Current Simvastatin News and Events

Current Simvastatin News and Events, Simvastatin News Articles.
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Oncotarget: Simvastatin is a potential candidate drug in ovarian clear cell carcinomas
''Simvastatin efficiently controlled OCCC proliferation and migration, thus showing potential as a candidate drug for the treatment of OCCC.'' (2021-02-01)

Clinical trial results address concerns about pharmacogenetic testing
Researchers conducted a randomized controlled trial of pharmacogenetic testing related to cholesterol-lowering medications called statins.After one year, the cholesterol levels in the group who received their pharmacogenetic results were not higher than those in the group who did not receive their results, and they were not less likely to receive medical care meeting recommended guidelines. (2020-12-03)

Sex-specific adverse drug effects identified by Columbia University algorithm
Columbia University researchers developed an algorithm that uses real-world data to identify sex-specific adverse drug effects, the fourth-leading cause of death in the U.S. (2020-10-02)

Drugs aren't typically tested on women. AI could correct that bias
Researchers at Columbia University have developed AwareDX--Analysing Women At Risk for Experiencing Drug toXicity--a machine learning algorithm that identifies and predicts differences in adverse drug effects between men and women by analyzing 50 years' worth of reports in an FDA database. The algorithm, described September 22 in the journal Patterns, automatically corrects for the biases in these data that stem from an overrepresentation of male subjects in clinical research trials. (2020-09-30)

Evidence lacking for drug treatment of multiple sclerosis-related cognitive impairment
There was insufficient evidence for cognitive efficacy across the spectrum of pharmacologic agents used in multiple sclerosis. 'Given the impact of cognitive dysfunction on individuals with MS, it is prudent to explore the potential for cognitive efficacy of available pharmaceuticals,'' explained Dr. Genova. ''The design of future studies, especially of DMTs, must focus on cognitive outcomes and follow standardized criteria. Randomized, controlled studies with cognition as the primary outcomes will provide clinicians with the information they need to choose optimal treatments for patients.' (2020-06-17)

Scientists reveal catalytic mechanism of lovastatin hydrolase
The research team led by Prof. LU Xuefeng from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences (CAS), revealed the catalytic mechanism and structure-function relationship of the specific and efficient lovastatin hydrolase PcEST. (2020-02-14)

Statins could increase or decrease osteoporosis risk -- the dosage makes the difference
A study by the Medical University of Vienna and the Complexity Science Hub Vienna shows for the first time a connection between the dosage of cholesterol-lowering drugs -- statins -- and the diagnosis of osteoporosis. (2019-09-30)

Is intensive treatment to lower lipid levels beneficial to older patients after acute coronary syndrome?
In this secondary analysis of a randomized clinical trial, researchers examined the association of age with the benefit of intensive treatment to lower lipid levels with a combination therapy of simvastatin and ezetimibe compared to treatment with simvastatin alone after acute coronary syndrome in older patients. (2019-07-17)

Statins' potential to treat MS unrelated to lowering cholesterol
The widely prescribed statin, simvastatin, can medically help patients with secondary progressive Multiple Sclerosis (SPMS) -- for reasons that might be unrelated to the drug's intended cholesterol lowering affects, a UCL study has found. (2019-05-10)

Statins overprescribed for primary prevention
Taking cholesterol-lowering drugs, or statins, as a preventive measure can reduce the risk of cardiovascular disease. A study by the University of Zurich now shows that this measure is recommended too often, as current guidelines fail to take into account the risks of side effects. (2018-12-06)

Study explores timing of muscle-related problems of statin use
Statins have been linked with muscle pain and other musculoskeletal adverse events (MAEs) in some patients. A new Pharmacology Research & Perspectives study has examined the timing of MAEs that develop during statin therapy and determined whether concomitant drugs used concurrently with statin therapy shifts the timing of MAEs. (2018-11-07)

Stabilizing endothelial cells could help tackle vascular dementia
Researchers have discovered that stabilizing dysfunctional endothelial cells with approved drugs reverses cellular dysfunction in a rat model of cerebral small vessel disease (SVD), hinting towards a new therapeutic. (2018-07-04)

Screening for vascular disease saves one life for every 169 patients assessed (VIVA)
A novel screening program for vascular disease saves one life for every 169 men assessed, according to late-breaking results from the VIVA trial presented today in a Hot Line LBCT Session at ESC Congress and published in the Lancet. The combined screening for abdominal aortic aneurysm, peripheral artery disease, and hypertension gained more living years for lower costs than European cancer screening programs. (2017-08-28)

