Current Stem Cells News and Events

Current Stem Cells News and Events, Stem Cells News Articles.
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Stem cell-based screen identifies potential new treatments
In a recent study published in Stem Cell Reports, Seba Almedawar, PhD, and colleagues with the Center for Regenerative Therapies TU Dresden, Germany, used induced pluripotent stem cells (iPSCs) derived from the skin of healthy donors and of patients with retinitis pigmentosa to find drugs with the potential to enhance RPE phagocytosis. (2020-11-25)

Mapping out the mystery of blood stem cells
Princess Margaret scientists have revealed how stem cells are able to generate new blood cells throughout our life by looking at vast, uncharted regions of our genetic material that hold important clues to subtle biological changes in these cells. (2020-11-25)

Researchers uncover the unique way stem cells protect their chromosome ends
Telomeres are specialized structures at the end of chromosomes which protect our DNA and ensure healthy division of cells. According to a new study from researchers at the Francis Crick Institute published in Nature, the mechanisms of telomere protection are surprisingly unique in stem cells. (2020-11-25)

Early trial hints CAR T cells may combat solid tumors in children with neuroblastoma
A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue. (2020-11-25)

Pre-treating progenitor cells with protein-activator slows progression of atherosclerosis
A new treatment for atherosclerosis, commonly known as hardening of the arteries, may be on the horizon, according to a study released in STEM CELLS Translational Medicine (SCTM). (2020-11-24)

World's first: Drug guides stem cells to desired location, improving their ability to heal
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy--a scientific first and major advance for the field of regenerative medicine. (2020-11-24)

Sestrin makes fruit flies live longer
Researchers identify positive effector behind reduced food intake. (2020-11-24)

Boosting stem cell activity can enhance immunotherapy benefits
Immune-system T cells have been reprogrammed into regenerative stem cell-like memory (TSCM) cells that are long-lived, highly active ''super immune cells'' with strong antitumor activity, according to new research from Georgetown Lombardi Comprehensive Cancer Center. (2020-11-23)

Scientists regenerate skin with stem cells to see how DNA defects in kids cause cancer
Physicians and scientists at Cincinnati Children's Hospital Medical Center used new stem cell technology to regenerate and study living patient-specific skin in the lab, giving them a precise close up view of how inherited DNA defects cause skin damage and deadly squamous cell carcinoma in children and young adults with Fanconi anemia (FA). (2020-11-23)

Researchers use cutting edge technology to bioprint mini-kidneys
Researchers have used cutting edge technology to bioprint miniature human kidneys in the lab, paving the way for new treatments for kidney failure and possibly lab-grown transplants. (2020-11-23)

Getting it just right - the Goldilocks model of cancer
Cancer is a disease driven by mutations that alter the way biochemical signals control cell growth, division and migration. Scientists at Duke-NUS Medical School found out that, like Goldilocks, cancer is very picky about getting rapid growth just right. (2020-11-20)

TTUHSC scientist takes next step in search for bone disease treatment
For more than a decade, TTUHSC's Hiranmoy Das, Ph.D., has been investigating how KLF2 influences the development of bone and musculoskeletal diseases. Most recently, Das attempted to determine if inducing KLF2 levels in dental pulp derived stem cells will promote osteoblast and the building of new bone. His study, ''KLF2 regulates dental pulp-derived stem cell differentiation through the induction of mitophagy and altering mitochondrial metabolism,'' was published in the September issue of Redox Biology. (2020-11-20)

Stem cell transplantation: undesirable rejection mechanism identified
In the treatment of leukaemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions - especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A team of researchers in Vienna has now identified an immune mechanism that is partially responsible for this. (2020-11-19)

Unraveling a mystery surrounding embryonic cells
Last year, researchers at the University of California, Riverside, identified the early origins of neural crest cells -- embryonic cells in vertebrates that travel throughout the body and generate many cell types -- in chick embryos. Now the researchers have used a human model to figure out when neural crest cells acquire distinctive molecular and functional attributes. (2020-11-18)

