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Statins could reduce risk of cardiovascular disease
The benefit of statins to prevent cardiovascular disease could extend to people receiving therapy for high blood pressure, conclude authors of an international study published in The Lancet this week. (2003-04-02)

Study finds drug can cut chance of a heart attack by more than a third
Results from the ASCOT (Anglo Scandinavian Cardiac Outcome Trial) study have shown that patients receiving the cholesterol controlling drug, atorvastatin, are more than a third less likely to have heart attacks, and more than a quarter less likely to suffer from strokes. (2003-04-02)

Statins before procedures reduce cardiovascular events and death
Taking cholesterol-lowering drugs before undergoing artery-clearing procedures appears to reduce deaths, heart attacks, and recurrent blockages among patients with elevated levels of an inflammation marker, according to research reported in today's rapid access issue of Circulation: Journal of the American Heart Association. (2003-03-24)

Study to determine the effects of statins and C-reactive protein on cardiovascular disease
The JUPITER study, lead by Paul Ridker, MD, MPH, Director of the Center of Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, is the first study of its kind designed to evaluate the effect of statin therapy on the reduction of cardiovascular morbidity and mortality among individuals with average or normal LDL-cholesterol levels and elevated C-reactive protein (CRP) levels. (2003-03-18)

New Jersey chemist wins national award for drug discoveries
A.K. Ganguly of Upper Montclair, N.J., will be honored March 25 by the American Chemical Society for designing compounds to treat disease, including cancer and high cholesterol. He will receive the 2003 E.B. Hershberg Award for Important Discoveries in Medicinally Active Substances at the Society's national meeting in New Orleans. (2003-03-04)

Ann Arbor chemist wins national award for drug discovery
Bruce D. Roth of Ann Arbor, Mich., will be honored March 25 by the American Chemical Society for inventing and helping develop the molecule that would become Lipitor(r), the most commonly prescribed drug to lower cholesterol. He will receive the 2003 ACS Award for Creative Invention at the Society's national meeting in New Orleans. (2003-03-04)

Apolipoproteins better than cholesterol for predicting cardiovascular disease?
Authors of a review in this week's issue of The Lancet outline how the measurement of lipid molecules called apolipoproteins could be more reliable indicators of cardiovascular disease than the measurement of LDL ('bad') cholesterol. (2003-02-27)

Anti-cholesterol statins do not reduce reproductive hormones in women of child-bearing age
A new study suggests that neither the use of statins nor low blood cholesterol levels significantly affected reproductive hormone levels in pre-, peri, or postmenopausal women. These findings are the subject of an article appearing in the current issue of the American Journal of Medicine. (2002-12-31)

Key gender difference found in sickle cell disease
Nitric oxide, a substance that helps blood vessels dilate, is up to two times more available in women than men with the genetic condition, sickle cell anemia. This may help explain gender differences in survival, researchers report in today's rapid access issue of Circulation: Journal of the American Heart Association. (2002-12-23)

Stroke in the 21st century
In the first issue of 2003, TLN examines stroke epidemiology and stroke trials. In their review, Valery Feigin and co-authors provide an overview of population-based studies of incidence, prevalence, mortality, and case-fatality of stroke based on studies reported between 1996 and 2002. From their analysis the authors conclude, (2002-12-19)

Study suggests inflammatory protein is strongly associated with heart disease
Exercise-induced cardiac ischemia, or reduced blood flow to the heart, is associated with high levels of C-reactive protein (CRP)--a marker of inflammation--in people with coronary heart disease, according to a new study by researchers at the San Francisco VA Medical Center (SFVAMC). The finding adds to the evidence that inflammation is associated with cardiovascular disease. (2002-12-16)

Combining key ingredients of vegetarian diet cuts cholesterol significantly, says study
A diet combining a handful of known cholesterol-lowering plant components cut bad cholesterol by close to 30 per cent in a study by researchers at the University of Toronto and St. Michael's Hospital. The reduction is similar to that achieved by some drug treatments for high cholesterol, suggesting a possible drug-free alternative for combating the condition. (2002-12-01)

