Current Stem Cell Research News and Events | Page 25

Current Stem Cell Research News and Events, Stem Cell Research News Articles.
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Scientists find new type of cell that helps tadpoles' tails regenerate
Researchers at the University of Cambridge have uncovered a specialised population of skin cells that coordinate tail regeneration in frogs. These 'Regeneration-Organizing Cells' help to explain one of the great mysteries of nature and may offer clues about how this ability might be achieved in mammalian tissues. (2019-05-16)

What do they mean by 'stem cells'? Recommended guidelines for reporting on cell therapies
Cell therapies including so-called 'stem cells' are increasingly being marketed and used for the treatment of musculoskeletal disorders -- despite questions about these treatments and their effectiveness. A new tool for standardizing communication about cell therapies is presented in the May 15, 2019 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer. (2019-05-16)

Blood biopsy: New technique enables detailed genetic analysis of cancer cells
A new way to cleanly separate out cancer cells from a blood sample enables comprehensive genetic profiling of the cancer cells, which could help doctors target tumors and monitor treatments more effectively. (2019-05-15)

Cellular rivalry promotes healthy skin development
Scientists have discovered a curious phenomenon taking place in mouse skin: cells compete with one another for the chance to develop into mature tissue. The findings indicate that this antagonism is key to creating healthy skin. (2019-05-15)

Early in vitro testing for adverse effects on embryos
ETH researchers have combined embryonic cells and liver cells in a new cell culture test. This combination lets them detect adverse effects that new medications may have on embryos early on in the drug development process. (2019-05-14)

A nerve cell serves as a 'single' for studies
Nerve cells derived from human stem cells often serve as the basis for research into brain diseases. However, these cells differ considerably in their quality and produce varying results. Scientists are therefore looking for simple cell models that lead to consistent results. Research teams from the University of Bonn, the Vrije Universiteit Amsterdam and the Max Planck Institute for Experimental Medicine in Göttingen describe a model that consists of only one human nerve cell. (2019-05-14)

Immune system discovery could aid quest for stem cell therapies
Scientists have discovered how stem cells can develop resistance against viruses, a finding that could aid the development of stem cell therapies. (2019-05-14)

A new way to wind the development clock of cardiac muscle cells
A study published in the journal Stem Cells describes a new and unexpected way to accelerate the maturation of induced pluripotent stem cells into cardiac muscle cells. (2019-05-14)

WVU researcher studies incurable blood disease usually diagnosed in children
Most people with Fanconi anemia are diagnosed before they turn 12 but don't live past 30. Wei Du -- a researcher in the WVU School of Pharmacy and the WVU Cancer Institute -- is exploring the metabolic processes the underlie this form of anemia. Her findings may lead to new gene therapies that help patients live better, longer. (2019-05-13)

Turning off growth to make flowers grow
Researchers at the Nara Institute of Science and Technology (NAIST) report the final epigenetic events that terminate stem cell growth for proper flower development. They show the series of steps the binding of the transcription factor KNUCKLES initiates to suppress the gene expression of WUSCHEL in Arabidopsis. The ability to control flower growth has implications on seed productivity and food technology. (2019-05-13)

Prince Charming's kiss unlocking brain's regenerative potential?
Kyoto University researchers find that 'waves' of Hes1 and Ascl1 gene expression control the quiescent and active state of adult neural stem cells. Hes1 expression promotes quiescence and suppresses Ascl1, and knocking out Hes1 increases Ascl1 expression and subsequent adult neural stem cell activation. (2019-05-10)

Scientists grow precursors for human pigment cells
Our hair, skin and eyes are colored by a pigment called melanin, which is produced by pigment cells called melanocytes. Scientists have used stem cell technology to successfully create melanocyte precursor cells. These cells can be used in research on melanoma and other pigment cell-related illnesses. The findings were published on March 6 in the online edition of Pigment Cell & Melanoma Research. (2019-05-09)

Location is everything for plant cell differentiation
During development, plant cell differentiation is guided by location rather than lineage. Now, researchers from Osaka University have shown that the accumulation and intracellular localization of regulatory protein ATML1, which controls the expression of genes associated with epidermal cell identity, are also critical for the differentiation of plant cells into an epidermal layer. (2019-05-09)

Stem cell scientists clear another hurdle in creating transplant arteries
Recent work highlights a better way to grow smooth muscle cells, one of the two cellular building blocks of arteries, from pluripotent stem cells. This research is part of an effort to create artery banks -- similar to blood banks common today -- with readily-available material to replace diseased arteries during surgery. (2019-05-09)

