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Barrow finds correlation in TBI and concussions
Physicians and researchers at Barrow Neurological Institute have identified a link between domestic violence and traumatic brain injury. The findings could have important implications in the treatment of domestic violence survivors, both in medical and social service communities. The research, led by Dr. Glynnis Zieman, was published in the July issue of Journal of Neurotrauma. (2016-10-11)

Ticagrelor after MI: Added benefit called into question by data subsequently submitted
New analyses increased consistency and certainty of conclusions of the results on harmful aspects. Non-severe but clinically relevant bleeding also occurred more frequently under ticagrelor. (2016-10-07)

Nivolumab plus ipilimumab in melanoma: Added benefit in certain patients
Treatment-naive patients with BRAF V600 mutation-negative tumor survive longer. This advantage depends on sex, however. And severe side effects are more common. (2016-10-06)

Age-specific strategies are needed when caring for older individuals with HIV
A new article highlights the differences between older and younger adults living with HIV, and offers age-specific strategies on how to provide care. (2016-10-04)

'Connectosomes' create gateway for improved chemo delivery, fewer side effects
Engineering researchers have developed a new method that delivers chemotherapy directly and efficiently to individual cells. The approach provides a faster means of targeting and killing cancer cells with significantly lower doses of chemo than conventional drug delivery methods, which could decrease side effects for patients. (2016-10-04)

New method, device aimed at controlling blood pressure levels automatically
Researchers at the University of Texas at Arlington are developing a new method and device for controlling blood pressure levels in cardiac care environments that use targeted electrical stimulation rather than drugs. (2016-10-04)

Anti-tumor immunity identified with new ovarian cancer treatment strategy
New research from The Wistar Institute demonstrates how a drug already in clinical trials could be used to boost anti-tumor immunity and cause T-cells to target the cancer directly while minimizing side effects. (2016-09-13)

Fruit flies yield clues on cancerous tumor hotspots
A Florida State University research team, in coordination with a team from Japan, has found that the epithelial tissues that line the surfaces of organs throughout the body intrinsically have hot spots for cancerous tumors. They discovered this by examining a common household pest -- the fruit fly. (2016-09-07)

Researchers find molecular link behind aspirin's protective powers
Researchers at Duke Health have identified a new mechanism of aspirin's action that appears to explain the drug's diverse benefits. (2016-09-07)

Nano-lipid particles from edible ginger could improve drug delivery for colon cancer, study finds
Edible ginger-derived nano-lipids created from a specific population of ginger nanoparticles show promise for effectively targeting and delivering chemotherapeutic drugs used to treat colon cancer, according to a study by researchers at the Institute for Biomedical Sciences at Georgia State University, the Atlanta Veterans Affairs Medical Center and Wenzhou Medical University and Southwest University in China. (2016-09-06)

High quality evidence suggests vitamin D can reduce asthma attacks
A new Cochrane Review, published in the Cochrane Library today and presented at the ERS International Congress, has found evidence from randomised trials, that taking an oral vitamin D supplement in addition to standard asthma medication is likely to reduce severe asthma attacks. (2016-09-05)

New knowledge about the building blocks of life
A study of an enzyme that helps build and repair DNA in living organisms increases our understanding of how these processes are controlled and how we can use this to combat infections. (2016-09-02)

Concerns over glutathione skin bleaching in the UK
Skin bleaching with the use of glutathione is on the rise, despite the potential ethical issues and adverse side effects associated with the practice, warns a doctor in The BMJ this week. (2016-08-31)

Scientists report on safe, non-addictive opioid analgesic in animal model
Since the isolation of morphine from opium in the 19th century, scientists have hoped to find a potent opioid analgesic that isn't addictive and doesn't cause respiratory arrest with increased doses. (2016-08-29)

Opioid receptors outside the brain targeted in rats; new direction for painkillers
Opioid abuse is a growing public health crisis, affecting up to 36 million people worldwide. Many of these individuals first get hooked on prescription painkillers that target mu opioid receptors in the brain. A study in rats published Aug. 25 in Cell Reports suggests that a different approach that targets delta opioid receptors on sensory neurons in peripheral tissues might avoid the side effects and high abuse potential of currently available pain relievers. (2016-08-25)

Hitching a ride: Misfiring drugs hit the wrong targets
Researchers have shown how anti-HIV protein inhibitor drugs can bind to the wrong protein, causing unwanted side effects. (2016-08-25)

Could physical activity be good for alcohol and substance use disorders?
A team of researchers from Plymouth University Peninsula Schools of Medicine and Dentistry has received funding of £154,000 from the NIHR Research for Patient Benefit program, to carry out a systematic review of research to see if and how physical activity and exercise could help those with alcohol and substance use disorders. (2016-08-24)

Study shows diabetes treatment helps reduce weight in children with autism
A drug that's been used for decades in the treatment of type 2 diabetes is proving effective in helping to control weight gain in children who are treated for autism spectrum disorder, according to a new study published in the Journal of the American Medical Association (JAMA). (2016-08-24)

Brief rapamycin therapy in middle-aged mice extends lives
In mice, the drug rapamycin is known to extend lives and delay some age-related problems. Questions remain about about how it promotes healthy aging, when, how much and how long to administer rapamycin, and how to avoid serious side effects. A new study showed brief therapy during middle age with rapamycin dramatically extended mouse lives. Findings revealed the need to further examine how gender and dose influence side effects and the drug's impact on susceptibility to and protection from different types of cancer. (2016-08-23)

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells
A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development. Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells. (2016-08-23)

Expecting the worst increases side-effects in breast cancer patients on hormone therapies
A study of women receiving hormone therapies such as tamoxifen as part of their treatment for breast cancer has found that the number and seriousness of side effects they experienced were influenced by their expectations. The study, published in Annals of Oncology, found that women who had higher expectations of suffering more and worse side-effects before their treatment began did, in fact, experience more after two years of adjuvant hormone therapy. (2016-08-22)