Are cholesterol-lowering statins associated with reduced Alzheimer risk?
An analysis of Medicare data suggests that high use of cholesterol-lowering statins was associated with a reduced risk for Alzheimer disease but that reduction in risk varied by type of statin and race/ethnicity, findings that must be confirmed in clinical trials, according to a new article published online by JAMA Neurology. (2016-12-12)

Cholesterol-fighting drugs lower risk of Alzheimer's disease
Medicare patients who took statins for two years or more showed a reduced risk of the memory-robbing disease, a USC-led study found. (2016-12-12)

Risk of hemorrhage with statins and stroke prevention drug combination
Two commonly used statins can increase the risk of hemorrhage when combined with dabigatran etexilate, a drug often used for preventing stroke in patients with atrial fibrillation, according to a study in CMAJ. (2016-11-21)

Study finds hemorrhage risk with combination of 2 common statins and anti-stroke drug
Two commonly prescribed statins appear to be associated with a higher risk of bleeding than others when combined with dabigatran, a new study finds. (2016-11-21)

Higher intensity of statin therapy associated with lower risk of death in patients with atherosclerotic cardiovascular disease
Among more than 500,000 patients with atherosclerotic cardiovascular disease, researchers found an inverse association between intensity of statin therapy and mortality, with patients who received high-intensity statins having the greatest reductions in risk of death, according to a study published online by JAMA Cardiology. (2016-11-09)

Effect of cholesterol medicine on inflammatory diseases mapped
The cholesterol medicine simvastatin, which is one of the most commonly used pharmaceuticals in the world, also has a beneficial effect on the immune defence system with regard to diseases such as type 1 diabetes, multiple sclerosis and rheumatoid arthritis. Danish researchers have now explored why this is so, and their findings may result in improved treatment. (2016-07-07)

How a metabolic pathway promotes breast cancer metastasis
A metabolic pathway that is up-regulated in some breast cancers promotes the disease's progression by activating a signaling protein called Arf6, according to a paper published in The Journal of Cell Biology. The study, 'P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance' by Ari Hashimoto and colleagues, suggests that statin-like drugs may be effective treatments for breast cancer patients whose tumors express high levels of Arf6 signaling proteins. (2016-04-06)

More elderly using dangerous drug combinations
One in six older adults now regularly use potentially deadly combinations of prescription and over-the-counter medications and dietary supplements -- a two-fold increase over a five-year period. (2016-03-21)

Statins cut tuberculosis treatment time in mice
In a study using mice, the Johns Hopkins University School of Medicine infectious disease experts have added to evidence that statin drugs -- known primarily for their cholesterol-lowering effects -- can significantly reduce the time it takes to clear tuberculosis infection. (2016-03-15)

Research finds new target in search for why statin drugs sometimes cause problems for some patients
Research by the University of Warwick, the University Hospital Coventry and Warwickshire NHS Trust (UHCW), and Tangent Reprofiling Limited, has discovered that statin drugs interact with a gap junction protein called GJC3 that releases ATP, a major signaling molecule for inflammation in the body. This discovery provides a significant new target in the search for why statin drugs can sometimes cause harmful effects such as muscle toxicity in some patients. (2016-02-10)

Could a cholesterol-lowering drug be a potential treatment for Parkinson's?
A clinical trial using cholesterol-lowering treatment Simvastatin in people living with Parkinson's is getting underway in centers across England -- with the hope that it could become one of a number of effective treatments available to treat Parkinson's. (2016-01-11)

Increase seen in prescription drug use in US
Between 1999-2012, overall prescription drug use increased among US adults, with this increase seen for the majority of but not all drug classes, according to a study in the Nov. 3 issue of JAMA. (2015-11-03)

Ezetimibe provides particular benefit in patients with diabetes and recent acute coronary syndrome
According to the United States Centers for Disease Control and Prevention, over 800,000 Americans die each year from heart disease and stroke. Acute coronary syndrome, which includes heart attack and unstable angina, a condition that can lead to a heart attack, are among the leading causes of death and disability worldwide. In addition to lifestyle changes, medications that lower blood cholesterol are helpful in preventing future cardiac and vascular events, including heart attack and stroke. (2015-08-30)