Stem cells provide information about neuron resilience in ALS
Researchers at Karolinska Institutet in Sweden have developed a stem cell based model in order to study the resilience and vulnerability of neurons in the neurodegenerative disease ALS. The results are published in the journal Stem Cell Reports and can aid in the identification of new genetic targets for treatments protecting sensitive neurons. (2019-05-09)

Personalized 'Eye-in-a-Dish' models reveal genetic underpinnings of macular degeneration
Using stem cells derived from six people, UC San Diego School of Medicine researchers recapitulated retinal cells in the lab. This 'eye-in-a-dish' model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss. (2019-05-09)

Will MSC micropellets outperform single cells for cartilage regeneration?
Repair of cartilage injuries or defects is aided by the introduction of mesenchymal stem cells (MSCs), which can be incorporated into hydrogels to amplify their effects. In a new report, researchers directly compared chondrogenic induction by hydrogels that were prepared using MSCs either as single cell suspensions or as 100-500-cell micropellets. (2019-05-09)

Back to the sources of neural diversity
The diversity of the tasks the cortex can perform is reflected in the diversity of the neurons that compose it. These neurons are spawned from progenitor stem cells, which divide and produce these different cell types. But how do these progenitors manage to generate specific types of neurons in the right place? By identifying the genetic scenarios at work, researchers (UNIGE/UNIL/ULiège) lift the veil on the birth of cells that make up brain circuits. (2019-05-09)

How to generate a brain of correct size and composition
To build the neocortex, a brain area involved in higher cognitive functions, stem cells produce billions of neurons of various types. In a Science study, neuroscientists from Switzerland, Belgium, and the Institute of Science and Technology Austria (IST Austria) have now shown that, over time, the neocortical stem cells go through various maturation states, each of them leading to a distinct neuron type. Production of the correct neuron type is bound to a specific protein complex. (2019-05-09)

Inhibition of ribosome biogenesis as a novel approach for multi-stage cancer treatment
Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study from Uppsala University shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced. The results open the possibility for new treatment strategies for advanced cancers. The study is published in Nature Communications. (2019-05-08)

New research shows promise for success of underrepresented scholars in STEM
With the goal of preparing scholars from underrepresented groups to succeed in graduate and professional programs, Penn State, the University of North Carolina at Chapel Hill (UNC) and the University of Maryland, Baltimore County (UMBC) partnered to develop undergraduate programs aimed at increasing retention and academic performance of historically racially underrepresented undergraduates in science, technology, engineering and mathematics (STEM) fields. (2019-05-08)

Advancing cell therapy for diabetes
Harvard University researchers used single-cell sequencing to identify a protein expressed uniquely by insulin-producing beta cells created from stem cells in the laboratory. By targeting the protein and adding a physical enrichment method developed by collaborators at Semma Therapeutics, the purity of beta cells improved from 30 to 80%. Improved control over the beta cell production process will allow researchers to refine cell therapy for patients with type 1 diabetes. (2019-05-08)

Innovative mechanobiology research expands understanding of cells
Researchers have developed a new technology that allows them to probe cell changes without disturbing the cell's physiology -- a major advancement that helps scientists look more closely at cell changes to solve human health problems, according to a new paper in Cell Reports. This technology, known as deformation microscopy, allows scientists to more accurately assess the interplay between biological systems and the mechanical environment in treating musculoskeletal, cardiac and neural diseases. (2019-05-08)

Genome editing helps decipher a congenital liver disease
Congenital hepatic fibrosis (CHF) is a rare genetic disease that can lead to severe liver impairment. The symptoms of CHF are distinct compared to other liver ailments, and while the PKHD1 gene has been implicated, the exact molecular basis for the unique disease pathology is unknown. Using a CRISPR-generated model, researchers at Tokyo Medical and Dental University (TMDU) identified molecular targets contributing to CHF. These targets may offer new therapeutic approaches to the disease. (2019-05-07)

Stem cells make more 'cargo' packets to carry cellular aging therapies
Johns Hopkins scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells (iPSCs), make tiny 'cargo packets' able to deliver potentially restorative or repairing proteins, antibodies or other therapies to aged cells. They say the human iPSCs they studied produced much more of the packets, formally known as extracellular vesicles, than other kinds of adult stem cells commonly used for this purpose in research. (2019-05-07)

UW-Madison research team finds new ways to generate stem cells more efficiently
A new study published in Cell Reports by a team of researchers at the University of Wisconsin-Madison's Wisconsin Institute for Discovery and School of Medicine and Public Health could improve the efficiency of creating induced pluripont stem cells. (2019-05-07)