Nivolumab in advanced lung cancer: Indication of major added benefit
Patients with advanced nonsquamous NSCLC who have already undergone chemotherapy survive longer with the drug than with docetaxel. (2016-08-18)

Study paves way for steroid treatments with fewer side effects
An improved therapy to replace essential steroids in the body is a step closer thanks to University of Edinburgh research. The treatment could help people unable to produce a class of steroids called corticosteroids, which are involved in physiological processes including regulating metabolism and blood pressure, and helping the body to cope with physical stress. The therapy for people with adrenal gland disorders is expected to have fewer side effects than existing treatments. (2016-08-17)

Designer agent blocks pain in mice without morphine's side effects
Scientists have synthesized a molecule with a unique profile of highly specific pain-relieving properties and demonstrated its efficacy in mice. PZM21 was not 'reinforcing' or prone to triggering respiratory impairment and was less constipating than existing analgesics. It had more effect on the brain-mediated emotional/experiential component of pain than on spinal cord reflexive responses. In addition to clinical potential, it holds promise as a 'tool molecule' for exploring the workings of brain pain systems. (2016-08-17)

Molecule prevents effect of chemotherapy
For the last three years the research team has been working on the development of a so-called biomarker to predict treatment effectiveness. Now the researchers found a molecule which is closely associated with the effect of Oxaliplatin treatment, an anti-cancer drug widely used in the treatment of colorectal cancer. (2016-08-16)

Bone marrow-derived stem cells offer blood transplant patients better quality of life
Large, nationwide study finds better psychological well-being, fewer graft-vs.-host disease symptoms and greater likelihood of returning to work among bone marrow transplant recipients. (2016-08-16)

Intestinal flora effects drug response
Intestinal flora has multiple influences on human health, but research from Kumamoto University in Japan has revealed that it is also likely to have an effect on the body's response to drugs. Individual changes in the intestinal flora caused by antibacterial and antibiotic drugs may affect the effectiveness and side effects of other medicines. (2016-08-12)

Nivolumab in renal cell cancer: Indication of added benefit
Patients with advanced renal cell cancer have weaker symptoms and side effects and patients with an unfavorable prognosis survive longer than those receiving the comparator therapy. (2016-08-10)

A single compound could treat 3 parasitic diseases
Scientists have identified a compound that can kill the parasites responsible for three neglected diseases: Chagas disease, leishmaniasis and sleeping sickness. (2016-08-08)

Targeting brain cells to alleviate neuropathic pain
Rutgers scientists discovered that chronic neuropathic pain -- caused by nerve damage as a result of an injury, surgery or a debilitating disease like diabetes or cancer -- could be greatly reduced in animals when the injury is treated targeting microglia brain cells within a few days. This research will help in the quest to help the more than 1 million Americans afflicted with this chronic pain. (2016-08-08)

'Pain paradox' discovery provides route to new pain control drugs
A natural substance known to activate pain in the central nervous system has been found to have the opposite effect in other parts of the body, potentially paving the way to new methods of pain control. (2016-07-28)

Markers that cause toxic radiotherapy side-effects in prostate cancer identified
A new study involving researchers from The University of Manchester looked at the genetic information of more than 1,500 prostate cancer patients and identified two variants linked to increased risk of radiotherapy side-effects. (2016-07-26)

New gene therapy prevents muscle wasting associated with cancer
A new gene therapy could be used to prevent the loss of muscle mass and physical strength associated with advanced cancer (2016-07-22)

Virtual development of real drugs
systemsDock is a new, free on-line resource that makes screening for drugs faster and more accurate. (2016-07-21)

GPM measured heavy rain in Tropical Storm Estelle
The Global Precipitation Measurement mission or GPM core observatory satellite traveled above tropical storm Estelle and found heavy rainfall occurring on its eastern side. (2016-07-21)

How to increase the fat burned during exercise
When we exercise, our body's oxidation of fat and carbohydrates depends on the intensity and duration of the activity. A new study analyses the effect of consuming an alkaloid, p-synephrine, on the burning of lipids and refutes the value of 'miracle' diets: it is not possible to lose more than a kilogram of fat per month. (2016-07-19)

Surface composition determines temperature and therefore habitability of a planet
Astronomers from KU Leuven, Belgium, have shown that the interaction between the surface and the atmosphere of an exoplanet has major consequences for the temperature on the planet. This temperature, in turn, is a crucial element in the quest for habitable planets outside our Solar System. (2016-07-14)

Local drug activation at solid tumor sites
Sarcoma is an aggressive form of cancer responsible for up to 20 percent of childhood cancers. Tumors often first appear in the extremities and the abdomen. Surgery is a primary treatment, but it often is combined with chemotherapy. This week in ACS Central Science, researchers propose a scheme to target chemotherapy medications specifically to sarcomas, leading to greater efficacy and fewer side effects. (2016-07-13)

Penn preclinical study outlines cardiovascular side effects of breast cancer drug
A receptor protein that is the target of the breast cancer drug trastuzumab (Herceptin) is needed for proper heart blood-vessel development. These discoveries have implications for better understanding the cardiovascular side effects of trastuzumab commonly used for cancer and provide an example of integration at the molecular level of pathways involved in tissue growth and blood-vessel patterning. (2016-07-13)

A comparison between quetiapine and aripiprazole for treatment of schizophrenia
Schizophrenia is a common cause of incapacity and is ranked as the third most disabling illness subsequent to dementia and quadriplegia. Nearly 75 percent of persons with schizophrenia have continuing problems with recurrent psychotic episodes. (2016-07-13)

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