Coinfection: more than the sum of its parts
Infections with two pathogens pose a serious threat in the clinics. Researchers from W├╝rzburg and Jena have developed a technique that provides new insights into this process and can be used as an early warning system. (2020-11-18)

Promising results from in vitro combination therapy against COVID-19
Researchers at Karolinska Institutet in Sweden report promising results from an in vitro combination therapy against COVID-19. In a study published in EMBO Molecular Medicine, the researchers show that a combination of remdesivir, an approved drug against COVID-19, and hrsACE2, a medicine currently in phase II trials for COVID-19 treatment, reduced the viral load of SARS-CoV-2 and inhibited viral replication in cell cultures and organoids. (2020-11-17)

Non-hereditary mutation acts as natural gene therapy in patient with rare disease
Scientists at a research center supported by FAPESP identified a non-inherited mutation in blood cells from a patient with GATA2 deficiency that may have prevented bone marrow failure and other clinical manifestations. (2020-11-17)

Study reveals how smoking worsens COVID-19 infection in the airways
UCLA researchers using a model of airway tissue created from human stem cells have pinpointed how smoking cigarettes causes more severe infection by SARS-CoV-2, the virus that causes COVID-19, in the airways of the lungs. (2020-11-17)

Scientists discover new mechanism controlling brain size
International research headed by Danish Scientists has led to the discovery of a new mechanism that controls the size of our brains. The finding, which is based on studies on a rare congenital brain disease, delivers an important piece of data in our knowledge about how the human brain is formed during development. (2020-11-16)

The right tune for blood
Repetitive elements trigger RIG-I-like receptors to enhance hematopoietic stem cell formation (2020-11-15)

Circular RNA regulates neuronal differentiation by scaffolding an inhibitory transcription complex
In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly 'taps the brake' on neurogenesis. The results provide an interesting example of co-evolution of a circRNA, and its host-encoded protein product, that regulate each other's function, to directly impact the fundamental process of neurogenesis. (2020-11-13)

Neurons stripped of their identity are hallmark of Alzheimer's disease, study finds
Researchers at the University of California San Diego have identified new mechanisms in neurons that cause Alzheimer's disease. In particular, they discovered that changes in the structure of chromatin, the tightly coiled form of DNA, trigger neurons to lose their specialized function and revert to an earlier cell state. This results in the loss of synaptic connections, an effect associated with memory loss and dementia. (2020-11-13)

Researchers generate a brain cell type crucial to support neural activity
Researchers of the Department of Cellular Biology, Genetics and Physiology of the University of Malaga (UMA) have succeeded in generating human OLs from pluripotent stem cells derived from patients with nervous system diseases, specifically multiple sclerosis or ALS. (2020-11-12)

New study outlines steps higher education should take to prepare a new quantum workforce
A new study outlines ways colleges and universities can update their curricula to prepare the workforce for a new wave of quantum technology jobs. Three researchers, including Rochester Institute of Technology Associate Professor Ben Zwickl, suggested steps that need to be taken in a new paper in Physical Review Physics Education Research after interviewing managers at more than 20 quantum technology companies across the U.S. (2020-11-12)

Scientists can now scoop contents of individual cells from their local environment
The new tool combines cell microscopy with the single-cell DNA and protein sequencing technology to enable connecting important information about the cell's physical features and its local environment to its molecular makeup. (2020-11-11)

Organoids produce embryonic heart
Bioengineers at EPFL have used organoids - tiny lab-grown organs - to mimic the early development of the heart in the mouse embryo. The work is another step towards future bioartificial organs for research and transplants. (2020-11-10)

Scientists speed up artificial organoid growth and selection
The method currently used to produce stem cell-derived tissues has a very limited throughput. By semi-automating tissue differentiation, researchers from MIPT and Harvard have made the process nearly four times faster, without compromising on quality.The new algorithm is also useful for analyzing the factors that affect cell specialization. (2020-11-10)

Racial/ethnic minorities comprise small portion of patients referred with AL amyloidosis
Despite being theoretically at an increased risk for AL amyloidosis, underrepresented minorities make up only a small percentage of patients seen at specialized treatment centers for this disease. (2020-11-10)

