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Current Stem Cells News and Events, Stem Cells News Articles.
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Stem cell treatment for vascular diseases can be predicted through real-time observation
The Korea Institute of Science and Technology(KIST) recently announced that the collaborative research team led by Dr. Kwangmeyung Kim from Center for Theragnosis and Sung-Hwan Moon from Stem Cell Research Institute, T&R Biofab Co. Ltd developed a method that can predict the therapeutic efficacy based on the distribution of the initial transplantation of hEPCs by tracking the initial distribution and migration of the transplanted cells using fluorescence romographic images. (2020-12-18)

Three-dimensionally reconstituted organoids that are just like human organs
POSTECH-Seoul National University Hospital research team publishes the new concept of assembloids in Nature. (2020-12-18)

UMD paves the way for growing human organs for transplantation with new proof-of-concept
With the number of people who suffer from organ failures and the growing need for available organs for transplant, finding a new way to provide organs and therapeutic options to transplant patients is a critical need. In a new paper, University of Maryland researchers show for the first time that newly established stem cells from pigs could provide a solution, laying the groundwork for growing transplantable human organs. (2020-12-17)

New insights into Fragile X syndrome and the fetal brain
Researchers at Tohoku University have revealed further insight into the fetal development of our brain and the potential causes of Fragile X syndrome (FSX). (2020-12-16)

Molecules derived from omega-3 can regenerate inflamed periodontal tissue
An in vitro study by a Brazilian researcher shows that maresin and resolvin synthesized from fatty acid stimulate periodontal ligament stem cells even in the presence of inflammation (2020-12-16)

Oh so simple: Eight genes enough to convert mouse stem cells into oocyte-like cells
By activating just eight genes for transcription factors, researchers at Kyushu University have directly converted mouse stem cells into oocyte-like cells that mature and can even be fertilized like egg cells. In addition to giving new insight into egg cell development, the research may lead to a simple route for generating large amounts of oocyte cytoplasm for use in reproductive biology and medicine. (2020-12-16)

The bull's eye: New modified stem cells can deliver drugs specifically to tumor cells
Targeting drugs to cancer tissues is a major challenge in cancer treatment. Mesenchymal stem cells (MSCs) are known for their ability to find and target tumor cells in the body, but using MSCs for drug delivery has been tricky, because upon loading with drugs, MSCs lose their viability and migratory ability. Now, researchers from Tokyo University of Science have successfully modified MSCs to deliver large quantities of anti-cancer drugs in a targeted manner to developing cancer cells. (2020-12-16)

Cells resistant to treatment already present before diagnosis of adult leukaemia
This work is a collaboration between Núria López-Bigas' lab at IRB Barcelona and the groups headed by Anna Bigas (Hospital del Mar Medical Research Institute) and Josep Maria Ribera (Josep Carreras Leukaemia Research Institute). The results have been published in Genome Biology. (2020-12-16)

Stem cell-derived extracellular vesicles ease brain bleeding in newborn rats
Murine study, by researchers at Sungkyunkwan University in Seoul, shows how extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) can ease IVH-induced brain injuries. (2020-12-15)

Scientists: Xenon improves properties of maxillofacial and orthopedic implants
Scientists of Tomsk Polytechnic University (TPU) jointly with the colleagues from Siberian State Medical University (SSMU) and Immanuel Kant Baltic Federal University (IKBFU) studied the properties of calcium phosphate coatings deposited on titanium implants in various inert gases environment. The researchers managed to discover that the use of xenon positively affects the physicochemical, mechanical and biological properties of the coatings used in oral and maxillofacial surgery, orthopedics and traumatology. (2020-12-15)

Cancer researchers identify potential new class of drugs to treat blood and bone marrow cancers
CLEVELAND - A new study by researchers in Cleveland Clinic's Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia. The results first appeared online in Blood Cancer Discovery. (2020-12-15)

Research dispels fears human stem cells contain cancer-causing mutations
Pioneering new research has made a pivotal breakthrough that dispel concerns that human stem cells could contain cancer-causing mutations. (2020-12-14)

