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Current Spinal Cord Injury News and Events, Spinal Cord Injury News Articles.
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Prenatal exposure to malaria may determine disease susceptibility early in life
Prenatal exposure to malaria considerably alters the newborn's innate immune response (i.e. its first line of defence), particularly when the placenta has been infected, according to a study led by ISGlobal, the Clinical Research Unit of Nanoro (CRUN) and the Institute of Tropical Medicine Antwerp (ITM). The results, published in BMC Medicine, could help explain why some babies are more susceptible to malaria than others during their first year of life. (2018-11-01)

Breakthrough neurotechnology for treating paralysis
Three patients with chronic paraplegia were able to walk over ground thanks to precise electrical stimulation of their spinal cords via a wireless implant. In a double study published in Nature and Nature Neuroscience, Swiss scientists Grégoire Courtine (EPFL and CHUV/Unil) and Jocelyne Bloch (CHUV/Unil) show that, after a few months of training, the patients were able to control previously paralyzed leg muscles even in the absence of electrical stimulation. (2018-10-31)

Pseudarthrosis following single-level ACDF is five times more likely when a PEEK interbody device is used
Researchers found pseudarthrosis (lack of new bone regrowth) to be five times more likely after a polyetheretherketone (PEEK) interbody spacer device had been used to bridge the gap between vertebrae during cervical spine surgery than after a structural (bone) allograft had been used. (2018-10-30)

University of Miami Miller School of Medicine -- managing common ankle fractures
'Management of Isolated Lateral Malleous Fractures' written by Aimethab A. Aiyer was published in the Journal of the American Academy of Orthopaedic Surgeons. (2018-10-30)

Gunshot wounds in children account for $270 million in emergency room and inpatient charges annually
A new Johns Hopkins study of more than 75,000 teenagers and children who suffered a firearm-related injury between 2006 and 2014 pinpoints the financial burden of gunshot wounds and highlights the increasing incidence of injury in certain age groups. (2018-10-29)

Evidence mounts that an eye scan may detect early Alzheimer's disease
Results from two studies show that a new, non-invasive imaging device can see signs of Alzheimer's disease in a matter of seconds. The researchers show that the small blood vessels in the retina at the back of the eye are altered in patients with Alzheimer's. (2018-10-28)

'Navigator' neurons play critical role in sense of smell
Researchers at the Stowers Institute for Medical Research have identified 'navigator' neurons that are key to setting up connections in the system responsible for the sense of smell. The new study builds on a breakthrough 2014 report from the laboratory of Stowers Investigator Ron Yu, Ph.D., which showed a critical period in olfactory wiring using mice as a model system. (2018-10-26)

Smoke alarms using mother's voice wake children better than high-pitch tone alarms
In a study published online today in the Journal of Pediatrics, researchers in the Center for Injury Research and Policy and the Sleep Disorders Center at Nationwide Children's Hospital examined characteristics of four different smoke alarms to determine which ones worked best to wake children. The researchers found that a sleeping child was about three times more likely to be awakened by one of the three voice alarms than by the tone alarm. (2018-10-25)

Scientists uncover why knee joint injury leads to osteoarthritis
The mechanisms leading to osteoarthritis are not known. Currently, it is not possible for a physician examining a patient to predict future joint condition and possible development of osteoarthritis. In the future, however, this may be possible, as a new study from the University of Eastern Finland and Massachusetts Institute of Technology now shows that articular cartilage degenerates specifically around injury areas when the fluid flow velocity becomes excessive. (2018-10-25)

IUPUI biologists use 'mini retinas' to better understand connection between eye and brain
IUPUI biologists are growing 'mini retinas' in the lab from stem cells to mimic the growth of the human retina. The researchers hope to restore sight when critical connections between the eye and the brain are damaged. These models also allow researchers to better understand how cells in the retina develop and are organized. These results are published online in Scientific Reports, a Nature Research journal. (2018-10-25)

Acute kidney injury linked to higher risk of dementia
Patients with acute kidney injury had more than a 3-fold higher risk of developing dementia compared with those without acute kidney injury during a median follow-up time of 5.8 years. Results from the study will be presented at ASN Kidney Week 2018 Oct. 23-28 at the San Diego Convention Center. (2018-10-25)

Landmark study reveals no benefit to costly and risky brain cooling after brain injury
A landmark study, led by Monash University researchers, has definitively found that the practice of cooling the body and brain in patients who have recently received a severe traumatic brain injury, has no impact on the patient's long-term outcome. (2018-10-24)