Statins benefit older people
Elderly people at high risk of cardiovascular disease could benefit substantially by treatment with statins, cholesterol-lowering drugs with known effectiveness among middle-aged people at risk of heart disease and stroke, conclude authors of a study in this week's issue of The Lancet. (2002-11-21)

Statin drugs may help patients with heart valve disease avoid surgery
A study by Mayo Clinic researchers indicates that narrowing of the heart's (2002-11-19)

Starting beta-blocker before discharge in patients hospitalized for heart failure increases usage
Initiating low-dose beta-blockers prior to discharge in heart failure patients hospitalized for worsening symptoms significantly improves the use of a drug that has been shown in previous studies to reduce death and morbidity by more than 35 percent. (2002-11-18)

Cholesterol drug could lead to new therapy for multiple sclerosis
While cautioning that their findings still must be evaluated in humans, University of California, San Francisco and Stanford University Medical Center researchers report that the cholesterol-lowering drug atorvastatin (Lipitor) significantly improved, prevented relapses or reversed paralysis in mice with an experimental disease that closely resembles multiple sclerosis. (2002-11-06)

Important information to consider about non-systemic cholesterol lowering agents
There's been quite a bit of (2002-10-29)

ACE linked to calcium growth on aortic valve
Future studies may find that ACE inhibitors, a class of drugs now taken by people with high blood pressure, could slow down or prevent the development of aortic valve calcium. Researchers analyzed 21 human aortic valves. Angiotensin-converting enzyme, or ACE, was not detected in normal aortic valves, but was present in all valves with lesions. (2002-10-22)

Cholesterol fighting drugs may also have protective effects against multiple sclerosis
A group of cholesterol-lowering drugs may also effectively interfere with the progression of multiple sclerosis (MS). These drugs, known as statins, greatly reduce hardening of the arteries (atherosclerosis) and heart disease, mainly by their cholesterol and low-density lipoprotein-lowering properties. (2002-10-07)

Annals of Internal Medicine, tip sheet, October 1, 2002
A study of Medicare and other government records of 130,099 elderly heart attack patients found that those with kidney disease were at much higher risk for death than other elderly heart attack patients during the month following hospitalization. (2002-09-30)

Cognitive decline after cardiac valve replacement not a given
A new study challenges previous findings that patients undergoing elective coronary bypass grafting (CABG), or valve replacement, experience long-term cognitive decline. According to the study published in Neurology, the scientific journal of the American Academy of Neurology, that's not always the case. (2002-09-09)

Inflammation reduced after just two weeks on statin drug
The cholesterol-lowering drug simvastatin reduces both cholesterol and an inflammation marker linked to heart disease within two weeks, according to a study in today's rapid access issue of Circulation: Journal of the American Heart Association. (2002-08-26)

Cholesterol-lowering drugs should revolutionise treatment of heart attack and stroke
Results of a landmark study published in the July 6 issue of THE LANCET highlight how the prescribing of statins to lower blood cholesterol could reduce rates of heart attack and stroke by at least a third. (2002-07-04)

Heart experts call for urgent action to implement new findings on cholesterol-lowering treatment
Research to be reported in 6 July issue of Lancet should lead to major treatment changes in prescribing cholesterol-lowering drugs say UK heart experts. Tens of thousands of lives could be saved each year by changing prescribing guidelines for statins, say UK researchers. (2002-07-04)

Early statin use refined
While a class of cholesterol-lowering drugs known as statins are effective in reducing the chances of a second heart event for patients with coronary artery disease, a new analysis shows that only patients whose cholesterol levels are above the recommended guidelines are likely to benefit from receiving these drugs earlier than usual. (2002-06-18)

High cholesterol and calcification are to blame for aortic valve disease
A study published today in Circulation authored by researchers at Northwestern Memorial Hospital is the first to explain the mechanism responsible for aortic valve disease and points to possible benefits of using statins to treat patients with early stages of the aortic valve disease process. (2002-06-03)

Statin drugs lower heart disease risk in postmenopausal women
Treatment with a cholesterol-lowering statin can significantly reduce the risk of heart disease and possibly death in postmenopausal women taking hormone replacement therapy (HRT), investigators report in the rapid access issue of Circulation: Journal of the American Heart Association. (2002-06-03)

