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Current Small Intestine News and Events, Small Intestine News Articles.
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Molecular marker identifies normal stem cells as intestinal tumor source
Scientists at St. Jude Children's Research Hospital have answered a central question in cancer biology: whether normal stem cells can give rise to tumors. Stem cells are immature cells that can renew themselves and give rise to mature differentiated cells that compose the range of body tissues. In recent years, researchers have developed evidence that cancers may arise from mutant forms of stem cells. (2008-12-17)

Irritable bowel syndrome can have genetic causes
Irritations of the bowel can have genetic causes. Researchers at the Institute of Human Genetics at Heidelberg University Hospital have discovered this correlation. The causes of what is known as irritable bowel syndrome, one of the most common disorders of the gastrointestinal tract, are considered unclear, making diagnosis and treatment extremely difficult. (2008-12-10)

Oetzi's last supper
From the analysis of the intestinal contents of the 5,200-year-old Iceman from the Eastern Alps, researchers have shed some light on the mummy's lifestyle and some of the events leading up to his death. By identifying six different mosses in his alimentary tract, they suggest that the Iceman may have travelled, injured himself and dressed his wounds. Their findings are published in the December issue of Springer's journal Vegetation History and Archaeobotany. (2008-12-01)

Yale researchers enlist a new recruit in battle of the bulge
In the battle against obesity, Yale University researchers may have discovered a new weapon -- a naturally occurring molecule secreted by the gut that makes rats and mice less hungry after fatty meals. (2008-11-26)

It takes guts to build bone, Columbia scientists discover
Bone growth is controlled in the gut through serotonin, the same naturally present chemical used by the brain to influence mood, appetite and sleep, according to a new discovery. Until now, the skeleton was thought to control bone growth and serotonin was known as a neurotransmitter acting in the brain. This insight could transform how osteoporosis is treated by giving doctors a way to increase bone mass, not just slow its loss. (2008-11-26)

How the brain senses fatty food
As you gorge on food this holiday season, you might not want to think about the fat content of all the goodies you've indulged in. Nevertheless, your brain will be keeping tabs directly, suggests a report in the Nov. 26 issue of the journal Cell, a Cell Press publication. (2008-11-26)

Study identifies double-balloon enteroscopy as cost-effective approach for obscure GI bleeding
A cost-effectiveness analysis conducted by researchers at Stanford University Hospital in Calif., shows that an initial double-balloon enteroscopy is a cost-effective approach for patients with obscure gastrointestinal bleeding. However, capsule-directed DBE, which is when the findings from an initial small bowel capsule endoscopy exam are used to guide the DBE procedure, may be preferred as the initial test due to the potential for fewer complications and decreased utilization of endoscopic resources. (2008-11-24)

Sealing off portion of intestinal lining treats obesity, resolves diabetes in animal model
Lining the upper portion of the small intestine with an impermeable sleeve led to both weight loss and restoration of normal glucose metabolism in an animal model of obesity-induced diabetes. Investigators from the Massachusetts General Hospital Weight Center and Gastrointestinal Unit report in the journal Obesity that the procedure reproducing several aspects of gastric bypass surgery led to a significant reduction in the animals' food intake and a resolution of diabetes symptoms. (2008-11-24)

Surgeons perform world's first pediatric robotic bladder reconstruction
A 10-year-old Chicago girl born with an abnormally small bladder that made her incontinent has become the first patient to benefit from a new robotic-assisted bladder-reconstruction procedure. The surgeons describe their innovative technique in the December 2008 issue of the journal Urology. They have now performed the operation six times, with good results and no significant complications. (2008-11-19)

Researchers discover gene that helps control the production of stomach acid
University of Cincinnati researchers have discovered a gene that helps control the secretion of acid in the stomach -- information that could one day aid scientists in creating more efficient treatment options for conditions such as acid reflux or peptic ulcers. (2008-11-03)

Study reports Double Balloon Endoscopy useful for diagnosis and treatment of obscure GI bleeding
A study by researchers in Japan concludes that Double Balloon Endoscopy was very useful in the diagnosis of obscure gastrointestinal bleeding and had a therapeutic impact on the majority of patients. The study appears in the October issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy. (2008-10-31)