Nerve-on-a-chip platform makes neuroprosthetics more effective
EPFL scientists have developed a miniaturized electronic platform for the stimulation and recording of peripheral nerve fibers on a chip. By modulating and rapidly recording nerve activity with a high signal-to-noise ratio, the platform paves the way to using chips to improve neuroprosthetic designs. (2018-10-23)

Medical crowdfunding for treatments unsupported by evidence or potentially unsafe
Medical crowdfunding is using social media to appeal for help in paying for medical care. These campaigns can fill insurance gaps but they can also raise money for scientifically unsupported, ineffective or potentially dangerous treatments. This study examined crowdfunding activity for five such treatments since November 2015 and identified more than 1,000 campaigns that raised nearly $6.8 million. (2018-10-23)

SBRT considered safe treatment option for patients with multiple (2-4) metastases
The NRG Oncology clinical trial BR001 tested the hypothesis that stereotactic body radiotherapy (SBRT) could be used safely in oligometastatic patients with multiple metastases. (2018-10-23)

Football players' concussions linked to dyslexia gene
A gene associated with dyslexia, a learning disorder, may make some athletes less susceptible to concussions, reports a new study. This is believed to be the first time that this gene has been implicated in concussion or mild traumatic brain injury in athletes of a high-impact sport. (2018-10-23)

How to help protect yourself from vaccine administration injury
A study by researchers at the University of Waterloo reiterates the need for health care professionals, including pharmacists, to take certain precautions to minimize the risk of their patients suffering shoulder injury related to vaccine administration (SIRVA). (2018-10-23)

New technique reveals limb control in flies -- and maybe robots
A new neural recording technique developed by EPFL bioengineers enables for the first time the comprehensive measurement of neural circuits that control limb movement. Tested on the fruit fly, results from the technique may inspire the development of more sophisticated robotic control approaches. (2018-10-22)

New tool gives deeper understanding of glioblastoma
Researchers in the lab of Charles Danko at the Baker Institute for Animal Health have developed a new tool to study genetic 'switches' active in glioblastoma tumors that drive growth of the cancer. In a new paper in Nature Genetics, they identified key switches in different types of tumors, including switches linked to how long a patient survives. (2018-10-22)

Mouse study supports stem cell therapy for cerebral palsy
Neural stem cells can repair damaged parts of the brain and restore motor impairments in mice that display features of cerebral palsy, according to new research published in eNeuro. These results demonstrate the feasibility of using stem cells to address the underlying brain injuries responsible for this group of common movement disorders. (2018-10-22)

Study points to new method to deliver drugs to the brain
Researchers at the University of Rochester Medical Center have discovered a potentially new approach to deliver therapeutics more effectively to the brain. The research could have implications for the treatment of a wide range of diseases, including Alzheimer's, Parkinson's, ALS, and brain cancer. (2018-10-18)

A new mechanism in the control of inflammation
Researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered a new inflammation control mechanism that shows how the damage caused by the immune response can be controlled. (2018-10-18)

Childhood abuse linked to increased arthritis risk in adulthood
In a survey-based study of 21,889 adults in Canada, severe and/or frequent physical abuse during childhood and frequent childhood exposure to intimate partner violence were linked with higher risks or arthritis during adulthood arthritis, even after controlling for a range of factors. (2018-10-17)

Bone cell response to mechanical force is balance of injury and repair
Scientists have revealed the intricate process that bone cells use to repair themselves after mechanical injury. (2018-10-17)

Exposure to malaria before birth may boost childhood immunity
Pamela Odorizzi and colleagues have discovered that human fetal immune cells can proliferate in response to malaria infection in pregnant women, a finding that helps to demystify fetal immunity and potentially has implications for malaria control programs. (2018-10-17)

Researchers propose conceptual framework to study role of exercise in multiple sclerosis
'Exercise is a low-cost, non-invasive modality,' noted Dr. John DeLuca, 'so we are very interested in learning more about how activity results in these improvements. Rethinking how we view exercise in the long-term management of MS and other neurological conditions is our first step. We anticipate that the PRIMERS framework will accelerate advances in treatment by integrating the contributions from neuroscience, neurophysiology, and neurorehabilitation.'' (2018-10-17)

A role for circadian enhancers to prevent myocardial injury in the perioperative setting
The current study demonstrates a deleterious effect of midazolam administration prior to myocardial ischemia and reveals reduced circadian protein Period 2 (PER2) levels as the underlying mechanism. These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancer nobiletin as preventative therapy for myocardial injury in the perioperative setting where midazolam pretreatment occurs frequently. (2018-10-17)