Statin drugs may increase risk of peripheral neuropathy
Statin drugs can increase the risk of developing peripheral neuropathy, according to a study published in the May 14 issue of Neurology, the scientific journal of the American Academy of Neurology. (2002-05-13)

Natural cholesterol-lowerer shows the way
Baylor College of Medicine scientists studying a natural product used in Indian traditional medicine for more than 2,500 years have unlocked the secret to its cholesterol-lowering success and possibly opened the door to production of more potent medicines. Dr. David D. Moore, professor of molecular and cell biology, and fourth-year Ph.D. student Nancy L. Urizar discovered that an extract of the resin of the guggul tree - approved as a cholesterol-fighter in India - actually targets the Farnesoid X Receptor. (2002-05-02)

Genetic 'bar codes' predict effect of statins
Searching for patterns of genetic variation, rather than a single variation, may be a more promising approach to predicting a person's response to cholesterol-lowering therapy, according to research presented today at the American Heart Association's Asia Pacific Scientific Forum. (2002-04-24)

Statin drugs may lower risk of Alzheimer's
Taking the cholesterol-lowering drugs called statins may reduce the risk of developing Alzheimer's disease, according to research presented during the American Academy of Neurology's 54th Annual Meeting in Denver, Colo., April 13-20, 2002. (2002-04-16)

Statins may prevent damage by Alzheimer's disease protein, USF study finds
Commonly-used cholesterol-lowering drugs, known as statins, block damage by an Alzheimer's-associated protein in neurons and blood vessels, a study by University of South Florida researchers found. The researchers looked at the biochemical effects of statins in reducing damage from Alzheimer's disease. (2002-04-02)

Statins may inhibit calcium growth on aortic valve in the elderly
People who take statins may have at least 60 percent less aortic valve calcium than people who do not take statins, according to a study in the March 30 edition of The Lancet. (2002-03-28)

Lower medication prices buy more years of life for the elderly
Policies that encourage lower drug costs could result in longer lives for many elderly patients who are dependent on these medications, according to a new study. (2002-03-26)

Cholesterol bad for brain too, UCSF study says
Higher cholesterol levels are not only bad for the heart and blood vessels, they increase the risk of cognitive impairment, the precursor to Alzheimer's disease, according to a study of elderly women by UCSF researchers (2002-03-14)

Stopping statins may cause rebound that triples risk of death
Heart disease patients who discontinued using cholesterol-lowering drugs while they were hospitalized for chest pain had triple the risk of death or heart attack as people who kept taking their medicine, say researchers in today's rapid access publication of Circulation: Journal of the American Heart Association. (2002-03-04)

Two cholesterol-lowering statin drugs reduce another marker of coronary-artery disease
Two out of three statins, powerful drugs lauded for dramatically lowering low-density lipoproteins (LDL) - the bad cholesterol - have been found to significantly decrease another risk factor for coronary-artery disease, researchers at UT Southwestern Medical Center at Dallas reported. (2001-12-12)

Treatment reduces risk of heart attack by 60 to 90 percent, reverses arterial plaque buildup; antioxidant vitamins diminish beneficial effect
Treatment with a combination of statin and niacin can slash the risk of a fatal or non-fatal heart attack or hospitalization for chest pain by 70 percent among patients who are likely to suffer heart attacks and/or death from coronary heart disease. The study also found that a mixture of antioxidant vitamins had no beneficial effect on cardiovascular outcomes. (2001-11-28)

Cholesterol-independent benefits of statins in cardiac hypertrophy
The statin drugs are best known for their ability to block cholesterol biosynthesis and have been widely prescribed to people at risk of heart disease because of high serum cholesterol. Takemoto and coworkers have now identified another beneficial effect of these drugs that might make them suitable for treating a different set of heart patients, those with cardiac hypertrophy. (2001-11-14)

LIFE-SAVER: World's largest cholesterol-lowering trial reveals massive benefits for high-risk patients
Around a third of all heart attacks and strokes can be avoided in people at risk of vascular disease by using statin drugs to lower blood cholesterol levels - irrespective of the person's age or sex, and even if their cholesterol levels do not seem high. That's the conclusion of UK researchers who have just completed the world's largest randomised trial on cholesterol-lowering therapy. (2001-11-13)

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