Study reveals networks of genes involved in congenital heart disease
A group researchers at Gladstone Institutes and UC San Francisco led by Benoit Bruneau have made inroads into understanding what genes are improperly deployed in some cases of congenital heart disease. Their study, published in Developmental Cell, could point toward new ways to prevent or treat one of the most common birth defects. (2020-12-14)

Aging, diet-induced obesity, and metabolic disease link explored in new research
Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science Center at Houston (UTHealth). (2020-12-14)

Scientists build whole functioning thymus from human cells
Researchers at the Francis Crick Institute and University College London have rebuilt a human thymus, an essential organ in the immune system, using human stem cells and a bioengineered scaffold. Their work is an important step towards being able to build artificial thymi which could be used as transplants. (2020-12-11)

Embryonic development in a petri dish
3D cell culturing technique could replace mouse embryos (2020-12-10)

Targeting T cell protein could prevent type 1 diabetes, study suggests
Researchers at the University of Utah School of Medicine have identified a new therapeutic target to treat patients with type 1 diabetes. The study, which will be published December 9 in the Journal of Experimental Medicine (JEM), reveals that inhibiting a protein called OCA-B protects mice from type 1 diabetes by limiting the activity of immune cells that would otherwise destroy the pancreas' insulin-producing β cells. (2020-12-09)

Racial microaggressions contribute to disparities in STEM education
Careers in science, technology, engineering, and mathematics (STEM) are one of the fastest-growing areas of work in the United States, yet racial and gender disparities remain in STEM occupations. A recent study from University of Illinois researchers examining reasons for such disparities shows the overall racial climate on a college campus--informed by experiences of racial microaggressions--is a contributing factor in the lack of representation of students of color in STEM education programs. (2020-12-08)

New method to boost supply of life-saving stem cells
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City have found a new method for growing a large quantity of life-saving blood stem cells. The scarcity of these cells is one of the greatest limitations for their use in a variety of medical procedures, from treatment of blood cancers to inherited blood disorders that require a bone marrow transplantation. (2020-12-08)

Lab-grown human brain organoids mimic an autism spectrum disorder, help test treatments
UC San Diego researchers used brain organoids to identify two drug candidates that counteract the genetic deficiencies that cause Rett syndrome, a rare form of autism spectrum disorder. (2020-12-08)

Children's Hospital Colorado study published in Science Immunology
Children's Hospital Colorado (Children's Colorado) Center for Cancer and Blood Disorders (CCBD) announced today that a study about the manipulation of bone marrow stem cells into innate lymphoid and natural killer cells will be published in Science Immunology, a well-respected, high-impact medical journal. (2020-12-07)

Circulating tumor DNA indicates risk of relapse after transplant in DLBCL patients
Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse. (2020-12-07)

New fundamental knowledge of the 'abdominal brain'
Researchers at Karolinska Institutet have succeeded in mapping the neuron types comprising the enteric nervous system in the intestine of mice. The study, which is published today in the scientific journal Nature Neuroscience, also describes how the different neurons form during fetal development, a process that follows different principles to brain neurons. (2020-12-07)

Study finds large-scale expansion of stem rust resistance gene in barley and oat lineages
Stem rust is one of the most devastating fungal diseases of wheat and historically has caused dramatic, widespread crop failures resulting in significant yield losses around the world. Stem rust epidemics in major wheat growing areas could cause a major threat to global food security. Scientists have identified a resistance gene, Sr22, as one of the few characterized genes that protects against a large array of stem rust races. (2020-12-07)

Scientists discover how COVID-19 virus causes multiple organ failure in mice
UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs. Using their model, the scientists discovered that the SARS-CoV-2 virus can shut down energy production in cells of the heart, kidneys, spleen and other organs. (2020-12-07)

Radicals seem to be good for the brain
Scientists of the German Center for Neurodegenerative Diseases (DZNE) report in the journal Cell Stem Cell that reactive oxygen molecules, also known as 'free radicals.' are important for the brain's ability to adapt -- at least in mice. (2020-12-04)

Donor stem cell transplant shown to improve survival in older patients with MDS
A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting. (2020-12-04)