Pigment-producing stem cells can regenerate vital part of nervous system
Neurodegenerative diseases like multiple sclerosis (MS) affect millions of people worldwide and occur when parts of the nervous system lose function over time. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered that a type of skin-related stem cell could be used to help regenerate myelin sheaths, a vital part of the nervous system linked to neurodegenerative disorders. (2019-05-06)

Messenger cells bring good news for bone healing, USC stem cell study finds
How do bones heal, and how could they heal better? The answer to these questions may lie in a newly discovered population of 'messenger' cells, according to a recent USC Stem Cell study published in the journal eLife. (2019-05-03)

The immaculate conception?
A new, groundbreaking study by the Hebrew University of Jerusalem (HU) found a way to transform skin cells into the three major stem cell types that comprise early-stage embryos. This work has significant implications for modelling embryonic disease and placental dysfunctions, as well as paving the way to create whole embryos from skin cells. (2019-05-02)

Specialized plant cells regain stem-cell features to heal wounds
If plants are injured, cells adjacent to the wound fill the gaps with their daughter cells. However, which cells divide to do the healing and how they manage to produce cells that match the cell type of the missing tissue has been unclear. Scientists from the Institute of Science and Technology Austria (IST Austria) have now shown that to correctly replace dead cells, neighbors to the inside of the wound re-activate their stem cell programs. (2019-05-02)

Pluripotency or differentiation -- That is the question
Induced pluripotent stem cells can turn into any type of cell in the body or remain in their original form. In Molecular Cell, scientists from the Helmholtz Zentrum München describe how cells 'decide' which of these two directions to take. During their research, they identified a protein and a ribonucleic acid (RNA) that play a highly significant role in this process. Their discovery also allows a better understanding of amyotrophic lateral sclerosis (ALS)*. (2019-05-02)

Removal of gene prevents development of pancreatic cancer in mice
The action of a gene called ATDC is required for the development of pancreatic cancer, a new study finds. (2019-05-01)

$4.6 million grant funds clinical trial of stem cell immunotherapy for metastatic sarcoma and other hard-to-treat cancers
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have been awarded a $4.6 million grant from the California Institute for Regenerative Medicine -- also known as CIRM -- to support a phase I clinical trial of a novel treatment for advanced sarcomas and other cancers with a specific tumor marker called NY-ESO-1. (2019-04-29)

NeurExo Sciences and Henry Ford present preclinical data on exposomes at ISEV2019
NeurExo Sciences, LLC and Henry Ford Health System today announced the presentation of new data on exosomes at the International Society for Extracellular Vesicles (ISEV) 2019 Annual Meeting being held April 24-28, 2019 in Kyoto, Japan. Among their key findings, Henry Ford researchers demonstrated the ability of exosomes to suppress chemotherapy-induced peripheral neuropathy and enhance the anti-tumor effects of platinum drugs, which are commonly used to treat cancers. (2019-04-26)

UBC Okanagan engineers make injectable tissues a reality
A simple injection that can help regrow damaged tissue has long been the dream of physicians and patients alike. A new study from researchers at UBC Okanagan moves that dream closer to reality with a device that makes encapsulating cells much faster, cheaper and more effective. (2019-04-25)

Blood cancer's Achilles' heel opens door for new treatments
New findings about an aggressive form of leukemia could aid the development of novel drugs to treat the condition. (2019-04-25)

UMBC program to support diverse students in STEM successfully replicated at PSU, UNC
Five years ago, Pennsylvania State University and University of North Carolina at Chapel Hill launched replications of UMBC's Meyerhoff Scholars Program, which over the last 30 years has earned national recognition for its strength in supporting diverse students in STEM. The positive results at PSU and UNC demonstrate that any institution committed to Meyerhoff principles can reproduce the program's results, and hopefully encourage other colleges and universities to partner with UMBC to launch similar initiatives. (2019-04-25)

The cellular source of fat tissue formation
Researchers working in mice and human tissue have identified several classes of adipocyte progenitor cells, which give rise to fat tissue, some of which reside in a recently discovered anatomical niche. (2019-04-25)

Seminal approach to recycle platelet concentrates for stem cell culture
In a paper to be published in a forthcoming issue of TECHNOLOGY, a consortium of researchers from Portugal have successfully conducted a proof-of-concept experiment to produce a new blood-derived product by application of pulsed electric fields (PEF) to platelet concentrates (PC) with no therapeutic value for transfusion medicine. This process guarantees the valorization of a blood-derived component that would otherwise be discarded. (2019-04-24)

Proteins stand up to nerve cell regression
Fruit fly studies reveal proteins that promote healthy nervous system development by preventing the reversal of nerve cell differentiation. (2019-04-24)

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