from genetic screening (cheek swab) before being prescribed common medications including antidepressants, stomach ulcer treatments and painkillers. More than 95 per cent of the population carry a genetic marker that predicts an atypical response to at least one medicine. The study looked at nine of these genetic markers, affecting 56 medicines where there are known drug-gene interactions. (2021-01-29)

Football and inclusion: It all comes down to the right motivational climate
Playing football has the potential to promote the inclusion of young people who are not from the predominant culture of a country, i.e. young migrants. Crucially, the feeling of belonging and being accepted depends on the trainer's approach to training - or more precisely, the motivational climate they create. Task-oriented training is significantly more suitable than training that is geared towards performance and competition. (2021-01-29)

Accurate drug dosages with proton traps
Researchers at Linköping University, Sweden, have developed a proton trap that makes organic electronic ion pumps more precise when delivering drugs. The new technique may reduce drug side effects, and in the long term, ion pumps may help patients with symptoms of neurological diseases for which effective treatments are not available. The results have been published in Science Advances. (2021-01-29)

Childhood cancer survivors are not more likely to terminate their pregnancies
Study finds they have a reduced likelihood of becoming pregnant, however. (2021-01-25)

Researchers develop promising way to find new cancer drugs
The enzymes in human cells known as histone deacetylases, or HDACs, are targets for a handful of anticancer drugs because of their ability to affect gene expression. Now, researchers from the University of Copenhagen have developed a new method to investigate how these enzymes work on a molecular level. This new method can also help identify more precise possible anti-cancer drug candidates at a very high pace. (2021-01-25)

Bioorthogonally catalyzed lethality strategy generates targeting drugs within tumor
Selectively killing tumor while not causing damage to normal cells still remains a challenge in cancer chemotherapy. Professor Hongke Liu from Nanjing Normal University together with Professor Jing Zhao and Professor Zijian Guo from Nanjing University developed a novel strategy---bioorthogonally-catalyzed lethality to generate efficient anticancer species between two non-toxic components only within cancer cells and tumors without external catalysts, realizing the precise and efficient anticancer chemotherapy. (2021-01-25)

Study finds shorter radiation regimen safe, effective for men with advanced prostate cancer
UCLA researchers found shortening a traditional 45-day course of radiation to a five-day course delivered in larger doses is safe and as effective as conventional radiation for men with high-risk forms of prostate cancer. (2021-01-25)

ACSL1 as a main catalyst of CoA conjugation of propionic acid-class NSAIDs in liver
Researchers from Kanazawa University have found that propionic acid-class nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, form ''conjugates'' with coenzyme A (CoA) by one of the acyl-CoA synthetases, ACSL1, in liver. These conjugates have the covalent binding ability to cellular proteins that may lead to liver injury, a rare severe side effect of NSAID treatment. This knowledge could help pharmaceutical companies to generate pain control options with fewer risks of severe side effects. (2021-01-22)

Strange colon discovery explains racial disparities in colorectal cancer
The colons of African-Americans and people of European descent age differently, new research reveals, helping explain racial disparities in colorectal cancer - the cancer that killed beloved 'Black Panther' star Chadwick Boseman at only 43. (2021-01-21)

Benvitimod cream: a new topical treatment for plaque psoriasis
Psoriasis is a chronic inflammatory skin condition characterized by skin plaques and itching. Currently, the most common topical treatments for psoriasis are corticosteroids and vitamin D3 analogs. But these drugs have various side-effects. A recent phase III clinical trial of the novel non-steroidal compound benvitimod in China, published in Chinese Medical Journal, shows that it is safe and effective and could be a promising new topical treatment for psoriasis. (2021-01-19)

New discovery in breast cancer treatment
Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. (2021-01-18)

NIH officials highlight COVID-19 vaccine facts, unknowns for healthcare providers
Healthcare providers must be able to explain the latest data supporting the safety and efficacy of vaccines for coronavirus disease 2019 (COVID-19) so they can strongly encourage vaccination when appropriate while acknowledging that uncertainty and unknowns remain. This message comes from a new commentary co-authored by Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and other leading NIAID scientists in the journal Annals of Internal Medicine. (2021-01-18)

New delivery method promises relief from antipsychotic medication's adverse side effects
A team of neuroscientists and engineers at McMaster University has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body. (2021-01-15)

Chemotherapy with light; only one injection required
Researchers in South Korea have developed a phototherapy technology that can significantly increase efficiency while reducing the pain of chemotherapy and minimizing side effects after treatment. The research team has developed a cancer-targeted phototherapeutic agent that promises complete elimination of cancer cells without side effects. It involves only one injection and repeated phototherapy. (2021-01-14)

COVID-19 vaccine creates incentive to improve our health
While we wait for our turn to get vaccinated against SARS-CoV-2, we could - and probably should - use the time to make sure we bring our healthiest emotional and physical selves to the treatment, a new review of previous research suggests. (2021-01-13)