Hippocampus yields clues to treatment strategies for cognitive deficits in MS
'Recent advances in neuroimaging have greatly improved our understanding of the involvement of the hippocampus in MS,' said John DeLuca, PhD, at Kessler Foundation. 'Now we are aware of subregions with different levels of susceptibility to damage, for example, and the potential for hippocampal plasticity and neurogenesis. The challenge is to correlate these findings with clinical manifestations and renew our efforts toward improving outcomes for the population with MS.' (2018-10-16)

Blood test biopsy for kids with brain tumors is simple, safe way to see if treatment is working
A new blood test for children with brain tumors offers a safer approach than surgical biopsies and may allow doctors to measure the effectiveness of treatment even before changes are identified on scans, according to research led by UCSF Benioff Children's Hospitals and Children's National Health System. (2018-10-15)

Pain disruption therapy treats source of chronic back pain
People with treatment-resistant back pain may get significant and lasting relief with dorsal root ganglion (DRG) stimulation therapy, an innovative treatment that short-circuits pain, suggests a study presented at the ANESTHESIOLOGY® 2018 annual meeting. (2018-10-14)

Study holds promise for new pediatric brain tumor treatment
New research published in Nature Communications from scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U), in collaboration with the Stanford University School of Medicine, shows a specific protein regulates both the initiation of cancer spreading and the self-renewal of cancer cells in medulloblastoma, a type of pediatric brain cancer. (2018-10-11)

The fine print
University of Utah biomedical engineering assistant professor Robby Bowles and his team have developed a method to 3D print cells to produce human tissue such as ligaments and tendons to greatly improve a patient's recovery. A person with a badly damaged ligament, tendon, or ruptured disc could simply have new replacement tissue printed and ultimately implanted in the damaged area. (2018-10-10)

New approach could jumpstart breathing after spinal cord injury
A research team at the Krembil Research Institute in Toronto has developed an innovative strategy that could help to restore breathing following traumatic spinal cord injury. (2018-10-10)

Scientists get in touch with the biology underlying pain
Scientists now have a better understanding of why sensory neurons sometimes register light touches as painful (a common and debilitating condition called mechanical allodynia) following injury in mice and humans, thanks to the results of two studies. (2018-10-10)

Organs-on-chip technology reveals new drug candidates for Lou Gehrig's disease
The investigation of amyotrophic lateral sclerosis (ALS) -- also known as Lou Gehrig's disease -- through muscle-on-a-chip technology has revealed a new drug combination that may serve as an effective treatment of the progressive neurodegenerative disease. (2018-10-10)

Study identifies gene that makes gentle touch feel painful after injury
In a study of four patients with a rare genetic disorder, NIH researchers found that the PIEZO2 gene may be responsible for tactile allodynia: the skin's reaction to injury that makes normally gentle touches feel painful. This and a second NIH-funded study showed how the gene may play an essential role in the nervous system's reaction to injury and inflammation, making PIEZO2 a target for developing precise treatments for relieving the pain caused by cuts, burns, and other skin injuries. (2018-10-10)

Neuron death in ALS more complex than previously thought
Brown University researchers have discovered that two different kinds of motor neurons that die in people with ALS may die in different ways -- an important insight for understanding the disease and, eventually, finding a cure. (2018-10-09)

Researchers demonstrate first example of a bioelectronic medicine
Northwestern University and Washington University School of Medicine researchers have developed the first example of a bioelectronic medicine: an implantable, biodegradable wireless device that speeds nerve regeneration and improves healing of a damaged nerve. Their device delivered pulses of electricity to damaged nerves in rats after a surgical repair process, accelerating the regrowth of nerves and enhancing the recovery of muscle strength and control. The device is the size of a dime and the thickness of a sheet of paper. (2018-10-08)

Implantable, biodegradable devices speed nerve regeneration in rats
Peripheral nerve injuries leave people with tingling, numbness and weakness in their arms, hands and legs. Researchers at Washington University School of Medicine in St. Louis and Northwestern have developed an implantable, bioabsorbable device that speeds recovery in rats by stimulating injured nerves with electricity. (2018-10-08)

US researchers explore variations in employment outcomes for people with disabilities
'Employment outcomes were most strongly related to the economic conditions and physical environment; the policy environment was less of an influence,' noted John O'Neill, Ph.D., director of disability and employment research at Kessler Foundation. 'None of these factors, were as strongly related as individual health and personal characteristics, which is why all of these factors need to be weighed and considered in order to find effective ways to improve employment outcomes for people with disabilities.' (2018-10-08)

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