Waste from gut bacteria helps host control weight, UT Southwestern researchers report
A single molecule in the intestinal wall, activated by the waste products from gut bacteria, plays a large role in controlling whether the host animals are lean or fatty, a research team, including scientists from UT Southwestern Medical Center, has found in a mouse study. (2008-10-17)

Bugs in the gut trigger production of important immune cells, NYU study finds
A new study reveals that specific types of bacteria in the intestine trigger the generation of pro-inflammatory immune cells, a finding that could eventually lead to novel treatments for inflammatory bowel disease and other diseases. (2008-10-15)

Small intestine can sense and react to bitter toxins in food
Toxins in food often have a bad, bitter taste that makes people want to spit them out. New UC Irvine research finds that bitterness also slows the digestive process, keeping bad food in the stomach longer and increasing the chances that it will be expelled. (2008-10-09)

Olive oil ingredient ups the time between meals
A fatty acid found in abundance in olive oil and other (2008-10-07)

UCI study shows how fatty foods curb hunger
Fatty foods may not be the healthiest diet choice, but those rich in unsaturated fats -- such as avocados, nuts and olive oil -- have been found to play a pivotal role in sending this important message to your brain: stop eating, you're full. (2008-10-07)

Scientists simulate gut reaction to arsenic exposure
A simulated gastrointestinal system is helping scientists test contaminated soil for its potential to harm humans. The method is likely to save time and money for people hoping to repurpose land with an industrial past. Most testing for potential arsenic exposure is conducted in recognition of a dirty little secret of modern life: Humans unknowingly eat a little bit of soil each day. For children who might play on contaminated soil and ingest dirt, the testing is considered particularly important. (2008-10-07)

Hopkins children's experts say doctors and parents can sort out symptoms with a checklist
A young child arrives at the emergency room after several days of abdominal pain, vomiting, and diarrhea and is sent home with a diagnosis of viral gastritis and treatment for the symptoms. The child seems better for a while, only to return to the ER with worse symptoms and a ruptured appendix, a life-threatening complication of appendicitis. (2008-10-06)

Form of Crohn's disease traced to disabled gut cells
Scientists report online this week in Nature that they have linked the health of specialized gut immune cells to a gene associated with Crohn's disease, an often debilitating and increasingly prevalent inflammatory bowel disorder. (2008-10-05)

Researchers take important steps forward in understanding cause of colon cancer
Scientists investigating a molecule known to play a key role in causing colon cancer have made a series of ground-breaking discoveries that could have major implications for future treatment of the disease. (2008-09-30)

What can we do for prevention and therapy of anaerobe-associated infections?
The aim of this study was to detect in vitro secretory inhibitor of platelet microbicidal protein phenotypes of faecal anaerobic isolates from patients with diarrhea. Fecal isolates of anaerobic bacteria from children with diarrhea were tested. SIPMP production was tested by inhibition of platelet microbicidal protein bioactivity against B. subtilis and was expressed as percentage of inhibition of PMP bactericidal activity. (2008-09-25)

What is the role of interleukin-10 in ischemia-reperfusion injury?
Ischemia-reperfusion injury of the small intestine is consequently a critical problem that is important. A group from Gunma University Graduate School of Medicine investigated the effectiveness of direct hemoperfusion with polymyxin B-immobilized fibers (DHP-PMX therapy) on warm I /R injury of the small intestine in a canine model. (2008-09-25)

Robotic surgery lowers risk of a rare but serious complication of gastric bypass
The use of a robot to assist with the most commonly performed weight-loss surgery appears to significantly lower a patient's risk of developing a rare but serious complication, according to a study published in the most recent edition of the Journal of Robotic Surgery. (2008-09-24)

Cancer-causing gut bacteria exposed
Normal gut bacteria are thought to be involved in colon cancer but the exact mechanisms have remained unknown. Now, scientists from the US have discovered that a molecule produced by a common gut bacterium activates signalling pathways that are associated with cancer cells. The research, published in the October issue of the Journal of Medical Microbiology, sheds light on the way gut bacteria can cause colon cancer. (2008-09-21)

ASGE encourages patients to speak to their doctor about colorectal cancer screening options
Results of the National CT Colonography Trial, published in the Sept. 18 issue of the New England Journal of Medicine, show improvements in the technology's ability to diagnose intermediate- to large-sized polyps in the colon, but this method of testing is not as effective in diagnosing small polyps. CT colonography is one of several colorectal cancer screening options. The American Society for Gastrointestinal Endoscopy encourages patients to speak to their doctor about the screening method that is best for them. (2008-09-17)

