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Sexual health often overlooked in cancer survivorship care, especially for female patients
A new study points to a need for oncologists to ask their patients about sexual health after chemotherapy, radiation and other cancer treatments. In a survey of nearly 400 cancer survivors, 87% said they experienced sexual side effects, but most also said their oncologist had not formally asked about them. Female patients were especially unlikely to be asked about sexual dysfunction. Findings will be presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting. (2020-10-30)

Muscle pain and energy-rich blood: Cholesterol medicine affects the organs differently
Contrary to expectation, treatment with statins has a different effect on blood cells than on muscle cells, a new study from the University of Copenhagen reveals. Today, statins are mainly used in the treatment of elevated cholesterol, but the new results may help design drugs for a number of conditions. (2020-10-29)

Stronger treatments could cure Chagas disease
Researchers in the University of Georgia's Center for Tropical and Emerging Global Diseases have found that a more intensive, less frequent drug regimen with currently available therapeutics could cure the infection that causes Chagas disease (2020-10-29)

Cancer treatment without side effects?
Treating cancer without debilitating side effects has long been the holy grail of oncologists, and researchers at the University of California, Irvine and Switzerland's Lausanne University Hospital may have found it. (2020-10-27)

Taking the itch out of cancer immunotherapy
Researchers from the University of Tsukuba have determined that PD-1 expression on CD8 T cells is the biological pathway that leads to psoriasis-like dermatitis, an unfavorable side effect of cancer immunotherapy with PD-1 inhibitors. This finding offers hope that blocking this pathway can prevent or reduce the undesirable side effect and help cancer patients continue their treatment with improved quality-of-life. (2020-10-26)

Targeted inhibitor of mutated KRAS gene shows promise in lung, bowel, & other solid tumors
A novel agent that targets a mutated form of the KRAS gene - the most commonly altered oncogene in human cancers and one long considered ''undruggable'' - shrank tumors in most patients in a clinical trial with manageable side effects, researchers reported today at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Therapeutic, which is taking place online. (2020-10-25)

Researchers develop a simplified method to modify disease signaling with light
Cellular optogenetics is a technique that allows researchers to use light to precisely control cell signaling and function in space and time enabling the investigation of mechanisms involved in disease processes. A research team from the University of Turku have developed a novel way to make cellular optogenetic tools much easier to monitor and apply, and showed how they can be used to investigate the cellular side effects of medicines used to treat cancer. (2020-10-22)

Vaccine to treat and prevent lung, bowel and pancreatic cancer shows promise in the lab
An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. (2020-10-22)

U of M trial shows hydroxychloroquine does not prevent COVID-19 in health care workers
University of Minnesota Medical School researchers found that taking hydroxychloroquine once or twice weekly did not prevent the development of COVID-19 in health care workers better than the placebo. (2020-10-21)

Researchers identify genetic variants linked to toxic side effects from bevacizumab
In the largest study of its kind, researchers have found two common genetic variants that can be used to predict whether or not cancer patients might suffer severe adverse side-effects, such as high blood pressure, from the drug bevacizumab. The genome-wide association study is the largest such study in patients being treated with bevacizumab and it is to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. (2020-10-21)

New approach to fighting cancer could reduce costs and side effects
CAR-T biotherapeutics company Carina Biotech and researchers at the University of South Australia have developed a novel approach based on microfluidic technology to ''purify'' the immune cells of patients in the fight against cancer. (2020-10-20)

Boron nitride nanofilms for protection from bacterial and fungal infections
NUST MISIS material scientists have presented antibacterial nano-coatings based on boron nitride, which are highly effective against microbial pathogens (up to 99.99%). They can become a safe alternative to the usual antibiotics in implantology since they do not have typical negative side effects. The results of the work are published in the international scientific journal ACS Applied Materials & Interfaces. (2020-10-20)

Efficacy, politics influence public trust in COVID-19 vaccine
If an initial COVID-19 vaccine is about as effective as a flu shot, uptake by the American public may fall far short of the 70% level needed to achieve herd immunity, new Cornell research suggests. (2020-10-20)

Study: There's work to be done before people feel ready for COVID-19 vaccine
A new study in the journal Vaccines indicates some significant public messaging should be communicated before any COVID-19 vaccines are made available in the US. And with vaccines potentially being approved by the end of the year or early next year, the clock is ticking. (2020-10-13)