First in nation treatment for chronic subdural hematoma at Los Robles Health System
Los Robles Health System is leading the way in neurovascular clinical trials. Interventional neurologist, Dr. Asif Taqi, is the principal investigator of the STEM Study, a landmark trial that can change the management of chronic subdural hematomas completely. Los Robles enrolled and treated the first patient in the nation into this trial. (2020-12-04)

Development of new stem cell type may lead to advances in regenerative medicine
A team led by UT Southwestern has derived a new ''intermediate'' embryonic stem cell type from multiple species that can contribute to chimeras and create precursors to sperm and eggs in a culture dish. (2020-12-03)

New theory of root competition reveals rules governing growth
In the presence of competitors, plants overproduce roots to snatch up nearby resources but avoid foraging for nutrients near their neighbors, according to a new study, which provides a new theoretical foundation for understanding the rules that govern competitive root behavior. (2020-12-03)

Retinal transplant boost opens door to treat eyesight loss
Researchers have identified two cell signals - Ccr5 and Cxcr6 - that are sent out by dying retinal cells to recruit stem cells and repair eye damage. When genetically engineered stem cells with an overabundance of Ccr5 and Cxcr6 cell receptors were transplanted into human and mouse models, they displayed a significantly higher rate of migration to degenerating retinal tissue, rescuing them from death and preserving their function. (2020-12-01)

CRISPR tagging improves accuracy of model cells grown from stem cells
CRISPR tags are being used to identify all of the transcription factors necessary to turn a pluripotent stem cell into a suitable adult cell for research, and possible future cell therapies. A paper in Cell Reports documents its use for making adult neuronal cells, but the technique could be applied to any cell type. (2020-12-01)

Why long-suffering hosts grow a thick skin
Researchers from the University of Tsukuba have shown that the skin fibrosis seen in chronic graft-versus-host disease is mediated by transforming growth factor-β1 expressed by epidermal cells undergoing programmed death when they are stimulated by interferon-γ. Further investigations elucidate the sclerodermatous changes characteristic of autoimmune and inflammatory conditions such as systemic sclerosis, discoid lupus erythematosus and toxic epidermal necrolysis, thus opening up research avenues in pharmacotherapeutics based on targeting apoptosis and interferon-γ. (2020-12-01)

Telomere shortening protects against cancer
Researchers have found the first evidence that telomere shortening is not just a sign of aging, but a key component of the body's cancer prevention system. (2020-12-01)

Researchers identify gene responsible for cellular aging
Cellular reprogramming can reverse the aging that leads to a decline in the activities and functions of mesenchymal stem/stromal cells (MSCs). A study released in STEM CELLS appears to have solved the mystery of which molecular mechanisms are responsible for this reversal and provides insight into developing pharmacological strategies to reduce or reverse the aging process. (2020-11-30)

Customized programming of human stem cells
Induced pluripotent stem cells (iPS) have the potential to convert into a wide variety of cell types and tissues. However, the ''recipes'' for this conversion are often complicated and difficult to implement. Researchers at TU Dresden, Harvard University (USA) and the University of Bonn have found a way to systematically extract hundreds of different cells quickly and easily from iPS using transcription factors. Researchers can use this transcription factor source through the non-profit organization Addgene. (2020-11-30)

Gene therapy gives man with sickle cell disease the chance for a better future
Watch a video about Evie's treatment with an experimental gene therapy for sickle cell disease here: https://www.youtube.com/watch?v=XmQJpuLx07Y (2020-11-30)

Researchers develop new biomaterial that helps bones heal faster
Scientists have developed a new biomaterial that helps bones heal faster by enhancing adults' stem cell regenerative ability. (2020-11-27)

Scientists describe the role of a p53 target gene in lymphoma and lung cancer development
An international team of scientists has studied whether Zmat3 could have critical functions that p53, the most important gene in preventing cancer, uses to prevent cancer. Their findings have shifted the focus of how Zmat3 could function in tumor development. (2020-11-27)

Stem cell-based screen identifies potential new treatments
In a recent study published in Stem Cell Reports, Seba Almedawar, PhD, and colleagues with the Center for Regenerative Therapies TU Dresden, Germany, used induced pluripotent stem cells (iPSCs) derived from the skin of healthy donors and of patients with retinitis pigmentosa to find drugs with the potential to enhance RPE phagocytosis. (2020-11-25)

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