Researchers study pre- and probiotic use in premature infants for a deadly intestinal disease
Scientists at UC Davis will launch a groundbreaking study to determine the best cocktail of pre- and probiotic supplements to give to premature infants to prevent a deadly intestinal disease. (2008-09-05)

Syracuse University partners with Serum Institute of India to develop vaccines for children
A unique partnership between Syracuse University and the Serum Institute of India could lead to better access to life-saving vaccines for children living in some of the most impoverished areas of the world. The Institute recently awarded $250,000 to a team of SU researchers led by Robert Doyle, assistant professor of chemistry in the College of Arts and Sciences, to develop new oral vaccines against tetanus and rotavirus, a severe form of diarrhea that affects infants and young children worldwide. (2008-09-04)

How gastric bypass rapidly reverses diabetes symptoms
A report in the September Cell Metabolism, a publication of Cell Press, offers new evidence to explain why those who undergo gastric bypass surgery often show greater control of their diabetes symptoms within days. (2008-09-02)

State's first single incision robotic kidney removal
For the first time in Michigan, a diseased kidney has been surgically removed at Henry Ford Hospital using highly sophisticated 3-D robotics through a single incision. (2008-08-25)

Nano-sized 'trojan horse' to aid nutrition
Researchers from Monash University have designed a nano-sized (2008-08-24)

UT Southwestern researchers uncover molecule that keeps pathogens like salmonella in check
Scientists at UT Southwestern Medical Center have found a potential new way to stop the bacteria that cause gastroenteritis, tularemia and severe diarrhea from making people sick. (2008-08-21)

Bone marrow stem cells may help control inflammatory bowel disease
Massachusetts General Hospital investigators have found that infusions of a particular bone marrow stem cell appeared to protect gastrointestinal tissue from autoimmune attack in a mouse model. (2008-08-20)

Penn researchers find a new role for a 'Foxy Old Gene'
Researchers at the University of Pennsylvania School of Medicine have discovered that a protein called FOXA2 controls genes that maintain the proper level of bile in the liver. FOXA2 may become the focus for new therapies to treat diseases that involve the regulation of bile salts. (2008-08-01)

String probes for devastating childhood digestive disease
A swallowed string may someday replace the invasive, uncomfortable endoscope now used to diagnose eosinophilic esophagitis, a devastating childhood disease of the esophagus. (2008-07-30)

ASGE issues guidelines on the role of endoscopy in the bariatric surgery patient
The American Society for Gastrointestinal Endoscopy has issued guidelines on the role of endoscopy in the bariatric surgery patient. The guidelines discuss endoscopy in the preoperative patient and the postoperative patient, and appear in the July issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the ASGE. (2008-07-25)

Cellular self-eating promotes pancreatitis
To survive tough times, cells sometimes resort to a form of self-cannibalism called autophagy. But as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by prematurely activating a digestive enzyme. The report is to be published in the June 30 issue of the Journal of Cell Biology. (2008-06-30)

Prebiotic potential of almonds
Recently published work by the Institute of Food Research has identified potential prebiotic properties of almonds that could help improve our digestive health by increasing levels of beneficial gut bacteria. (2008-06-27)

Study links gastric bypass surgery to increased risk of kidney stones
Morbidly obese patients who undergo a particular type of gastric bypass surgery called Roux-en-Y gastric bypass are at an increased risk of developing kidney stones -- small, pebble-like deposits that can result in severe pain and require an operation to remove them -- earlier than previously thought. (2008-06-26)

Study underway to find an alternative cure for Crohn's disease and ulcerative colitis
Two research studies evaluating dietary changes and complementary medicine for the treatment of inflammatory bowel diseases have been launched at Rush University Medical Center. Funded by the National Institute of Health, one study will look at the impact of mind/body medicine on patients suffering from ulcerative colitis and the other will assess how diet impacts patients with Crohn's disease. (2008-06-16)

Novel compound may treat acute diarrhea
In a development that may lessen the epidemic of diarrhea-related deaths among children in developing countries, scientists in the laboratory of Nobel Laureate Ferid Murad, M.D., Ph.D., at the University of Texas Health Science Center at Houston have discovered a novel compound that might lead to an inexpensive, easy-to-take treatment. (2008-06-16)

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