Mysterious molecular phenomenon could boost precision of targeted drug delivery
Scientists have shown how a type of cellular binding could help pave the way for highly targeted therapies against diseases like cancer. (2020-10-06)

Study identifies characteristics of infused CAR T cells associated with efficacy and toxicity in in patients with large B-cell lymphoma
Researchers at The University of Texas MD Anderson Cancer Center have identified molecular and cellular characteristics of anti-CD19 CAR T cell infusion products associated with how patients with large B-cell lymphoma (LBCL) respond to treatment and develop side effects. (2020-10-05)

Risk of heart disease in breast cancer patients can be predicted from routine scans
Automated analysis of breast cancer patients' routine scans can predict which women have a greater than one in four risk of going on to develop cardiovascular disease, according to research presented at the 12th European Breast Cancer Conference. (2020-10-01)

Cannabinoids associated with negative respiratory health effects in older adults with COPD
Cannabinoids, a class of prescription pills that contain synthetically-made chemicals found in marijuana, are associated with a 64 per cent increase in death among older adults with chronic obstructive pulmonary disease (COPD), according to the first published data on the impact of cannabinoids on the respiratory health of individuals with the lung disease. (2020-09-30)

Mussels connect antibodies to treat cancer
POSTECH research team develops innovative local anticancer immunotherapy technology using mussel protein. (2020-09-29)

Clinical trial of selpercatinib shows strong response for patients with non-small cell lung cancer
Drug shown to precisely target non-small cell lung cancer driven by mutations to gene RET. Majority of patients on trial experience shrinking tumours and live for more than a year without disease progression. National Cancer Centre Singapore, one of a handful of three Asian centres to participate in the trial, has implemented routine testing of the gene RET for all lung cancer patients. Findings published in high impact factor journal, New England Journal of Medicine. (2020-09-28)

Antacid monotherapy more effective in relieving epigastric pain than in combination with lidocain
Antacid monotherapy is more effective in relieving epigastric pain than in combination with lidocaine. That is the conclusion of a study to be published in the September 2020 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM). (2020-09-28)

New Duchenne muscular dystrophy drug shows benefit in Duke trial
A new drug offers hope for young boys with the progressive neuromuscular disease Duchenne muscular dystrophy (DMD) by potentially offering an alternative to high-dose glucocorticoids that have significant side effects. (2020-09-25)

Don't sleep on the hypnotic potential of thalidomide
Researchers from the University of Tsukuba identified a novel molecular pathway for the hypnotic effects of thalidomide. By comparing the effects of thalidomide on the sleep of normal mice and mice in which the protein cereblon was resistant to thalidomide, the researchers found that thalidomide acted independently of cereblon but similarly to general anesthetics and sedatives to induce sleep. These findings could help develop thalidomide-like hypnotic drugs without its teratogenic effects. (2020-09-23)

Taking in refugees does not strongly influence xenophobia in East German communities
The reception of refugees in East German communities did not lead to changes in voting behaviour or attitudes to migration. This is the main finding of a study conducted by Max Schaub (WZB), Johanna Gereke (MZES), and Delia Baldassarri (New York University). In the over 200 East German communities they examined, negative attitudes to migration were widespread. However, the arrival of refugees in the immediate neighbourhood had hardly any influence on these attitudes. (2020-09-22)

Metformin for type 2 diabetes patients or not? Researchers now have the answer
Metformin is the first-line drug that can lower blood sugar levels in type 2 diabetes patients. One third of patients do not respond to metformin treatment and 5 per cent experience serious side effects, which is the reason many choose to stop medicating. Researchers at Lund University in Sweden have now identified biomarkers that can show in advance how the patient will respond to metformin treatment via a simple blood test. (2020-09-17)

Researchers use soy to improve bone cancer treatment
Researchers showed that the slow release of soy-based chemical compounds from a 3D-printed bone-like scaffold resulted in a reduction in bone cancer cells while building up healthy cells and reducing harmful inflammation. (2020-09-15)