Ezetimibe reduces cardiovascular events in diabetics with recent acute coronary syndrome
Ezetimibe reduces cardiovascular events in patients with diabetes and a recent acute coronary syndrome, according to a subgroup analysis of the IMPROVE-IT trial presented at ESC Congress today by co-principal investigator Dr Robert Giugliano, physician in cardiovascular medicine at Brigham and Women's Hospital in Boston, US.1 Ezetimibe achieved greater reductions in LDL cholesterol than statins alone, resulting in lower risks of cardiovascular events in patients with diabetes. (2015-08-30)

Primary prevention use of statins increases among the oldest old
The use of statins for primary prevention in patients without vascular disease older than 79 increased between 1999 and 2012, although there is little randomized evidence to guide the use of these cholesterol-lowering medications in this patient population, according to a research letter published online by JAMA Internal Medicine. (2015-08-24)

Statins linked to lower aggression in men, but higher in women
In the first randomized trial to look at statin effects on behavior, researchers at the University of California, San Diego School of Medicine report that aggressive behavior typically declined among men placed on statins (compared to placebo), but typically increased among women placed on statins. (2015-07-01)

Taking statins? Don't worry about memory loss, Rutgers, Penn study finds
Cholesterol-lowering statin drugs most likely do not cause short-term memory loss, according to a Rutgers University and University of Pennsylvania study of nearly one million patients -- contrary to prior assertions. Limited previous studies and some statin-drug takers have anecdotally reported memory lapses after taking popular lipid-lowering drugs, which researchers say has inappropriately led some people to stop taking their statins. (2015-06-08)

Available genetic data could help doctors prescribe more effective cardiovascular drugs
Few heart specialists make use of published information about interactions between drugs used to treat cardiovascular disease and the genetic variations that affect how patients respond to them. So physicians at U Chicago and Stanford combed through the literature on the pharmacogenomics of the leading cardiovascular drugs and compiled summaries. (2015-06-01)

Preoperative statins reduce mortality in coronary artery bypass graft surgery
Research presented at this year's Euroanaesthesia exploring the protective effect of various heart medications that patients are taking before undergoing coronary artery bypass graft surgery concludes that statins reduce the risk of death by two thirds, or 67 percent, while no consistent effects were seen for other medications. (2015-05-31)

Strong statin-diabetes link seen in large study of Tricare patients
In a Veterans Affairs study of nearly 26,000 beneficiaries of Tricare, the military health system, those taking statin drugs to control their cholesterol were 87 percent more likely to develop diabetes. (2015-05-07)

Prolonged statin use may lower risk of lung cancer death
Lung cancer patients who used statins in the year prior to a lung cancer diagnosis or after a lung cancer diagnosis had a reduction in the risk of death from the disease. (2015-05-01)

Targeting dangerous inflammation inside artery plaque
A research team showed that a nanotherapeutic medicine can halt the growth of artery plaque cells resulting in the fast reduction of the inflammation that may cause a heart attack. (2015-04-03)

Doctor explains why a popular statin should not be prescribed
A doctor today reviews why the US Food and Drug Administration should have withdrawn the popular cholesterol lowering drug rosuvastatin (Crestor) and why it should not be prescribed. (2015-03-17)

Study shows that use of statins increases risk of developing diabetes by 46 percent
New research published in Diabetologia, the journal of the European Association for the Study of Diabetes, shows that use of statins is associated with a 46 percent increase in the risk of developing diabetes, even after adjustment for confounding factors. (2015-03-04)

Researchers present highly anticipated IMPROVE-IT results
Results of the highly anticipated IMProved Reduction of Outcomes: Vytorin Efficacy International Trial, also known as IMPROVE-IT, co-led by researchers at Brigham and Women's Hospital and Duke Medicine, indicate that adding a second drug, ezetimibe, that blocks cholesterol absorption, resulted in a significant 6.4 percent reduction in the number of cardiovascular events. (2014-11-17)

Common cholesterol-fighting drug may prevent hysterectomies in women with uterine fibroids
Researchers at the University of Texas Medical Branch at Galveston, in collaboration with The University of Texas Health Science Center at Houston, Baylor College of Medicine and the Georgia Regents University, report for the first time that the cholesterol-lowering drug simvastatin inhibits the growth of human uterine fibroid tumors. These new data are published online and scheduled to appear in the January print edition of the Journal of Biological Chemistry. (2014-11-13)

Genomic data could help doctors know whether to prescribe statins
Genomic data could predict whether statins will benefit a patient or not, according to an article in the open access journal Genome Biology. The research suggests that genomic data alone can explain around 15 percent of patients' responses to a cholesterol-lowering statin, and further studies could increase the accuracy of these predictions. (2014-09-29)

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