Study sheds light on how MSCs suppress inflammation long after they leave the body
A new study released in STEM CELLS might just have solved the mystery behind why mesenchymal stem cells (MSCs) continue to suppress inflammation in the body long after the MSCs are cleared from the system. (2020-11-09)

The natural artistry of disease: a wintry landscape in the eye
Researchers from Tokyo Medical and Dental University (TMDU) report a case of frosted branch angiitis in a woman presenting years after being treated for leukemia-lymphoma with allogeneic human stem cell transplant. The relevance of this ocular finding is discussed and its value as an early warning sign of immune activation following therapeutic immunological interventions is highlighted. (2020-11-09)

A novel finding on Kabuki syndrome, a rare genetic disease
It has a long time since the cause of the disease has been identified: mutations of KMT2D gene codify for MLL4, a protein involved in the regulation of chromatin, which is the complex of proteins and nucleic acids contained in the nucleus of cells. However, research still has a long way to go to identify therapeutic approaches. An Italian team, coordinated by the University of Trento, has taken a step forward in this direction (2020-11-09)

An Amazonian tea stimulates the formation of new neurons
For centuries, indigenous societies in the Amazon have used ayahuasca, a hallucinogenic tea, for shamanic purposes. A research group led by the Complutense University of Madrid has shown that in animal models, this drink stimulates the formation of neurons and other brain cells, and thus offers a potential therapy for psychiatric disorders and neurodegenerative diseases. (2020-11-06)

Neural stem and progenitor cell diversity in brain development may contribute to cortical complexity
Stem and progenitor cells exhibit diversity in early brain development that likely contributes to later neural complexity in the adult cerebral cortex, this according to a new study published Nov. 6, 2020 in Science Advances. Researchers from the Center for Neuroscience Research (CNR) at Children's National Hospital say this research expands on existing ideas about brain development, and could significantly impact the clinical care of neurodevelopmental diseases in the future. (2020-11-06)

Blocking energy pathway reduces GVHD while retaining anti-cancer effects of T-cells
MUSC Hollings Cancer Center researchers identified that blocking an alternative energy pathway for T-cells after hematopoietic stem cell transplant helps reduce graft-versus-host disease in an animal model of leukemia. (2020-11-05)

'Monster tumors' could offer new glimpse at human development
Finding just the right model to study human development--from the early embryonic stage onward--has been a challenge for scientists over the last decade. Now, bioengineers at the University of California San Diego have homed in on an unusual candidate: teratomas. (2020-11-04)

Study points way to possible new treatment for ligament injuries
A new exosomes study released in STEM CELLS may lead to future treatment for ligament injuries. (2020-11-03)

Breakdown of gene coordination during aging suggests a substantial challenge to longevity
In a study published in the journal Nature Metabolism, researchers from Bar-Ilan University in Israel report evidence that supports, for the first time, a longstanding theory on the aging process in cells. Using a novel approach from physics, they developed a computational method that quantifies the coordination level between different genes. With this approach, they measured the gene activity of individual cells and compared cells from old and young subjects, discovering phenomena never before observed. (2020-11-02)

Stem cells: new insights for future regenerative medicine approaches
The study published in Open Biology unravels important data for a better understanding of the process of division in stem cells and for the development of safer ways to use them in medicine. (2020-10-28)

Scientists discover second key pathway in colon cancer stem cell growth
Scientists have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The scientists identified the link between the retinoic acid or RA signaling pathway and another pathway critical to tumor development, called the Wingless-related integration site or WNT pathway. WNT signaling gone wrong is associated with numerous cancers, likely contributing to drug resistance and tumor recurrence. (2020-10-28)

Baking soda treatment may help prevent leukemia relapse after stem cell transplants
Scientists have discovered that sodium bicarbonate - also known as baking soda or bicarbonate of soda - can reprogram T cells in leukemia patients to resist the immune-suppressing effects of cancer cells, which can drive leukemia relapse after stem cell transplants. (2020-10-28)

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