Structure of ATPase, the world's smallest turbine, solved
The chemical ATP, adenosine triphosphate, is the fuel that powers all life. Despite ATP's central role, the structure of the enzyme generating ATP, F1Fo-ATP synthase, in mammals, including humans, has not been known so far. Now, scientists from IST Austria report the first complete structure of the mammalian F1Fo-ATP synthase. This structure also settles a debate on how the permeability transition pore, a structure involved in cell death, cancer, and heart attacks, forms. (2020-09-14)

Asthma patients given risky levels of steroid tablets
More than one quarter of asthma patients have been prescribed potentially dangerous amounts of steroid tablets, with researchers warning this puts them at greater risk of serious side-effects. (2020-09-13)

Site of male sexual desire uncovered in brain
The locus of male sexual desire has been uncovered in specific regions of brain tissue where a key gene named aromatase is present, reports a new study in mice. The gene regulates sexual behavior in men, and thus can be targeted by drugs to either increase its function for low sexual desire or decrease its function for compulsive sexual desire, scientists said. Aromatase converts testosterone to estrogen in the brain, which drives male sexual activity. (2020-09-11)

The web of death
Cancer is one of the most frequent causes of death. Chemotherapy is often used as a treatment, but also brings side effects for healthy organs. Scientists around David Ng, group leader at the Max Planck Institute for Polymer Research, are now trying to take a completely different approach: By means of targeted and localized disruption of the cancer cells' structure, its self-destruction mechanism can be activated. In laboratory experiments, they have already demonstrated initial successes. (2020-09-10)

NASA's Terra highlights aerosols from western fires in danger zone
The year 2020 will be remembered for being a very trying year and western wildfires have just added to the year's woes. (2020-09-10)

Skin lightening products linked to altered steroid hormone levels
Women who misuse corticosteroid creams for cosmetic skin lightening may be at risk of developing adrenal insufficiency, according to research presented at e-ECE 2020. (2020-09-08)

New computational tool enables prediction of key functional sites in proteins based on structure
A new technology that uses a protein's structure to predict the inner wiring that controls the protein's function and dynamics is now available for scientists to utilize. The tool, developed by researchers at Penn State, may be useful for protein engineering and drug design. (2020-09-03)

Texas A&M researchers develop treatment for canine ocular condition using turmeric
Researchers at Texas A&M University have produced a therapeutic derived from turmeric, a spice long-praised for its natural anti-inflammatory properties, that shows promise in decreasing ocular inflammation in dogs suffering from uveitis, an inflammation of the eye that leads to pain and reduced vision. (2020-09-03)

Finding cortisone alternatives with fewer side effects
Many people use cortisone of a regular basis. It is used for treating rheumatism, asthma, multiple sclerosis, or even COVID-19. Steroidal medication such as cortisone is highly effective but also possesses severe side effects. Henriette Uhlenhaut, professor at Technical University of Munich (TUM), and her team are examining the beneficial effects of cortisone in order to lay the groundwork for the development of similar drugs with fewer side effects. (2020-09-02)

Black children with cancer three times less likely to receive proton radiotherapy than White children
A retrospective analysis led by investigators from Brigham and Women's Hospital has found racial disparities in the use of the therapy for patients enrolled in trials. (2020-08-27)

Phase 1 human trials suggest UIC-developed breast cancer drug is safe, effective
A new type of breast cancer drug can help halt progression of disease and is not toxic, according to phase 1 clinical trials. (2020-08-27)

In one cancer therapy, two halves are safer than a whole
Splitting one type of cancer drug in half and delivering the pieces separately to cancer cells could reduce life-threatening side effects and protect healthy, non-cancerous cells, a new study suggests. (2020-08-24)

Long-acting, injectable drug could strengthen efforts to prevent, treat HIV
Scientists have developed an injectable drug that blocks HIV from entering cells. They say the new drug potentially offers long-lasting protection from the infection with fewer side effects. The drug, which was tested in non-human primates, could eventually replace or supplement components of combination drug ''cocktail'' therapies currently used to prevent or treat the virus. (2020-08-21)

Castration-resistant prostate cancer at high risk of metastasis: enzalutamide has added benefit
Castration-resistant prostate cancer at high risk of metastasis: enzalutamide has added benefit. For the first time, new data from the PROSPER study show an advantage in overall survival that outweighs the disadvantages in some side effects. (2020-08-19)

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