Faulty metabolism of Parkinson's medication in the brain linked to severe side effects
Until now, the reason why the drug levodopa (L-Dopa), which reduces the motor symptoms of Parkinson's disease, declines in efficacy after a few years' use has been unknown. A side effect that then often occur is involuntary movements. A Swedish-French collaboration, led from Uppsala University, has now been able to connect the problems with defective metabolism of L-Dopa in the brain. The study is published in Science Advances. (2021-01-07)

Ibrutinib with rituximab in previously untreated CLL: indication of added benefit over FCR
Ibrutinib with rituximab in previously untreated CLL: indication of added benefit over FCR. The new drug combination prolongs overall survival in patients in good general health. No study data are available for other patient groups. (2021-01-05)

Heat treatment may make chemotherapy more effective
The study, published in the Journal of Materials Chemistry B, found that ''loading'' a chemotherapy drug on to tiny magnetic particles that can heat up the cancer cells at the same time as delivering the drug to them was up to 34% more effective at destroying the cancer cells than the chemotherapy drug without added heat. (2021-01-05)

New energy conversion layer for biosolar cells
A research team from the Ruhr-Universität Bochum, together with colleagues from Lisbon, has produced a semi-artificial electrode that could convert light energy into other forms of energy in biosolar cells. The technique is based on the photosynthesis protein Photosystem I from cyanobacteria. The group showed that they could couple their system with an enzyme that used the converted light energy to produce hydrogen. (2020-12-21)

Nanotechnology -- nanoparticles as weapons against cancer
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have developed a novel type of nanoparticle that efficiently and selectively kills cancer cells, thus opening up new therapeutic options for the treatment of tumors. (2020-12-18)

Oral contraceptive pills protect against ovarian and endometrial cancer
A comprehensive study from Uppsala University, involving more than 250,000 women, shows that oral contraceptive use protects against ovarian and endometrial cancer. The protective effect remains for several decades after discontinuing the use. The study is published in the journal Cancer Research. (2020-12-17)

Colorful, magnetic Janus balls could help foil counterfeiters (video)
Counterfeiters who sell knockoffs of popular shoes, handbags and other items are becoming increasingly sophisticated, forcing manufacturers to find new technologies to stay one step ahead. Now, researchers reporting in ACS Nano have developed tiny ''Janus balls'' that show their colored side under a magnetic field. These microparticles could be useful in inks for anti-counterfeiting tags, which could be verified with an ordinary magnet, the researchers say. (2020-12-16)

Drugs create balancing act for patients with non-small cell lung cancer
Johns Hopkins Kimmel Cancer Center and Bloomberg~Kimmel Institute for Cancer Immunotherapy researchers identified a correlation between multisystem immune-related adverse events and improved rates of survival. This new information will be helpful in discussing with patients the spectrum of immune side effects that may occur from immunotherapy and the implications for their future. (2020-12-14)

Rewiring stroke survivors brains could alleviate depression
University of South Australia researchers have made a major breakthrough in the treatment of depression after stroke, using a high frequency brain stimulation device to improve low moods. (2020-12-11)

Immunotherapy improves responses w/o reducing quality of life in early breast cancer
Adding an immune checkpoint inhibitor to the standard chemotherapy regimen for patients with early-stage breast cancer places no greater burden on patients' ability to perform day-to-day activities than chemotherapy alone, new research by Dana-Farber/Brigham and Women's Cancer Center investigators shows. (2020-12-10)

Calibrating kidney function for cancer patients
A new model to evaluate kidney function can help clinicians find the right balance between treating cancer and avoiding chemotherapy's dangerous side effects. (2020-12-10)

New treatment could spare early-stage rectal cancer patients life-altering side effects
A new and less invasive treatment developed by Cancer Research UK researchers is safer than standard major surgery for early-stage rectal cancer, giving patients a better quality of life with fewer life-altering side effects, results from a pilot study show. (2020-12-10)

Physicians don't always recognize patients' radiation therapy side effects
Physicians did not recognize side effects from radiation therapy in more than half of breast cancer patients who reported a significant symptom, a new study finds. (2020-12-09)

Drug for rare disorder shows promise for treating herpes viruses
New research shows that the antiviral activity of the drug -- called phenylbutyrate, or PBA -- was even better when used along with acyclovir, a common HSV-1 treatment. When used in combination, less acyclovir is needed to effectively suppress the virus compared to acyclovir alone -- this is important because acyclovir is also known to have toxic side effects in the kidneys. (2020-12-07)

ASH: Off-the-shelf immune drug shows promise in aggressive multiple myeloma
A subcutaneous injection of the immune-boosting drug teclistamab was found to be safe and elicit responses in a majority of patients with relapsed or refractory multiple myeloma. (2020-12-05)

Microswimmers move like moths to the light
The Freigeist group at TU Dresden, led by chemist Dr Juliane Simmchen, has studied an impressive behavior of synthetic microswimmers: as soon as the photocatalytic particles leave an illuminated zone, they flip independently and swim back into the light. This promising observation and its analysis was recently published in the scientific journal ''Soft Matter'' as an ''Emerging Investigator'' article. (2020-11-26)

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